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https://www.readbyqxmd.com/read/27738822/the-role-of-laryngeal-electromyography-in-vagus-nerve-stimulation-related-vocal-fold-dysmotility
#1
Alberto M Saibene, Elena Zambrelli, Carlotta Pipolo, Alberto Maccari, Giovanni Felisati, Elena Felisati, Francesca Furia, Aglaia Vignoli, Maria Paola Canevini, Enrico Alfonsi
Vagus nerve stimulation (VNS) is a useful tool for drug-resistant epilepsy, but it induces known laryngeal side effects, with a significant role on patients' quality of life. VNS patients may show persistent left vocal fold (LVF) palsy at rest and/or recurrent LVF adduction during stimulation. This study aims at electromyographically evaluating laryngeal muscles abnormalities in VNS patients. We compared endoscopic laryngeal evaluation data in six VNS patients with laryngeal muscle electromyography (LMEMG) carried out on the thyroarytenoid, cricothyroid, posterior cricoarytenoid, and cricopharyngeal muscles...
October 13, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27579580/diagnosing-and-assessing-pain-in-neurorehabilitation-from-translational-research-to-the-clinical-setting-evidence-and-recommendations-from-the-italian-consensus-conference-on-pain-in-neurorehabilitation
#2
Carlo A Porro, Giorgio Sandrini, Andrea Truini, Valeria Tugnoli, Enrico Alfonsi, Laura Berliocchi, Carlo Cacciatori, Silvia LA Cesa, Francesca Magrinelli, Paola Sacerdote, Massimiliano Valeriani
Pain is very common in neurorehabilitation, where it may be a target for treatment and have a negative effect on rehabilitation procedures and outcomes. Promising preliminary preclinical data support some therapeutic approaches to pain, but there is a strong need of adequate preclinical models, experimental settings, outcome measures, and biomarkers that could be more relevant for pain within the neurorehabilitation field. Data on diagnosis and assessment of nociceptive and neuropathic pain (NP) are very scanty in neurorehabilitation, but those from other contexts can be adapted and translated in this specific setting...
August 31, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27444734/cross-cultural-adaptation-and-validation-of-the-italian-version-of-swal-qol
#3
Daniela Ginocchio, Enrico Alfonsi, Francesco Mozzanica, Anna Rosa Accornero, Antonella Bergonzoni, Giulia Chiarello, Nicoletta De Luca, Daniele Farneti, Simonelli Marilia, Paola Calcagno, Valentina Turroni, Antonio Schindler
The aim of the study was to evaluate the reliability and validity of the Italian SWAL-QOL (I-SWAL-QOL). The study consisted of five phases: item generation, reliability analysis, normative data generation, validity analysis, and responsiveness analysis. The item generation phase followed the five-step, cross-cultural, adaptation process of translation and back-translation. A group of 92 dysphagic patients was enrolled for the internal consistency analysis. Seventy-eight patients completed the I-SWAL-QOL twice, 2 weeks apart, for test-retest reliability analysis...
October 2016: Dysphagia
https://www.readbyqxmd.com/read/27308303/neurofascin-155-as-a-putative-antigen-in-combined-central-and-peripheral-demyelination
#4
Andrea Cortese, Jérôme J Devaux, Elisabetta Zardini, Constance Manso, Guillaume Taieb, Clarisse Carra Dallière, Philippe Merle, Cecilia Osera, Silvia Romagnolo, Nicolò Visigalli, Giuseppe Piscosquito, Ettore Salsano, Enrico Alfonsi, Arrigo Moglia, Davide Pareyson, Enrico Marchioni, Diego Franciotta
No abstract text is available yet for this article.
