Elie Nader, Marc Romana, Nicolas Guillot, Romain Fort, Emeric Stauffer, Nathalie Lemonne, Yohann Garnier, Sarah Chambers Skinner, Maryse Etienne-Julan, Mélanie Robert, Alexandra Gauthier, Giovanna Cannas, Sophie Antoine-Jonville, Benoît Tressières, Marie-Dominique Hardy-Dessources, Yves Bertrand, Cyril Martin, Céline Renoux, Philippe Joly, Marijke Grau, Philippe Connes
Chronic hemolysis, enhanced oxidative stress, and decreased nitric oxide (NO) bioavailability promote vasculopathy in sickle cell anemia (SCA). Oxidative stress and NO are known to modulate eryptosis in healthy red blood cells (RBCs); however, their role in SCA eryptosis and their impact on the genesis of RBC-derived microparticles (RBC-MPs) remains poorly described. RBC-MPs could play a role in vascular dysfunction in SCA. The aims of this study were to evaluate the roles of oxidative stress and NO in eryptosis and RBC-MPs release, and to determine whether RBC-MPs could be involved in vascular dysfunction in SCA...
2020: Frontiers in Immunology