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Amyloid angiography

Kazuhiro Honda
BACKGROUND: An impairment of amyloid-β (Aβ) clearance has been suggested in Alzheimer's disease. Perivascular drainage along cerebrovascular vessels is considered an important amyloid clearance pathway. OBJECTIVE: This study examined the effect of reduced arterial pulsation that could cause an impairment in cerebral amyloid drainage on the prevalence of cortical microbleeds (CMBs), a surrogate marker for cerebral amyloid angiopathy (CAA). METHODS: Patients who lost depiction of either side of the carotid artery or the middle cerebral artery on magnetic resonance angiography were studied...
August 1, 2016: Journal of Alzheimer's Disease: JAD
Arifumi Matsumoto, Hiroyoshi Suzuki, Muneshige Tobita, Kinya Hisanaga
A 74-year-old female patient, who was diagnosed with neurofibromatosis type 1 (NF1) at the age of 40, was admitted with complaints of flickering vision and gait disturbance for the last 2 years. On admission, neurological examination revealed mild bilateral hearing loss and ataxia in the limb and trunk. Laboratory tests revealed anti-hepatitis C virus (HCV) antibody positivity and elevated HCV RNA by real-time polymerase chain reaction. The cerebrospinal fluid examination revealed a slightly yellowish appearance with elevated total protein levels...
July 28, 2016: Rinshō Shinkeigaku, Clinical Neurology
Elona Dhrami-Gavazi, K Bailey Freund, Winston Lee, Ben Z Cohen, Surya V Seshan, Lawrence A Yannuzzi
PURPOSE: To demonstrate unusual retinal findings in a patient with progressive renal failure due to idiopathic monoclonal immunoglobulin light chain deposition disease, using multimodal imaging. METHODS: Observational case report of a 43-year-old white man with renal failure due to light chain deposition disease. His course over 6 years was documented with multimodal imaging including fundus photography, fundus autofluorescence, fluorescein angiography, and spectral domain optical coherence tomography...
June 16, 2016: Retinal Cases & Brief Reports
Michael Chi Yuan Nam, Karen Nel, Roxy Senior, Kim Greaves
We performed real-time myocardial contrast echocardiography on a patient with cardiac amyloidosis and previous normal coronary angiography presenting with atypical chest pain to assess myocardial blood flow reserve (MBFR). Myocardial contrast echocardiography was performed and flash microbubble destruction and replenishment analysis was used to calculate myocardial blood flow. Dipyridamole was used to achieve hyperemia. MBFR was derived from the ratio of peak myocardial blood flow at hyperemia and rest. The results show a marked reduction in MBFR in our patient...
March 2016: Journal of Cardiovascular Ultrasound
D A García Estévez, R M García-Dorrego, B Nieto-Baltar, M Marey-Garrido, T Hierro-Torner
INTRODUCTION: Convexity subarachnoid haemorrhage (cSAH) is a rare type of spontaneous, non-traumatic, and nonaneurysmal SAH characterised by blood collections in one or more cortical sulci in the convexity of the brain; the aetiology varies. We report a clinical case series of 3 patients with cSAH associated with probable cerebral amyloid angiopathy (CAA) who presented with focal sensory seizures and responded well to corticosteroid treatment. PATIENTS: Case 1 was a 67-year-old man reporting right-sided paroxysmal sensory episodes with Jacksonian progression, cheiro-oral symptoms, and motor dysphasia...
January 6, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Jane McEneny, Peter McKavanagh, Edmund York, Nida Nadeem, Mark Harbinson, Michael Stevenson, Peter Ball, Lisa Lusk, Thomas Trinick, Ian S Young, Gareth J McKay, Patrick M Donnelly
BACKGROUND: High density lipoproteins (HDL) protect against cardiovascular disease (CVD). However, increased serum amyloid-A (SAA) related inflammation may negate this property. This study investigated if SAA was related to CVD-burden. METHODS: Subjects referred to the rapid chest pain clinic (n = 240) had atherosclerotic burden assessed by cardiac computerised tomography angiography. Subjects were classified as: no-CVD (n = 106), non-obstructive-CVD, stenosis<50% (n = 58) or moderate/significant-CVD, stenosis ≥50% (n = 76)...
