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Glycosylated Albumin

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https://www.readbyqxmd.com/read/29671580/site-specific-profiling-of-serum-glycoproteins-using-n-linked-glycan-and-glycosite-analysis-reveals-atypical-n-glycosylation-sites-on-albumin-and-alpha-1b-glycoprotein
#1
Shisheng Sun, Yingwei Hu, Li Jia, Shadi Toghi Eshghi, Yang Liu, Punit Shah, Hui Zhang
Most serum proteins are N-linked glycosylated and therefore the glycoproteomic profiling of serum is essential for characterization of serum proteins. In this study, we profiled serum N-glycoproteome by our recently developed N-glycoproteomic method using solid-phase extraction of N-linked Glycans And Glycosite-containing peptides (NGAG) coupled with LC-MS/MS and site-specific glycosylation analysis using GPQuest software. Our data indicated that half of identified N-glycosites were modified by at least two glycans, with a majority of them were sialylated...
April 19, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29619625/effects-of-plasma-glycosyltransferase-on-the-abo-h-blood-group-antigens-of-human-von-willebrand-factor
#2
Taiki Kano, Kazunao Kondo, Jiharu Hamako, Fumio Matsushita, Kazuya Sakai, Taei Matsui
Von Willebrand factor (VWF) is one of the plasma protein carrying ABO(H) blood group antigens, but the combining process of these antigens is not clear. In the present study, we examined whether plasma glycosyltransferase affects the blood group antigens on VWF. VWF expressing H-antigen (H-VWF) from blood group O and bovine serum albumin conjugated with H-antigen (H-BSA) were incubated with recombinant α1-3-N-acetylgalactosaminyltransferase (rA-transferase) and A-plasma with or without an additional UDP-GalNAc...
April 4, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29474087/thiodigalactoside-bsa-conjugates-as-high-potency-inhibitors-of-ga-lectin-3-an-outstanding-example-of-multivalent-presentation-of-small-molecule-inhibitors
#3
Hao Zhang, Dominic Laaf, Lothar Elling, Roland J Pieters
Galectin inhibitors are urgently needed to understand the mode of action and druggability of different galectins, but potent and selective agents still eludes researchers to date. Small-sized inhibitors based on thiodigalactoside (TDG) have shown their potential while modifications at their C3 position indicated a strategy to improve selectivity and potency. Considering the role of galectins as a glycoprotein traffic police, involved in multivalent bridging interac-tions, we aimed to create multivalent versions of the potent TDG inhibitors...
February 23, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29473206/association-of-mac-2-binding-protein-glycosylation-isomer-level-with-nutritional-status-in-chronic-liver-disease
#4
Yuji Eso, Atsushi Takai, Kojiro Taura, Ken Takahashi, Yoshihide Ueda, Hiroyuki Marusawa, Hiroshi Seno
BACKGROUND AND AIM: Mac-2-binding protein glycosylation isomer (M2BPGi) was recently identified as a serum glycobiomarker for liver fibrosis. However, the relationship between M2BPGi and malnutrition in patients with chronic liver disease (CLD) is unknown. We aimed to evaluate whether M2BPGi could be a surrogate marker for malnutrition in patients with CLD. METHODS: In total, 338 outpatients with CLD were enrolled (median age: 67 years). We evaluated the associations among liver fibrosis markers (M2BPGi, fibrosis-4 index, and aspartate aminotransferase-to-platelet count ratio index), Child-Pugh stages, and nutritional status markers...