August 2016: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/26901877/key-role-of-sequencing-to-trace-hepatitis-a-viruses-circulating-in-italy-during-a-large-multi-country-european-foodborne-outbreak-in-2013
#5
Roberto Bruni, Stefania Taffon, Michele Equestre, Paola Chionne, Elisabetta Madonna, Caterina Rizzo, Maria Elena Tosti, Valeria Alfonsi, Lara Ricotta, Dario De Medici, Simona Di Pasquale, Gaia Scavia, Enrico Pavoni, Marina Nadia Losio, Luisa Romanò, Alessandro Remo Zanetti, Anna Morea, Monia Pacenti, Giorgio Palù, Maria Rosaria Capobianchi, Maria Chironna, Maria Grazia Pompa, Anna Rita Ciccaglione
BACKGROUND: Foodborne Hepatitis A Virus (HAV) outbreaks are being recognized as an emerging public health problem in industrialized countries. In 2013 three foodborne HAV outbreaks occurred in Europe and one in USA. During the largest of the three European outbreaks, most cases occurred in Italy (>1,200 cases as of March 31, 2014). A national Task Force was established at the beginning of the outbreak by the Ministry of Health. Mixed frozen berries were early demonstrated to be the source of infection by the identity of viral sequences in patients and in food...
2016: PloS One
https://www.readbyqxmd.com/read/26727706/acute-effects-of-high-frequency-microfocal-vibratory-stimulation-on-the-h-reflex-of-the-soleus-muscle-a-double-blind-study-in-healthy-subjects
#6
RANDOMIZED CONTROLLED TRIAL
Enrico Alfonsi, Paolo Paone, Cristina Tassorelli, Roberto De Icco, Arrigo Moglia, Elena Alvisi, Lucky Marchetta, Mauro Fresia, Alessandra Montini, Marzia Calabrese, Vittorio Versiglia, Giorgio Sandrini
This study in healthy subjects examined the effects of a system delivering focal microvibrations at high frequency (Equistasi®) on tonic vibration stimulus (TVS)-induced inhibition of the soleus muscle H reflex. Highfrequency microvibrations significantly increased the inhibitory effect of TVS on the H reflex for up to three minutes. Moreover, Equistasi® also significantly reduced alpha-motoneuron excitability, as indicated by the changes in the ratio between the maximumamplitude H reflex (Hmax reflex) and the maximumamplitude muscle response (Mmax response); this effect was due to reduction of the amplitude of the H reflex because the amplitude of muscle response remained unchanged...
October 2015: Functional Neurology
https://www.readbyqxmd.com/read/26649163/successful-reconstruction-of-nerve-defects-using-distraction-neurogenesis-with-a-new-experimental-device
#7
Mohamed Abdelhamid Ali Yousef, Paolo Dionigi, Stefania Marconi, Alberto Calligaro, Antonia Icaro Cornaglia, Enrico Alfonsi, Ferdinando Auricchio
INTRODUCTION: Repair of peripheral nerve injuries is an intensive area of challenge and research in modern reconstructive microsurgery. Intensive research is being carried out to develop effective alternatives to the standard nerve autografting, avoiding its drawbacks. The aim of the study was to evaluate the effectiveness of a newly designed mechanical device for the reconstruction of the sciatic nerve in rats in comparison to nerve autografting and to assess the pain during the period of distraction neurogenesis...
October 2015: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/26271609/electrophysiological-investigations-of-shape-and-reproducibility-of-oropharyngeal-swallowing-interaction-with-bolus-volume-and-age
#8
Enrico Alfonsi, Giuseppe Cosentino, Luca Mainardi, Antonio Schindler, Mauro Fresia, Filippo Brighina, Marco Benazzo, Arrigo Moglia, Elena Alvisi, Brigida Fierro, Giorgio Sandrini
Electrophysiological assessment provides valuable information on physiological and pathophysiological characteristics of human swallowing. Here, new electrophysiological measures for the evaluation of oropharyngeal swallowing were assessed: (1) the activation pattern of the submental/suprahyoid EMG activity (SHEMG); (2) the reproducibility of the oral and pharyngeal phases of swallowing, by calculating the similarity index (SI) of the SHEMG (SI-SHEMG) and of the laryngeal-pharyngeal mechanogram (SI-LPM) during repeated swallows; and (3) kinesiological measures related to the LPM...
