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IL-33 intestine

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https://www.readbyqxmd.com/read/29049008/exogenous-murine-antimicrobial-peptide-cramp-significantly-exacerbates-ovalbumin-induced-airway-inflammation-but-ameliorates-oxazolone-induced-intestinal-colitis-in-balb-c-mice
#1
Yang Li, Xiaojie Chu, Cunbao Liu, Weiwei Huang, Yufeng Yao, Ye Xia, Pengyan Sun, Qiong Long, Xuejun Feng, Kui Li, Xu Yang, Hongmei Bai, Wenjia Sun, Yanbing Ma
Cathelicidin has been reported to be multifunctional. The current study aimed to investigate the influences of exogenous cathelicidin-related antimicrobial peptide (CRAMP) on inflammatory responses in different disease models. In OVA-induced allergic airway inflammation, CRAMP significantly enhanced the infiltration of inflammatory cells and accumulation of proinflammatory Th2 cytokine IL-13 and IL-33 in bronchial alveolar lavage fluid (BALF), exacerbated lung tissue inflammation and airway goblet cell hyperplasia, and elevated OVA-specific IgE level in serum...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29045902/epidermal-growth-factor-receptor-expression-licenses-type-2-helper-t-cells-to-function-in-a-t-cell-receptor-independent-fashion
#2
Carlos M Minutti, Sebastian Drube, Natalie Blair, Christian Schwartz, Jame C McCrae, Andrew N McKenzie, Thomas Kamradt, Michal Mokry, Paul J Coffer, Maria Sibilia, Alice J Sijts, Padraic G Fallon, Rick M Maizels, Dietmar M Zaiss
Gastro-intestinal helminth infections trigger the release of interleukin-33 (IL-33), which induces type-2 helper T cells (Th2 cells) at the site of infection to produce IL-13, thereby contributing to host resistance in a T cell receptor (TCR)-independent manner. Here, we show that, as a prerequisite for IL-33-induced IL-13 secretion, Th2 cells required the expression of the epidermal growth factor receptor (EGFR) and of its ligand, amphiregulin, for the formation of a signaling complex between T1/ST2 (the IL-33R) and EGFR...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/28943769/effect-of-lactic-acid-bacteria-fermented-mulberry-leaf-extract-on-the-improvement-of-intestinal-function-in-rats
#3
Hyun-Joo Lee, Hwan Lee, Yang-Il Choi, Jae-Joon Lee
This study examined the laxative effects of mulberry leaf extract (MLE) fermented by lactic acid bacteria (LAB), which contains high levels of polyphenolic and flavonoid compounds, against loperamide-induced constipation in rats. Sprague-Dawley rats were divided into a normal group (N) and three experimental groups; loperamide treated group (C), loperamide and LAB-fermented MLE 300 mg/kg treated group (MLEL), and loperamide and LAB-fermented MLE 600 mg/kg treated group (MLEH). After 33 d, fecal pellet amount, fecal weight, water content of fecal, gastrointestinal transit time and length, and serum lipid profiles were measured...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28870670/il-1-receptor-like-1-protects-against-alcoholic-liver-injury-by-limiting-nf-%C3%AE%C2%BAb-activation-in-hepatic-macrophages
#4
Meng Wang, Guannan Shen, Liangguo Xu, Xiaodong Liu, Jared M Brown, Dechun Feng, Ruth Ann Ross, Bin Gao, Suthat Liangpunsakul, Cynthia Ju
BACKGROUND & AIM: Alcohol consumption, through increasing intestinal permeability and causing hepatocytes damage, leads to the release of pathogen- and damage-associated molecular pattern molecules (PAMPs and DAMPs). These molecules stimulate hepatic macrophages (MΦs) and activate NF-κB, resulting in inflammation and exacerbating alcoholic liver disease (ALD). However, much less is known about the mechanisms attenuating inflammation and preventing disease progression in the majority of the heavy drinkers...
September 1, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28844856/rip3-and-pmlkl-promote-necroptosis-induced-inflammation-and-alter-membrane-permeability-in-intestinal-epithelial-cells
#5
Anna Negroni, Eleonora Colantoni, Maria Pierdomenico, Francesca Palone, Manuela Costanzo, Salvatore Oliva, Antonio Tiberti, Salvatore Cucchiara, Laura Stronati
BACKGROUND: Necroptosis is an inflammatory form of programmed cell death requiring receptor-interacting protein kinase 3 (RIP3) and mixed lineage kinase domain-like protein (MLKL). AIMS: The aim of this study is to examine in depth in vitro and ex vivo the contribution of necroptosis to intestinal inflammation. METHODS: In vitro: we used an intestinal cell line, HCT116RIP3, produced in our laboratory and overexpressing RIP3. Ex vivo: intestinal mucosal biopsies were taken from patients with inflammatory bowel disease (IBD) (20 with Crohn's disease; 20 with ulcerative colitis) and from 20 controls...
