ishemic heart disease

PURPOSE: Data on cell therapy in heart failure patients listed for heart transplantation (HTX) are lacking. We sought to investigate the clinical effects of CD34+ cell therapy in this patient cohort. METHODS: In a single-center retrospective study we analysed data of all patients listed for heart transplantation between 2007 and 2017. Pediatric patients (<18 years), patients with congenital heart disease, mechanical circulatory support, and patients awaiting multi-organ transplantation were excluded...

BACKGROUND: wis a disease with constantly rising economic and social burden; it is associated with multiple comorbidities which contribute to the disease severity. AIM: To investigate the prevalence of co-morbidities in COPD patients and their association with the disease severity and CRP levels. PATIENTS AND METHODS: We conducted a retrospective study among 338 COPD patients (mean age 65.2±7.6 years) with assessment of comorbidities, spirometry measurements and serum levels of CRP...

Intraoperative bradycardia (IOB) is one of the most common cardiac arrhythmias observed in clinical anaesthetic practice. Controlled hypotension, as a strategy of lowering patient's blood pressure during anesthesia has been practiced for decades in head and neck surgery. The aim of our study was to determine the incidence and the risk factors for intraoperative bradycardia in maxillofacial, ear, nose and throat surgery, as well as to determine whether controlled hypotension affects the occurrence of IOB. The retrospective study included 2304 patients who underwent maxillofacial, ear, nose or throat surgery...

The aim of the study to assess the influence of medicamentous therapy to the quality of life of ischemic heart disease patients with stable angina pectoris by activator potassium channels nicorandil in comparison with traditional therapy by isosorbide dinitrate. The study included 84 ischemic heart disease patients. Authors consider quality of life as an estimated category of state of the subject in an illness situation. The dynamic of physical and psychological components of quality of life are compared in ischemic heart disease patients under the treatment by nicorandil and isosorbide dinitrate...

The adaptive mechanisms of action of reflexotherapy are analysed. It was shown in physiological and biochemical experiments on the whole organism, the isolated hearts and strips of resistive arteries of animals that stimulation of acupuncture points by different physical factors increased the activity of opioid, antioxidative, and other stress-limiting systems, reduced secretion of corticosteron during stress, stimulated biosynthesis of stress proteins, induced cyto- and cardioprotective effects, prevented or limited functional and structural hyperadrenal damages...

Using previously developed spectro-photonmetrical method (Bioorg. Khim. 2009. V. 35. pp. 629-639), a significant increase of myeloperoxidase (MPO) activity was found in blood plasma of patients with type 2 diabetes mellitus (DM2) without of cardiovascular complications, as well as with ischemic heart disease (IHD). Plasma MPO concentration measured by an enzyme-linked immunosorbent assay was significantly higher only in blood plasma of patient with DM2 and IHD. A direct and significant correlation between MPO activity and MPO concentration was observed only in blood plasma samples from healthy donors...

581 patients with chronic heart failure (CHF) of ischemic origin with systolic left ventricular dysfunction (SLVD) and preserved left ventricular ejection fraction (PLVEF) were examined. The aim of the study was to investigate the comparative aspect of laboratory examination of patients with chronic heart failure of ischemic origin with left ventricular systolic dysfunction and patients with heart failure and preserved left ventricular ejection fraction. The study found no differences in the groups on the basic parameters: the number of white blood cells, hemoglobin concentration, red blood cell count, platelet count, the number of potassium and sodium ions...

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The prognostic value of some risk factors in emergence of ishemic heart disease and insult were analyzed. 1500 healthy men from 40 to 59 years old were under investigation. Reinvestigation of 71% responses was conducted after 10 years. The prognostic role of different risk factors of ishemic heart disease was revealed. Multifactorial prophylaxis carried out for 5 years among men aged 40 to 59 years brought about a significant decrease in the total death rate (by 22,2%), Mainly because of the lowering of the death rate due to cardiovascular diseases (by 41,3%), determined by a reduction of these indicators among persons who initially had coronary heart disease...

Tissue content of chemical elements indirectly characterizes some metabolic processes. We have analyzed content of chemical elements in left and right ventricular myocardium of patients with ischemic heart disease with progressing heart failure and have shown that during development and progression of heart failure metabolic processes have unidirectional character in myocardium of both ventricles. Derangement of left ventricular contractile capacity is associated with lowering of content of microelements involved in antioxidant processes and energy metabolism in tissues (Cu, Mn, Cr) and elevated concentration of elements characterizing progressive of myocardial stiffness (Ca, Fe)...

