keyword
https://read.qxmd.com/read/38476437/tumefactive-perivascular-space-of-the-anterior-temporal-lobe
#21
JOURNAL ARTICLE
Amit Agarwal, Prasanna Vibhute
No abstract text is available yet for this article.
2024: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/38475818/transient-but-not-chronic-hyperglycemia-accelerates-ocular-glymphatic-transport
#22
JOURNAL ARTICLE
Christine Delle, Xiaowei Wang, Michael Giannetto, Evan Newbold, Weiguo Peng, Ryszard Stefan Gomolka, Antonio Ladrón-de-Guevara, Neža Cankar, Elise Schiøler Nielsen, Celia Kjaerby, Pia Weikop, Yuki Mori, Maiken Nedergaard
Glymphatic transport is vital for the physiological homeostasis of the retina and optic nerve. Pathological alterations of ocular glymphatic fluid transport and enlarged perivascular spaces have been described in glaucomatous mice. It remains to be established how diabetic retinopathy, which impairs vision in about 50% of diabetes patients, impacts ocular glymphatic fluid transport. Here, we examined ocular glymphatic transport in chronic hyperglycemic diabetic mice as well as in healthy mice experiencing a daily transient increase in blood glucose...
March 12, 2024: Fluids and Barriers of the CNS
https://read.qxmd.com/read/38473727/diffusion-mediates-molecular-transport-through-the-perivascular-space-in-the-brain
#23
JOURNAL ARTICLE
Marie Tanaka, Yoko Hirayoshi, Shinobu Minatani, Itsuki Hasegawa, Yoshiaki Itoh
The perivascular space has been proposed as a clearance pathway for degradation products in the brain, including amyloid β, the accumulation of which may induce Alzheimer's disease. Live images were acquired using a two-photon microscope through a closed cranial window in mice. In topical application experiments, the dynamics of FITC-dextran were evaluated from 30 to 150 min after the application and closure of the window. In continuous injection experiments, image acquisition began before the continuous injection of FITC-dextran...
February 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38465965/dominance-of-tau-burden-in-cortical-over-subcortical-regions-mediates-glymphatic-activity-and-clinical-severity-in-psp
#24
JOURNAL ARTICLE
Jung-Lung Hsu, Yi-Chia Wei, Ing-Tsung Hsiao, Kun-Ju Lin, Tzu-Chen Yen, Chin-Song Lu, Han-Cheng Wang, Alexander Leemans, Yi-Hsin Weng, Kuo-Lun Huang
BACKGROUND: Progressive supranuclear palsy (PSP) is a tauopathy that involves subcortical regions but also extends to cortical areas. The clinical impact of different tau protein sites and their influence on glymphatic dysfunction have not been investigated. PATIENTS AND METHODS: Participants (n = 55; 65.6 ± 7.1 years; 29 women) with PSP (n = 32) and age-matched normal controls (NCs; n = 23) underwent 18F-Florzolotau tau PET, MRI, PSP Rating Scale (PSPRS), and Mini-Mental State Examination...
March 7, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38465814/-cerebral-amyloid-angiopathy
#25
JOURNAL ARTICLE
E A Mkhitaryan, V V Fateeva, P R Kamchatnov
Cerebral amyloid angiopathy (CAA) is a progressive disease characterized by the deposition of β-amyloid in the walls of blood vessels in the brain, which leads to their damage and disruption of normal blood flow. Morphologically, CAA is characterized by both isolated lesions (microhemorrhages with the appearance of cortical superficial siderosis, lacunar infarctions) and widespread changes (hyperintensity of the deep and periventricular white matter, expansion of the perivascular spaces) of cortical and subcortical localization...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38465597/relationship-of-perivascular-space-markers-with-incident-dementia-in-cerebral-small-vessel-disease
#26
JOURNAL ARTICLE
Hui Hong, Daniel J Tozer, Hugh S Markus
BACKGROUND: Recent studies, using diffusion tensor image analysis along the perivascular space (DTI-ALPS), suggest impaired perivascular space (PVS) function in cerebral small vessel disease, but they were cross-sectional, making inferences on causality difficult. We determined associations between impaired PVS, measured using DTI-ALPS and PVS volume, and cognition and incident dementia. METHODS: In patients with lacunar stroke and confluent white matter hyperintensities, without dementia at baseline, recruited prospectively in a single center, magnetic resonance imaging was performed annually for 3 years, and cognitive assessments, including global, memory, executive function, and processing speed, were performed annually for 5 years...