February 22, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29445378/fc-glycosylation-in-human-igg1-and-igg3-is-similar-for-both-total-and-anti-red-blood-cell-anti-k-antibodies
#5
Myrthe E Sonneveld, Carolien A M Koeleman, H Rosina Plomp, Manfred Wuhrer, C Ellen van der Schoot, Gestur Vidarsson
After albumin, immunoglobulin G (IgG) are the most abundant proteins in human serum, with IgG1 and IgG3 being the most abundant subclasses directed against protein antigens. The quality of the IgG-Fc-glycosylation has important functional consequences, which have been found to be skewed toward low fucosylation in some antigen-specific immune responses. This increases the affinity to IgG1-Fc-receptor (FcγR)IIIa/b and thereby directly affects downstream effector functions and disease severity. To date, antigen-specific IgG-glycosylation have not been analyzed for IgG3...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29424910/correlations-between-blood-uric-acid-and-the-incidence-and-progression-of-type-2-diabetes-nephropathy
#6
G-X Li, X-H Jiao, X-B Cheng
OBJECTIVE: To investigate the relationships between blood uric acid (BUA) level and the incidence, progression and deterioration of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: A total of fifty patients with T2DM alone whose glycosylated hemoglobin (HbA1c) were under normal range (4-6.5%) at their admission to our hospital were randomly selected as diabetes mellitus (DM) group. Fifty patients with hyperuricemia alone were randomly selected as hyperuricemia (HUA) group...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29416575/a-randomized-controlled-trial-of-a-mini-low-carbohydrate-diet-and-an-energy-controlled-diet-among-japanese-patients-with-type-2-diabetes
#7
Masayo Kimura, Yoshinobu Kondo, Kazutaka Aoki, Jun Shirakawa, Hiroshi Kamiyama, Kazunari Kamiko, Shigeru Nakajima, Yasuo Terauchi
Background: Low-carbohydrate diets have been shown to effectively improve the metabolic status of patients with type 2 diabetes mellitus. However, patients may find it challenging to maintain a strict low-carbohydrate diet. The objective of this study was to determine if a one-meal, low-carbohydrate diet is as effective in improving metabolic status as a conventional, energy-restricted diet among patients with type 2 diabetes mellitus. Methods: In this 12-week randomized controlled study, the primary endpoint was differences in the changes of plasma glycosylated hemoglobin (HbA1c) levels between the two experimental groups...
March 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29367111/zingerone-attenuates-diabetic-nephropathy-through-inhibition-of-nicotinamide-adenine-dinucleotide-phosphate-oxidase-4
#8
Yan Cui, Yan Shi, Yan Bao, Shulong Wang, Qiuju Hua, Yun Liu
Diabetes affects a large proportion of population wide across the world and kidney is a main target organ of diabetic complications. Zingerone is a stable active component derived from dry ginger rhizome. We investigated the effect of zingerone on diabetic nephropathy and explored the possible mechanisms. We showed that zingerone decreased the levels of serum insulin, C-peptide and glycosylated hemoglobin A1c. The levels of blood urea nitrogen (BUN), serum creatinine, urinary albumin content and albumin/creatinine ratio (ACR) were reduced by zingerone...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29362622/apelin-nitric-oxide-and-vascular-affection-in-adolescent-type-1-diabetic-patients
#9
Soha M Abd El Dayem, Ahmed A Battah, Abo El Maged El Bohy, Rash Nazih Yousef, Azza M Ahmed, Ahmed A Talaat
AIM: To evaluate the relationship of apelin and nitric oxide (NO) to endothelial dysfunction in type 1 diabetics. PATIENTS AND METHODS: Sixty two type 1 diabetics and 30 healthy age and sex matched controls were included. Blood samples for apelin, NO, glycosylated hemoglobin (HbA1c), and lipid profile were collected. Albumin/creatinine ratio was assessed in urine. Flow mediated dilatation (FMD) via ultrasound was done. RESULTS: The mean age of diabetics were 16...
December 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29229075/does-periodontal-inflammation-affect-glycosylated-haemoglobin-level-in-otherwise-systemically-healthy-individuals-a-hospital-based-study
#10
Rosamma Joseph Vadakkekuttical, Priyanka Chand Kaushik, Jerry Mammen, Joseraj Manaloor George
BACKGROUND AND OBJECTIVES: Microbial biofilm and host susceptibility play an important role in the initiation and progression of periodontitis. Periodontitis is considered the sixth complication of diabetes mellitus and a bidirectional relationship exists between diabetes and periodontitis. This cross-sectional observational study was undertaken to evaluate the glycosylated haemoglobin (HbA1c) level in chronic periodontitis. METHODS: The study involved 100 subjects...
December 2017: Singapore Dental Journal
https://www.readbyqxmd.com/read/29153006/effect-of-bariatric-surgery-on-diabetic-nephropathy-in-obese-type-2-diabetes-patients-in-a-retrospective-2-year-study-a-local-pilot
#11
Anthony Tl Chao, Sum Chee Fang, Benjamin Cc Lam, Anton Ks Cheng, Serena Km Low, Lim Su Chi
PURPOSE: To determine the effects of bariatric surgery on albuminuria in obese patients with type 2 diabetes mellitus. METHODS: Retrospective analyses of clinical records of obese patients with type 2 diabetes mellitus who had either micro- or macroalbuminuria and had undergone various bariatric surgery were retrieved from a local hospital database. Their clinical data from follow-up appointments including albuminuria were analysed. RESULTS: Of the 46 subjects with type 2 diabetes mellitus, 15 subjects had diabetic nephropathy and had pre- and post-bariatric surgery urine albumin-to-creatinine ratio or urine protein-to-creatinine ratio data available for analysis; 13 out of the 15 subjects (86...