August 10, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28770467/candidate-gene-analysis-in-pathogenesis-of-surgically-and-non-surgically-treated-necrotizing-enterocolitis-in-preterm-infants
#6
Dawid Szpecht, Natalia Neumann-Klimasińska, Michał Błaszczyński, Agnieszka Seremak-Mrozikiewicz, Grażyna Kurzawińska, Dorothy Cygan, Marta Szymankiewicz, Krzysztof Drews, Janusz Gadzinowski
Necrotizing enterocolitis (NEC) is one of the most severe and unpredictable complications of prematurity. There are two possible mechanisms involved in the pathogenesis of NEC: individual inflammatory response and impaired blood flow in mesenteric vessels with secondary ischemia of the intestine. The aim of this study was to evaluate the possible relationship between polymorphisms: Il-1β 3953C>T, Il-6 -174G>C and -596G>A, TNFα -308G>A, and 86 bp variable number tandem repeat polymorphism of interleukin-1 receptor antagonist (Il-1RN VNTR 86 bp) and three polymorphisms that may participate in arteries tension regulation and in consequence in intestine blood flow impairment: eNOS (894G>T and -786T>C) and END-1 (5665G>T) and NEC in 100 infants born from singleton pregnancy, before 32 + 0 weeks of gestation, exposed to antenatal steroids therapy, and without congenital abnormalities...
August 2, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28710436/epithelial-derived-il-33-promotes-intestinal-tumorigenesis-in-apc-min-mice
#7
Zhengxiang He, Lili Chen, Fabricio O Souto, Claudia Canasto-Chibuque, Gerold Bongers, Madhura Deshpande, Noam Harpaz, Huaibin M Ko, Kevin Kelley, Glaucia C Furtado, Sergio A Lira
Increased expression of Interleukin (IL)-33 has been detected in intestinal samples of patients with ulcerative colitis, a condition associated with increased risk for colon cancer, but its role in the development of colorectal cancer has yet to be fully examined. Here, we investigated the role of epithelial expressed IL-33 during development of intestinal tumors. IL-33 expression was detected in epithelial cells in colorectal cancer specimens and in the Apc (Min/+) mice. To better understand the role of epithelial-derived IL-33 in the intestinal tumorigenesis, we generated transgenic mice expressing IL-33 in intestinal epithelial cells (V33 mice)...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28687373/il-33-and-the-intestine-the-good-the-bad-and-the-inflammatory
#8
REVIEW
Zerina Hodzic, Ellen Merrick Schill, Alexa M Bolock, Misty Good
Interleukin-33 (IL-33) is a member of the IL-1 cytokine family that has been widely studied since its discovery in 2005 for its dichotomous functions in homeostasis and inflammation. IL-33, along with its receptor suppression of tumorigenicity 2 (ST2), has been shown to modulate both the innate and adaptive immune system. Originally, the IL-33/ST2 signaling axis was studied in the context of inducing type 2 immune responses with the expression of ST2 by T helper 2 (TH2) cells. However, the role of IL-33 is not limited to TH2 responses...
July 4, 2017: Cytokine
https://www.readbyqxmd.com/read/28627342/-baicalein-attenuates-acute-lung-injury-induced-by-intestinal-ischemia-reperfusion-via-inhibition-of-nuclear-factor-%C3%AE%C2%BAb-pathway-in-mice
#9
Lei Chu, Fenyong Zhu, Wenjun Zhou, Zhongxiang Du, Jie Li, Xiaohong Wang, Lihui Wang, Anding Liu
OBJECTIVE: To investigate the effects of baicalein (Bai) on acute lung injury (ALI) induced by intestinal ischemia/reperfusion (I/R) and its mechanism in mice. METHODS: Twenty-four male C57BL/6J mice were divided into three groups by random number table: namely sham group, I/R group and Bai+I/R group, with 8 mice in each group. Intestinal I/R induced lung injury model was reproduced by clamping superior mesenteric artery for 90 minutes, followed by reperfusion. Bai (100 mg/kg) was intraperitoneally injected 1 hour before ischemic challenge in the Bai+I/R group...
