Katrina M Pollock, Álvaro H Borges, Hannah M Cheeseman, Ida Rosenkrands, Kirstine L Schmidt, Rie E Søndergaard, Suzanne Day, Abbey Evans, Leon R McFarlane, Jennifer Joypooranachandran, Fahimah Amini, Per Skallerup, Rebecca B Dohn, Charlotte G Jensen, Anja W Olsen, Peter Bang, Tom Cole, Joanna Schronce, Nana-Marie Lemm, Max P Kristiansen, Peter L Andersen, Jes Dietrich, Robin J Shattock, Frank Follmann
BACKGROUND: There is no vaccine against the major global pathogen Chlamydia trachomatis; its different serovars cause trachoma in the eye or chlamydia in the genital tract. We did a clinical trial administering CTH522, a recombinant version of the C trachomatis major outer membrane molecule, in different dose concentrations with and without adjuvant, to establish its safety and immunogenicity when administered intramuscularly, intradermally, and topically into the eye, in prime-boost regimens...
April 10, 2024: Lancet Infectious Diseases