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Keywords Metabolic changes with psychia...

Metabolic changes with psychiatric medication

https://read.qxmd.com/read/38531835/identifying-plasma-metabolic-characteristics-of-major-depressive-disorder-bipolar-disorder-and-schizophrenia-in-adolescents
#1
JOURNAL ARTICLE
Bangmin Yin, Yuping Cai, Teng Teng, Xiaolin Wang, Xueer Liu, Xuemei Li, Jie Wang, Hongyan Wu, Yuqian He, Fandong Ren, Tianzhang Kou, Zheng-Jiang Zhu, Xinyu Zhou
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are classified as major mental disorders and together account for the second-highest global disease burden, and half of these patients experience symptom onset in adolescence. Several studies have reported both similar and unique features regarding the risk factors and clinical symptoms of these three disorders. However, it is still unclear whether these disorders have similar or unique metabolic characteristics in adolescents. We conducted a metabolomics analysis of plasma samples from adolescent healthy controls (HCs) and patients with MDD, BD, and SCZ...
March 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38494132/high-persistence-and-low-treatment-rates-of-metabolic-syndrome-in-patients-with-mood-and-anxiety-disorders-a-naturalistic-follow-up-study
#2
JOURNAL ARTICLE
Jurriaan J M J L Brouwer, Klaas J Wardenaar, Edith J Liemburg, Bennard Doornbos, Hans Mulder, Danielle C Cath
BACKGROUND: Patients with affective and anxiety disorders are at risk of metabolic syndrome (MetS) and, consequently, cardiovascular disease and premature death. In this study, the course and treatment of MetS was investigated using longitudinal data from a naturalistic sample of affective- and anxiety-disordered outpatients (Monitoring Outcome of psychiatric PHARmacotherapy [MOPHAR]). METHODS: Demographics, clinical characteristics, medication use, and MetS components were obtained for n = 2098 patients at baseline and, in a FU-subsample of n = 507 patients, after a median follow-up (FU) of 11 months...
March 15, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38482703/-comorbidities-in-multiple-sclerosis-and-their-influence-on-the-choice-of-treatment
#3
REVIEW
A Barboza, V Sinay, R Alonso, E Carnero-Contentti, J Hryb, B Silva, D Tavolini, M C Ysrraelit, J Correale
Clinical trials of disease-modifying therapies (DMTs) for people with multiple sclerosis (pMS) are conducted in selected populations, excluding patients with comorbidities or concomitant medications. However, a large percentage of pMS have some additional disease, which could affect the response and choice of the DMT. The objective of this review is to assess how concurrent pathologies can impact the choice of DMTs. Relevant articles were selected through a systematic search in PubMed. Comorbidities were grouped for better classification into autoimmune, chronic infections, cardiovascular and metabolic, oncological and neuropsychiatric...
March 16, 2024: Revista de Neurologia
https://read.qxmd.com/read/38427674/management-of-antipsychotics-in-primary-care-insights-from-healthcare-professionals-and-policy-makers-in-the-united-kingdom
#4
JOURNAL ARTICLE
Alan A Woodall, Aseel S Abuzour, Samantha A Wilson, Frances S Mair, Iain Buchan, Sally B Sheard, Paul Atkinson, Dan W Joyce, Pyers Symon, Lauren E Walker
INTRODUCTION: Antipsychotic medication is increasingly prescribed to patients with serious mental illness. Patients with serious mental illness often have cardiovascular and metabolic comorbidities, and antipsychotics independently increase the risk of cardiometabolic disease. Despite this, many patients prescribed antipsychotics are discharged to primary care without planned psychiatric review. We explore perceptions of healthcare professionals and managers/directors of policy regarding reasons for increasing prevalence and management of antipsychotics in primary care...
2024: PloS One
https://read.qxmd.com/read/38419952/case-report-uncovering-hidden-glucose-patterns-in-medicated-versus-unmedicated-bipolar-disorder-and-comorbid-type-1-diabetes-mellitus
#5
Dagmar Breznoscakova, Maria Pallayova
INTRODUCTION: Type 1 diabetes mellitus is characterized by an absolute insulin deficiency requiring the lifetime intensive insulin therapy accompanied by daily self-monitoring, self-management, ongoing education, and complex diabetes care. Regular patient-clinician shared therapeutic decisions based on age, sex, comorbidities, medications, predicted impact of meals, physical activity, stress, hormonal changes, insulin therapy, and patterns of glycemic changes are key for achieving glycemic targets...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38418685/untargeted-metabolomic-and-proteomic-analysis-identifies-metabolic-biomarkers-and-pathway-alterations-in-individuals-with-22q11-2-deletion-syndrome
#6
JOURNAL ARTICLE
Marwa Zafarullah, Kathleen Angkustsiri, Austin Quach, Seungjun Yeo, Blythe P Durbin-Johnson, Heather Bowling, Flora Tassone
INTRODUCTION: The chromosome 22q11.2 deletion syndrome (22q11.2DS) is characterized by a well-defined microdeletion and is associated with a wide range of brain-related phenotypes including schizophrenia spectrum disorders (SCZ), autism spectrum disorders (ASD), anxiety disorders and attention deficit disorders (ADHD). The typically deleted region in 22q11.2DS contains multiple genes which haploinsufficiency has the potential of altering the protein and the metabolic profiles. OBJECTIVES: Alteration in metabolic processes and downstream protein pathways during the early brain development may help to explain the increased prevalence of the observed neurodevelopmental phenotypes in 22q11...
