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https://www.readbyqxmd.com/read/28221302/diagnostic-criteria-for-small-fiber-neuropathy
#1
Derrick Blackmore, Zaeem A Siddiqi
OBJECTIVES: Despite its relative common occurrence, definitive diagnosis of small fiber neuropathy (SFN) remains problematic. In practice, patients with pain, numbness, and/or paresthesias in their lower limbs are diagnosed with SFN if found to have dissociated sensory loss in their feet, that is, impaired pinprick perception (PP) but relatively preserved vibration. We sought to assess the sensitivity and specificity of clinical examination and various diagnostic tools available for screening SFN...
March 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/28221085/goal-relevance-as-a-quantitative-model-of-human-task-relevance
#2
James Tanner, Laurent Itti
The concept of relevance is used ubiquitously in everyday life. However, a general quantitative definition of relevance has been lacking, especially as pertains to quantifying the relevance of sensory observations to one's goals. We propose a theoretical definition for the information value of data observations with respect to a goal, which we call "goal relevance." We consider the probability distribution of an agent's subjective beliefs over how a goal can be achieved. When new data are observed, its goal relevance is measured as the Kullback-Leibler divergence between belief distributions before and after the observation...
March 2017: Psychological Review
https://www.readbyqxmd.com/read/28215248/quantitative-sensory-test-for-primary-restless-legs-syndrome-willis-ekbom-disease-using-the-current-perception%C3%A2-threshold-test
#3
Yong Won Cho, Min-Sung Kang, Keun Tae Kim, So Young Do, Jung-Geun Lim, So Young Lee, Gholam K Motamedi
BACKGROUND: Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is a sensorimotor neurological disorder, and it is especially aggravated at night. The purpose of this study was to investigate the diurnal sensory dysfunction in primary RLS/WED using the current perception threshold (CPT) test, compared to healthy controls. METHODS: Thirty primary RLS/WED subjects and 30 healthy controls were enrolled. The severity of RLS/WED and sleep problems were evaluated in all subjects...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28197202/expression-changes-of-nerve-cell-adhesion-molecules-l1-and-semaphorin-3a-after-peripheral-nerve-injury
#4
Qian-Ru He, Meng Cong, Qing-Zhong Chen, Ya-Feng Sheng, Jian Li, Qi Zhang, Fei Ding, Yan-Pei Gong
The expression of nerve cell adhesion molecule L1 in the neuronal growth cone of the central nervous system is strongly associated with the direction of growth of the axon, but its role in the regeneration of the peripheral nerve is still unknown. This study explored the problem in a femoral nerve section model in rats. L1 and semaphorin 3A mRNA and protein expressions were measured over the 4-week recovery period. Quantitative polymerase chain reaction showed that nerve cell adhesion molecule L1 expression was higher in the sensory nerves than in motor nerves at 2 weeks after injury, but vice versa for the expression of semaphorin 3A...
December 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28191033/algorithm-and-software-to-automatically-identify-latency-and-amplitude-features-of-local-field-potentials-recorded-in-electrophysiological-investigation
#5
Maria Rubega, Claudia Cecchetto, Stefano Vassanelli, Giovanni Sparacino
BACKGROUND: Local field potentials (LFPs) evoked by sensory stimulation are particularly useful in electrophysiological research. For instance, spike timing and current transmembrane current flow estimated from LFPs recorded in the barrel cortex in rats and mice are exploited to investigate how the brain represents sensory stimuli. Recent improvements in microelectrodes technology enable neuroscientists to acquire a great amount of LFPs during the same experimental session, calling for algorithms for their quantitative automatic analysis...
