Brad H Rovin, Jonathan Barratt, Hiddo J L Heerspink, Charles E Alpers, Stewart Bieler, Dong-Wan Chae, Ulysses A Diva, Jürgen Floege, Loreto Gesualdo, Jula K Inrig, Donald E Kohan, Radko Komers, Laura Ann Kooienga, Richard Lafayette, Bart Maes, Robert Małecki, Alex Mercer, Irene L Noronha, Se Won Oh, Chen Au Peh, Manuel Praga, Priscila Preciado, Jai Radhakrishnan, Michelle N Rheault, William E Rote, Sydney C W Tang, Vladimir Tesar, Howard Trachtman, Hernán Trimarchi, James A Tumlin, Muh Geot Wong, Vlado Perkovic
BACKGROUND: Sparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis. METHODS: PROTECT, a double-blind, randomised, active-controlled, phase 3 study, was done across 134 clinical practice sites in 18 countries throughout the Americas, Asia, and Europe...
December 2, 2023: Lancet