Nick Strayer, Tess Vessels, Karmel Choi, Siwei Zhang, Yajing Li, Brian Sharber, Ryan S Hsi, Cosmin A Bejan, Alexander G Bick, Justin M Balko, Douglas B Johnson, Lee E Wheless, Quinn S Wells, Ravi Shah, Elizabeth J Philips, Wesley H Self, Jill M Pulley, Consuelo H Wilkins, Qingxia Chen, Tina Hartert, Michael R Savona, Yu Shyr, Dan M Roden, Jordan W Smoller, Douglas M Ruderfer, Yaomin Xu
BACKGROUND: Electronic health records (EHR) are increasingly used for studying multimorbidities. However, concerns about accuracy, completeness, and EHRs being primarily designed for billing and administration raise questions about the consistency and reproducibility of EHR-based multimorbidity research. METHODS: Utilizing phecodes to represent the disease phenome, we analyzed pairwise comorbidity strengths using a dual logistic regression approach and constructed multimorbidity as an undirected weighted graph...
March 30, 2024: medRxiv