March 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28627210/lactobacillus-rhamnosusgg-reduces-hepatic-fibrosis-in-a-model-of-chronic-liver-disease-in-rats
#10
Thais Ortiz Hammes, Renata Leke, Thayssa Dalla Costa Escobar, Laisa Beduschi Fracasso, Fabiola Schons Meyer, Michael Éverton Andrades, Themis Reverbel da Silveira
BACKGROUND: The intestinal dysbiosis is common in chronic liver disease and can induce to inflammatory responses and mediate the collagen deposition in the liver. AIM: To evaluate the probiotic Lactobacillus rhamnosus GG (LGG) for the treatment of liver fibrosis in a model of chronic cholestatic liver disease in rats. METHODS: Male adult Wistar rats (n = 29) were submitted to common bile duct ligation (BDL groups) or manipulation of common bile duct without ligation (Ctrl groups)...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28622455/intestinal-metabolites-are-profoundly-altered-in-the-context-of-hla-b27-expression-and-functionally-modulate-disease-in-a-rat-model-of-spondyloarthritis
#11
Mark Asquith, Sean Davin, Patrick Stauffer, Claire Michell, Cathleen Janowitz, Phoebe Lin, Joe Ensign-Lewis, Jason M Kinchen, Dennis R Koop, James T Rosenbaum
OBJECTIVE: HLA-B27-associated spondyloarthritides are associated with an altered intestinal microbiota and bowel inflammation. We undertook this study to identify HLA-B27-dependent changes in both host and microbial metabolites in the HLA-B27/β2 -microglobulin (β2 m)-transgenic rat and to determine whether microbiota-derived metabolites could impact disease in this major model of spondyloarthritis. METHODS: Cecal contents were collected from Fischer 344 33-3 HLA-B27/β2 m-transgenic rats and wild-type controls at 6 weeks (before disease) and 16 weeks (with active bowel inflammation)...
October 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28533995/crohn-s-disease-and-ulcerative-colitis-show-unique-cytokine-profiles
#12
Zoltan H Nemeth, Dorian A Bogdanovski, Patricia Barratt-Stopper, Samantha R Paglinco, Luca Antonioli, Rolando H Rolandelli
INTRODUCTION: Networks of cytokines have been implicated in both forms of inflammatory bowel disease (IBD): Crohn's disease (CD) and ulcerative colitis (UC). While CD has associated with T-helper type 1 (Th1) immune responses, UC shows Th2 patterns. Recent studies reported that the inflamed intestinal regions in both CD and UC are significantly infiltrated with a newly described set of T helper, the Th17 cells. These cells have unique cytokine responses. These findings prompted us to further explore the cytokine profiles of CD and UC with a special focus on the Th2 and Th17 related mediators...
April 19, 2017: Curēus
https://www.readbyqxmd.com/read/28514691/mast-cells-are-crucial-for-induction-of-group-2-innate-lymphoid-cells-and-clearance-of-helminth-infections
#13
Chikako Shimokawa, Takashi Kanaya, Masami Hachisuka, Kenji Ishiwata, Hajime Hisaeda, Yosuke Kurashima, Hiroshi Kiyono, Tomohiro Yoshimoto, Tsuneyasu Kaisho, Hiroshi Ohno
Mast cells are important for eradication of intestinal nematodes; however, their precise mechanisms of action have remained elusive, especially in the early phase of infection. We found that Spi-B-deficient mice had increased numbers of mast cells and rapidly expelled the Heligmosomoides polygyrus (Hp) nematode. This was accompanied by induction of interleukin-13 (IL-13)-producing group 2 innate lymphoid cells (ILC2) and goblet cell hyperplasia. Immediately after Hp infection, mast cells were rapidly activated to produce IL-33 in response to ATP released from apoptotic intestinal epithelial cells...
May 16, 2017: Immunity
https://www.readbyqxmd.com/read/28500039/selected-probiotic-lactobacilli-have-the-capacity-to-hydrolyze-gluten-peptides-during-simulated-gastrointestinal-digestion
#14
Ruggiero Francavilla, Maria De Angelis, Carlo Giuseppe Rizzello, Noemi Cavallo, Fabio Dal Bello, Marco Gobbetti
The aim of this study was to demonstrate the capacity of probiotic lactobacilli to hydrolyze immunogenic gluten peptides. Eighteen commercial strains of probiotic lactobacilli with highly variable peptidase activity (i.e., aminopeptidase N, iminopeptidase, prolyl endopeptidyl peptidase, tripeptidase, prolidase, prolinase, and dipeptidase), including toward Pro-rich peptides, were tested in this study. Ten probiotic strains were selected on the basis of their specific enzyme activity. When pooled, these 10 strains provided the peptidase portfolio that is required to completely degrade the immunogenic gluten peptides involved in celiac disease (CD)...