March 11, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38465514/clinical-magnetic-resonance-imaging-evaluation-of-glymphatic-function
#27
REVIEW
Edward D Boyd, Jasleen Kaur, Guangliang Ding, Michael Chopp, Quan Jiang
The glymphatic system is a system of specialized perivascular spaces in the brain that facilitates removal of toxic waste solutes from the brain. Evaluation of glymphatic system function by means of magnetic resonance imaging (MRI) has thus far been largely focused on rodents because of the limitations of intrathecal delivery of gadolinium-based contrast agents to humans. This review discusses MRI methods that can be employed clinically for glymphatic-related measurements intended for early diagnosis, prevention, and the treatment of various neurological conditions...
March 11, 2024: NMR in Biomedicine
https://read.qxmd.com/read/38463439/quantitative-analysis-of-multimodal-mri-markers-and-clinical-risk-factors-for-cerebral-small-vessel-disease-based-on-deep-learning
#28
JOURNAL ARTICLE
Zhiliang Zhang, Zhongxiang Ding, Fenyang Chen, Rui Hua, Jiaojiao Wu, Zhefan Shen, Feng Shi, Xiufang Xu
BACKGROUND: Cerebral small vessel disease lacks specific clinical manifestations, and extraction of valuable features from multimodal images is expected to improve its diagnostic accuracy. In this study, we used deep learning techniques to segment cerebral small vessel disease imaging markers in multimodal magnetic resonance images and analyze them with clinical risk factors. METHODS AND RESULTS: We recruited 211 lacunar stroke patients and 83 control patients. The patients' cerebral small vessel disease markers were automatically segmented using a V-shaped bottleneck network, and the number and volume were calculated after manual correction...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38462633/the-glymphatic-system-in-migraine-and-other-headaches
#29
REVIEW
Maria Grazia Vittorini, Aysenur Sahin, Antonin Trojan, Sevil Yusifli, Tamta Alashvili, Gonçalo V Bonifácio, Ketevan Paposhvili, Viktoria Tischler, Christian Lampl, Simona Sacco
Glymphatic system is an emerging pathway of removing metabolic waste products and toxic solutes from the brain tissue. It is made of a network of perivascular spaces, filled in cerebrospinal and interstitial fluid, encompassing penetrating and pial vessels and communicating with the subarachnoid space. It is separated from vessels by the blood brain barrier and from brain tissue by the endfeet of the astrocytes rich in aquaporin 4, a membrane protein which controls the water flow along the perivascular space...
March 11, 2024: Journal of Headache and Pain
https://read.qxmd.com/read/38460050/the-prevalence-and-topography-of-spinal-cord-demyelination-in-multiple-sclerosis-a-retrospective-study
#30
JOURNAL ARTICLE
Alex D Waldman, Cecilia Catania, Marco Pisa, Mark Jenkinson, Michael J Lenardo, Gabriele C DeLuca
Spinal cord pathology is a major determinant of irreversible disability in progressive multiple sclerosis. The demyelinated lesion is a cardinal feature. The well-characterised anatomy of the spinal cord and new analytic approaches allows the systematic study of lesion topography and its extent of inflammatory activity unveiling new insights into disease pathogenesis. We studied cervical, thoracic, and lumbar spinal cord tissue from 119 pathologically confirmed multiple sclerosis cases. Immunohistochemistry was used to detect demyelination (PLP) and classify lesional inflammatory activity (CD68)...
March 9, 2024: Acta Neuropathologica
https://read.qxmd.com/read/38459400/meta-analysis-of-the-relationship-between-the-number-and-location-of-perivascular-spaces-in-the-brain-and-cognitive-function
#31
JOURNAL ARTICLE
Ling Liu, Liangdan Tu, Qiuyan Shen, Yi Bao, Fang Xu, Dan Zhang, Yanming Xu
BACKGROUND: Cerebral perivascular spaces are part of the cerebral microvascular structure and play a role in lymphatic drainage and the removal of waste products from the brain. Relationships of the number and location of such spaces with cognition are unclear. OBJECTIVE: To meta-analyze available data on potential associations of severity and location of perivascular spaces with cognitive performance. METHODS: We searched PubMed, EMBASE, Web of Science and the Cochrane Central Registry of Controlled Trials for relevant studies published between January 2000 and July 2023...
