Jiwon Lee, Xiangning Xue, Emily Au, William B McIntyre, Roshanak Asgariroozbehani, Kristoffer Panganiban, George C Tseng, Maria Papoulias, Emily Smith, Jonathan Monteiro, Divia Shah, Kateryna Maksyutynska, Samantha Cavalier, Emril Radoncic, Femin Prasad, Sri Mahavir Agarwal, Robert Mccullumsmith, Zachary Freyberg, Ryan W Logan, Margaret K Hahn
Antipsychotic (AP)-naive first-episode psychosis (FEP) patients display early dysglycemia, including insulin resistance and prediabetes. Metabolic dysregulation may therefore be intrinsic to psychosis spectrum disorders (PSDs), independent of the metabolic effects of APs. However, the potential biological pathways that overlap between PSDs and dysglycemic states remain to be identified. Using meta-analytic approaches of transcriptomic datasets, we investigated whether AP-naive FEP patients share overlapping gene expression signatures with non-psychiatrically ill early dysglycemia individuals...
January 10, 2024: Translational Psychiatry