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IL-33 intestine

Mona Dixon Gundersen, Rasmus Goll, Johanna Hol, Trine Olsen, Renathe Rismo, Sveinung W Sørbye, Olav Sundnes, Guttorm Haraldsen, Jon Florholmen
Interleukin 33 (IL-33) is a cytokine preferentially elevated in acute ulcerative colitis (UC), inferring a role in its pathogenesis. The role of IL-33 in intestinal inflammation is incompletely understood, with both pro-inflammatory and regulatory properties described. There are also conflicting reports on cellular sources and subcellular location of IL-33 in the colonic mucosa, justifying a closer look at IL-33 expression in well-defined clinical stages of UC. A total of 50 study participants (29 UC patients and 21 healthy controls) were included from a prospective cohort of inflammatory bowel disease patients treated to disease remission with infliximab, a tumour necrosis factor alpha (TNF) inhibitor...
October 17, 2016: Scientific Reports
Giorgos Bamias, Fabio Cominelli
PURPOSE OF REVIEW: Cytokines of the intestinal microenvironment largely dictate immunological responses after mucosal insults and the dominance of homeostatic or proinflammatory pathways. This review presents important recent studies on the role of specific cytokines in the pathogenesis of intestinal inflammation. RECENT FINDINGS: The particular mucosal effects of cytokines depend on their inherent properties but also the cellular origin, type of stimulatory antigens, intermolecular interactions, and the particular immunological milieu...
November 2016: Current Opinion in Gastroenterology
Chang Hwan Choi, In Do Song, Young Ho Kim, Ja Seol Koo, You Sun Kim, Joo Sung Kim, Nayoung Kim, Eun Soo Kim, Jae Hak Kim, Ji Won Kim, Tae Oh Kim, Hyun Soo Kim, Hyo Jong Kim, Young Sook Park, Dong Il Park, Soo Jung Park, Hyun Joo Song, Sung Jae Shin, Suk Kyun Yang, Byong Duk Ye, Kang Moon Lee, Bo In Lee, Sun Young Lee, Chang Kyun Lee, Jong Pil Im, Byung Ik Jang, Tae Joo Jeon, Yu Kyung Cho, Sae Kyung Chang, Seong Ran Jeon, Sung Ae Jung, Yoon Tae Jeen, Jae Myung Cha, Dong Soo Han, Won Ho Kim
PURPOSE: Infliximab is currently used for the treatment of active Crohn's disease (CD). We aimed to assess the efficacy and safety of infliximab therapy and to determine the predictors of response in Korean patients with CD. MATERIALS AND METHODS: A total of 317 patients who received at least one infliximab infusion for active luminal CD (n=198) and fistulizing CD (n=86) or both (n=33) were reviewed retrospectively in 29 Korean referral centers. Clinical outcomes of induction and maintenance therapy with infliximab, predictors of response, and adverse events were evaluated...
November 2016: Yonsei Medical Journal
Ronaldo A Ribeiro, Carlos W S Wanderley, Deysi V T Wong, José Maurício S C Mota, Caio A V G Leite, Marcellus H L P Souza, Fernando Q Cunha, Roberto C P Lima-Júnior
PURPOSE: Intestinal mucositis and diarrhea are common manifestations of anticancer regimens that include irinotecan, 5-fluorouracil (5-FU), and other cytotoxic drugs. These side effects negatively impact therapeutic outcomes and delay subsequent cycles of chemotherapy, resulting in dose reductions and treatment discontinuation. Here, we aimed to review the experimental evidence regarding possible new targets for the management of irinotecan- and 5-FU-related intestinal mucositis. METHODS: A literature search was performed using the PubMed and MEDLINE databases...
September 2, 2016: Cancer Chemotherapy and Pharmacology
David Díaz-Jiménez, Marjorie De la Fuente, Karen Dubois-Camacho, Glauben Landskron, Janitza Fuentes, Tamara Pérez, María Julieta González, Daniela Simian, Marcela A Hermoso, Rodrigo Quera
BACKGROUND: The ST2/IL-33 pathway has been related to ulcerative colitis (UC), and soluble ST2 (sST2), to disease severity. We tested the potential usefulness of sST2 as a predictive marker of treatment response and patients' outcome. METHODS: Twenty-six patients with active UC were prospectively recruited and grouped according to an endoscopic score and therapy response. Colonoscopic biopsies were collected at baseline and 6 months or when patients showed clinical activity...
2016: BMC Gastroenterology
Lei Yan, Chun-Rong Wu, Chen Wang, Chun-Hui Yang, Guang-Zhi Tong, Jian-Guo Tang
BACKGROUND: Inflammation is supposed to play a key role in the pathophysiological processes of intestinal ischemia-reperfusion injury (IIRI), and Candida albicans in human gut commonly elevates inflammatory cytokines in intestinal mucosa. This study aimed to explore the effect of C. albicans on IIRI. METHODS: Fifty female Wistar rats were divided into five groups according to the status of C. albicans infection and IIRI operation: group blank and sham; group blank and IIRI; group cefoperazone plus IIRI; group C...
