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https://www.readbyqxmd.com/read/28927039/an-unexpected-invasive-hydatidiform-mole-in-a-rudimentary-uterine-horn-a-case-report
#1
Manfei Si, Peng Li, Zeng Yuan, Hui Ma, Baoxia Cui, Beihua Kong
Rudimentary horns of the uterus develop as a result of a partial non-development of one Müllerian duct, a type of congenital uterine anomaly. Pregnancy in a rudimentary horn is uncommon and the outcome tends to be poor, with the majority of cases resulting in rupture between 10 and 15 gestational weeks, with significant risk of morbidity and mortality. Regardless of the availability of imagiological procedures and the advances being made in this field, the diagnosis of this type of ectopic pregnancy often only occurs during laparotomy or laparoscopy subsequent to abdominal pain and collapse...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28924538/molecular-and-immunohistochemical-characteristics-of-complete-hydatidiform-moles
#2
K B Kubelka-Sabit, I Prodanova, D Jasar, G Bozinovski, V Filipovski, S Drakulevski, D Plaseska-Karanfilska
Molar pregnancy is a gestational trophoblastic disease that belongs to the category of precancerous lesions. On the other end of the spectrum are gestational trophoblastic neoplasms such as invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor, which are considered malignant tumors. Based on defined histopathological criteria, molar pregnancy is divided into partial and complete hydatidiform mole. Especially in the case of early complete mole, the diagnosis can be quite challenging and often necessitates additional molecular or immunohistochemical methods...
June 30, 2017: Balkan Journal of Medical Genetics: BJMG
https://www.readbyqxmd.com/read/28922401/rab11-family-expression-in-the-human-placenta-localization-at-the-maternal-fetal-interface
#3
Elizabeth S Taglauer, Patrycja A Artemiuk, Sara R Hanscom, Andrew J Lindsay, Danielle Wuebbolt, Fionnuala M Breathnach, Elizabeth C Tully, Amir R Khan, Mary W McCaffrey
Rab proteins are a family of small GTPases involved in a variety of cellular processes. The Rab11 subfamily in particular directs key steps of intracellular functions involving vesicle trafficking of the endosomal recycling pathway. This Rab subfamily works through a series of effector proteins including the Rab11-FIPs (Rab11 Family-Interacting Proteins). While the Rab11 subfamily has been well characterized at the cellular level, its function within human organ systems is still being explored. In an effort to further study these proteins, we conducted a preliminary investigation of a subgroup of endosomal Rab proteins in a range of human cell lines by Western blotting...
2017: PloS One
https://www.readbyqxmd.com/read/28919298/mxra5-is-decreased-in-preeclampsia-and-affects-trophoblast-cell-invasion-through-the-mapk-pathway
#4
Lan Ding, Shaocong Li, Yanshang Zhang, Junfeng Gai, Jianfang Kou
Preeclampsia causes gestational failure in a significant number of women annually. Insufficient trophoblast cell invasion plays an essential role in preeclampsia pathogenesis. Matrix-remodeling associated 5 (MXRA5) is a proteoglycan involved in adhesion and matrix remodeling. This study sought to explore the role of MXRA5 in trophoblast cell invasion. Preeclamptic villi were obtained for the delineation of MXRA5 expression. Specific MXRA5 siRNA and pcDNA3.1/MXRA5 were used to manipulate MXRA5 expression in HTR-8/SVneo...
September 14, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28915123/placental-examination-in-nonmacerated-stillbirth-versus-neonatal-mortality
#5
Jerzy Stanek
AIM: To retrospectively statistically compare clinical and placental phenotypes of nonmacerated fetuses and live-born perinatal deaths in 3rd trimester pregnancies. METHODS: Twenty-five clinical and 47 placental phenotypes were statistically compared among 93 cases of nonmacerated (intrapartum, or recent antepartum death) 3rd trimester fetal deaths (Group 1), 118 3rd trimester neonatal deaths (Group 2) and 4285 cases without perinatal mortality (Group 3). RESULTS: Sixteen clinical and placental phenotypes were statistically significantly different between Group 3 and the two groups of perinatal deaths, which included eight placental phenotypes of fetal vascular malperfusion and eight other placental phenotypes of various etiology (amnion nodosum, 2-vessel umbilical cord, villous edema, increased extracellular matrix of chorionic villi, erythroblasts in fetal blood and trophoblastic lesions of shallow placentation)...
