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immunology of food allergy

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https://www.readbyqxmd.com/read/28936357/food-avoidance-and-restriction-in-adults-a-cross-sectional-pilot-study-comparing-patients-from-an-immunology-clinic-to-a-general-practice
#1
Michael Fitzgerald, Brad Frankum
BACKGROUND: With the introduction of avoidant/restrictive food intake disorder (ARFID) in the Diagnostic and Statistical Manual - fifth edition, there is an increased need to understand the prevalence and pattern of food avoidance and restriction in adults. High rates of food allergy and intolerance in immunology clinic populations, and subsequent high rates of elimination diets, place these individuals at a greater risk of developing pathological eating behaviours. This descriptive cross sectional pilot study aims to provide preliminary data on the prevalence and nature of food avoidance and restriction in an adult population, and to explore the reasons for this behaviour...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28916424/predictors-of-epinephrine-dispensing-and-allergy-follow-up-after-emergency-department-visit-for-anaphylaxis
#2
Megan Motosue, M Fernanda Bellolio, Holly K Van Houten, Nilay D Shah, Ronna L Campbell
BACKGROUND: National guidelines recommend that patients with anaphylaxis be prescribed an epinephrine auto-injector (EAI) and referred to an allergy/immunology (A/I) specialist. OBJECTIVE: To evaluate guideline concordance and identify predictors of EAI dispensing and A/I follow-up in patients with anaphylaxis treated in the emergency department (ED). METHODS: We identified patients seen in the ED for anaphylaxis from 2010 through 2014 from an administrative claims database using an expanded International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code algorithm...
September 12, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28895784/immunotherapy-for-ige-mediated-wheat-allergy
#3
P Pacharn, P Vichyanond
Among various routes of immunotherapy for food allergy, oral immunotherapy (OIT) appears to have a promising result due to its ability to modify abnormal immunologic mechanism of IgE-mediated food allergy. Other methods for immunomodulation such as sublingual (SLIT) or epicutaneous (EPIT) immunotherapy which carry lower rates of systemic reactions, may have less efficacy. Wheat has recently been recognized as a more common cause of food-induced anaphylaxis than previously recognized, especially among young children, around the world...
September 12, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28870489/bisphenol-a-and-immunotoxic-potential-a-commentary
#4
Ian Kimber
Bisphenol A (BPA) is used in the manufacture of polycarbonate and epoxy resin plastics. There has been interest in the possibility that BPA has immunotoxic properties, and a variety of investigations have explored this. Among the approaches taken have been human observational and cross-sectional studies, investigations using experimental animals, and in vitro studies, some of which have been reviewed previously by the European Food Safety Authority (EFSA). This commentary aims to provide a focused review of data regarding the ability of BPA to perturb the immune system, including the developing immune system, and to cause related adverse health effects...
September 1, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28865877/oral-immunotherapy-for-food-allergy
#5
REVIEW
Deborah M Hussey Freeland, Monali Manohar, Sandra Andorf, Benjamin D Hobson, Wenming Zhang, Kari C Nadeau
Food allergy is a pathological, potentially deadly cascade of immune responses to molecules or molecular fragments that are normally innocuous when encountered in foods, such as milk, egg, or peanut. As the incidence and prevalence of food allergy rise, the standard of care is poised to advance beyond food allergen avoidance coupled with injectable epinephrine treatment of allergen-induced systemic reactions. Recent studies provide evidence that oral immunotherapy may effectively redirect the atopic immune responses of food allergy patients as they ingest small but gradually increasing allergen doses over many months, eliciting safer immune responses to these antigens...
August 30, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28842925/polyphenol-rich-pomegranate-juice-reduces-ige-binding-to-cashew-nut-allergens
#6
Yichen Li, Christopher P Mattison
BACKGROUND: Food allergy negatively impacts quality of life and can be life-threatening. Cashew nuts can cause severe reactions in very small amounts, and they are included in a group of foods most commonly responsible for causing food allergy. Polyphenols and polyphenol rich juices have been demonstrated to complex with peanut allergens. Here, the interaction between cashew nut allergens and polyphenol rich juices is evaluated biochemically and immunologically. RESULTS: Various juices, including pomegranate (POM), blueberry (BB), and concord grape (CG) juices, were evaluated for polyphenol content and formation of polyphenol-cashew allergen complexes...
August 26, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28818095/frequency-distribution-and-immunologic-nature-of-infusion-reactions-in-subjects-receiving-pegloticase-for-chronic-refractory-gout
#7
Leonard H Calabrese, Arthur Kavanaugh, Anthony E Yeo, Peter E Lipsky
BACKGROUND: To assess frequency and distribution of infusion reactions (IRs) in responders and nonresponders in randomized clinical trials (RCTs) of intravenous pegloticase and the utility of the National Institute of Allergy and Infectious Disease/Food and Allergy and Anaphylaxis Network (NIAID/FAAN) criteria for identifying anaphylaxis in subjects experiencing IRs. METHODS: IRs from two RCTs of pegloticase were evaluated and categorized as anaphylaxis, hypersensitivity, or other...