2017: Source Code for Biology and Medicine
https://www.readbyqxmd.com/read/28190353/identification-and-organoleptic-contribution-of-z-1-5-octadien-3-one-to-the-flavor-of-vitis-vinifera-cv-merlot-and-cabernet-sauvignon-musts
#6
Lucile Allamy, Philippe Darriet, Alexandre Pons
The main goal of this research was to identify key aroma compounds involved in the dried fruits (prune and dry fig) aroma of musts. An odoriferous zone (OZ) was detected by gas chromatography coupled with olfactometry (GC-O) and identified as (Z)-1,5-octadien-3-one (geranium). A quantitation method by SPME-GC-MS (CI, MeOH) was developed and validated for assaying this very fragrant ketone in musts for the first time (LOD: 0.15 ng/L; LOQ: 0.5 ng/L). Concentrations of (Z)-1,5-octadien-3-one in musts marked by dried fruits flavors reached 90 ng/L, thus exceeding its detection threshold (Dth 9 ng/L)...
February 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28187311/candidate-chemosensory-genes-identified-in-the-endoparasitoid-meteorus-pulchricornis-hymenoptera-braconidae-by-antennal-transcriptome-analysis
#7
Sheng Sheng, Cheng-Wu Liao, Yu Zheng, Yu Zhou, Yan Xu, Wen-Miao Song, Peng He, Jian Zhang, Fu-An Wu
Meteorus pulchricornis is an endoparasitoid wasp which attacks the larvae of various lepidopteran pests. We present the first antennal transcriptome dataset for M. pulchricornis. A total of 48,845,072 clean reads were obtained and 34,967 unigenes were assembled. Of these, 15,458 unigenes showed a significant similarity (E-value <10(-5)) to known proteins in the NCBI non-redundant protein database. Gene ontology (GO) and cluster of orthologous groups (COG) analyses were used to classify the functions of M...
January 31, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28187102/physical-activity-behavior-predicts-endogenous-pain-modulation-in-older-adults
#8
Kelly M Naugle, Thomas Ohlman, Keith E Naugle, Zachary A Riley, NiCole R Keith
Older adults compared with younger adults are characterized by greater endogenous pain facilitation and a reduced capacity to endogenously inhibit pain, potentially placing them at a greater risk for chronic pain. Previous research suggests that higher levels of self-reported physical activity are associated with more effective pain inhibition and less pain facilitation on quantitative sensory tests in healthy adults. However, no studies have directly tested the relationship between physical activity behavior and pain modulatory function in older adults...
March 2017: Pain
https://www.readbyqxmd.com/read/28184316/perceptual-distortions-and-deceptions-what-computers-can-teach-us
#9
Matthew M Nour, Joseph M Nour
The nature of perception has fascinated philosophers for centuries, and has more recently been the focus of research in psychology and neuroscience. Many psychiatric disorders are characterised by perceptual abnormalities, ranging from sensory distortions to illusions and hallucinations. The distinction between normal and abnormal perception is, however, hard to articulate. In this article we argue that the distinction between normal perception and abnormal perception is best seen as a quantitative one, resting on the degree to which the observer's prior expectations influence perceptual inference...
February 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28181856/repeatability-of-quantitative-sensory-testing-in-healthy-cats-in-a-clinical-setting-with-comparison-to-cats-with-osteoarthritis
#10
Elena S Addison, Dylan N Clements
Objectives The aim of this study was to evaluate the repeatability of quantitative sensory tests (QSTs) in a group of healthy untrained cats (n = 14) and to compare the results with those from cats with osteoarthritis (n = 7). Methods Peak vertical force (PVF) and vertical impulse were measured on a pressure plate system. Thermal sensitivity was assessed using a temperature-controlled plate at 7°C and 40°C. Individual paw lifts and overall duration of paw lifts were counted and measured for each limb. Paw withdrawal thresholds were measured using manual and electronic von Frey monofilaments (MVF and EVF, respectively) applied to the metacarpal or metatarsal pads...
