G Lu, H Sun, Z Sun, L Liu, L Wang, N Zhang, Y Wang, Y He, J Ji, X Li, P Kang, B Tang
OBJECTIVE: To investigate the effect of asiaticoside on blood pressure and relaxation of thoracic aorta in rats and explore the underlying mechanism. METHODS: SD rats treated with 50 and 100 mg/kg asiaticoside by daily gavage for 2 weeks were monitored for systolic blood pressure changes, and histological changes of the thoracic aorta were evaluated using HE staining. In isolated rat endothelium-intact and endothelium-denuded thoracic aorta rings, the effects of asiaticoside on relaxation of the aortic rings were tested at baseline and following norepinephrine (NE)- and KCl-induced constriction...
March 20, 2024: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University