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https://www.readbyqxmd.com/read/29475165/non-acidic-1-3-4-trisubstituted-pyrazole-derivatives-as-lonazolac-analogs-with-promising-cox-2-selectivity-anti-inflammatory-activity-and-gastric-safety-profile
#1
Khaled R A Abdellatif, Wael A A Fadaly, Yaseen A M M Elshaier, Waleed A M Ali, Gehan M Kamel
Twelve new compounds of 1,3,4-trisubstituted-pyrazole derivatives possessing two cyclooxygenase-2 (COX-2) pharmacophoric moieties (SO2 Me or/and SO2 NH2 ) 11a-c, 12a-c, 13a-c and 14a-c were designed and synthesized to be evaluated for their COX inhibition, anti-inflammatory activity, ulcerogenic liability. All compounds were more selective for COX-2 isozyme and showed good in vivo anti-inflammatory activity. The bisaminosulphonyl derivatives (14a-c) were the most COX-2 selective compounds (S.I. = 9.87, 9...
February 16, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29475099/andrographolide-derivative-cx-10-ameliorates-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice-involvement-of-nf-%C3%AE%C2%BAb-and-mapk-signalling-pathways
#2
Zhenfang Gao, Cuicui Yu, Haiyue Liang, Xuekai Wang, Yue Liu, Xin Li, Kai Ji, Hui Xu, Mingyan Yang, Ke Liu, Dong Qi, Huaying Fan
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which is characterized by chronic intestinal inflammation and leads to an increased risk of colon cancer. There are many studies using phyto-ingredients as a novel approach for the treatment of UC. The plant Andrographis paniculata (Acanthaceae) is a safe and edible vegetable that has been extensively adopted in traditional Chinese medicine for conditions involving inflammation, and the most active phytochemical agent is andrographolide...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29474745/nk-cell-enteropathy-a-case-report-with-ten-years-of-indolent-clinical-behavior
#3
James Isom, May R Arroyo, Deepa Reddy, Priti Joshi-Guske, Samer Z Al-Quran, Ying Li, Robert W Allan
NK-cell enteropathy is a recently described clinically indolent condition characterized by atypical NK-cell infiltrates in the gastrointestinal mucosa that mimics malignant lymphoma. We report the case of a 69-year-old female who clinically had long-standing abdominal pain and recurrent mucosal ulcerations associated with atypical NK-cell infiltrates. The clinical, morphologic, and immunophenotypic findings in this case were diagnostic of NK-cell enteropathy. Review of the patient's prior biopsies demonstrated that this persisted without clinical progression for ten years-confirming the clinical indolent course...
February 23, 2018: Histopathology
https://www.readbyqxmd.com/read/29474736/gastrointestinal-beh%C3%A3-et-s-disease-periodic-fever-multiple-ulcers-and-trisomy-8-in-elderly-man
#4
Kentaro Awaji, Ryota Inokuchi, Hiromu Maehara, Makoto Moriyama, Tomoya Omae, Makoto Okamoto, Yasuhiro Suyama
No abstract text is available yet for this article.
February 20, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29474532/infliximab-as-rescue-treatment-in-a-sweet-s-syndrome-related-to-corticodependent-ulcerative-colitis
#5
C Moreno Márquez, B Maldonado Pérez, L Castro Laria
No abstract text is available yet for this article.
February 21, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29474359/support-surfaces-for-pressure-ulcer-prevention-a-network-meta-analysis
#6
Chunhu Shi, Jo C Dumville, Nicky Cullum
BACKGROUND: Pressure ulcers are a prevalent and global issue and support surfaces are widely used for preventing ulceration. However, the diversity of available support surfaces and the lack of direct comparisons in RCTs make decision-making difficult. OBJECTIVES: To determine, using network meta-analysis, the relative effects of different support surfaces in reducing pressure ulcer incidence and comfort and to rank these support surfaces in order of their effectiveness...
2018: PloS One
https://www.readbyqxmd.com/read/29474308/risk-factors-treatment-strategies-and-outcomes-of-endophthalmitis-associated-with-severe-fungal-keratitis
#7
Lei Wan, Jun Cheng, Jing Zhang, Nan Chen, Yan Gao, Li-Xin Xie
PURPOSE: To investigate risk factors, treatment strategies, and outcomes of endophthalmitis associated with severe fungal keratitis. METHODS: Data from 392 patients diagnosed with fungal keratitis were retrospectively examined. Patients had severe disease that was refractory to topical or systemic antifungal therapy, and the infection involved the endothelium or perforated the cornea. The incidence and risk factors for endophthalmitis, and treatment outcomes were evaluated...
February 22, 2018: Retina
https://www.readbyqxmd.com/read/29473835/hydroa-vacciniforme-like-cutaneous-t-cell-lymphoma-in-an-adult-presenting-with-facial-edema-and-recurrent-oral-ulceration
#8
Peng-Fei Wen, Hongjie Liu
No abstract text is available yet for this article.