October 2015: Dysphagia
https://www.readbyqxmd.com/read/25476449/gli1-dna-interaction-is-a-druggable-target-for-hedgehog-dependent-tumors
#9
Paola Infante, Mattia Mori, Romina Alfonsi, Francesca Ghirga, Federica Aiello, Sara Toscano, Cinzia Ingallina, Mariangela Siler, Danilo Cucchi, Agnese Po, Evelina Miele, Davide D'Amico, Gianluca Canettieri, Enrico De Smaele, Elisabetta Ferretti, Isabella Screpanti, Gloria Uccello Barretta, Maurizio Botta, Bruno Botta, Alberto Gulino, Lucia Di Marcotullio
Hedgehog signaling is essential for tissue development and stemness, and its deregulation has been observed in many tumors. Aberrant activation of Hedgehog signaling is the result of genetic mutations of pathway components or other Smo-dependent or independent mechanisms, all triggering the downstream effector Gli1. For this reason, understanding the poorly elucidated mechanism of Gli1-mediated transcription allows to identify novel molecules blocking the pathway at a downstream level, representing a critical goal in tumor biology...
January 13, 2015: EMBO Journal
https://www.readbyqxmd.com/read/25454732/suitability-of-north-star-ambulatory-assessment-in-young-boys-with-duchenne-muscular-dystrophy
#10
MULTICENTER STUDY
Roberto De Sanctis, Marika Pane, Serena Sivo, Valeria Ricotti, Giovanni Baranello, Silvia Frosini, Elena Mazzone, Flaviana Bianco, Lavinia Fanelli, Marion Main, Alice Corlatti, Adele D'Amico, Giulia Colia, Roberta Scalise, Concetta Palermo, Chiara Alfonsi, Giovanna Tritto, Domenico M Romeo, Alessandra Graziano, Roberta Battini, Lucia Morandi, Enrico Bertini, Francesco Muntoni, Eugenio Mercuri
The aim of this study was to establish the suitability of the North Star Ambulatory Assessment for use in young boys with Duchenne muscular dystrophy. We studied 147 typically developing and 144 boys affected by Duchenne muscular dystrophy between the ages of 3 and 5 years. More than 85% of the typically developing boys by the age of 4 years had full scores on all the items with total scores ≥33/34. Before the age of 4 years more than 15% of the typically developing boys did not achieve full scores on all the items...
January 2015: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/25301763/transcranial-direct-current-stimulation-enhances-sucking-of-a-liquid-bolus-in-healthy-humans
#11
RANDOMIZED CONTROLLED TRIAL
Giuseppe Cosentino, Enrico Alfonsi, Filippo Brighina, Mauro Fresia, Brigida Fierro, Giorgio Sandrini, Antonio Schindler, Francesca Valentino, Danilo Fontana, Alberto Priori
BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive technique used for modulating cortical excitability in vivo in humans. Here we evaluated the effect of tDCS on behavioral and electrophysiological aspects of physiological sucking and swallowing. METHODS: Twelve healthy subjects underwent three tDCS sessions (anodal, cathodal and sham stimulation) on separate days in a double-blind randomized order. The active electrode was placed over the right swallowing motor cortex...
November 2014: Brain Stimulation
https://www.readbyqxmd.com/read/24822247/reduced-threshold-for-inhibitory-homeostatic-responses-in-migraine-motor-cortex-a-tdcs-tms-study
#12
Giuseppe Cosentino, Filippo Brighina, Simona Talamanca, Piera Paladino, Simone Vigneri, Roberta Baschi, Serena Indovino, Simona Maccora, Enrico Alfonsi, Brigida Fierro
BACKGROUND AND OBJECTIVE: Neurophysiological studies in migraine have reported conflicting findings of either cortical hyper- or hypoexcitability. In migraine with aura (MwA) patients, we recently documented an inhibitory response to suprathreshold, high-frequency repetitive transcranial magnetic stimulation (hf-rTMS) trains applied to the primary motor cortex, which is in contrast with the facilitatory response observed in the healthy subjects. The aim of the present study was to support the hypothesis that in migraine, because of a condition of basal increased cortical responsivity, inhibitory homeostatic like mechanisms of cortical excitability could be induced by high magnitude stimulation...