November 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29146600/n-glycan-profile-and-kidney-disease-in-type-1-diabetes
#12
Mairead L Bermingham, Marco Colombo, Stuart J McGurnaghan, Luke A K Blackbourn, Frano Vučković, Maja Pučić Baković, Irena Trbojević-Akmačić, Gordan Lauc, Felix Agakov, Anna S Agakova, Caroline Hayward, Lucija Klarić, Colin N A Palmer, John R Petrie, John Chalmers, Andrew Collier, Fiona Green, Robert S Lindsay, Sandra Macrury, John A McKnight, Alan W Patrick, Sandeep Thekkepat, Olga Gornik, Paul M McKeigue, Helen M Colhoun
OBJECTIVE: Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulating glycoproteins, and these alterations may be linked with diabetic kidney disease (DKD). We investigated associations between N-glycans and glycemic control and renal function in type 1 diabetes. RESEARCH DESIGN AND METHODS: Using serum samples from 818 adults who were considered to have extreme annual loss in estimated glomerular filtration rate (eGFR; i.e., slope) based on retrospective clinical records, from among 6,127 adults in the Scottish Diabetes Research Network Type 1 Bioresource Study, we measured total and IgG-specific N-glycan profiles...
January 2018: Diabetes Care
https://www.readbyqxmd.com/read/29146135/multivalent-oleanolic-acid-human-serum-albumin-conjugate-as-nonglycosylated-neomucin-for-influenza-virus-capture-and-entry-inhibition
#13
Yang Yang, Hao-Jie He, Hao Chang, Yao Yu, Mei-Bing Yang, Yun He, Zhen-Chuan Fan, Suri S Iyer, Peng Yu
We report the synthesis of multivalent oleanolic acid (OA) protein conjugates as nonglycosylated neomucin mimic for the capture and entry inhibition of influenza viruses. Oleanolic acid derivatives bearing an amine-terminated linker were synthesized by esterification of carboxylic acid and further grafted onto the human serum albumin (HSA) via diethyl squarate method. The binding of hemagglutinin (HA) on the virion surface to the synthetic neomucin was evaluated by hemagglutination inhibition assay. The influenza virus capture ability of the PEGylated OA-HSA conjugate was further investigated by Dynamic Light Scattering (DLS), virus capture assay and Isothermal Titration Calorimeter (ITC) techniques...
January 1, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29113983/fgf23-concentration-and-apol1-genotype-are-novel-predictors-of-mortality-in-african-americans-with-type-2-diabetes
#14
Gary C Chan, Jasmin Divers, Gregory B Russell, Carl D Langefeld, Lynne E Wagenknecht, Fang-Chi Hsu, Jianzhao Xu, S Carrie Smith, Nicholette D Palmer, Pamela J Hicks, Donald W Bowden, Thomas C Register, Lijun Ma, J Jeffrey Carr, Barry I Freedman
OBJECTIVE: Cardiovascular and renal complications contribute to higher mortality in patients with diabetes. We assessed novel and conventional predictors of mortality in African American-Diabetes Heart Study (AA-DHS) participants. RESEARCH DESIGN AND METHODS: Associations between mortality and subclinical atherosclerosis, urine albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), plasma fibroblast growth factor 23 (FGF23) concentration, African ancestry proportion, and apolipoprotein L1 genotypes ( APOL1 ) were assessed in 513 African Americans with type 2 diabetes; analyses were performed using Cox proportional hazards models...
