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Quantitative sensorial

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https://www.readbyqxmd.com/read/28929829/quantitative-sensory-testing-for-assessment-of-somatosensory-function-in-human-oral-mucosa-a-review
#1
Pin Zhou, Yaming Chen, Jinglu Zhang, Kelun Wang, Peter Svensson
OBJECTIVE: This narrative review provides an overview of the quantitative sensory testing (QST) to assess somatosensory function in human oral mucosa. MATERIAL AND METHODS: A literature search was conducted in the PubMed database to identify studies in vivo on human oral mucosa using QST methods. A list of 149 articles was obtained and screened. A total of 36 relevant articles remained and were read in full text. Manual search of the reference lists identified eight additional relevant studies...
September 20, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28928571/dexmedetomidine-as-adjuvant-to-lower-doses-of-intrathecal-bupivacaine-for-lower-limb-orthopedic-surgeries
#2
Taznim Mohamed, Indu Susheela, Beena P Balakrishnan, Suvarna Kaniyil
BACKGROUND: Dexmedetomidine, an α2 adrenergic agonist, has been found to be a useful adjuvant to local anesthetics. It has been found to produce satisfactory block with lower doses of spinal bupivacaine. AIM: The aim of this study is to compare the difference in spinal block characteristics and hemodynamic effects of 7, 8, and 9 mg hyperbaric bupivacaine combined with 5 μg dexmedetomidine and to find out the optimum dose that would provide satisfactory block and hemodynamic stability for lower limb orthopedic surgeries...
July 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28928563/comparative-study-of-constant-dose-intrathecal-hypobaric-levobupivacaine-with-varying-baricities-in-lower-limb-surgeries
#3
K P Biji, M Sunil, K T Ramadas
BACKGROUND: Hypobaric spinal anesthesia is advantageous for unilateral lower extremity fractures as it obviates pain of lying on fractured limb for performing subarachnoid block. AIMS: This study compares block characteristics and complications of three different baricities of constant dose intrathecal hypobaric levobupivacaine to determine an optimum baricity. SETTINGS AND DESIGN: One-twenty American Society of Anesthesiologists Physical Status 1 and 2 patients aged 18-65 years undergoing unilateral lower limb surgeries were divided into three equal groups for this prospective cohort study...
July 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28926414/exploration-of-quantitative-sensory-testing-in-latent-trigger-points-and-referred-pain-areas
#4
Silvia Ambite-Quesada, José L Arías-Buría, Carol A Courtney, Lars Arendt-Nielsen, César Fernández-de-Las-Peñas
OBJECTIVE: To investigate somato-sensory nerve fibre function by applying different quantitative sensory testing including thermal, mechanical and vibration thresholds over latent trigger points (TrP) and in its associated referred pain area. METHODS: A total of 20 subjects with unilateral latent TrPs in the extensor carpi radialis brevis were included. Warmth detection threshold (WDT), cold detection threshold CDT) and heat/cold pain thresholds (HPT, CPT), mechanical detection (MDT) and pain (MPT) thresholds, vibration threshold (VT), and pressure pain thresholds (PPT) were blinded assessed over the TrP, in the referred pain area, and in the respective contra-lateral mirror areas...
September 15, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28926131/region-specific-impairment-of-the-cervical-spinal-cord-sc-in-amyotrophic-lateral-sclerosis-a-preliminary-study-using-sc-templates-and-quantitative-mri-diffusion-tensor-imaging-inhomogeneous-magnetization-transfer
#5
Henitsoa Rasoanandrianina, Aude-Marie Grapperon, Manuel Taso, Olivier M Girard, Guillaume Duhamel, Maxime Guye, Jean-Philippe Ranjeva, Shahram Attarian, Annie Verschueren, Virginie Callot
In this preliminary study, our objective was to investigate the potential of high-resolution anatomical imaging, diffusion tensor imaging (DTI) and conventional/inhomogeneous magnetization transfer imaging [magnetization transfer (MT)/inhomogeneous magnetization transfer (ihMT)] at 3 T, analyzed with template-extracted regions of interest, to measure the atrophy and structural changes of white (WM) and gray (GM) matter spinal cord (SC) occurring in patients with amyotrophic lateral sclerosis (ALS). Ten patients with ALS and 20 age-matched healthy controls were recruited...
