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immunology of food allergy

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https://www.readbyqxmd.com/read/28091362/epicutaneous-immunotherapy-for-the-treatment-of-peanut-allergy-in-children-and-young-adults
#1
Stacie M Jones, Scott H Sicherer, A Wesley Burks, Donald Y M Leung, Robert W Lindblad, Peter Dawson, Alice K Henning, M Cecilia Berin, David Chiang, Brian P Vickery, Robbie D Pesek, Christine B Cho, Wendy F Davidson, Marshall Plaut, Hugh A Sampson, Robert A Wood
BACKGROUND: Peanut allergy is common, life-threatening, and without therapeutic options. We evaluated peanut epicutaneous immunotherapy (EPIT) by using Viaskin Peanut for peanut allergy treatment. OBJECTIVE: We sought to evaluate the clinical, safety, and immunologic effects of EPIT for the treatment of peanut allergy. METHODS: In this multicenter, double-blind, randomized, placebo-controlled study, 74 participants with peanut allergy (ages 4-25 years) were treated with placebo (n = 25), Viaskin Peanut 100 μg (VP100; n = 24) or Viaskin Peanut 250 μg (VP250; n = 25; DBV Technologies, Montrouge, France)...
October 20, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28080988/medical-mycology-and-fungal-immunology-new-research-perspectives-addressing-a-major-world-health-challenge
#2
REVIEW
Neil A R Gow, Mihai G Netea
Fungi cause more than a billion skin infections, more than 100 million mucosal infections, 10 million serious allergies and more than a million deaths each year. Global mortality owing to fungal infections is greater than for malaria and breast cancer and is equivalent to that owing to tuberculosis (TB) and HIV. These statistics evidence fungal infections as a major threat to human health and a major burden to healthcare budgets worldwide. Those patients who are at greatest risk of life-threatening fungal infections include those who have weakened immunity or have suffered trauma or other predisposing infections such as HIV...
December 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28058751/allergen-immunotherapy-for-ige-mediated-food-allergy-a-systematic-review-and-meta-analysis
#3
REVIEW
Ulugbek Nurmatov, Sangeeta Dhami, Stefania Arasi, Giovanni Battista Pajno, Montserrat Fernandez-Rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-Lozano, Kirsten Beyer, Carsten Bindslev-Jensen, Wesley Burks, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela, Kari Christine Nadeau, Liam O'Mahony, Nikolaos Papadopoulos, Lars K Poulsen, Cansin Sackesen, Hugh Sampson, Alexandra Santos, Ronald van Ree, Frans Timmermans, Aziz Sheikh
BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated Food Allergy. To inform the development of clinical recommendations, we sought to critically assess evidence on the effectiveness, safety and cost-effectiveness of AIT in the management of food allergy. METHODS: We undertook a systematic review and meta-analysis that involved searching nine international electronic databases for randomized controlled trials (RCTs) and non-randomized studies (NRS)...
January 6, 2017: Allergy
https://www.readbyqxmd.com/read/28002520/clinical-immunological-and-pathological-profile-of-infants-suffering-from-cow-s-milk-protein-allergy
#4
Elena Tătăranu, Smaranda Diaconescu, Camelia Geanina Ivănescu, Ioan Sârbu, Maria Stamatin
Cow's milk protein allergy (CMPA) is the most frequently encountered form of food allergy in pediatric patients and occurs secondary to cow's milk proteins (CMP) ingestion. The aim of this study is to define the profile of children suffering from CMPA and to describe the associated pathological findings. The authors performed a retrospective case-control study on 160 infants that presented with CMPA symptoms at "Sf. Maria" Emergency Clinical Hospital for Children, Iassy, Romania, between January 2013 and January 2015...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27939703/tackling-bet-v-1-and-associated-food-allergies-with-a-single-hybrid-protein
#5
Heidi Hofer, Claudia Asam, Michael Hauser, Birgit Nagl, Josef Laimer, Martin Himly, Peter Briza, Christof Ebner, Roland Lang, Thomas Hawranek, Barbara Bohle, Peter Lackner, Fátima Ferreira, Michael Wallner
BACKGROUND: Allergy vaccines should be easily applicable, safe, and efficacious. For Bet v 1-mediated birch pollen and associated food allergies, a single wild-type allergen does not provide a complete solution. OBJECTIVE: We aimed to combine immunologically relevant epitopes of Bet v 1 and the 2 clinically most important related food allergens from apple and hazelnut to a single hybrid protein, termed MBC4. METHODS: After identification of T cell epitope-containing parts on each of the 3 parental allergens, the hybrid molecule was designed to cover relevant epitopes and evaluated in silico...
