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https://www.readbyqxmd.com/read/28532133/neutrophil-lymphocyte-ratio-in-different-stages-of-breast-cancer
#1
Fezzeh Elyasinia, Mohammad Reza Keramati, Farham Ahmadi, Susan Rezaei, Mohammad Ashouri, Reza Parsaei, Maryam Yaghoubi, Fahimeh Elyasinia, Armita Aboutorabi, Ahmad Kaviani
Despite many advances in the treatment of breast cancer, it is still the second most common cause of death in women in the United States. It has been shown that inflammation plays a major role in the treatment of these cancers and inflammatory factors enhance tumor growth, invasion, metastasis, and vascularization. In this study, we would like to analyze peripheral blood neutrophil-lymphocyte ratio (NLR) in breast cancer patients and its correlation with disease staging. This cross-sectional analytic study was conducted in Imam Hospital, affiliated with Tehran University of Medical Sciences; a total of 195 female patients with breast cancer met the inclusion criteria...
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28530847/repeatability-of-mr-elastography-of-liver-a-meta-analysis
#2
Suraj D Serai, Nancy A Obuchowski, Sudhakar K Ventakesh, Claude B Sirlin, Frank H Miller, Edward Ashton, Patricia E Cole, Richard L Ehman
Purpose To perform a meta-analysis to generate an estimate of the repeatability coefficient (RC) for magnetic resonance (MR) elastography of the liver. Materials and Methods A systematic search of databases was performed for publications on MR elastography during the 10-year period between 2006 and 2015. The identified studies were screened independently and were verified reciprocally by all authors. Two reviewers independently determined the percentage RC and effective sample size from each article. A forest plot was constructed of the percentage RC estimates from the 12 studies...
May 22, 2017: Radiology
https://www.readbyqxmd.com/read/28530180/red-eye-a-guide-for-non-specialists
#3
Andreas Frings, Gerd Geerling, Marc Schargus
BACKGROUND: Red eye can arise as a manifestation of many different systemic and ophthalmological diseases. The physician whom the patient first consults for this problem is often not an ophthalmologist. A correct assessment of the urgency of the situation is vitally important for the planning of further diagnostic evaluation and treatment. METHODS: This review is based on pertinent publications retrieved by a selective literature search in PubMed in August 2016 as well as on the authors' own clinical and scientific experience...
April 28, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28530106/serrated-lesions-and-serrated-polyposis-syndrome
#4
Alberto Herreros de Tejada, Carmen González-Lois, José Santiago
The serrated pathway has been shown to be an alternative colorectal carcinogenetic route potentially accounting for up to one third of all CRCs. Serrated lesions, particularly SSPs, have been a focus of research during the past few years. They have well-established histological and molecular characteristics that account for their potential carcinogenetic risk through the accumulation BRAF, KRAS and methylator profile (CpG) mutations. Their endoscopic identification and resection represent a challenge because of their specific characteristics, and the need for an adequate specimen for histological diagnosis...
May 22, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28529914/characteristics-of-postintensive-care-syndrome-in-survivors-of-pediatric-critical-illness-a-systematic-review
#5
Elizabeth A Herrup, Beth Wieczorek, Sapna R Kudchadkar
AIM: To synthesize the available evidence focusing on morbidities in pediatric survivors of critical illness that fall within the defined construct of postintensive care syndrome (PICS) in adults, including physical, neurocognitive and psychological morbidities. METHODS: A comprehensive search was conducted in MEDLINE, EMBASE, the Cochrane Library, PsycINFO, and CINAHL using controlled vocabulary and key word terms to identify studies reporting characteristics of PICS in pediatric intensive care unit (PICU) patients...
May 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28529709/last-rolls-of-the-yoyo-assessing-the-human-canonical-protein-count
#6
REVIEW
Christopher Southan
In 2004, when the protein estimate from the finished human genome was only 24,000, the surprise was compounded as reviewed estimates fell to 19,000 by 2014. However, variability in the total canonical protein counts (i.e. excluding alternative splice forms) of open reading frames (ORFs) in different annotation portals persists. This work assesses these differences and possible causes. A 16-year analysis of Ensembl and UniProtKB/Swiss-Prot shows convergence to a protein number of ~20,000. The former had shown some yo-yoing, but both have now plateaued...