September 19, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28922915/influence-of-fermentation-temperature-yeast-strain-and-grape-juice-on-the-aroma-chemistry-and-sensory-profile-of-sauvignon-blanc-wines
#6
Rebecca Christina Deed, Bruno Fedrizzi, Richard C Gardner
Sauvignon blanc wine, balanced by herbaceous and tropical aromas, is fermented at low temperatures (10-15 °C). Anecdotal accounts from winemakers suggest that cold ferments produce and retain more 'fruity' aroma compounds; nonetheless, studies have not confirmed why low temperatures are optimal for Sauvignon blanc. Thirty-two aroma compounds were quantitated from two Marlborough Sauvignon blanc juices fermented at 12.5 °C and 25 °C, using Saccharomyces cerevisiae strains EC1118, L-1528, M2 and X5. Fourteen compounds were responsible for driving differences in aroma chemistry...
September 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28922831/the-transcription-factors-coup-tfi-and-coup-tfii-have-distinct-roles-in-arealisation-and-gabaergic-interneuron-specification-in-the-early-human-fetal-telencephalon
#7
Ayman Alzu'bi, Susan J Lindsay, Lauren F Harkin, Jack McIntyre, Steven N Lisgo, Gavin J Clowry
In human telencephalon at 8-12 postconceptional weeks, ribonucleic acid quantitative sequencing and immunohistochemistry revealed cortical chicken ovalbumin upstream promotor-transcription factor 1 (COUP-TFI) expression in a high ventro-posterior to low anterior gradient except for raised immunoreactivity in the anterior ventral pallium. Unlike in mouse, COUP-TFI and SP8 were extensively co-expressed in dorsal sensory neocortex and dorsal hippocampus whereas COUPTFI/COUPTFII co-expression defined ventral temporal cortex and ventral hippocampus...
October 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28919806/how-stable-are-quantitative-sensory-testing-measurements-over-time-report-on-10-week-reliability-and-agreement-of-results-in-healthy-volunteers
#8
Helen Nothnagel, Christian Puta, Thomas Lehmann, Philipp Baumbach, Martha B Menard, Brunhild Gabriel, Holger H W Gabriel, Thomas Weiss, Frauke Musial
BACKGROUND: Quantitative sensory testing (QST) is a diagnostic tool for the assessment of the somatosensory system. To establish QST as an outcome measure for clinical trials, the question of how similar the measurements are over time is crucial. Therefore, long-term reliability and limits of agreement of the standardized QST protocol of the German Research Network on Neuropathic Pain were tested. METHODS: QST on the lower back and hand dorsum (dominant hand) were assessed twice in 22 healthy volunteers (10 males and 12 females; mean age: 46...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28916394/a-useful-strategy-based-on-chromatographic-data-combined-with-quality-by-design-approach-for-food-analysis-applications-the-case-study-of-furanic-derivatives-in-sugarcane-honey
#9
Pedro Silva, Catarina L Silva, Rosa Perestrelo, Fernando M Nunes, José S Câmara
Sugarcane honey (SCH) is one of the Madeira Island products par excellence and it is now popular worldwide. Its sui generis and peculiar sensory properties, explained by a variety of volatile compounds including furanic derivatives (FDs), arise mainly from manufacturing and storage conditions. A simple high-throughput approach based on semi-automatic microextraction by packed sorbent (MEPS) combined with ultra-high performance liquid chromatography (UHPLC) was developed and validated for identification and quantification of target FDs in sugarcane honey...
September 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28914457/gross-brain-morphology-of-the-armoured-catfish-rineloricaria-heteroptera-isbr%C3%A3-cker-and-nijssen-1976-siluriformes-loricariidae-loricariinae-a-descriptive-and-quantitative-approach
#10
Arturo Angulo, Francisco Langeani
The gross morphology of the brain of Rineloricaria heteroptera and its relation to the sensory/behavioural ecology of the species is described and discussed. The sexual and ontogenetic intraspecific variation in the whole brain length and mass, as well as within/between the eight different brain subdivisions volumes, is also examined and discussed. Negative allometry for the whole brain length/mass and relative growth of the telencephalon and optic tecta was observed. Positive allometry was observed for the relative growth of the olfactory bulbs and medulla oblongata...