July 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28484466/the-st2-il-33-axis-in-immune-cells-during-inflammatory-diseases
#15
REVIEW
Brad Griesenauer, Sophie Paczesny
Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a decoy receptor, sequesters free IL-33, and does not signal, and a membrane-bound form (ST2), which activates the MyD88/NF-κB signaling pathway to enhance mast cell, Th2, regulatory T cell (Treg), and innate lymphoid cell type 2 functions. sST2 levels are increased in patients with active inflammatory bowel disease, acute cardiac and small bowel transplant allograft rejection, colon and gastric cancers, gut mucosal damage during viral infection, pulmonary disease, heart disease, and graft-versus-host disease...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28437001/tumour-associated-changes-in-intestinal-epithelial-cells-cause-local-accumulation-of-klrg1-gata3-regulatory-t-cells-in-mice
#16
Holger Meinicke, Anna Bremser, Maria Brack, Paulina Akeus, Claire Pearson, Samuel Bullers, Katrin Hoffmeyer, Marc P Stemmler, Marianne Quiding-Järbrink, Ana Izcue
CD4(+) Foxp3(+) regulatory T (Treg) cells include differentiated populations of effector Treg cells characterized by the expression of specific transcription factors. Tumours, including intestinal malignancies, often present with local accumulation of Treg cells that can prevent tumour clearance, but how tumour progression leads to Treg cell accumulation is incompletely understood. Here using genetically modified mouse models we show that ablation of E-cadherin, a process associated with epithelial to mesenchymal transition and tumour progression, promotes the accumulation of intestinal Treg cells by the specific accumulation of the KLRG1(+) GATA3(+) Treg subset...
September 2017: Immunology
https://www.readbyqxmd.com/read/28428709/disruption-of-the-tweak-fn14-pathway-prevents-5-fluorouracil-induced-diarrhea-in-mice
#17
Takuhito Sezaki, Yuki Hirata, Teruki Hagiwara, Yuki I Kawamura, Tadashi Okamura, Rieko Takanashi, Kenta Nakano, Miwa Tamura-Nakano, Linda C Burkly, Taeko Dohi
AIM: To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil (5-FU)-induced diarrhea. METHODS: Diarrhea was induced in wild-type (WT), Fn14 knockout (KO), and IL-13 receptor (IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinoma-bearing mice were co-treated with an anti-TWEAK antibody and 5-FU. Embryonic fibroblast response to cytokines was also analyzed...
April 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28404987/interleukin-33-regulates-intestinal-inflammation-by-modulating-macrophages-in-inflammatory-bowel-disease
#18
Dong Hyuk Seo, Xiumei Che, Min Seob Kwak, Soochan Kim, Jae Hyeon Kim, Hyun Woo Ma, Da Hye Kim, Tae Il Kim, Won Ho Kim, Seung Won Kim, Jae Hee Cheon
Interleukin 33 (IL-33) that signals through the ST2 receptor has emerged as a critical modulator in several inflammatory disorders, including inflammatory bowel disease (IBD). However, the precise mechanisms by which IL-33 modulates IBD are controversial. The aim of this study was thus to clarify the role of IL-33 in IBD. The plasma levels of IL-33 were significantly decreased, but soluble ST2 levels were increased in patients with IBD compared to healthy individuals. Moreover, IL-33 restored goblet cell numbers and induced macrophage switching from the M1 to the M2 phenotype...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28273631/protective-effects-of-n-acetylcystein-and-atorvastatin-against-renal-and-hepatic-injury-in-a-rat-model-of-intestinal-ischemia-reperfusion
#19
Dimitrios Alexandropoulos, Gerasimos V Bazigos, Ilias P Doulamis, Aspasia Tzani, Panagiotis Konstantopoulos, Nikolitsa Tragotsalou, Agathi Kondi-Pafiti, Thomas Kotsis, Nikolaos Arkadopoulos, Vasileios Smyrniotis, Despina N Perrea
AIM OF THE STUDY: We sought to examine whether the separate and combined effect of N-acetylcystein (NAC) and atorvastatin prevented hepatic and renal tissue injury induced by intestinal ischemia-reperfusion (I/R). MATERIAL AND METHODS: 40 male Wistar rats were allocated into 5 experimental groups; Control (n=8): sham, I/R (n=8): rats underwent occlusion of superior mesenteric artery for 45min, Atorvastatin (n=8): rats received 10mg/kg atorvastatin, NAC (n=8): rats received 160mg/kg NAC, NAC&Atorvastatin (n=8): rats received both aforementioned agents...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28198366/th17-cells-express-st2-and-are-controlled-by-the-alarmin-il-33-in-the-small-intestine
#20
A Pascual-Reguant, J Bayat Sarmadi, C Baumann, R Noster, D Cirera-Salinas, C Curato, P Pelczar, S Huber, C E Zielinski, M Löhning, A E Hauser, E Esplugues
TH17 cells are major drivers of inflammation and involved in several autoimmune diseases. Tissue inflammation is a beneficial host response to infection, but it can also contribute to autoimmunity. The crosstalk between a tissue and the immune system during an inflammatory response is key for preserving tissue integrity and restoring physiological processes. However, how the inflamed tissue regulates the magnitude of an immune response by controlling pro-inflammatory T cells is not well characterized so far...
November 2017: Mucosal Immunology
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