February 28, 2024: Metabolomics: Official Journal of the Metabolomic Society
https://read.qxmd.com/read/38389341/applications-of-pet-and-spect-in-patients-with-autism-spectrum-disorder
#7
JOURNAL ARTICLE
Anna Lisa Martini, Natale Quartuccio, Irene Giovanna Schiera, Valentina Berti, Luca Burroni, Angelina Cistaro
Autism spectrum disorder (ASD) consists of neurological development disorders that manifest before three years of age and affect social interactions, markedly restricting range of interests and activities, often associated with some degree of intellectual disability. Single-photon emission computed tomography (SPECT) and positron emission tomography (PET) are non-invasive imaging tools to investigate the function of the brain in vivo. SPECT and PET studies exploring rCBF and brain glucose metabolism in patients with ASD have been performed, providing important insights into the brain regions involved in ASD...
2024: Current medical imaging
https://read.qxmd.com/read/38332172/psychologic-assessment-in-patients-undergoing-bariatric-surgery
#8
JOURNAL ARTICLE
Neal Ferrin, Alain Elian, Kayla Flewelling, Muhammed Nadeem, Kristofer Nava, Shamsi Daneshvari Berry, Kevin Stehlik, Almontasser Kassier Bella, Peter Awad, Andrew Alfred, Andre Ksajikian, Kevin Chen, Saad Shebrain
BACKGROUND: Psychological Clearance level (PCL) for patients undergoing metabolic and bariatric surgery (MBS) is a critical step for successful postoperative outcomes. This study aims to assess the relationship between the level of psychologic fitness and postoperative outcomes in patients undergoing MBS. METHODS: We retrospectively analyzed the data of patients who underwent MBS (laparoscopic sleeve gastrectomy [LSG] and laparoscopic Roux-en-Y Gastric Bypass [LRYGB]) and completed two years follow-up, between 2012 and 2019, in a single medical center...
February 8, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38310082/recent-progress-in-understanding-the-intracellular-domain-s-gating-and-functional-roles-in-trimeric-ligand-gated-ion-channels
#9
JOURNAL ARTICLE
Yan Lu, Yi Yu Lin, Jin Wang
Ligand-gated ion channels are a large category of essential ion channels, whose superfamily members may modulate their state by binding to specific ligands, allowing specific ions to pass through the cell membrane. Purinergic ligand- gated ion channel(P2X)and ASIC (acid-sensitive ion channel) are representative members of trimeric ligand-gated ion channels. Recent studies have shown that structural differences in the intracellular domain of P2X receptors (P2XR) may determine the desensitization process. The lateral fenestrations of P2XR potentially serve as a pathway for ion conduction and play a decisive role in ion selectivity...
February 2, 2024: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://read.qxmd.com/read/38272892/the-effect-of-continuous-theta-burst-stimulation-on-antipsychotic-induced-weight-gain-in-first-episode-drug-naive-individuals-with-schizophrenia-a-double-blind-randomized-sham-controlled-feasibility-trial
#10
JOURNAL ARTICLE
Dongyu Kang, Chuhan Song, Xingjie Peng, Guo Yu, Ye Yang, Chuwei Chen, Yujun Long, Ping Shao, Renrong Wu
Antipsychotic intake may induce weight gain in drug-naive individuals with schizophrenia, leading to poor compliance in clinical management. However, there is still a lack of effective approaches to treat or prevent this side-effect. Therefore, we conducted this pilot study to investigate the effect of continuous theta burst stimulation (cTBS), a non-invasive magnetic stimulation technique, on preventing olanzapine-induced weight gain. Thirty-nine first-episode drug-naive individuals with schizophrenia were randomly assigned to receive either the active or sham cTBS intervention for 25 sessions (5 times per day for 5 consecutive days)...