January 2016: Atherosclerosis
Stephen Zewinger, Christiane Drechsler, Marcus E Kleber, Alexander Dressel, Julia Riffel, Sarah Triem, Marlene Lehmann, Chantal Kopecky, Marcus D Säemann, Philipp M Lepper, Günther Silbernagel, Hubert Scharnagl, Andreas Ritsch, Barbara Thorand, Tonia de las Heras Gala, Stefan Wagenpfeil, Wolfgang Koenig, Annette Peters, Ulrich Laufs, Christoph Wanner, Danilo Fliser, Thimoteus Speer, Winfried März
AIMS: High-density lipoproteins (HDLs) are considered as anti-atherogenic. Recent experimental findings suggest that their biological properties can be modified in certain clinical conditions by accumulation of serum amyloid A (SAA). The effect of SAA on the association between HDL-cholesterol (HDL-C) and cardiovascular outcome remains unknown. METHODS AND RESULTS: We examined the association of SAA and HDL-C with mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study, which included 3310 patients undergoing coronary angiography...
November 14, 2015: European Heart Journal
Masatsune Ishikawa, Shigeki Yamada, Kazuo Yamamoto
BACKGROUND: Virchow-Robin spaces (VRS) are brain perivascular spaces containing perforating arteries. Although enlarged VRS are associated with various disorders such as Alzheimer's disease, cerebrovascular disease, and head trauma, their functional role remains unclear. Using highly fluid-sensitive magnetic resonance imaging (MRI) sequences, fine morphological features of VRS and their relevance to idiopathic normal pressure hydrocephalus (iNPH) were investigated. METHODS: Three-dimensional constructive interference in steady state (3D-CISS) on 3 Tesla MRI was applied to 29 individuals...
2015: Fluids and Barriers of the CNS
Xing-Lin Tan, Yue-Qiang Xue, Tao Ma, Xiaofang Wang, Jing Jing Li, Lubin Lan, Kafait U Malik, Michael P McDonald, Alejandro M Dopico, Francesca-Fang Liao
BACKGROUND: Cerebral infarction due to thrombosis leads to the most common type of stroke and a likely cause of age-related cognitive decline and dementia. Endothelial nitric oxide synthase (eNOS) generates NO, which plays a crucial role in maintaining vascular function and exerting an antithrombotic action. Reduced eNOS expression and eNOS polymorphisms have been associated with stroke and Alzheimer's disease (AD), the most common type of dementia associated with neurovascular dysfunction...
2015: Molecular Neurodegeneration
Kazuki Fukuma, Masafumi Ihara, Tomotaka Tanaka, Yoshiaki Morita, Kazunori Toyoda, Kazuyuki Nagatsuka
BACKGROUND: Convexity subarachnoid hemorrhage (cSAH), defined as intrasulcal bleeding restricted to hemispheric convexities, has several etiologies: reversible cerebral vasoconstriction syndrome, cerebral amyloid angiopathy, and internal carotid artery (ICA) stenosis or occlusion. However, it remains unknown whether cerebral artery dissection causes cSAH. METHODS: We retrospectively investigated patients admitted to our hospital between 2005 and 2013 with ischemic stroke or transient ischemic attack caused by cerebral artery dissection...
2015: Cerebrovascular Diseases
Ismet Sarikaya
Routine use of cardiac positron emission tomography (PET) applications has been increasing but has not replaced cardiac single-photon emission computerized tomography (SPECT) studies yet. The majority of cardiac PET tracers, with the exception of fluorine-18 fluorodeoxyglucose (18F-FDG), are not widely available, as they require either an onsite cyclotron or a costly generator for their production. 18F-FDG PET imaging has high sensitivity for the detection of hibernating/viable myocardium and has replaced Tl-201 SPECT imaging in centers equipped with a PET/CT camera...
October 2015: Nuclear Medicine Communications
Carlo Salvarani, Robert D Brown, Teresa Christianson, Dylan V Miller, Caterina Giannini, John Huston, Gene G Hunder
Primary central nervous system vasculitis (PCNSV) is an uncommon condition in which lesions are limited to vessels of the brain and spinal cord. Because the clinical manifestations are not specific, the diagnosis is often difficult, and permanent disability and death are frequent outcomes. This study is based on a cohort of 163 consecutive patients with PCNSV who were examined at the Mayo Clinic over a 29-year period from 1983 to 2011. The aim of the study was to define the characteristics of these patients, which represents the largest series in adults reported to date...
May 2015: Medicine (Baltimore)
Markus Beitzke, Christian Enzinger, Gerit Wünsch, Martin Asslaber, Thomas Gattringer, Franz Fazekas
BACKGROUND AND PURPOSE: Cerebral amyloid angiopathy-related cortical superficial siderosis (cSS) seems to indicate an increased risk of subsequent intracerebral hemorrhage (ICH). We wanted to identify the mechanisms and sequence of hemorrhagic events which are responsible for this association. METHODS: During a 9-year-period, we identified patients with spontaneous convexal subarachnoid hemorrhage (cSAH) and performed a careful longitudinal analysis of clinical and neuroimaging data...