September 18, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28912304/e-cadherin-and-zeb2-modulate-trophoblast-cells-differentiation-during-placental-development-in-pigs
#6
Linjun Hong, Kun Han, Kejia Wu, Ruize Liu, Ji Huang, Joan K Lunney, Shuhong Zhao, Mei Yu
It is one of the important events that trophoblast cells within the placental folds differentiate into two types that differ in cell shape during placental development in pigs. This study showed that all the trophoblast cells were in similar shape between Yorkshire and Chinese Meishan pigs on day 26 of gestation, thereafter, the trophoblast cells located at the top of the placental folds became high columnar while those cells at the base of the placental folds were cuboidal on day 50 of gestation. Additionally, on day 95 of gestation, all the trophoblast cells in Meishan pigs became cuboidal, but the trophoblast cells located at the top of the placental folds in Yorkshire pigs still remained columnar...
September 14, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28911212/apposition-to-endometrial-epithelial-cells-activates-mouse-blastocysts-for-implantation
#7
Peter T Ruane, Stéphane C Berneau, Rebekka Koeck, Jessica Watts, Susan J Kimber, Daniel R Brison, Melissa Westwood, John D Aplin
STUDY QUESTION: How do interactions between blastocyst-stage embryos and endometrial epithelial cells regulate the early stages of implantation in an in vitro model? SUMMARY ANSWER: Mouse blastocyst apposition with human endometrial epithelial cells initiates trophectoderm differentiation to trophoblast, which goes on to breach the endometrial epithelium. WHAT IS KNOWN ALREADY: In vitro models using mouse blastocysts and human endometrial cell lines have proven invaluable in the molecular characterisation of embryo attachment to endometrial epithelium at the onset of implantation...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28904069/disturbed-placental-imprinting-in-preeclampsia-leads-to-altered-expression-of-dlx5-a-human-specific-early-trophoblast-marker
#8
Julianna Zadora, Manvendra Singh, Florian Herse, Lukasz Przybyl, Nadine Haase, Michaela Golic, Hong Wa Yung, Berthold Huppertz, Judith E Cartwright, Guy S Whitley, Guro M Johnsen, Giovanni Levi, Annette Isbruch, Herbert Schulz, Friedrich C Luft, Dominik N Müller, Anne C Staff, Laurence D Hurst, Ralf Dechend, Zsuzsanna Izsvák
Background -Preeclampsia (PE) is a complex and common human-specific pregnancy syndrome associated with placental pathology. The human-specificity provides both intellectual and methodological challenges, lacking a robust model system. Given the role of imprinted genes in human placentation and the vulnerability of imprinted genes to loss of imprinting changes, there has been extensive speculation, but no robust evidence, that imprinted genes are involved in PE. Our study aims at investigating whether disturbed imprinting contributes to PE...
September 13, 2017: Circulation
https://www.readbyqxmd.com/read/28903888/serum-angiogenic-and-anti-angiogenic-markers-in-pregnant-women-with-placenta-percreta
#9
Hacer Uyanıkoğlu, Adnan İncebıyık, Ahmet B Turp, Güler Çakmak, Sibel Sak, Neşe G Hilali
BACKGROUNDS: Placenta percreta (PP) is the morbidly adherent form of placental invasion abnormalities. The pathology that underlies the PP is poorly understood. AIMS: To compare the levels of circulating vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and soluble fms like tyrosine kinase 1 (sFlt-1) in pregnant women with PP and control group. STUDY DESIGN: Case-control study. METHODS: Twenty two women who underwent cesarean section (CS) due to PP and 22 women who underwent CS for other obstetric reasons were included in this study...
September 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28903546/cellular-and-molecular-mechanisms-of-viral-infection-in-the-human-placenta
#10
Moises León-Juárez, Macario Martínez-Castillo, Luis Didier González-García, Addy Cecilia Helguera-Repetto, Verónica Zaga-Clavellina, Julio García-Cordero, Arturo Flores-Pliego, Alma Herrera-Salazar, Edgar Ricardo Vázquez-Martínez, Enrique Reyes-Muñoz
The placenta is a highly specialized organ that is formed during human gestation for conferring protection and generating an optimal microenvironment to maintain the equilibrium between immunological and biochemical factors for fetal development. Diverse pathogens, including viruses, can infect several cellular components of the placenta, such as trophoblasts, syncytiotrophoblasts and other hematopoietic cells. Viral infections during pregnancy have been associated with fetal malformation and pregnancy complications such as preterm labor...