January 25, 2024: Translational Psychiatry
https://read.qxmd.com/read/38248841/disorders-of-copper-metabolism-in-children-a-problem-too-rarely-recognized
#11
REVIEW
Sabina Więcek, Justyna Paprocka
Copper plays an important role in metabolic processes. Both deficiency and excess of this element have a negative effect and lead to pathological conditions. Copper is a cofactor of many enzymatic reactions. Its concentration depends on the delivery in the diet, the absorption in enterocytes, transport with the participation of ATP7A/ATP7B protein, and proper excretion. Copper homeostasis disorders lead to serious medical conditions such as Menkes disease (MD) and Wilson's disease (WD). A mutation in the ATP7A gene is the cause of Menkes disease, it prevents the supply of copper ions to enzymes dependent on them, such as dopamine β-hydroxylase and lysyl oxidase...
January 7, 2024: Metabolites
https://read.qxmd.com/read/38233033/all-cause-and-cause-specific-mortality-in-obsessive-compulsive-disorder-nationwide-matched-cohort-and-sibling-cohort-study
#12
JOURNAL ARTICLE
Lorena Fernández de la Cruz, Kayoko Isomura, Paul Lichtenstein, Henrik Larsson, Ralf Kuja-Halkola, Zheng Chang, Brian M D'Onofrio, Isabell Brikell, Christian Rück, Anna Sidorchuk, David Mataix-Cols
OBJECTIVE: To estimate the risk of all cause and cause specific mortality in people with obsessive-compulsive disorder (OCD) compared with matched unaffected people from the general population and with their unaffected siblings. DESIGN: Population based matched cohort and sibling cohort study. SETTING: Register linkage in Sweden. PARTICIPANTS: Population based cohort including 61 378 people with OCD and 613 780 unaffected people matched (1:10) on sex, birth year, and county of residence; sibling cohort consisting of 34 085 people with OCD and 47 874 unaffected full siblings...
January 17, 2024: BMJ: British Medical Journal
https://read.qxmd.com/read/38225232/are-probiotics-effective-in-reducing-the-metabolic-side-effects-of-psychiatric-medication-a-scoping-review-of-evidence-from-clinical-studies
#13
REVIEW
Sonja Mötteli, Stefan Vetter, Michael Colla, Florian Hotzy
The psychopharmacological treatment of patients with schizophrenia or depression is often accompanied by serious side effects. In particular, the clinical findings of weight gain are worrying, as this side effect can lead to various medical sequelae in the future. However, the treatment of metabolic changes in psychiatric patients is often neglected or unsuccessful. An improved knowledge of possible therapeutic approaches is needed. The aim of this study was to provide an overview of the utilisation and effectiveness of probiotics in reducing weight gain in patients with severe mental illness...
January 15, 2024: Translational Psychiatry
https://read.qxmd.com/read/38199991/glucose-dysregulation-in-antipsychotic-naive-first-episode-psychosis-in-silico-exploration-of-gene-expression-signatures
#14
JOURNAL ARTICLE
Jiwon Lee, Xiangning Xue, Emily Au, William B McIntyre, Roshanak Asgariroozbehani, Kristoffer Panganiban, George C Tseng, Maria Papoulias, Emily Smith, Jonathan Monteiro, Divia Shah, Kateryna Maksyutynska, Samantha Cavalier, Emril Radoncic, Femin Prasad, Sri Mahavir Agarwal, Robert Mccullumsmith, Zachary Freyberg, Ryan W Logan, Margaret K Hahn
Antipsychotic (AP)-naive first-episode psychosis (FEP) patients display early dysglycemia, including insulin resistance and prediabetes. Metabolic dysregulation may therefore be intrinsic to psychosis spectrum disorders (PSDs), independent of the metabolic effects of APs. However, the potential biological pathways that overlap between PSDs and dysglycemic states remain to be identified. Using meta-analytic approaches of transcriptomic datasets, we investigated whether AP-naive FEP patients share overlapping gene expression signatures with non-psychiatrically ill early dysglycemia individuals...
January 10, 2024: Translational Psychiatry
https://read.qxmd.com/read/38148982/late-onset-cobalamin-c-deficiency-type-in-adult-with-cognitive-and-behavioral-disturbances-and-significant-cortical-atrophy-and-cerebellar-damage-in-the-mri-a-case-report
#15
Miao Sun, Yingjie Dai
BACKGROUND: Late-onset cobalamin C (cblC) deficiency is associated with a wide range of neurological and psychiatric symptoms, hematological manifestations, anorexia, renal failure, ocular abnormalities, dermatitis, and pancreatitis. However, the neuroimaging characteristics of late-onset cblC deficiency remain insufficiently documented. Common findings include diffuse white matter swelling, varying degrees of severe leukoaraiosis, hydrocephalus, corpus callosum atrophy, and symmetric bilateral basal ganglia lesions...