August 17, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28808910/nmr-resonance-assignments-of-a-hypoallergenic-isoform-of-the-major-birch-pollen-allergen-bet-v-1
#8
Linda Ahammer, Sarina Grutsch, Michael Wallner, Fatima Ferreira, Martin Tollinger
In Northern America and Europe a great number of people are suffering from birch pollen allergy and pollen related food allergies. The trigger for these immunological reactions is the 17.5 kDa major birch pollen allergen Bet v 1, which belongs to the family of PR-10 (pathogenesis-related) proteins. In nature, Bet v 1 occurs as a mixture of various isoforms that possess different immunological properties despite their high sequence identities. Bet v 1.0102 (Bet v 1d), which is investigated here, is a hypoallergenic isoform of Bet v 1 and a potential candidate for allergen-specific immunotherapy...
August 14, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28802077/helicobacter-pylori-and-its-secreted-immunomodulator-vaca-protect-against-anaphylaxis-in-experimental-models-of-food-allergy
#9
A Kyburz, S Urban, A Altobelli, S Floess, J Huehn, T L Cover, A Müller
BACKGROUND: Food allergy is an increasingly common health problem in Western populations. Epidemiological studies have suggested both positive and negative associations between food allergy and infection with the gastric bacterium Helicobacter pylori. OBJECTIVE: The objective of this work was to investigate whether experimental infection with H. pylori, or prophylactic treatment with H. pylori-derived immunomodulatory molecules, affects the onset and severity of food allergy, either positively or negatively...
August 12, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28792480/the-role-of-nutritional-aspects-in-food-allergy-prevention-and-management
#10
REVIEW
Alessandra Mazzocchi, Carina Venter, Kate Maslin, Carlo Agostoni
The prevalence of food allergy in childhood appears to be increasing in both developed and transitional countries. The aim of this paper is to review and summarise key findings in the prevention and management of food allergy, focusing on the role of dietary components and nutritional habits in the development and optimal functioning of the immune system. Essential fatty acids, zinc and vitamin D are likely to enhance the anti-inflammatory and antioxidative barrier and promote immunologic tolerance. Additionally, nutritional components such as pre- and probiotics represent a novel research approach in the attempt to induce a tolerogenic immune environment...
August 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28775294/anti-allergic-activity-of-glycyrrhizic-acid-on-ige-mediated-allergic-reaction-by-regulation-of-allergy-related-immune-cells
#11
Shiwen Han, Lu Sun, Feng He, Huilian Che
Glycyrrhizic acid (GA), the major bioactive triterpene glycoside of glycyrrhiza, has been shown to possess a wide range of pharmacological properties, including anti-inflammatory and anti-viral properties. However, few studies have examined the anti-allergic activity and exact mechanism of action of GA. In the present work, the anti-allergic activity and possible mechanisms of action of GA on an immunoglobulin (Ig) E-mediated allergic reaction has been studied using three models of allergic reaction in vivo and in vitro...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28770042/national-clinical-practice-guidelines-for-food-allergy-and-anaphylaxis-an-international-assessment
#12
Asiyah Sheikh, Zakariya Sheikh, Graham Roberts, Antonella Muraro, Sangeeta Dhami, Aziz Sheikh
BACKGROUND: Clinical practice guidelines are important tools to promote evidence-based clinical care, but not all countries have the capacity or infrastructure to develop these in-house. The European Academy of Allergy and Clinical Immunology has recently developed guidelines for the prevention, diagnosis and management of food allergy and the management of anaphylaxis. In order to inform dissemination, adaptation and implementation plans, we sought to identify countries that have/do not have national guidelines for food allergy and anaphylaxis...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28757197/correlation-between-serum-vitamin-d-status-and-immunological-changes-in-children-affected-by-gastrointestinal-food-allergy
#13
H Guo, Y Zheng, X Cai, H Yang, Y Zhang, L Hao, Y Jin, G Yang
BACKGROUND: Low vitamin D status is linked to increased incidence of food allergy and intestinal inflammation. Whether vitamin D status is associated with immunological changes in children with gastrointestinal food allergy (GFA) remains unclear. METHODS: Forty-nine GFA children (aged 2-11 years old) were enrolled in this study. Serum 25-hydroxyvitamin D (25OHD) level, total immunoglobulin E (IgE), specific IgE against allergens, circulating regulatory T lymphocytes (Tregs), and blood eosinophil numbers were measured...
July 27, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28757143/methods-in-allergy-immunology-food-challenges
#14
EDITORIAL
Barbara K Ballmer-Weber, Kirsten Beyer
Since there is no in vitro test, which can accurately predict the clinical relevance of a sensitization to food, the oral food challenge still remains the most reliable procedure to confirm or exclude food allergy and to assess the development of tolerance in children with potentially transient food allergies such as to cow's milk, hen's egg, wheat or soy. Although in the last few years component-resolved diagnostic has improved the food allergy diagnostics, especially in peanut and tree nut allergy, the majority of patients still need to undergo oral food challenge...