September 15, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28912959/research-protocol-for-a-complex-intervention-to-support-hearing-and-vision-function-to-improve-the-lives-of-people-with-dementia
#11
Iracema Leroi, Annie Pye, Christopher J Armitage, Anna Pavlina Charalambous, Fofi Constantinidou, Catherine Helmer, Ines Himmelsbach, Sarah Marié, Jahanara Miah, Suzanne Parsons, Jemma Regan, Chryssoula Thodi, Lucas Wolski, Abebaw Mengistu Yohannes, Piers Dawes
BACKGROUND: Hearing and vision impairments are among the most common and disabling comorbidities in people living with dementia. Intervening to improve sensory function could be a means by which the lives of people living with dementia may be improved. However, very few studies have tried to ameliorate outcomes in dementia by improving sensory function. This paper describes the multi-step development of a new intervention designed to support hearing and vision function in people living with dementia in their own homes...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28905408/resting-state-functional-connectivity-in-the-rat-cervical-spinal-cord-at-9-4-t
#12
Tung-Lin Wu, Feng Wang, Arabinda Mishra, George H Wilson, Nellie Byun, Li Min Chen, John C Gore
PURPOSE: Numerous studies have adopted resting-state functional MRI methods to infer functional connectivity between cortical regions, but very few have translated them to the spinal cord, despite its critical role in the central nervous system. Resting-state functional connectivity between gray matter horns of the spinal cord has previously been shown to be detectable in humans and nonhuman primates, but it has not been reported previously in rodents. METHODS: Resting-state functional MRI of the cervical spinal cord of live anesthetized rats was performed at 9...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28905239/expression-and-distribution-of-three-transient-receptor-potential-vanilloid-trpv-channel-proteins-in-human-odontoblast-like-cells
#13
Wen Wen, Kehua Que, Chengcheng Zang, Jing Wen, Guangxu Sun, Zhiying Zhao, Yanzhong Li
Odontoblasts have been suggested to contribute to nociceptive sensation in the tooth via expression of the transient receptor potential (TRP) channels. The TRP channels as a family of nonselective cation permeable channels play an important role in sensory transduction of human. In this study, we examined the expression of transient receptor potential vanilloid-1 (TRPV1), transient receptor potential vanilloid-2 (TRPV2) and transient receptor potential vanilloid-3 (TRPV3) channels in native human odontoblasts (HODs) and long-term cultured human dental pulp cells with odontoblast phenotyoe (LHOPs) obtained from healthy wisdom teeth with the use of immunohistochemistry (IHC), immunofluorescence (IF), quantitative real-time polymerase chain reaction (qRT-PCR),western blotting (WB) and immunoelectron microscopy (IEM) assay...
September 13, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28894907/challenges-in-translational-drug-research-in-neuropathic-and-inflammatory-pain-the-prerequisites-for-a-new-paradigm
#14
REVIEW
A Taneja, O Della Pasqua, M Danhof
AIM: Despite an improved understanding of the molecular mechanisms of nociception, existing analgesic drugs remain limited in terms of efficacy in chronic conditions, such as neuropathic pain. Here, we explore the underlying pathophysiological mechanisms of neuropathic and inflammatory pain and discuss the prerequisites and opportunities to reduce attrition and high-failure rate in the development of analgesic drugs. METHODS: A literature search was performed on preclinical and clinical publications aimed at the evaluation of analgesic compounds using MESH terms in PubMed...
September 11, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28894389/quantification-of-small-fiber-pathology-in-patients-with-sarcoidosis-and-chronic-pain-using-cornea-confocal-microscopy-and-skin-biopsies
#15
Linda Cj Oudejans, Marieke Niesters, Michael Brines, Albert Dahan, Monique van Velzen
Small fiber pathology with concomitant chronic neuropathic pain is a common complication of sarcoidosis. The gold standard of diagnosis of small fiber neuropathy (SFN) is the quantification of small nerve fibers in skin biopsies in combination with patient history and psychophysical tests; a new technique is the quantification of small nerve fibers in the cornea using cornea confocal microscopy (CCM). Here, we studied small fiber morphology in sarcoidosis patients with neuropathic pain using skin biopsies, CCM, and quantitative sensory testing (QST)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28893979/exposure-to-unpredictable-maternal-sensory-signals-influences-cognitive-development-across-species
#16
Elysia Poggi Davis, Stephanie A Stout, Jenny Molet, Brian Vegetabile, Laura M Glynn, Curt A Sandman, Kevin Heins, Hal Stern, Tallie Z Baram
Maternal care is a critical determinant of child development. However, our understanding of processes and mechanisms by which maternal behavior influences the developing human brain remains limited. Animal research has illustrated that patterns of sensory information is important in shaping neural circuits during development. Here we examined the relation between degree of predictability of maternal sensory signals early in life and subsequent cognitive function in both humans (n = 128 mother/infant dyads) and rats (n = 12 dams; 28 adolescents)...