March 9, 2024: Neurological Sciences
https://read.qxmd.com/read/38456438/high-sensitivity-cardiac-troponin-t-and-cognitive-function-over-12%C3%A2-months-after-stroke-results-of-the-demdas-study
#32
JOURNAL ARTICLE
Regina von Rennenberg, Christian H Nolte, Thomas G Liman, Simon Hellwig, Christoph Riegler, Jan F Scheitz, Marios K Georgakis, Rong Fang, Felix J Bode, Gabor C Petzold, Peter Hermann, Inga Zerr, Michael Goertler, Kathleen Bernkopf, Silke Wunderlich, Martin Dichgans, Matthias Endres
BACKGROUND: Subclinical myocardial injury in form of hs-cTn (high-sensitivity cardiac troponin)  levels has been associated with cognitive impairment and imaging markers of cerebral small vessel disease (SVD) in population-based and cardiovascular cohorts. Whether hs-cTn is associated with domain-specific cognitive decline and SVD burden in patients with stroke remains unknown. METHODS AND RESULTS: We analyzed patients with acute stroke without premorbid dementia from the prospective multicenter DEMDAS (DZNE [German Center for Neurodegenerative Disease]-Mechanisms of Dementia after Stroke) study...
March 8, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38454101/clinical-features-and-associated-factors-of-coexisting-intracerebral-hemorrhage-in-patients-with-cerebral-small-vessel-disease-a-cross-sectional-study
#33
JOURNAL ARTICLE
Yuan Gao, Ce Zong, Hongbing Liu, Ke Zhang, Hongxun Yang, Yunchao Wang, Yusheng Li, Bo Song, Yuming Xu
Intracerebral hemorrhage (ICH) is generally considered to be closely related to cerebral small vessel disease (CSVD), leading to a poor prognosis. However, the coexistence of ICH in general CSVD patients and related factors remain underreported. In our cross-sectional study, we screened 414 CSVD patients from a database at the Department of Neurology, First Affiliated Hospital of Zhengzhou University (September 2018 to April 2022). Imaging biomarkers of CSVD and coexisting ICH lesion were assessed. Factors associated with coexisting ICH in CSVD were determined using multivariate logistic regression analysis...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38445479/temporal-ordering-of-biomarkers-in-dutch-type-hereditary-cerebral-amyloid-angiopathy
#34
JOURNAL ARTICLE
Emma A Koemans, Ingeborg Rasing, Sabine Voigt, Thijs W van Harten, Reinier G J van der Zwet, Kanishk Kaushik, Manon R Schipper, Nelleke van der Weerd, Erik W van Zwet, Ellis S van Etten, Matthias J P van Osch, Bea Kuiperij, Marcel M Verbeek, Gisela M Terwindt, Steven M Greenberg, Marianne A A van Walderveen, Marieke J H Wermer
BACKGROUND: The temporal ordering of biomarkers for cerebral amyloid angiopathy (CAA) is important for their use in trials and for the understanding of the pathological cascade of CAA. We investigated the presence and abnormality of the most common biomarkers in the largest (pre)symptomatic Dutch-type hereditary CAA (D-CAA) cohort to date. METHODS: We included cross-sectional data from participants with (pre)symptomatic D-CAA and controls without CAA. We investigated CAA-related cerebral small vessel disease markers on 3T-MRI, cerebrovascular reactivity with functional 7T-MRI (fMRI) and amyloid-β40 and amyloid-β42 levels in cerebrospinal fluid...
March 6, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38444323/sensitivity-of-the-boston-criteria-version-2-0-in-dutch-type-hereditary-cerebral-amyloid-angiopathy
#35
JOURNAL ARTICLE
Reinier van der Zwet, Emma Koemans, Sabine Voigt, Rosemarie van Dort, Ingeborg Rasing, Kanishk Kaushik, Thijs van Harten, Manon Schipper, Gisela M Terwindt, Thijs van Osch, Marianne Aa van Walderveen, Ellis van Etten, Marieke Wermer
BACKGROUND AND AIM: The revised Boston criteria v2.0 for cerebral amyloid angiopathy (CAA) add two radiological markers to the existing criteria: severe visible perivascular spaces in the centrum semiovale and white matter hyperintensities (WMH) in a multispot pattern. This study aims to determine the sensitivity of the updated criteria in mutation carriers with Dutch-type hereditary CAA (D-CAA) in an early and later disease stage. METHODS: In this cross-sectional study, we included presymptomatic and symptomatic D-CAA mutation carriers from our prospective natural history study (AURORA) at the Leiden University Medical Center between 2018 and 2021...