July 27, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28756081/temporal-trends-in-epinephrine-dispensing-and-allergy-immunology-follow-up-among-emergency-department-anaphylaxis-patients-in-the-united-states-2005-2014
#15
Megan S Motosue, M Fernanda Bellolio, Holly K Van Houten, Nilay D Shah, Venkatesh R Bellamkonda, David M Nestler, Ronna L Campbell
BACKGROUND: Anaphylaxis is a potentially life-threatening allergic reaction; measures including prescription of an epinephrine autoinjector (EAI) and allergy/immunology (A/I) follow-up may prevent future morbidity. OBJECTIVE: The objective of this study was to evaluate trends in outpatient management of anaphylaxis by studying EAI dispensing and A/I follow-up among patients seen in the emergency department (ED) for anaphylaxis from 2005 through 2014. METHODS: We analyzed administrative claims data from the OptumLabs Data Warehouse database using an expanded International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code algorithm...
September 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28731411/oral-immunotherapy-for-food-allergy-a-spanish-guideline-immunotherapy-egg-and-milk-spanish-guide-items-guide-part-i-cow-milk-and-egg-oral-immunotherapy-introduction-methodology-rationale-current-state-indications-contraindications-and-oral-immunotherapy-build
#16
REVIEW
A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, J L Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez Del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
BACKGROUND AND OBJECTIVE: Cow milk and egg are the most frequent causes of food allergy in the first years of life. Oral immunotherapy (OIT) has been investigated as an alternative to avoidance diets. No clinical practice guidelines on the management of OIT with milk and egg are currently available. Objectives: To develop clinical guidelines for OIT based on available scientific evidence and the opinions of experts. METHODS: A review was made of studies published between 1984 and June 2016, doctoral theses published in Spain, summaries of communications at scientific meetings (SEAIC, SEICAP, EAACI, and AAAAI), and the consensus of opinion established by a group of experts from the scientific societies SEICAP and SEAIC...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28729318/a-national-survey-of-russian-physicians-knowledge-of-diagnosis-and-management-of-food-induced-anaphylaxis
#17
Daniel Munblit, Marina Treneva, Ilya Korsunskiy, Alan Asmanov, Alexander Pampura, John O Warner
OBJECTIVES: Food allergy is an increasing burden worldwide and is a common problem within paediatric populations, affecting 5%-8% of children. Anaphylaxis caused by food proteins is a potentially life-threatening condition and all healthcare practitioners should be aware of its recognition and management. Russia is the largest country in Europe but it is still unknown whether physicians are prepared to diagnose and manage food-induced anaphylaxis effectively. We aimed to examine physicians' knowledge of diagnosis and management of food-induced anaphylaxis...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28723552/immunology-of-food-allergy
#18
REVIEW
Leticia Tordesillas, M Cecilia Berin, Hugh A Sampson
Many consider food allergy as the "second wave" of the allergy epidemic following the "first wave" of respiratory allergy, i.e., asthma and allergic rhinitis, plaguing westernized countries, with up to 8% of young children and 2%-3% of adults in the United States now affected by hypersensitivity reactions to various foods. In the past decade, there have been great strides in our understanding of the underlying immunopathogenesis of these disorders, which have led to improved diagnostic techniques, management strategies, and therapeutic approaches...
July 18, 2017: Immunity
https://www.readbyqxmd.com/read/28718981/health-economic-analysis-of-allergen-immunotherapy-ait-for-the-management-of-allergic-rhinitis-asthma-food-allergy-and-venom-allergy-a-systematic-overview
#19
REVIEW
Miqdad Asaria, Sangeeta Dhami, Ronald van Ree, Roy Gerth van Wijk, Antonella Muraro, Graham Roberts, Aziz Sheikh
BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is developing guidelines for allergen immunotherapy (AIT) for the management of allergic rhinitis, allergic asthma, IgE-mediated food allergy and venom allergy. To inform the development of clinical recommendations, we undertook systematic reviews to critically assess evidence on the effectiveness, safety and cost-effectiveness of AIT for these conditions. This paper focusses on synthesizing data and gaps in the evidence on the cost-effectiveness of AIT for these conditions...
July 18, 2017: Allergy
https://www.readbyqxmd.com/read/28710890/food-allergy-phenotypes-the-key-to-personalized-therapy
#20
Antoine Deschildre, Stéphanie Lejeune, Mélanie Cap, Sophie Flammarion, Line Jouannic, Flore Amat, Jocelyne Just
Food allergies (FAs) are of increasing public health concern and are characterized by a large spectrum of diseases. Their diversity is well known for immunologic pathways (IgE, non-IgE mediated FAs), and natural history. Many other factors and patient characteristics are involved including type of food, exposure route, allergic comorbidities, gender, racial and ethnic backgrounds, co-factors and health conditions. Food allergen components and sensitization profiles are also involved in FA phenotypes. A new approach to chronic disorders based on the identification of phenotypes through extensive knowledge of all the complex components is also applicable to FAs and could lead towards integrative care management...
July 15, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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