Pia Renk, Melissa Sgodzai, Rafael Klimas, Alina Blusch, Thomas Grüter, Jeremias Motte, Xiomara Pedreiturria, Jeannette Gebel, Philipp Gobrecht, Dietmar Fischer, Ralf Gold, Kalliopi Pitarokoili
Experimental autoimmune neuritis is a common animal model for acute human immune-mediated polyneuropathies. Although already established in 1955, a number of pathophysiological mechanisms remain unknown. In this study, we extensively characterize experimental autoimmune neuritis progression in Lewis rats, including new insights into the integrity of small nerve fibres, neuropathic pain and macrophage activation. Acute experimental autoimmune neuritis was induced with P253-78 peptide and consequently investigated using the gait analysis system CatWalk XT, electrophysiological and histopathological analyses, quantitative polymerase chain reaction (PCR), dorsal root ganglia outgrowth studies, as well as the von Frey hair and Hargreaves tests...
2024: Brain communications