April 2014: Headache
https://www.readbyqxmd.com/read/24421885/6-minute-walk-test-in-duchenne-md-patients-with-different-mutations-12-month-changes
#13
Marika Pane, Elena S Mazzone, Maria Pia Sormani, Sonia Messina, Gian Luca Vita, Lavinia Fanelli, Angela Berardinelli, Yvan Torrente, Adele D'Amico, Valentina Lanzillotta, Emanuela Viggiano, Paola D'Ambrosio, Filippo Cavallaro, Silvia Frosini, Luca Bello, Serena Bonfiglio, Roberta Scalise, Roberto De Sanctis, Enrica Rolle, Flaviana Bianco, Marlene Van der Haawue, Francesca Magri, Concetta Palermo, Francesca Rossi, Maria Alice Donati, Chiara Alfonsi, Michele Sacchini, Maria Teresa Arnoldi, Giovanni Baranello, Tiziana Mongini, Antonella Pini, Roberta Battini, Elena Pegoraro, Stefano C Previtali, Sara Napolitano, Claudio Bruno, Luisa Politano, Giacomo P Comi, Enrico Bertini, Lucia Morandi, Francesca Gualandi, Alessandra Ferlini, Nathalie Goemans, Eugenio Mercuri
OBJECTIVE: In the last few years some of the therapeutical approaches for Duchenne muscular dystrophy (DMD) are specifically targeting distinct groups of mutations, such as deletions eligible for skipping of individual exons. The aim of this observational study was to establish whether patients with distinct groups of mutations have different profiles of changes on the 6 minute walk test (6MWT) over a 12 month period. METHODS: The 6MWT was performed in 191 ambulant DMD boys at baseline and 12 months later...
2014: PloS One
https://www.readbyqxmd.com/read/24117647/upper-esophageal-sphincter-dysfunction-diverticula-globus-pharyngeus
#14
REVIEW
Antonio Schindler, Francesco Mozzanica, Enrico Alfonsi, Daniela Ginocchio, Erwin Rieder, Johannes Lenglinger, Sebastian F Schoppmann, Martina Scharitzer, Peter Pokieser, Shiko Kuribayashi, Osamu Kawamura, Motoyasu Kusano, Karol Zelenik
The following discussion of upper esophageal sphincter dysfunction includes commentaries on the role of the cricopharyngeus muscle in reflux disease; the etiology and treatment of Zenker diverticulum; the use of videofluoroscopy in patients with dysphagia, suspicion of aspiration, or globus; the role of pH-impedance monitoring in globus evaluation; and treatment for reflux-associated globus.
October 2013: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/23345638/als-dysphagia-pathophysiology-differential-botulinum-toxin-response
#15
Domenico A Restivo, Antonino Casabona, Alessia Nicotra, Mario Zappia, Maurizio Elia, Marcello C Romano, Enrico Alfonsi, Rosario Marchese-Ragona
OBJECTIVES: This study looked at the effect of botulinum toxin type A (BoTox-A) in patients with amyotrophic lateral sclerosis (ALS) with dysphagia due to isolated upper motor neuron (UMN) involvement or combined UMN/lower motor neuron (LMN) impairment associated with oral phase or oropharyngeal muscles involvement. Establishing whether different pathophysiologic mechanisms underlie different responses to BoTox-A treatment may have important implications for patient management. PATIENTS AND METHODS: We screened 35 patients with sporadic ALS with dysphagia and included in the study 20 out of 35 with upper esophageal sphincter (UES) hyperactivity...
February 12, 2013: Neurology
https://www.readbyqxmd.com/read/23325908/postinfectious-neurologic-syndromes-a-prospective-cohort-study
#16
Enrico Marchioni, Sabrina Ravaglia, Cristina Montomoli, Eleonora Tavazzi, Lorenzo Minoli, Fausto Baldanti, Milena Furione, Enrico Alfonsi, Roberto Bergamaschi, Alfredo Romani, Laura Piccolo, Elisabetta Zardini, Stefano Bastianello, Anna Pichiecchio, Pasquale Ferrante, Serena Delbue, Diego Franciotta, Giorgio Bono, Mauro Ceroni
OBJECTIVES: Postinfectious neurologic syndromes (PINSs) of the CNS include heterogeneous disorders, sometimes relapsing. In this study, we aimed to a) describe the spectrum of PINSs; b) define predictors of outcome in PINSs; and c) assess the clinical/paraclinical features that help differentiate PINSs from multiple sclerosis (MS). METHODS: In this prospective cohort study, adult inpatients with PINSs underwent extensive diagnostic assessment and therapeutic protocols at inclusion and during a minimum 2-year follow-up...