March 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29473429/a-safety-evaluation-of-budesonide-mmx-for-the-treatment-of-ulcerative-colitis
#9
Cristina Bezzio, Stefano Festa, Giulia Zerboni, Claudio Papi, Gianpiero Manes, Simone Saibeni
Budesonide belongs to low-bioavailability steroids class. A novel oral formulation of budesonide, which uses the Multi-Matrix System (MMX) for delivering drugs to the colon, is now available as a possible treatment of ulcerative colitis patients intolerant or not-responding to first-line therapy with 5-ASA. Areas covered: in this review we present information about the development and the use of budesonide MMX and we provide data about its mechanism of action as well as, pharmacodynamics and pharmacokynetics...
February 23, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29473423/implementation-of-proton-pump-inhibitor-deprescription-protocol-in-geriatric-residents
#10
Ovadyah Avraham, Michael Biglow
BACKGROUND: Deprescribing is a recommended intervention to reduce morbidity and mortality caused by polypharmacy in older residents. However, a lack of definite deprescription guidelines and evidence of clinically meaningful outcomes complicates or precludes the practicality of such an approach. OBJECTIVE: The objective of the present pilot study is to establish and implement a stepwise taper protocol that can potentially minimize overuse of proton pump inhibitors in a safe, effective, and feasible manner in the nursing home...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29473247/double-blind-placebo-controlled-multicenter-phase-ii-trial-to-evaluate-d-methionine-in-preventing-reducing-oral-mucositis-induced-by-radiation-and-chemotherapy-for-head-and-neck-cancer
#11
Daniel A Hamstra, Kuei C Lee, Avraham Eisbruch, Prasad Sunkara, Sudhir Borgonha, Babu Phillip, Kathleen C M Campbell, Brian D Ross, Alnawaz Rehemtulla
BACKGROUND: The purpose of this study was to test if oral D-methionine (D-met) reduced mucositis during chemoradiotherapy. METHODS: We conducted a placebo-controlled double-blind randomized phase II trial of D-met (100 mg/kg p.o. b.i.d.) testing the rate of severe (grades 3-4) mucositis. RESULTS: Sixty patients were randomized. Grade 2 + oral pain was higher with placebo (79% vs 45%; P = .0165), whereas grade 2 + body odor was greater with D-met (3% vs 41%; P = ...
February 23, 2018: Head & Neck
https://www.readbyqxmd.com/read/29472916/fortunellin-induced-modulation-of-phosphatase-and-tensin-homolog-by-microrna-374a-decreases-inflammation-and-maintains-intestinal-barrier-function-in-colitis
#12
Yongjian Xiong, Juanjuan Qiu, Changyi Li, Yang Qiu, Li Guo, Yuejian Liu, Jiajia Wan, Yuchun Li, Guokai Wu, Liang Wang, Zijuan Zhou, Jianyi Dong, Chunhua Du, Dapeng Chen, Huishu Guo
Activation of phosphatase and tensin homolog (PTEN) is known to induce cell apoptosis. MicroRNA-374a (miR-374a), which can suppress PTEN expression, has been found abnormally expressed in inflammatory bowel disease (IBD). Fortunellin is a citrus flavonoid that is a potential anti-inflammation agent in inflammatory diseases. The present study investigated the effects and mechanisms underlying fortunellin-induced inhibition of PTEN in IBD. Colitis was established in rats by the intracolonic administration of 2,4,6-trinitrobenzene sulfonic acid to mimic human ulcerative colitis, which is the main type of IBD...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29472781/evaluation-of-traditional-medicinal-plant-cissus-setosa-roxb-vitaceae-for-antiulcer-property
#13
Chinnamaruthu Jayachitra, Senguttuvan Jamuna, Mohammad Ajmal Ali, Subramaniam Paulsamy, Fahad M A Al-Hemaid
Cissus setosa is an indigenous medicinal herb commonly used for the treatment of gastro ulcers. In the current investigation the aerial methanolic extract of C. setosa was investigated for their antiulcer activity using pylorus ligation and ethanol in experimental rats. The extract was administered at the doses of 200 and 400 mg/kg b.w. orally for 3 days. However, higher dose of the extract subsequently reduced gastric ulcer induced aberrations by pylorus ligation (70.05%) and ethanol (78.16%) as judged by their altered biochemical parameters such as free acidity, total acidity, total carbohydrate, total protein and pepsin activity...
February 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29472423/dieulafoy-s-lesion-of-the-duodenum-a-comparative-review-of-37-cases
#14
Faisal Inayat, Waseem Amjad, Qulsoom Hussain, Abu Hurairah
Dieulafoy's lesion is an abnormally large, tortuous, submucosal vessel that erodes the overlying epithelium without primary ulceration or erosion. The lesion predominantly occurs in the proximal stomach but it is also reported in extragastric sites. The pathogenesis and precipitating factors are poorly understood. Patients frequently present with gastrointestinal haemorrhage that can range from being self-limited to massive life threatening. Although there are no standard guidelines, endoscopy has significantly impacted the diagnosis and management...