2017: F1000Research
https://www.readbyqxmd.com/read/28527187/quantitative-stereological-analysis-of-the-highly-porous-hydroxyapatite-scaffolds-using-x-ray-cm-and-sem
#7
Justyna Zygmuntowicz, Aneta Zima, Joanna Czechowska, Karol Szlazak, Anna Ślosarczyk, Katarzyna Konopka
BACKGROUND: Material properties of the scaffolds as well as their microstructure are vital in determining in vivo cellular response. Three-dimensional (3D), highly porous scaffolds are used in tissue engineering to provide a suitable microenvironment and to support regeneration of bone. Both pore sizes and their architecture, in particular interconnection density, impact functionality of scaffold during its biomedical applications. OBJECTIVE: In this paper a comparative study of the microstructure of highly porous hydroxyapatite scaffolds produced via gelcasting of foamed slurries and replication of polyurethane sponge were carried out...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28526961/simultaneous-conversion-of-gastric-band-to-sleeve-gastrectomy-is-associated-with-increased-postoperative-complications-an-analysis-of-the-american-college-of-surgeons-national-surgical-quality-improvement-program
#8
Zachary C Dietch, Bruce D Schirmer, Peter T Hallowell
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has gained popularity for the treatment of morbid obesity as gastric banding (BAND) has fallen out of favor. As a result, simultaneous conversion (CONV) of BAND to LSG is commonly performed. We hypothesized that CONV is associated with higher 30-day risk-adjusted serious morbidity. METHODS: Preoperative characteristics and 30-day outcomes from the American College of Surgeons National Surgical Quality Improvement Program Participant Use Files 2010-2014 were selected for patients who underwent LSG...
May 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28526957/cytomorphology-review-of-100-newly-diagnosed-lower-risk-mds-patients-in-the-european-leukemianet-mds-eumds-registry-reveals-a-high-inter-observer-concordance
#9
Louise de Swart, Alex Smith, Marius MacKenzie, Argiris Symeonidis, Judith Neukirchen, Dana Mikulenková, Teresa Vallespí, Gina Zini, Malgorzata Paszkowska-Kowalewska, Anton Kruger, Leonie Saft, Pierre Fenaux, David Bowen, Eva Hellström-Lindberg, Jaroslav Čermák, Reinhard Stauder, Aurelia Tatic, Mette Skov Holm, Luca Malcovati, Krzysztof Mądry, Jackie Droste, Nicole Blijlevens, Theo de Witte, Ulrich Germing
The European LeukemiaNet MDS (EUMDS) registry is collecting data of myelodysplastic syndrome (MDS) patients belonging to the IPSS low or intermediate-1 category, newly diagnosed by local cytologists. The diagnosis of MDS can be challenging, and some data report inter-observer variability with regard to the assessment of the MDS subtype. In order to ensure that correct diagnoses were made by the participating centres, blood and bone marrow slides of 10% of the first 1000 patients were reviewed by an 11-person panel of cytomorphologists...
May 20, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28526767/migraine-and-cerebrovascular-atherosclerosis-in-patients-with-ischemic-stroke
#10
Hendrikus J A van Os, Inge A Mulder, Alexander Broersen, Ale Algra, Irene C van der Schaaf, L Jaap Kappelle, Birgitta K Velthuis, Gisela M Terwindt, Wouter J Schonewille, Marieke C Visser, Michel D Ferrari, Marianne A A van Walderveen, Marieke J H Wermer
BACKGROUND AND PURPOSE: Migraine is a well-established risk factor for ischemic stroke, but migraine is also related to other vascular diseases. This study aims to investigate the association between migraine and cerebrovascular atherosclerosis in patients with acute ischemic stroke. METHODS: We retrieved data on patients with ischemic stroke from the DUST (Dutch Acute Stroke Study). Migraine history was assessed with a migraine screener and confirmed by telephone interview based on the ICHD criteria (International Classification of Headache Disorders)...