June 2015: Stroke; a Journal of Cerebral Circulation
Andreas Charidimou, Young T Hong, Hans R Jäger, Zoe Fox, Franklin I Aigbirhio, Tim D Fryer, David K Menon, Elizabeth A Warburton, David J Werring, Jean-Claude Baron
BACKGROUND AND PURPOSE: We investigated the relationship between magnetic resonance imaging-visible centrum semiovale perivascular spaces (CSO-PVS), a biomarker of impaired interstitial fluid drainage, and positron emission tomography-based amyloid-β burden across a wide range of cerebrovascular amyloid deposition. METHODS: Thirty-one nondemented subjects (11 probable cerebral amyloid angiopathy patients and 10 healthy subjects≥60 years; 10 older individuals, <60 years) had brain magnetic resonance imaging and Pittsburgh compound B-positron emission tomography...
June 2015: Stroke; a Journal of Cerebral Circulation
Yi Su, Tyler M Blazey, Abraham Z Snyder, Marcus E Raichle, Russ C Hornbeck, Patricia Aldea, John C Morris, Tammie L S Benzinger
Amyloid PET imaging is an indispensable tool widely used in the investigation, diagnosis and monitoring of Alzheimer's disease (AD). Currently, a reference region based approach is used as the mainstream quantification technique for amyloid imaging. This approach assumes the reference region is amyloid free and has the same tracer influx and washout kinetics as the regions of interest. However, this assumption may not always be valid. The goal of this work is to evaluate an amyloid imaging quantification technique that uses arterial region of interest as the reference to avoid potential bias caused by specific binding in the reference region...
2015: PloS One
Umair Khalid, Omar Awar, Gordana Verstovsek, Benjamin Cheong, Sarvari Venkata Yellapragada, Hani Jneid, Anita Deswal, Salim S Virani
Amyloidosis is a rare, multisystem disease characterized by deposition of fibrils in extracellular tissue involving kidney, liver, heart, autonomic nervous system, and several other organs. This report discusses a 75-year-old male who presented with worsening dyspnea on exertion, orthopnea, and lower-extremity edema. On physical exam, he had elevated jugular venous pressure and lower-extremity edema. Electrocardiogram depicted low voltage in limb leads and a prolonged PR interval. Echocardiogram revealed left ventricular hypertrophy, severe biatrial dilatation, and restrictive filling physiology...
January 2015: Methodist DeBakey Cardiovascular Journal
Jasper M Morrow, Mary M Reilly
No abstract text is available yet for this article.
March 2015: Brain: a Journal of Neurology
Carlo Salvarani, Robert D Brown, Teresa J H Christianson, John Huston, Caterina Giannini, Dylan V Miller, Gene G Hunder
OBJECTIVE: To describe the treatment and outcomes of patients with primary central nervous system (CNS) vasculitis. METHODS: We retrospectively studied a cohort of 163 consecutive patients with primary CNS vasculitis who were seen at the Mayo Clinic over a 29-year period. We analyzed treatments, treatment responses, and factors predictive of outcomes. RESULTS: A favorable response was observed in 85% of patients treated with prednisone alone and in 80% of patients treated with prednisone and cyclophosphamide...
June 2015: Arthritis & Rheumatology
Jennifer Kollmer, Ernst Hund, Benjamin Hornung, Ute Hegenbart, Stefan O Schönland, Christoph Kimmich, Arnt V Kristen, Jan Purrucker, Christoph Röcken, Sabine Heiland, Martin Bendszus, Mirko Pham
Transthyretin familial amyloid polyneuropathy is a rare, autosomal-dominant inherited multisystem disorder usually manifesting with a rapidly progressive, axonal, distally-symmetric polyneuropathy. The detection of nerve injury by nerve conduction studies is limited, due to preferential involvement of small-fibres in early stages. We investigated whether lower limb nerve-injury can be detected, localized and quantified in vivo by high-resolution magnetic resonance neurography. We prospectively included 20 patients (12 male and eight female patients, mean age 47...
March 2015: Brain: a Journal of Neurology
John V Ly, Shaloo Singhal, Christopher C Rowe, Peter Kempster, Simon Bower, Thanh G Phan
BACKGROUND: Cerebral amyloid angiopathy (CAA) has been reported to present as convexity subarachnoid hemorrhage (cSAH). Lesser known is that cSAH can herald intracerebral hemorrhage (ICH) and ischemic lesions. We present seven new cases with (11) C-Pittsburgh compound B (PiB) positive positron emission tomography (PET) scans including two with biopsy, review the literature and comment on clinical and radiological findings. METHODS: Patients with cSAH identified on CT, underwent MR imaging and MR angiography to exclude intracranial aneurysm...
May 2015: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
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