September 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28885016/characterization-of-the-key-aroma-compounds-in-five-varieties-of-mandarins-by-gas-chromatography-olfactometry-odor-active-values-aroma-recombination-and-omission-analysis
#17
Zuobing Xiao, Quyang Wu, Yunwei Niu, Minling Wu, Jiancai Zhu, Xuan Zhou, Xiaomei Chen, Hongling Wang, Jing Li, Jiali Kong
In this study, volatile compounds of five varieties mandarin juices (Tankan, JG; Miyagawa, YQ; Mashui, MS; Skiranui, CJ; Ponkan, PG) were investigated by gas chromatography-olfactometry (GC-O) and gas chromatography-mass spectrometry (GC-MS). A total of 47 volatile compounds were identified by use of gas chromatography-mass spectrometry (GC-MS). Partial least squares regression (PLSR) was used to process the mean scores from sensory evaluation by the panelists, volatile compounds and samples. The sample PG was associated with "fruity", "floral" and "sweet" notes, while MS was correlated with "green" and "peely"...
September 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28883634/association-of-the-resolvin-precursor-17-hdha-but-not-d-or-e-series-resolvins-with-heat-pain-sensitivity-and-osteoarthritis-pain-in-humans
#18
Ana M Valdes, Srinivasarao Ravipati, Cristina Menni, Abhishek Abhishek, Sarah Metrustry, Juliette Harris, Ayrun Nessa, Frances M K Williams, Tim D Spector, Michael Doherty, Victoria Chapman, David A Barrett
Resolvins are omega-3 fatty acid derived potent bioactive lipids that resolve inflammation and modulate transient receptor potential channels. Exogenous administration of the resolvin precursor 17-HDHA shows a strong analgesic effect in animal models of osteoarthritis and acute inflammatory pain, but has not been studied in humans. Our aim was to assess the role of 17-HDHA and resolvins in heat pain sensitivity and in osteoarthritis pain in humans. Resolvins D1, D2, D3, D5, E1 and 17-HDHA, were measured by liquid chromatography-mass spectrometry and tested for association with heat pain thresholds in 250 healthy volunteers who had undergone quantitative sensory testing...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28883455/sensory-cue-combination-in-the-context-of-newly-learned-categories
#19
Kaitlyn R Bankieris, Vikranth Rao Bejjanki, Richard N Aslin
A large body of prior research has evaluated how humans combine multiple sources of information pertaining to stimuli drawn from continuous dimensions, such as distance or size. These prior studies have repeatedly demonstrated that in these circumstances humans integrate cues in a near-optimal fashion, weighting cues according to their reliability. However, most of our interactions with sensory information are in the context of categories such as objects and phonemes, thereby requiring a solution to the cue combination problem by mapping sensory estimates from continuous dimensions onto task-relevant categories...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28881477/multimodal-quantitative-examination-of-nerve-function-in-colorectal-cancer-patients-prior-to-chemotherapy
#20
Tejaswi Kandula, Michelle A Farrar, Arun V Krishnan, Jenna Murray, Hannah C Timmins, David Goldstein, Cindy S-Y Lin, Matthew C Kiernan, Susanna B Park
INTRODUCTION: Given recent findings of subclinical sensory deficits in colorectal cancer patients prior to oxaliplatin treatment, the current study aimed to identify evidence of subclinical peripheral neuropathy on multimodal testing before chemotherapy commencement. METHODS: Clinical, functional and neurophysiological assessments were undertaken in 93 colorectal cancer patients prior to chemotherapy. RESULTS: There was no neurophysiological evidence of neuropathy, with 92/93 sural sensory values within normative reference values for age and no significant abnormalities detected in nerve conduction or nerve excitability studies...
September 7, 2017: Muscle & Nerve
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