Clinico-instrumental characteristics of arterial hypertension, liable to the ishemic stroke were studied. The pecularities of clinical, neurological picture of disease and results of instrumental methods of examination were determined. These peculiarities let to educe the course of arterial hypertension, liable to the ishemic stroke. This course appeared because of hypertensional macroangiopathy during 3-5 years, two atherosclerotic stenosis of brachiocephalic arteria, occlusions and stenosis of these arterias, left ventricular hypertrophy of hypodynamic type, circulatory dynamics against the bad daily profile of arterial pressure and/or increased variability of arterial pressure accompanied with ischemic attacks, signs of chronicle heart failure and circulatory encephalopathy...

INTRODUCTION: Treatment of ischemic mitral regurgitation in patients that require revascularization of myocardium is still debatable. OBJECTIVE: The aim of this study was to compare three surgical approaches: valve repair and revascularization; valve replacement and revascularization, and revascularization alone. METHODS: In 2006 and 2007 at the Institute for Cardiovascular Diseases, Clinical Centre of Serbia, Belgrade, 1,040 patients with coronary disease underwent surgery...

BACKGROUND: We have investigated variations in the C-reactive protein levels in groups of patients with left ventricular dysfunction of various causes. MATERIALS AND METHODS: We have studied 59 patients (ranging from 40 to 80 years, mean age of 64, SD 9) with left ventricular dysfunction caused by dilated cardiomyopathy, valvular heart disease, chronic ischemic cardiomyopathy. These patients have been compared to 30 healthy subjects and to 15 others with acute myocardial infarction...

Erythropoietin level was studied in blood plasma of humans from different age groups and in patients with chronic hearts failure of ishemic genesis. It was determined that there was no statistically significant difference of erythropoietin level among the age groups. Erythropoietin level in patients with chronic heart failure was 16-fold greater (102.86 +/- 29.04 mU/ml) than in the studied elder aged groups (6.38 +/- 1.82 mU/ml). The data obtained indicate that elderly (60 to 85 years) persons' organisms retain the ability of response to hypoxia by intensive erythropoietin production...

AIM: To study prevalence of arterial hypertension (AH) in relation to gender, age, profession, risk factors (RF), RF combination; efficacy of active long-term multifactor prevention among the employees of industrial enterprises in some regions of Russia. MATERIAL AND METHODS: 14000 males and 20969 females from industrial enterprises of Cheboksary, Pskov, St-Petersburg were examined. 8974 males and 14515 females worked at enterprises of active intervention (EAI) while 1848 males and 1643 females were employed at comparison enterprises...

Continuous brain blood supply in healthy individuals is warranted by brain autoregulation, the borders of which are not completely strict and can be changed as a part of dynamic physiological control. In acute neurological diseases like hypertensive encephalopathy, brain infarction, intracerebral hemorrhage and subarachnoid hemorrhage, a great attention should be paid to cerebral perfusion pressure preservation (which represents a difference between mean arterial pressure and intracranial pressure) when blood pressure is regulated...

INTRODUCTION: Homocysteine is a sulphur amino acid produced by demethylation of the essential amino acid methionine. Dysfunction of certain enzymes or insufficient intake of nutrients may cause increase of intracellular homocysteine, which is then exported into plasma. ETIOPATHOGENESIS OF CARDIOVASCULAR DISEASES ACCOMPANIED WITH HIGHER LEVEL OF HOMOCYSTEINE: McCully's theory suggests that high levels of homocysteine are associated with cardiovascular diseases, arteriosclerosis and endothelial dysfunction...

This research highlights high clinical affectivity of Amlodipine in patients with essential hypertension complicated by ishemic heart disease. Monotherapy with Amlodipine doesn't deteriorate contractive quality of the left ventricle. Therapy with Amlodipine considerably improves the diastolic function of the left ventricle and adjusts it. These positive changes are expressed in decreasing preload, end-diastolic pressure of the left ventricle.

BACKGROUND: Obesity is an independent risk factor for ischemic heart disease and affects the status of other risk factors for cardiovascular disease. OBJECTIVE: To study the attitude of physicians to obesity by examining discharge letters of overweight patients with ischemic heart disease. METHODS: We used the HOLEM database for this analysis. The HOLEM project was designed to study the NCEP (National Cholesterol Education Program) guideline implementation among patients with IHD at hospital discharge...

The investigation of influent of antiatherosclerotic diets with inulin on clinical and metabolic parameters in patients with cardiovascular diseases. Results of the study show that enrichment of a diets with inulin in patients with ishemic heart disease and hypertension improved clinic status, antropometric levels, lipid spectrum of blood and immune status. The research has shown, that the use in the treat-preventive purposes inulin is rather perspective.