December 7, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27931535/advances-in-food-allergy-in-2015
#6
REVIEW
Robert A Wood
This review highlights research advances in food allergy that were published in the Journal in 2015. The world of food allergy research continues to rapidly accelerate, with increasing numbers of outstanding submissions to the Journal. In 2015, important studies on the epidemiology of food allergy were published, suggesting differential rates of food allergy in specific racial and ethnic groups. Even more importantly, studies were published identifying specific risk factors for the development of peanut allergy, as well as specific prevention strategies...
December 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27888035/racial-differences-in-food-allergy-phenotype-and-health-care-utilization-among-us-children
#7
Mahboobeh Mahdavinia, Susan R Fox, Bridget M Smith, Christine James, Erica L Palmisano, Aisha Mohamed, Zeeshan Zahid, Amal H Assa'ad, Mary C Tobin, Ruchi S Gupta
BACKGROUND: Food allergy (FA) is a prevalent condition in the United States, but little is known about its phenotypes in racial minority groups. OBJECTIVE: The objective of this study was to characterize disease phenotypes and disparities in health care utilization among African American (AA), Hispanic, and white children with FA. METHODS: We conducted a large, 2-center, retrospective cohort study of children aged 0-17 years with FA seen in allergy/immunology clinics at 2 urban tertiary care centers in the United States...
November 22, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27886908/cutaneous-manifestation-of-food-allergy
#8
REVIEW
Jonathan S Tam
Hypersensitivity reactions to foods can have diverse and highly variable manifestations. Cutaneous reactions, such as acute urticaria and angioedema, are among the most common manifestations of food allergy. However, cutaneous manifestations of food allergy encompass more than just IgE-mediated processes and include atopic dermatitis, contact dermatitis, and even dermatitis herpetiformis. These cutaneous manifestations provide an opportunity to better understand the diversity of adverse immunologic responses to food and the interconnected pathways that produce them...
February 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/27853507/developing-food-allergy-a-potential-immunologic-pathway-linking-skin-barrier-to-gut
#9
REVIEW
Yui-Hsi Wang
Immunoglobulin E (IgE)-mediated food allergy is an adverse reaction to foods and is driven by uncontrolled type-2 immune responses. Current knowledge cannot explain why only some individuals among those with food allergy are prone to develop life-threatening anaphylaxis. It is increasingly evident that the immunologic mechanisms involved in developing IgE-mediated food allergy are far more complex than allergic sensitization. Clinical observations suggest that patients who develop severe allergic reactions to food are often sensitized through the skin in early infancy...