January 2018: Diabetes Care
https://www.readbyqxmd.com/read/29101807/6-shogaol-ameliorates-diabetic-nephropathy-through-anti-inflammatory-hyperlipidemic-anti-oxidative-activity-in-db-db-mice
#15
Yun Xu, Liwei Bai, Xuehui Chen, Yan Li, Yan Qin, Xiangyu Meng, Qinggui Zhang
The prevalence of type 2 diabetes mellitus has been increasing worldwide and more than two thirds of the patients may develop diabetic nephropathy (DN). However, the efficiency of existing approaches on DN progression is limited. 6-Shogaol (6-SG), a major dehydrated derivative of gingerols, possesses various biological properties. The present study was designed to evaluate the possible effects of 6-SG on DN in db/db mice and to investigate the mechanisms. We revealed that 6-SG reduced the levels of fasting blood glucose, serum insulin, C-peptide, glycosylated hemoglobin A1c, and systolic blood pressure...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29099118/relaci%C3%A3-n-de-la-hiperuricemia-con-las-lipoprote%C3%A3-nas-de-baja-densidad-las-pruebas-de-funcionamiento-hep%C3%A3-tico-y-los-marcadores-de-inflamaci%C3%A3-n-sist%C3%A3-mica-en-pacientes-con-obesidad-m%C3%A3-rbida
#16
José Israel León-Pedroza, Galileo Escobedo, Antonio González-Chávez
Objective: To examine the relationship of uric acid levels with parameters of systemic inflammation, metabolic dysfunction as well as anthropometric parameters and liver function tests in subjects with morbid obesity. Methods: C-reactive protein (CRP), tumour necrosis factor-alpha, and interleukin 10 (IL-10) were analyzed in 49 women and men with morbid obesity, relating these markers with uric acid, hepatic function tests, anthropometric and metabolic parameters...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29098408/increased-serum-wisteria-floribunda-agglutinin-positive-mac-2-binding-protein-mac-2-binding-protein-glycosylation-isomer-in-chronic-heart-failure-a-pilot-study
#17
Atsushi Okada, Hideaki Kanzaki, Yasuhiro Hamatani, Seiji Takashio, Hiroyuki Takahama, Makoto Amaki, Takuya Hasegawa, Yasuo Sugano, Satoshi Yasuda, Toshihisa Anzai
BACKGROUND: Serum Wisteria floribunda agglutinin positive Mac-2 binding protein (WFA(+)-M2BP) or Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) is a novel biomarker currently applied for evaluating hepatic fibrosis. The aim of this study was to evaluate the utility of serum WFA(+)-M2BP level as a biomarker in chronic heart failure (HF) patients with abnormal liver function. METHODS AND RESULTS: Fifty chronic HF patients who underwent measurement of serum WFA(+)-M2BP were evaluated...
November 2, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29068216/tumor-progression-of-non-small-cell-lung-cancer-controlled-by-albumin-and-micellar-nanoparticles-of-itraconazole-a-multitarget-angiogenesis-inhibitor
#18
Ling Zhang, Zhengsheng Liu, Kuan Yang, Chao Kong, Chun Liu, Huijun Chen, Jinfeng Huang, Feng Qian
Itraconazole (ITA), an old and widely prescribed antifungal drug with excellent safety profile, has more recently been demonstrated to be a multitarget antiangiogenesis agent affecting multiple angiogenic stimulatory signals and pathways, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and mammalian target of rapamycin (mTOR). In this study, we developed two nanoparticle formulations, i.e., polymer micelles (IP2K) and albumin nanoparticles (IBSA), to solubilize the extremely hydrophobic and insoluble ITA to allow intravenous administration and pharmacokinetics (PK)/pharmacodynamics (PD) comparisons...
December 4, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29062338/allostatic-load-and-heart-rate-variability-as-health-risk-indicators
#19
Margaretha Viljoen, Nicolaas Claassen
BACKGROUND: Uncertainty often exists about the comparability of results obtained by different health risk indicator systems. OBJECTIVES: To compare two health risk indicator systems, i.e, allostatic load and heart rate variability (HRV). Additionally, to investigate the feasibility of inclusion of HRV indicators into allostatic load assessments and which HRV indicators are best to introduce. METHODS: Allostatic loads were calculated based on blood pressure, waist-to-hip ratio, BMI, cholesterol, HDL-C, LDL-C, CRP, albumin, glycosylated haemoglobin, blood glucose and cortisol excretion...
June 2017: African Health Sciences
https://www.readbyqxmd.com/read/29050702/relationship-between-a-fragmented-qrs-and-microalbuminuria-in-patients-with-type-2-diabetes-mellitus
#20
Sukru Cetin, Suleyman Sezai Yıldız, Emrah Erkan Mazı, Kudret Keskin, Gokhan Cetinkal, Ahmet Gurdal, Umut Karabay, Kadriye Orta Kilickesmez
INTRODUCTION: Microalbuminuria (MAU), a complication of diabetes, is closely related to cardiovascular events. A fragmented QRS (fQRS) in the electrocardiogram (ECG) was found to be strongly associated to cardiovascular morbidity and mortality. OBJECTIVE: The aim of this study was to assess the association between a fQRS and MAU in patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: One hundred and twenty-seven patients (mean age, 50...
November 2017: Endocrinología, Diabetes y Nutrición
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