September 29, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28899975/antagonism-of-eg-vegf-receptors-as-targeted-therapy-for-choriocarcinoma-progression-in-vitro-and-in-vivo
#11
Wael Traboulsi, Frederic Sergent, Houssine Boufettal, Sophie Brouillet, Rima Slim, Pascale Hoffmann, Mohammed Benlahfid, Qun Yong Zhou, Giafranco Balboni, Valentina Onnis, Pierre-Adrien Bolze, Aude Salomon, Philippe Sauthier, François Mallet, Touria Aboussaouira, Jean-Jacques Feige, Mohamed Benharouga, Nadia Alfaidy
PURPOSE: Choriocarcinoma (CC) is the most malignant gestational trophoblastic disease that often develops from complete hydatidiform moles (CHM). Neither the mechanism of CC development nor its progression is yet characterized. We have recently identified EG-VEGF as a novel key placental growth factor that controls trophoblast proliferation and invasion. EG-VEGF acts via two receptors PROKR1 and PROKR2. Here, we demonstrate that EG-VEGF receptors can be targeted for CC therapy. EXPERIMENTAL DESIGN: Three approaches were used, i) a clinical investigation comparing circulating EG-VEGF in Control (n=20) and in distinctive CHM (n=38) and CC (n=9) cohorts, ii) an in vitro study investigating EG-VEGF effects on the CC cell line JEG3, and iii) an in vivo study including the development of a novel CC mouse model, through a direct injection of JEG3-luciferase into the placenta of gravid SCID-mice...
September 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28899944/novel-endogenous-retrovirus-derived-transcript-expressed-in-the-bovine-placenta-is-regulated-by-wnt-signaling
#12
Toshihiro Sakurai, So Nakagawa, Hanako Bai, Rulan Bai, Kazuya Kusama, Atsushi Ideta, Yoshito Aoyagi, Kazuyuki Kaneko, Kosuke Iga, Jiro Yasuda, Takayuki Miyazawa, Kazuhiko Imakawa
Endogenous retroviruses (ERVs) are involved in placentation; perhaps the most well-known ERV s are the syncytins, actively transcribed env genes involved in cell-cell fusion and possible morphological variations. However, ERVs other than syncytins that play an important role in placental development have not been well characterized. To identify ERV genes expressed during the onset of placentation in the bovine species, we characterized the expression profiles of bovine conceptus transcripts during the peri-attachment period using RNA-seq analysis, and confirming some candidates through real-time PCR...
September 12, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28899691/transcriptome-modulation-of-bovine-trophoblast-cells-in-vitro-by-neospora-caninum
#13
Pilar Horcajo, Laura Jiménez-Pelayo, Marta García-Sánchez, Javier Regidor-Cerrillo, Esther Collantes-Fernández, Daniel Rozas, Nina Hambruch, Christiane Pfarrer, Luis Miguel Ortega-Mora
Neospora caninum is one of the most efficient transplacentally transmitted pathogens in cattle and is a cause of abortion in this domestic species. The invasion and proliferation of Neospora caninum in the placenta and its dissemination to the foetus are crucial events in the outcome of an infection. In the bovine placenta, the placentomes are formed by maternal caruncles, which are delimited by a maternal epithelium and foetal cotyledons, which are delimited by an epithelial layer named the trophoblast. These epithelia form a physical barrier against foetal infection...
September 9, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28893191/recent-expansion-and-adaptive-evolution-of-the-carcinoembryonic-antigen-family-in-bats-of-the-yangochiroptera-subgroup
#14
Robert Kammerer, Martin Mansfeld, Jana Hänske, Sophie Mißbach, Xiaocui He, Bernd Köllner, Susan Mouchantat, Wolfgang Zimmermann
BACKGROUND: Expansions of gene families are predictive for ongoing genetic adaptation to environmental cues. We describe such an expansion of the carcinoembryonic antigen (CEA) gene family in certain bat families. Members of the CEA family in humans and mice are exploited as cellular receptors by a number of pathogens, possibly due to their function in immunity and reproduction. The CEA family is composed of CEA-related cell adhesion molecules (CEACAMs) and secreted pregnancy-specific glycoproteins (PSGs)...
September 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28892983/transient-thyrotoxicosis-in-molar-pregnancy
#15
Samarth Virmani, Sujatha B Srinivas, Rama Bhat, Raghavendra Rao, Ranjini Kudva
Molar pregnancy is one of the components of a broader spectrum of diseases known as Gestational Trophoblastic Disease (GTD), presenting with amenorrhoea and irregular bleeding which may be rarely associated with passage of vesicles per vagina. However, it can rarely be associated with hyperthyroidism, which may be associated with clinical features of hyperthyroidism. The following is a report of a 20-year-old woman who presented with amenorrhea followed by irregular bleeding per vagina, thyromegaly and abnormal levels of thyroid hormones...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892119/prophylactic-chemotherapy-for-hydatidiform-mole-to-prevent-gestational-trophoblastic-neoplasia
#16
REVIEW
Qiuyi Wang, Jing Fu, Lina Hu, Fang Fang, Lingxia Xie, Hengxi Chen, Fan He, Taixiang Wu, Theresa A Lawrie
BACKGROUND: This is an update of the original Cochrane Review published in Cochrane Library, Issue 10, 2012.Hydatidiform mole (HM), also called a molar pregnancy, is characterised by an overgrowth of foetal chorionic tissue within the uterus. HMs may be partial (PM) or complete (CM) depending on their gross appearance, histopathology and karyotype. PMs usually have a triploid karyotype, derived from maternal and paternal origins, whereas CMs are diploid and have paternal origins only...