February 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28181242/sensory-profile-and-consumer-acceptability-of-prebiotic-white-chocolate-with-sucrose-substitutes-and-the-addition-of-goji-berry-lycium-barbarum
#11
Janaína Madruga Morais Ferreira, Bruna Marcacini Azevedo, Valdecir Luccas, Helena Maria André Bolini
Functional food is a product containing nutrients that provide health benefits beyond basic nutrition. The objective of the present study was to evaluate the descriptive sensory profile and consumers' acceptance of functional (prebiotic) white chocolates with and without the addition of an antioxidant source (goji berry [GB]) and sucrose replacement. The descriptive sensory profile was determined by quantitative descriptive analysis (QDA) with trained assessors (n = 12), and the acceptance test was performed with 120 consumers...
February 9, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28166631/the-cyclic-diarylheptanoid-asadanin-as-the-main-contributor-to-the-bitter-off-taste-in-hazelnuts-corylus-avellana-l
#12
Barbara Singldinger, Andreas Dunkel, Thomas Hofmann
Activity-guided fractionation and taste dilution analysis (TDA), followed by LC-MS/MS, LC-TOF-MS, and 1D/2D-NMR spectroscopy, led to the identification of the cyclic diarylheptanoid asadanin exhibiting a human bitter recognition threshold of 13 μmol/kg, as the major inducer of the sporadic bitter off-taste of hazelnut kernels (Corylus avellana L.). Sensory analysis of hazelnut samples from two origins (Ordu/2013 and Akçakoca/2014) and from Cimiciato-infected hazelnut kernels, followed by LC-MS/MS quantitation of 1 and calculation of dose-over-threshold (DoT) factors, showed established evidence for the Cimiciato infection as the major inductor of asadanin biosynthesis in hazelnut kernels and, as a consequence, as the reason for bitter off-taste development...
February 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28162413/-187-normative-values-for-quantitative-sensory-testing-in-african-americans
#13
M Ezenwa, Y Yao, M Suarez, Z Zhao, J Carrasco, V Angulo, D Shuey, K Roach, Z Wang, R Molokie, D Wilkie
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28161767/pain-extent-is-associated-with-pain-intensity-but-not-with-widespread-pressure-or-thermal-pain-sensitivity-in-women-with-fibromyalgia-syndrome
#14
Marco Barbero, César Fernández-de-Las-Peñas, María Palacios-Ceña, Corrado Cescon, Deborah Falla
Widespread pain is considered a sign of central sensitization in people with chronic pain. Our aim was to examine whether pain extent, assessed from the pain drawing, relates to measures from quantitative sensory testing in fibromyalgia syndrome (FMS). Thirty women with FMS and no other co-morbid conditions completed pain drawings (dorsal and ventral views) and clinical and related disability questionnaires. Pain extent and pain frequency maps were obtained from the pain drawings using a novel customized software...
February 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28160223/quantitative-sensory-testing-in-adults-with-autism-spectrum-disorders
#15
Odette Fründt, Wiebke Grashorn, Daniel Schöttle, Ina Peiker, Nicole David, Andreas K Engel, Katarina Forkmann, Nathalie Wrobel, Alexander Münchau, Ulrike Bingel
Altered sensory perception has been found in patients with autism spectrum disorders (ASD) and might be related to aberrant sensory perception thresholds. We used the well-established, standardized Quantitative sensory testing (QST) protocol of the German Research Network on Neuropathic Pain to investigate 13 somatosensory parameters including thermal and tactile detection and pain thresholds in 13 ASD adults and 13 matched healthy controls with normal IQ values. There were no group differences between somatosensory detection and pain thresholds...