February 22, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29472420/budd-chiari-syndrome-in-a-patient-with-ulcerative-colitis
#15
Gopal Krishana Bohra, Vivek Chhabra, Naresh Midha, Binit Sureka
We report a case of 26-year-old man who was admitted on our ward for the evaluation of ascites. He was a known case of inflammatory bowel disease(ulcerative colitis) and was on regular mesalamine therapy. On evaluation, he was having high serum ascites albumin gradient. CT scan of the abdomen revealed features of portal hypertension and non-visualisation of right and middle hepatic veins along with thrombus in inferior vena cava, suggesting a diagnosis of Budd-Chiari syndrome (BCS). There are only few case reports available showing association of BCS with UC...
February 22, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29472048/oral-lichen-planus-differential-diagnoses-serum-autoantibodies-hematinic-deficiencies-and-management
#16
REVIEW
Chun-Pin Chiang, Julia Yu-Fong Chang, Yi-Ping Wang, Yu-Hsueh Wu, Shin-Yu Lu, Andy Sun
Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease that occurs more frequently in middle-aged and elderly female patients. Previous studies indicate that OLP is a T-cell dysfunction-induced localized autoimmune disease. Clinically, six types of OLP, namely reticular, papular, plaque-like, atrophic/erosive, ulcerative, and bullous types, can be identified. OLP more commonly affects buccal mucosa, tongue, and gingiva. It always has a bilateral and symmetric distribution of the oral lesions...
February 19, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29471870/autologous-bone-marrow-derived-mononuclear-cell-therapy-in-chinese-patients-with-critical-limb-ischemia-due-to-thromboangiitis-obliterans-10-year-results
#17
Jianming Guo, Lianrui Guo, Shijun Cui, Zhu Tong, Alan Dardik, Yongquan Gu
BACKGROUND: For patients with thromboangiitis obliterans (TAO), revascularization with bypass or angioplasty is frequently not feasible due to the poor outflow of the distal small vessels. We evaluated the long-term results of our experience treating patients with TAO with autologous bone marrow-derived mononuclear cells (ABMMNCs) to determine the safety and efficacy of ABMMNC therapy in patients with critical limb ischemia due to TAO. METHODS: This was a retrospective chart review from a single university hospital vascular surgery center between January 2005 and July 2006...
February 22, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29471605/-emerging-therapies-what-are-promising-in-the-near-future
#18
REVIEW
Geom Seog Seo, Sung Hee Lee
The treatment of inflammatory bowel disease has evolved with the development of anti-TNF agents. In spite of long-term effectiveness, many patients do not respond or no longer responds to these drugs. Therefore, the development of new drugs that act on different inflammatory pathways has become necessary. Vedolizumab, a gut-specific biological agent, inhibits interaction α4β7 integrin with mucosal addressin cell adhesion molecule-1 without inhibiting systemic immune responses. Long-term vedolizumab therapy in patients with Crohn's disease and ulcerative colitis was safe and effective...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471602/-evolving-therapeutic-strategies-in-the-inflammatory-bowel-disease
#19
REVIEW
Soo Young Na, Won Moon
It is important to have effective therapeutic strategies and goals in clinical practice and research of inflammatory bowel disease. Conventional end points for clinical trials in Crohn's disease and ulcerative colitis have been based on composite indices, such as the Crohn's Disease Activity Index and the Mayo Clinic Score. Although these indices have been shown to reduce the intestinal injury to some extent, satisfactory results have not been obtained in improving the quality of life of patients. Recently, alternative measures of outcome and definitions of response are being developed beyond symptoms...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471416/anti-interleukin-6-receptor-tocilizumab-in-refractory-uveitis-associated-with-beh%C3%A3-et-s-disease-multicentre-retrospective-study
#20
Belén Atienza-Mateo, Vanesa Calvo-Río, Emma Beltrán, Lucía Martínez-Costa, Elia Valls-Pascual, Marisa Hernández-Garfella, Antonio Atanes, Miguel Cordero-Coma, Joan Miquel Nolla, Carmen Carrasco-Cubero, Javier Loricera, María C González-Vela, Nuria Vegas-Revenga, Carlos Fernández-Díaz, Rosalía Demetrio-Pablo, Lucía C Domínguez-Casas, José Luis Martín-Varillas, Natalia Palmou-Fontana, José L Hernández, Miguel Á González-Gay, Ricardo Blanco
Objective: To assess the efficacy of tocilizumab (TCZ) in refractory uveitis of Behçet's disease (BD). Methods: Multicentre study of patients with BD-associated uveitis. Patients were refractory to conventional and biologic immunosuppressive drugs. The main outcome measures were intraocular inflammation, macular thickness, visual acuity and corticosteroid-sparing effects. Results: We studied 11 patients (7 men) (20 affected eyes); median age 35 years...
February 19, 2018: Rheumatology
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