September 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28888180/density-of-tubal-ring-vascularization-a-new-marker-for-prediction-of-success-of-medical-treatment-in-tubal-ectopic-pregnancy
#17
Serpil Aydoğmuş, Hüseyin Aydoğmuş, Servet Gençdal, Sefa Kelekçi
OBJECTIVES: The diagnosis of ectopic pregnancy has been facilitated especially by the use of Doppler ultrasonography. In previous studies the presence of peri-trophoblastic blood flow by Doppler ultrasound and the detection of a low-resistance, high-velocity flow pattern were defined as specific signs for trophoblastic tissue. The aim of this study was to evaluate the efficacy of Doppler ultrasonography in the prediction of treatment success in tubal pregnancies being treated with single dose conservative methotrexate...
August 26, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28881663/bisphenol-a-exposure-promotes-htr-8-svneo-cell-migration-and-impairs-mouse-placentation-involving-upregulation-of-integrin-%C3%AE-1-and-mmp-9-and-stimulation-of-mapk-and-pi3k-signaling-pathways
#18
Xi Lan, Li-Juan Fu, Jun Zhang, Xue-Qing Liu, Hui-Jie Zhang, Xue Zhang, Ming-Fu Ma, Xue-Mei Chen, Jun-Lin He, Lian-Bing Li, Ying-Xiong Wang, Yu-Bin Ding
In this study, we investigated the effect of Bisphenol A (BPA), an endocrine-disrupting chemical, on the migration of human trophoblasts and mouse placentation by using the primary extravillous trophoblast (EVT) and its cell line HTR-8/SVneo, villous explant cultures, and pregnant mice. BPA increased EVT motility and the outgrowth of villous explants in a dose-dependent manner. BPA also increased the protein levels of integrin-β1 and matrix metalloproteinase (MMP)-9 in human EVTs. Low-dose BPA (≤50 mg) increased the protein levels of MMP-9 and MMP-2 as well as integrin-β1 and integrin-α5 in mouse placenta and decreased the proportion of the labyrinth and spongiotrophoblast layers...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881392/on-the-road-to-replacing-invasive-testing-with-cell-based-nipt-five-clinical-cases-with-aneuploidies-microduplication-unbalanced-structural-rearrangement-or-mosaicism
#19
Else Marie Vestergaard, Ripudaman Singh, Palle Schelde, Lotte Hatt, Katarina Ravn, Rikke Christensen, Dorte Launholt Lildballe, Olav Bjørn Petersen, Niels Uldbjerg, Ida Vogel
OBJECTIVE: Trophoblastic fetal cells harvested from maternal blood have the capacity to be used for copy number analyses in a non-invasive prenatal test (cbNIPT). Potentially this will result in increased resolution for detection of subchromosomal aberrations due to high quality DNA not intermixed with maternal DNA. We present five selected clinical cases from first trimester pregnancies where cbNIPT was used to demonstrate a wide range of clinically relevant aberrations. METHOD: Blood samples were collected from high risk pregnancies in gestational week 12+1 to 12+5...
September 7, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28878648/acquired-pulmonary-arteriovenous-fistula-within-metastasis-from-choriocarcinoma-a-case-report
#20
Tassia Yamanari, Marcio Sawamura, Hye Ju Lee, Chang Kai Chi, Artur Katz
Choriocarcinoma is a highly malignant neoplasm arising from the trophoblast of a human pregnancy, which may have distant spread to multiple organs, particularly to the lung. We report a case of a pulmonary arteriovenous fistula that developed after chemotherapy within a choriocarcinoma metastasis. A 24-year-old female with a history of uterine choriocarcinoma presented with multiple hypervascular pulmonary nodules on the initial chest computed tomography (CT) scan, consistent with lung metastases. Four months after chemotherapy, follow-up chest CT revealed a decrease in the size and vascularity of the lung metastases, except for 1 nodule that persisted with marked contrast enhancement and developed a communication with a pulmonary artery and vein...
May 2017: Case Reports in Oncology
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