May 19, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28526624/guideline-recommendations-on-the-use-of-allergen-immunotherapy-in-house-dust-mite-allergy-time-for-a-change
#11
Moisés A Calderón, Jean Bousquet, G Walter Canonica, Lars-Olaf Cardell, Dolores Hernandez Fernandez de Rojas, Jörg Kleine-Tebbe, Pascal Demoly
Guidelines on the treatment of asthma, allergic rhinitis (AR) and allergen immunotherapy (AIT) lack recommendations for house dust mite (HDM) allergy. An expert panel reviewed current guidelines in the light of new data, to assess whether guidelines could be improved. Most guidelines and key position papers did not provide specific recommendations on treatment of allergic asthma (AA) caused by HDM allergy, although some included AIT as a treatment option for AA in general. Around half of the guidelines stated that AIT with HDM extract was an effective treatment for AR, with several indicating sublingual immunotherapy (SLIT) as an option...
May 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28526451/inter-delivery-weight-gain-and-risk-of-cesarean-delivery-following-a-prior-vaginal-delivery
#12
Annie M Dude, Abbi D Lane-Cordova, William A Grobman
BACKGROUND: Approximately 1/3 of all deliveries in the United States are via cesarean. Previous research indicates weight gain during pregnancy is associated with an increased risk of cesarean delivery. It remains unclear, however, whether and to what degree weight gain between deliveries (i.e., inter-delivery weight gain) is associated with cesarean delivery in a subsequent pregnancy following a vaginal delivery. OBJECTIVES: To determine whether inter-delivery weight gain is associated with an increased risk of intrapartum cesarean delivery following a vaginal delivery...
May 16, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28526427/atypical-presentations-of-cutaneous-leishmaniasis-a-systematic-review
#13
REVIEW
Camilla Barros Meireles, Laís Chaves Maia, Gustavo Coelho Soares, Ilara Parente Pinheiro Teodoro, Maria do Socorro Vieira Gadelha, Cláudio Gleidiston Lima da Silva, Marcos Antonio Pereira de Lima
Cutaneous Leishmaniasis (CL) is endemic in 88 countries, showing relevant prevalences. The aim of this study was to perform a systematic review on atypical lesions of CL around the world, addressing clinico-epidemiological, immunological and therapeutic aspects. A search of the literature was conducted via electronic databases Scopus and PubMed for articles published between 2010 and 2015. The search terms browsed were "cutaneous leishmaniasis", "atypical" and "unusual". Based on the eligibility criteria, 34 out of 122 articles were included in the final sample...
May 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28526009/measuring-health-literacy-among-low-literate-people-an-exploratory-feasibility-study-with-the-hls-eu-questionnaire
#14
Hannelore Storms, Neree Claes, Bert Aertgeerts, Stephan Van den Broucke
BACKGROUND: Health literacy (HL) is defined as necessary competencies to make well-informed decisions. As patients' decision making is a key element of patient-centered health care, insight in patients' HL might help healthcare professionals to organize their care accordingly. This is particularly true for people in a vulnerable situation, potentially with limited HL, who are, for instance, at greater risk of having limited access to care [1, 2]. As HL correlates with education, instruments should allow inclusion of low literate people...
May 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28525960/the-behavioral-and-neural-signatures-of-distinct-conceptions-of-fairness
#15
Laura Niemi, Emily Wasserman, Liane Young
Adhering to standard procedures (impartiality), returning favors (reciprocity), or giving based on individuals' needs (charity) may all be considered moral and/or fair ways to allocate resources. However, these allocation behaviors may be perceived as differently motivated, and their moral evaluation may make different demands on theory of mind (ToM)-the capacity to process information about mental states, including motives. In Studies 1-2, we examined participants' moral judgments of allocations based on (a) impartiality, (b) reciprocity, (c) charity, and (d) unspecified criteria as depicted in vignettes, as well as participants' perceptions of allocators' motivations...