July 20, 2016: Chinese Medical Journal
M S Islam, K Horiguchi, S Iino, N Kaji, S Mikawa, M Hori, H Ozaki
BACKGROUND AND PURPOSE: IL-33 is a novel cytokine that is believed to be involved in inflammation and carcinogenesis. However, its source, its production and its secretion process remain unclear. Recently, we have reported that IL-33 is up-regulated in dextran sulfate sodium (DSS) colitis in mice. EXPERIMENTAL APPROACH: Production of IL-33 from intestinal tissue was studied in a murine cancer model induced by azoxymethane (AOM) and DSS in vivo and in cultures of IEC-6 epithelial cells...
August 2016: British Journal of Pharmacology
Hélène Donnadieu-Rigole, Thibault Mura, Pierre Portales, Isabelle Duroux-Richard, Martine Bouthier, Jean-François Eliaou, Pascal Perney, Florence Apparailly
Excessive alcohol consumption has a modulating effect on immune functions that may contribute to decreased immunity and host defense. It is associated with increased intestinal permeability to endotoxins that is normalized after 14 d of abstinence. Whether and how blood monocyte subsets are impaired in patients with an AUD and what their evolution is after alcohol withdrawal are the paper's objectives. With the use of flow cytometry, blood monocyte subsets were quantified in AUDs before (n = 40) and 2 wk after (n = 33) alcohol withdrawal and compared with HC donors (n = 20)...
June 2, 2016: Journal of Leukocyte Biology
Li Liu, Binru Wang, Gengtian Liang, Ling Lu, Liping Yang
OBJECTIVE: To explore the expression and significance of vasoactive intestinal peptide and Pituitary adenylate cyclase activiting polypeptide (VIP/PACAP) of nasal mucosa in rats with allergic rhinitis (AR), and the function of botulinum toxin-A(BTX-A) to inhibit the expression of VIP/PACAP in AR. METHOD: Thirty Sprague-Dawley rats were randomly divided into 3 groups, which were the AR group, the intervention group, and the control group. In the AR group, ovalbumin was used to sensitize healthy rats...
January 2016: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Hong'ao Deng, Hongyan Zhang, Linpeng Xiong, Yan Peng
OBJECTIVE: To explore the change in the expression of extracellular heat shock protein 70 (eHSP70) and interleukin 2 (IL-2) and their correlation in intestine of rats with severe scald injury, and to observe the effects of eHSP70 on CD3(+) T lymphocytes in Peyer's patch of intestine in rats with severe scald injury in vitro. METHODS: (1) Sixty male SD rats were divided into normal control group (NC, n=10, only anesthetized) and scald group (S, n=50) according to the random number table...
May 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Satiesh Kumar Ramadass, Sugin Lal Jabaris, Ramesh Kannan Perumal, Villianur Ibrahim HairulIslam, Arun Gopinath, Balaraman Madhan
Ulcerative colitis, particularly the chronic persistent form is characterized by the presence of active inflammation and extensive areas of ulceration in the colonic mucosa. The existing treatment protocol aims at only reducing intestinal inflammation, rather than targeting mucosal ulceration. In this study, type I collagen and its daughter peptides called collagen hydrolysate, highly popular reconstructive materials for tissue engineering applications, are hypothesized as healing matrices to target the recuperation of internal mucosal ulceration...
August 25, 2016: European Journal of Pharmaceutical Sciences
Mousumi Mahapatro, Sebastian Foersch, Manuela Hefele, Gui-Wei He, Elisa Giner-Ventura, Tamar Mchedlidze, Markus Kindermann, Stefania Vetrano, Silvio Danese, Claudia Günther, Markus F Neurath, Stefan Wirtz, Christoph Becker
The intestinal epithelium constitutes an efficient barrier against the microbial flora. Here, we demonstrate an unexpected function of IL-33 as a regulator of epithelial barrier functions. Mice lacking IL-33 showed decreased Paneth cell numbers and lethal systemic infection in response to Salmonella typhimurium. IL-33 was produced upon microbial challenge by a distinct population of pericryptal fibroblasts neighboring the intestinal stem cell niche. IL-33 programmed the differentiation of epithelial progenitors toward secretory IEC including Paneth and goblet cells...
May 24, 2016: Cell Reports
Mark Asquith, James T Rosenbaum
PURPOSE OF REVIEW: The intestinal microbiome is increasingly implicated in the pathogenesis of ankylosing spondylitis, reactive arthritis, and other diseases collectively known as the spondyloarthropathies (SpAs). In common with other complex inflammatory diseases, SpAs have both a strong genetic and environmental component. Recent genetic studies have highlighted host pathways that may intersect the host-microbiota interaction and offer novel paradigms to understand the pathophysiology of these diseases...
July 2016: Current Opinion in Rheumatology
Dun Liu, Xiao-Ying Jiang, Lan-Shu Zhou, Ji-Hong Song, Xuan Zhang
Many studies have found that probiotics or synbiotics can be used in patients with diarrhea or inflammatory bowel disease for the prevention and treatment of some pathologies by improving gastrointestinal barrier function. However, there are few studies availing the use of probiotics in patients with colorectal cancer. To lay the foundation for the study of nutritional support in colorectal cancer patients, a meta-analysis has been carried out to assess the efficacy of probiotics on the intestinal mucosa barrier in patients with colorectal cancer after operation...