2016: F1000Research
https://www.readbyqxmd.com/read/27826960/oral-food-desensitization-in-children-with-ige-mediated-cow-s-milk-allergy-immunological-changes-underlying-desensitization
#10
Laura Perezábad, Marta Reche, Teresa Valbuena, Rosina López-Fandiño, Elena Molina, Iván López-Expósito
PURPOSE: This study aimed to evaluate the safety and efficacy to induce clinical desensitization to cow's milk (CM) of an oral immunotherapy (OIT) protocol in a pediatric population with cow's milk allergy (CMA). In addition, the immune responses against β-casein, of peripheral blood mononuclear cells (PBMCs) from CMA patients, before and after the protocol were evaluated and compared to a nonallergic population. METHODS: A group of 20 children with IgE-mediated CMA and 15 nonallergic children were recruited...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27799957/prospective-evaluation-of-testing-with-baked-milk-to-predict-safe-ingestion-of-baked-milk-in-unheated-milk-allergic-children
#11
Allison Kwan, Maria Asper, Sasson Lavi, Elana Lavine, David Hummel, Julia E Upton
BACKGROUND: Cow's milk allergy is one of the most common food allergies affecting young children. A subset of milk-allergic individuals can eat baked milk without allergic symptoms which is beneficial in terms of prognostication and liberalization of the diet. A retrospective study suggested that skin prick testing (SPT) with a baked milk (muffin) slurry may provide a sensitive means of predicting the outcome of a medically supervised baked milk oral food challenge. We evaluated the predictive value of SPT with baked milk to identify unheated milk-allergic children who are able to safely eat baked milk...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27788149/transcriptional-profiling-of-egg-allergy-and-relationship-to-disease-phenotype
#12
Roman Kosoy, Charuta Agashe, Alexander Grishin, Donald Y Leung, Robert A Wood, Scott H Sicherer, Stacie M Jones, A Wesley Burks, Wendy F Davidson, Robert W Lindblad, Peter Dawson, Miriam Merad, Brian A Kidd, Joel T Dudley, Hugh A Sampson, M Cecilia Berin
BACKGROUND: Egg allergy is one of the most common food allergies of childhood. There is a lack of information on the immunologic basis of egg allergy beyond the role of IgE. OBJECTIVE: To use transcriptional profiling as a novel approach to uncover immunologic processes associated with different phenotypes of egg allergy. METHODS: Peripheral blood mononuclear cells (PBMCs) were obtained from egg-allergic children who were defined as reactive (BER) or tolerant (BET) to baked egg, and from food allergic controls (AC) who were egg non-allergic...
2016: PloS One
https://www.readbyqxmd.com/read/27732129/new-pharmaceutical-approaches-for-the-treatment-of-food-allergies
#13
Ana Brotons-Canto, Nekane Martín-Arbella, Carlos Gamazo, Juan M Irache
Allergic diseases constitute one of the most common causes of chronic illness in developed countries. The main mechanism determining allergy is an imbalance between Th1 and Th2 response towards Th2. Areas covered: This review describes the mechanisms underlying the natural tolerance to food components and the development of an allergic response in sensitized individuals. Furthermore, therapeutic approaches proposed to manage these abnormal immunologic responses food are also presented and discussed. Expert opinion: In the past, management of food allergies has consisted of the education of patients to avoid the ingestion of the culprit food and to initiate the therapy (e...
October 12, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27637372/non-ige-mediated-gastrointestinal-food-allergies-in-children
#14
Jean-Christoph Caubet, Hania Szajewska, Raanan Shamir, Anna Nowak-Węgrzyn
Non-IgE-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) including food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPIAP) are relatively uncommon in infants and young children, but are likely under-diagnosed. Non-IgE-GI-FA have a favorable prognosis, with majority resolving by age 3-5 years. Diagnosis relies on the recognition of symptoms pattern in FPIAP and FPIES and biopsy in FPE. Further studies are needed for a better understanding of the pathomechanism, which will lead eventually to the development of diagnostic tests and treatments...
September 17, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27605899/food-allergies-in-rural-areas
#15
Monika Stoma, Beata Ślaska-Grzywna, Wioletta A Żukiewicz-Sobczak, Małgorzata Kostecka, Monika Bojanowska, Agnieszka Dudziak, Agnieszka Kuna-Broniowska, Piotr Adamczuk, Paweł Sobczak, Dariusz Andrejko
INTRODUCTION: A food allergy is a group of symptoms occurring in the organism and resulting from consuming some food, where the problems are conditioned by immunological mechanisms. The symptoms may become apparent first in adulthood and they may be an initial manifestation of a latent allergy. Typical symptoms of a food allergy occur in different organs, thus not only in the digestive system, but also in the skin, respiratory system and circulatory system. AIM: To assess the frequency of food allergy onset in rural areas of the Lublin region as well as to determine which factors induce such allergies...