2023: Frontiers in Neurology
https://read.qxmd.com/read/38115298/the-diagnosis-of-acute-intermittent-porphyria-combined-with-seizures-case-report
#16
JOURNAL ARTICLE
Zhen Wang, Liniu Cheng, Xianyang Liang, Han Jiang, Ruile Shen
RATIONALE: Acute intermittent porphyria (AIP) is a rare metabolic disorder affecting heme production due to enzyme porphobilinogen deaminase deficiency. Diagnosing acute intermittent porphyria is difficult because its symptoms interrelate with those of other common diseases. When AIP is combined with seizures, the diagnosis process is more complicated. This case report shows all tests and criteria used to arrive at the final stage of diagnosis. PATIENT CONCERNS: The patient complained of severe abdominal pain, nausea, vomiting, and intermittent convulsions...
December 15, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38073894/safety-and-effectiveness-of-lurasidone-in-the-treatment-of-chinese-schizophrenia-patients-an-interim-analysis-of-post-marketing-surveillance
#17
JOURNAL ARTICLE
Yu-Mei Wei, Xi-Jin Wang, Xiao-Dong Yang, Chuan-Sheng Wang, Li-Li Wang, Xiao-Ying Xu, Gui-Jun Zhao, Bin Li, Dao-Min Zhu, Qi Wu, Yi-Feng Shen
BACKGROUND: Schizophrenia is a psychiatric disorder characterized by chronic or recurrent symptoms. Lurasidone was licensed in China in 2019 for the treatment of adult schizophrenia in adults with a maximum dose of 80 mg/d. However, post-market surveillance (PMS) with an adequate sample size is required for further validation of the drug's safety profile and effectiveness. AIM: To conduct PMS in real-world clinical settings and evaluate the safety and effectiveness of lurasidone in the Chinese population...
November 19, 2023: World Journal of Psychiatry
https://read.qxmd.com/read/38042056/association-of-clinical-parameters-and-polygenic-risk-scores-for-body-mass-index-schizophrenia-and-diabetes-with-antipsychotic-induced-weight-gain
#18
JOURNAL ARTICLE
Maria Franz, Sergi Papiol, Maria S Simon, Barbara B Barton, Catherine Glockner, Ilja Spellmann, Michael Riedel, Urs Heilbronner, Peter Zill, Thomas G Schulze, Richard Musil
Antipsychotic-induced weight gain (AIWG) is a common adverse event in schizophrenia. Genome-wide association studies (GWAS) and polygenic risk scores (PRS) for other diseases or traits are recent approaches to disentangling the genetic architecture of AIWG. 200 patients with schizophrenia treated monotherapeutically with antipsychotics were included in this study. A multiple linear regression analysis with ten-fold crossvalidation was performed to predict the percentage weight change after five weeks of treatment...
November 25, 2023: Journal of Psychiatric Research
https://read.qxmd.com/read/37993878/attention-deficit-hyperactivity-disorder-symptoms-and-subsequent-cardiometabolic-disorders-in-adults-investigating-underlying-mechanisms-using-a-longitudinal-twin-study
#19
JOURNAL ARTICLE
Maja Dobrosavljevic, Ralf Kuja-Halkola, Lin Li, Zheng Chang, Henrik Larsson, Ebba Du Rietz
BACKGROUND: Emerging research suggests that attention-deficit/hyperactivity disorder (ADHD) increases the risk for cardiovascular (CVDs) and metabolic disorders (i.e., cardiometabolic disorders) in adulthood. Yet, available studies are scarce and have mainly been focused on individuals receiving clinical ADHD diagnoses. We aimed to investigate the prospective associations of ADHD symptoms in young and mid-adulthood with subsequent cardiometabolic disorders and the underlying mechanisms...
November 22, 2023: BMC Medicine
https://read.qxmd.com/read/37918033/weight-change-in-a-national-cohort-of-u-s-military-veterans-engaged-in-medication-treatment-for-opioid-use-disorder
#20
JOURNAL ARTICLE
Meagan M Carr, Noah R Wolkowicz, Shayna Cave, Steve Martino, Robin Masheb, Amanda M Midboe
Medication treatments for opioid use disorder (MOUD) save lives and improve outcomes for countless individuals. However, data suggest the potential for significant weight gain during methadone treatment and little is known about weight change during buprenorphine treatment. Using Veteran Health Administration administrative data from fiscal year 2017 to fiscal year 2019, two cohorts were created: 1) Veterans diagnosed with opioid use disorder (OUD) taking methadone (N = 1425); and 2) Veterans diagnosed with OUD taking buprenorphine (N = 3756)...
October 13, 2023: Journal of Psychiatric Research
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