February 3, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28158269/predictors-of-opioid-efficacy-in-patients-with-chronic-pain-a-prospective-multicenter-observational-cohort-study
#16
Kasper Grosen, Anne E Olesen, Mikkel Gram, Torsten Jonsson, Michael Kamp-Jensen, Trine Andresen, Christian Nielsen, Gorazd Pozlep, Mogens Pfeiffer-Jensen, Bart Morlion, Asbjørn M Drewes
Opioids are increasingly used for treatment of chronic pain. However, they are only effective in a subset of patients and have multiple side effects. Thus, studies using biomarkers for response are highly warranted. The current study prospectively examined 63 opioid-naïve patients initiating opioid use for diverse types of chronic pain at five European centers. Quantitative sensory testing, electroencephalography (EEG) recordings, and assessment of pain catastrophizing were performed prior to treatment. The co-primary outcomes were change from baseline in ratings of chronic pain and quality of life after 14 days of opioid treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28153311/multiple-internal-standard-normalization-for-improving-hs-spme-gc-ms-quantitation-in-virgin-olive-oil-volatile-organic-compounds-voo-vocs-profile
#17
Martina Fortini, Marzia Migliorini, Chiara Cherubini, Lorenzo Cecchi, Luca Calamai
The commercial value of virgin olive oils (VOOs) strongly depends on their classification, also based on the aroma of the oils, usually evaluated by a panel test. Nowadays, a reliable analytical method is still needed to evaluate the volatile organic compounds (VOCs) and support the standard panel test method. To date, the use of HS-SPME sampling coupled to GC-MS is generally accepted for the analysis of VOCs in VOOs. However, VOO is a challenging matrix due to the simultaneous presence of: i) compounds at ppm and ppb concentrations; ii) molecules belonging to different chemical classes and iii) analytes with a wide range of molecular mass...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28148644/characteristics-of-the-local-cutaneous-sensory-thermo-neutral-zone
#18
Davide Filingeri, Hui Zhang, Edward A Arens
Skin temperature detection thresholds have been used to measure human cold and warm sensitivity across the temperature continuum. They exhibit a sensory zone within which neither warm nor cold sensations prevail. This zone has been widely assumed to coincide with steady-state local skin temperatures between 32-34ᵒC, but its underlying neurophysiology has been rarely investigated. Here we employ two approaches to characterize the properties of sensory thermo-neutrality, testing for each whether neutrality shifts along the temperature continuum depending on adaptation to a preceding thermal state...
February 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28146319/unimpaired-endogenous-pain-inhibition-in-the-early-phase-of-complex-regional-pain-syndrome
#19
N Kumowski, T Hegelmaier, J Kolbenschlag, C Maier, T Mainka, J Vollert, E Enax-Krumova
BACKGROUND: The complex regional pain syndrome (CRPS) is characterized by distal generalisation of pain beyond the initial trauma. This might be the result of impaired endogenous pain inhibition. METHOD: We compared Conditioned Pain Modulation (CPM) between patients with CRPS (n = 24; pain: 4.5 ± 2.2, NRS 0-10; disease duration <1 year), neuralgia (n = 17; pain: 5.5 ± 1.1) and healthy subjects (n = 23) and its correlation with loss and gain of function as assessed by Quantitative Sensory Testing (QST)...
February 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28131214/quantitative-sensory-testing-and-structural-assessment-of-sensory-nerve-fibres-in-amyotrophic-lateral-sclerosis
#20
Baris Isak, Kirsten Pugdahl, Páll Karlsson, Hatice Tankisi, Nanna Brix Finnerup, Jasna Furtula, Birger Johnsen, Niels Sunde, Johannes Jakobsen, Anders Fuglsang-Frederiksen
OBJECTIVE: In this prospective study, involvement of sensory nerve fibres in ALS patients was assessed using functional and structural measures in the form of quantitative sensory testing (QST) and skin and nerve biopsies. METHODS: Thirty-two ALS patients and 32 healthy subjects were evaluated with a QST battery comprising thresholds of mechanical detection, mechanical pain, vibration detection, cold detection, warm detection, heat pain, and pinprick sensation. Skin biopsies were evaluated in 31 ALS patients by intraepidermal nerve fibre density (IENFD) and axonal swelling ratios, and growth-associated protein 43 (GAP-43) antibody staining...
February 15, 2017: Journal of the Neurological Sciences
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