March 5, 2013: Neurology
https://www.readbyqxmd.com/read/21997192/pisa-syndrome-in-parkinson-s-disease-clinical-electromyographic-and-radiological-characterization
#17
Cristina Tassorelli, Anna Furnari, Simona Buscone, Enrico Alfonsi, Claudio Pacchetti, Roberta Zangaglia, Anna Pichiecchio, Stefano Bastianello, Alessandro Lozza, Marta Allena, Monica Bolla, Giorgio Sandrini, Giuseppe Nappi, Emilia Martignoni
Abnormal postures of the trunk are a typical feature of Parkinson's disease (PD). These include Pisa syndrome (PS), a tonic lateral flexion of the trunk associated with slight rotation along the sagittal plane. In this study we describe clinical, electromyographic (EMG), and radiological features of PS in a group of 20 PD patients. All patients with trunk deviation underwent EMG and radiological (RX and CT scan) investigation. Clinical characteristics of patients with PS were compared with a control group of PD patients without trunk deviation...
February 2012: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/21871075/psychopathological-features-of-irritable-bowel-syndrome-patients-with-and-without-functional-dyspepsia-a-cross-sectional-study
#18
COMPARATIVE STUDY
Daria Piacentino, Rosanna Cantarini, Marianna Alfonsi, Danilo Badiali, Nadia Pallotta, Massimo Biondi, Enrico S Corazziari
BACKGROUND: Irritable bowel syndrome (IBS) and functional dyspepsia (FD) show considerable overlap and are both associated with psychiatric comorbidity. The present study aimed to investigate whether IBS patients with FD show higher levels of psychopathology than those without FD. As a preliminary analysis, it also evaluated the psychopathological differences, if any, between IBS patients featuring the two Rome III-defined FD subtypes, i.e. postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS)...
2011: BMC Gastroenterology
https://www.readbyqxmd.com/read/21369848/anti-ma2-ta-antibodies-in-a-woman-with-primary-lateral-sclerosis-like-phenotype-and-sj%C3%A3-gren-syndrome
#19
Giovanni Piccolo, Eleonora Tavazzi, Sven Jarius, Enrico Alfonsi, Lorenzo Cavagna, Laura Piccolo, Elisabetta Zardini, Raymond Voltz, Diego Franciotta
Anti-Ma2/Ta antibodies are rare paraneoplastic antibodies, which are mostly associated with limbic encephalitis in male patients with testicular cancer. We report on a 50-year-old woman with a pure progressive spastic paraparesis. Next, she was diagnosed as having a Sjögren syndrome, with serological positivity for anti-SS-Ro antibodies. The patient's serum and cerebrospinal fluid samples were positive for anti-Ma2/Ta antibodies, which were also proved to be intrathecally produced. These findings, and the coexistence of systemic autoimmunity, led us to treat the patient with corticosteroids first, and then with plasma exchange...
October 2011: Neurological Sciences
https://www.readbyqxmd.com/read/19089677/dysphagia-in-multiple-sclerosis-from-pathogenesis-to-diagnosis
#20
REVIEW
Cristina Tassorelli, Roberto Bergamaschi, Simona Buscone, Michelangelo Bartolo, Anna Furnari, Paola Crivelli, Enrico Alfonsi, Elisa Alberici, Giulia Bertino, Giorgio Sandrini, Giuseppe Nappi
Abnormalities of swallowing are commonly encountered in Multiple Sclerosis (MS), especially in the most disabled patients. The disturbances usually involve oral and pharyngeal phases of swallowing, although upper oesophageal sphincter dysfunction has also been detected. MS patients need to be effectively evaluated and managed in order to recognize dysphagia before any medical complications such as aspiration pneumonia appear. An integrated approach is proposed to define the severity of dysphagia and to devise the most appropriate therapeutic/rehabilitative methodology...
December 2008: Neurological Sciences
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