March 6, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38443539/the-structural-functional-connectivity-coupling-of-the-aging-brain
#36
JOURNAL ARTICLE
Hui Zhang, Peng Cao, Henry K F Mak, Edward S Hui
Aging primarily affects memory and executive functions, a relationship that may be underpinned by the fact that almost all adults over 60 years old develop small vessel disease (SVD). The fact that a wide range of neuropathologies could only explain up to 43% of the variation in age-related cognitive impairment suggests that other factors, such as cognitive reserve, may play a role in the brain's resilience against aging-related cognitive decline. This study aims to examine the relationship between structural-functional-connectivity coupling (SFC), and aging, cognitive abilities and reserve, and SVD-related neuropathologies using a cohort of n = 176 healthy elders from the Harvard Aging Brain Study...
March 6, 2024: GeroScience
https://read.qxmd.com/read/38443374/functional-analysis-of-the-human-perivascular-subarachnoid-space
#37
JOURNAL ARTICLE
Per Kristian Eide, Geir Ringstad
The human subarachnoid space harbors the cerebrospinal fluid, which flows within a landscape of blood vessels and trabeculae. Functional implications of subarachnoid space anatomy remain far less understood. This study of 75 patients utilizes a cerebrospinal fluid tracer (gadobutrol) and consecutive magnetic resonance imaging to investigate features of early (i.e. within 2-3 h after injection) tracer propagation within the subarachnoid space. There is a time-dependent perivascular pattern of enrichment antegrade along the major cerebral artery trunks; the anterior-, middle-, and posterior cerebral arteries...
March 5, 2024: Nature Communications
https://read.qxmd.com/read/38430071/bi-allelic-nit1-variants-cause-a-brain-small-vessel-disease-characterized-by-movement-disorders-massively-dilated-perivascular-spaces-and-intracerebral-hemorrhage
#38
JOURNAL ARTICLE
Julie W Rutten, Minne N Cerfontaine, Kyra L Dijkstra, Aat A Mulder, Jeroen Vreijling, Mark Kruit, Roman I Koning, Susanne T de Bot, Koen M van Nieuwenhuizen, Hans J Baelde, Henk W Berendse, Leon H Mei, George J G Ruijter, Frank Baas, Carolina R Jost, Sjoerd G van Duinen, Esther A R Nibbeling, Gido Gravesteijn, Saskia A J Lesnik Oberstein
PURPOSE: To describe a recessively inherited cerebral small vessel disease, caused by loss-of-function variants in Nitrilase1 (NIT1). METHODS: We performed exome sequencing, brain MRI, neuropathology, electron microscopy, Western Blotting and transcriptomic and metabolic analyses in seven NIT1-small vessel disease patients from five unrelated pedigrees. RESULTS: The first identified patients were three siblings, compound heterozygous for the NIT1 c...
February 27, 2024: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://read.qxmd.com/read/38429289/dynamic-changes-in-perivascular-space-morphology-predict-signs-of-spaceflight-associated-neuro-ocular-syndrome-in-bed-rest
#39
JOURNAL ARTICLE
Sutton B Richmond, Rachael D Seidler, Jeffrey J Iliff, Daniel L Schwartz, Madison Luther, Lisa C Silbert, Scott J Wood, Jacob J Bloomberg, Edwin Mulder, Jessica K Lee, Alberto De Luca, Juan Piantino
During long-duration spaceflight, astronauts experience headward fluid shifts and expansion of the cerebral perivascular spaces (PVS). A major limitation to our understanding of the changes in brain structure and physiology induced by spaceflight stems from the logistical difficulties of studying astronauts. The current study aimed to determine whether PVS changes also occur on Earth with the spaceflight analog head-down tilt bed rest (HDBR). We examined how the number and morphology of magnetic resonance imaging-visible PVS (MV-PVS) are affected by HDBR with and without elevated carbon dioxide (CO2 )...
March 1, 2024: NPJ Microgravity
https://read.qxmd.com/read/38422746/peripheral-apolipoprotein-is-an-independent-factor-for-enlarged-perivascular-space-in-small-vessel-disease
#40
JOURNAL ARTICLE
Wenhua Zhang, Ruiming Wang, Fangying Shi
OBJECTIVE: The purpose of this study is to the relationship between peripheral apolipoproteins and cerebral small vessel disease (CSVD) imaging markers. METHODS: We reviewed the data of a population that above 40 years old with CSVD, while free of known dementia or acute stroke. We evaluated CSVD imaging markers, including white matter hyperintensities (WMHs), enlarged perivascular spaces (EPVS), lacunas, microbleeds by MRI scans, and measured peripheral apolipoproteins...
February 20, 2024: Clinical Neurology and Neurosurgery
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