May 19, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/28525923/a-national-implementation-project-to-prevent-catheter-associated-urinary-tract-infection-in-nursing-home-residents
#16
Lona Mody, M Todd Greene, Jennifer Meddings, Sarah L Krein, Sara E McNamara, Barbara W Trautner, David Ratz, Nimalie D Stone, Lillian Min, Steven J Schweon, Andrew J Rolle, Russell N Olmsted, Dale R Burwen, James Battles, Barbara Edson, Sanjay Saint
Importance: Catheter-associated urinary tract infection (UTI) in nursing home residents is a common cause of sepsis, hospital admission, and antimicrobial use leading to colonization with multidrug-resistant organisms. Objective: To develop, implement, and evaluate an intervention to reduce catheter-associated UTI. Design, Setting, and Participants: A large-scale prospective implementation project was conducted in community-based nursing homes participating in the Agency for Healthcare Research and Quality Safety Program for Long-Term Care...
May 19, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28525573/noreva-normalization-and-evaluation-of-ms-based-metabolomics-data
#17
Bo Li, Jing Tang, Qingxia Yang, Shuang Li, Xuejiao Cui, Yinghong Li, Yuzong Chen, Weiwei Xue, Xiaofeng Li, Feng Zhu
Diverse forms of unwanted signal variations in mass spectrometry-based metabolomics data adversely affect the accuracies of metabolic profiling. A variety of normalization methods have been developed for addressing this problem. However, their performances vary greatly and depend heavily on the nature of the studied data. Moreover, given the complexity of the actual data, it is not feasible to assess the performance of methods by single criterion. We therefore developed NOREVA to enable performance evaluation of various normalization methods from multiple perspectives...
May 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28524930/nutrition-support-in-hospitalised-adults-at-nutritional-risk
#18
REVIEW
Joshua Feinberg, Emil Eik Nielsen, Steven Kwasi Korang, Kirstine Halberg Engell, Marie Skøtt Nielsen, Kang Zhang, Maria Didriksen, Lisbeth Lund, Niklas Lindahl, Sara Hallum, Ning Liang, Wenjing Xiong, Xuemei Yang, Pernille Brunsgaard, Alexandre Garioud, Sanam Safi, Jane Lindschou, Jens Kondrup, Christian Gluud, Janus C Jakobsen
BACKGROUND: The prevalence of disease-related malnutrition in Western European hospitals is estimated to be about 30%. There is no consensus whether poor nutritional status causes poorer clinical outcome or if it is merely associated with it. The intention with all forms of nutrition support is to increase uptake of essential nutrients and improve clinical outcome. Previous reviews have shown conflicting results with regard to the effects of nutrition support. OBJECTIVES: To assess the benefits and harms of nutrition support versus no intervention, treatment as usual, or placebo in hospitalised adults at nutritional risk...
May 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28524461/editorial-the-continuing-contributions-of-multimodal-treatment-of-attention-over-nearly-two-decades-to-initial-attention-deficit-hyperactivity-disorder-pharmacotherapy-and-long-term-clinical-course
#19
EDITORIAL
Michael H Bloch
The initial results of the Multimodal Treatment of Attention Deficit Hyperactivity Disorder (MTA) trial had profound effects on the way that Attention-Deficit Hyperactivity Disorder (ADHD) is managed clinically. Children from the original MTA cohort as well as a control group have been followed longitudinally for well over a decade and are beginning to provide important data regarding the long-term clinical course, treatment and consequences of ADHD into adulthood. Two articles in this issue of JCPP highlight important contributions from the MTA cohort...
June 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28524143/-features-of-psycho-emotional-state-of-patients-with-central-serous-chorioretinopathy
#20
A A Shchuko, T N Yureva, A N Zlobina
AIM: to investigate peculiarities of psycho-emotional reactions in patients with central serous chorioretinopathy (CSCR). MATERIAL AND METHODS: The study involved 35 patients with CSCR (mean age of 47.7±8.5 years) and 26 volunteers without visual impairment (mean age of 35.8±4.5 years). Their psycho-emotional state was studied using the SCL-90-R questionnaire (the severity of psychopathological symptomatology), TOBOL method (the type of attitude to the disease), Ways of Coping Questionnaire (WCQ) (strategies for controlling behavior), Spielberger-Hanin method (the level of anxiety), and the VFQ-25 questionnaire (quality of life)...
2017: Vestnik Oftalmologii
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