April 2016: Medicine (Baltimore)
Wei Zhu, Zaishun Jin, Jianbo Yu, Jun Liang, Qingdong Yang, Fujuan Li, Xuekui Shi, Xiaodong Zhu, Xiaoli Zhang
Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the intestinal tract. Baicalin, originally isolated from the root of the Chinese herb Huangqin (Scutellaria baicalensis Georgi) and its main active ingredient, has a protective effect against inflammatory responses in several diseases. The present study investigated the effects of baicalin on macrophage polarization and its therapeutic role in IBD. Murine peritoneal macrophages and mice with colitis were treated with baicalin. Macrophage subset distribution, M1 and M2 macrophage-associated mRNA expression, and interferon regulatory factor 4 and 5 (IRF4 and IRF5) expression were analyzed...
June 2016: International Immunopharmacology
Anika Vogt, Philipp A Reuken, Sven Stengel, Andreas Stallmach, Tony Bruns
AIM: To prospectively analyze the impact of increased intestinal permeability (IP) on mortality and the occurrence of infections in patients with cirrhosis. METHODS: IP was quantified using the lactulose/mannitol (L/M) test in 46 hospitalized patients with cirrhosis (25 Child-Pugh A/B, 21 Child-Pugh C) and in 16 healthy controls. Markers of inflammation [LPS-binding protein, Interleukin-6 (IL-6)] and enterocyte death [intestinal fatty-acid binding protein (I-FABP)] were determined in serum using enzyme-linked immunosorbent assays...
March 21, 2016: World Journal of Gastroenterology: WJG
Christian Schwartz, Katie O'Grady, Ed C Lavelle, Padraic G Fallon
Interleukin (IL)-33, a member of the IL-1 family, was originally described in 2005 as a potent initiator of type 2 immunity found during allergic inflammation and parasitic infections. IL-33 has been shown to play important and potent roles bridging innate and adaptive immunity in the regulation of tissue homeostasis, injury, and repair. Recent discoveries have extended the range of functions for IL-33 beyond type 2 conditions and its role as an alarmin at barrier sites, with emerging central roles for IL-33 in T-cell regulation, obesity, viral and tumor immunity...
May 2016: European Journal of Immunology
Marina Saresella, Federica Piancone, Ivana Marventano, Martina Zoppis, Ambra Hernis, Michela Zanette, Daria Trabattoni, Matteo Chiappedi, Alessandro Ghezzo, Maria Paola Canevini, Francesca la Rosa, Susanna Esposito, Mario Clerici
BACKGROUND: Inflammasomes are multimeric protein platforms involved in the regulation of inflammatory responses whose activity results in the production of proinflammatory cytokines. Because neuroinflammation is observed in autistic spectrum disorders (ASD), a neurologic condition of childhood resulting in a complex behavioural impairment, we analyzed the inflammasomes activity in ASD. Additionally we verified whether alterations of the gastrointestinal (GI) barriers might play a role in inflammasomes activation...
October 2016: Brain, Behavior, and Immunity
Juliana Santos Bittencourt Menegat, Ronaldo Lira-Junior, Mariana Alves Siqueira, Fernanda Brito, Ana Teresa Carvalho, Ricardo Guimarães Fischer, Carlos Marcelo Figueredo
OBJECTIVE: To evaluate the expression of the cytokines IFN-γ, IL-1β, IL-4, IL-6, IL-10, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IL-17A, IL-17F, sCD40L, and TNF-α in gingival tissue and intestinal mucosa of patients having both periodontitis and inflammatory bowel disease (IBD) and assess how they cluster in both tissues. METHODS: This cross-sectional study selected 28 patients with periodontitis (18 with Crohn's disease and 10 with ulcerative colitis) from the IBD gastroenterology outpatient clinic at the Pedro Ernesto University Hospital...
June 2016: Archives of Oral Biology
Kirsten D Mertz, Lukas F Mager, Marie-Hélène Wasmer, Thore Thiesler, Viktor H Koelzer, Giulia Ruzzante, Stefanie Joller, Jenna R Murdoch, Thomas Brümmendorf, Vera Genitsch, Alessandro Lugli, Gieri Cathomas, Holger Moch, Achim Weber, Inti Zlobec, Tobias Junt, Philippe Krebs
Colorectal cancer (CRC) develops through a multistep process and is modulated by inflammation. However, the inflammatory pathways that support intestinal tumors at different stages remain incompletely understood. Interleukin (IL)-33 signaling plays a role in intestinal inflammation, yet its contribution to the pathogenesis of CRC is unknown. Using immunohistochemistry on 713 resected human CRC specimens, we show here that IL-33 and its receptor ST2 are expressed in low-grade and early-stage human CRCs, and to a lesser extent in higher-grade and more advanced-stage tumors...
2016: Oncoimmunology
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