August 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27605894/role-of-immunoglobulin-g-antibodies-in-diagnosis-of-food-allergy
#16
REVIEW
Jacek Gocki, Zbigniew Bartuzi
This paper presents current views on the role of immunoglobulin G (IgG) antibodies in the reactions with food antigens in the digestive tract and their role in the diagnosis of food allergy based on the assays of specific IgG class antibodies, with a special focus on contemporary practice guidelines. In the light of current scientific knowledge, the IgG-specific antibody-mediated reactions are a body's natural and normal defensive reactions to infiltrating food antigens, which are considered as pathogens. On the other hand, specific IgG antibodies against food allergens play a crucial role in the induction and maintaining of immunological tolerance to food antigens...
August 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27583103/prevention-of-food-and-airway-allergy-consensus-of-the-italian-society-of-preventive-and-social-paediatrics-the-italian-society-of-paediatric-allergy-and-immunology-and-italian-society-of-pediatrics
#17
REVIEW
Giuseppe di Mauro, Roberto Bernardini, Salvatore Barberi, Annalisa Capuano, Antonio Correra, Gian Luigi De' Angelis, Iride Dello Iacono, Maurizio de Martino, Daniele Ghiglioni, Dora Di Mauro, Marcello Giovannini, Massimo Landi, Gian Luigi Marseglia, Alberto Martelli, Vito Leonardo Miniello, Diego Peroni, Lucilla Ricottini Maria Giuseppa Sullo, Luigi Terracciano, Cristina Vascone, Elvira Verduci, Maria Carmen Verga, Elena Chiappini
BACKGROUND: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades. Several interventions, functional foods, pro- and prebiotics, vitamins are proposed for the prevention of allergies and they can't be uncritically adopted. OBJECTIVE: This Consensus document was developed by the Italian Society of Preventive and Social Paediatrics and the Italian Society of Paediatric Allergy and Immunology. The aim is to provide updated recommendations regarding allergy prevention in children...
2016: World Allergy Organization Journal
https://www.readbyqxmd.com/read/27574500/regulation-of-ige-mediated-food-allergy-by-il-9-producing-mucosal-mast-cells-and-type-2-innate-lymphoid-cells
#18
REVIEW
Jee-Boong Lee
Due to the increasing prevalence and number of life-threatening cases, food allergy has emerged as a major health concern. The classic immune response seen during food allergy is allergen-specific IgE sensitization and hypersensitivity reactions to foods occur in the effector phase with often severe and deleterious outcomes. Recent research has advanced understanding of the immunological mechanisms occurring during the effector phase of allergic reactions to ingested food. Therefore, this review will not only cover the mucosal immune system of the gastrointestinal tract and the immunological mechanisms underlying IgE-mediated food allergy, but will also introduce cells recently identified to have a role in the hypersensitivity reaction to food allergens...
August 2016: Immune Network
https://www.readbyqxmd.com/read/27554295/mechanisms-of-inflammation-driven-bacterial-dysbiosis-in-the-gut
#19
M Y Zeng, N Inohara, G Nuñez
The gut microbiota has diverse and essential roles in host metabolism, development of the immune system and as resistance to pathogen colonization. Perturbations of the gut microbiota, termed gut dysbiosis, are commonly observed in diseases involving inflammation in the gut, including inflammatory bowel disease, infection, colorectal cancer and food allergies. Importantly, the inflamed microenvironment in the gut is particularly conducive to blooms of Enterobacteriaceae, which acquire fitness benefits while other families of symbiotic bacteria succumb to environmental changes inflicted by inflammation...
August 24, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27534448/immunomodulation-by-gastrointestinal-carbon-black-nanoparticle-exposure-in-ovalbumin-t-cell-receptor-transgenic-mice
#20
Jason H Fine, Genevieve S Bondy, Laurie Coady, Bevan Pearce, Nikia Ross, Azam F Tayabali, Sabina Halappanavar, Don Caldwell, Ivan Curran, David E Lefebvre
Humans could become exposed to carbon black nanoparticles (CBNPs) in consumer products or an occupational setting. In rodent models, acute respiratory, subcutaneous, and direct immune cell exposure to CBNPs has been shown to enhance allergic sensitization to co-administered ovalbumin (OVA) protein from chicken egg. However, little is known about the effects of ingested CBNPs on immunological responses and oral tolerance to food antigens. We hypothesized that ingestion of CBNPs would enhance the development of food allergy to OVA...
September 9, 2016: Nanotoxicology
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