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Quantitative sensorial

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https://www.readbyqxmd.com/read/29149236/mutations-affecting-glycinergic-neurotransmission-in-hyperekplexia-increase-pain-sensitivity
#1
Pascal Henri Vuilleumier, Raphael Fritsche, Jürg Schliessbach, Bernhard Schmitt, Lars Arendt-Nielsen, Hanns Ulrich Zeilhofer, Michele Curatolo
Inhibitory interneurons in the spinal cord use glycine and GABA for fast inhibitory neurotransmission. While there is abundant research on these inhibitory pain pathways in animal models, their relevance in humans remains unclear, largely due to the limited possibility to manipulate selectively these pathways in humans. Hyperekplexia is a rare human disease that is caused by loss-of-function mutations in genes encoding for glycine receptors and glycine transporters. In the present study, we tested whether hyperekplexia patients display altered pain perception or central pain modulation compared with healthy subjects...
November 15, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29148845/speech-recovery-and-language-plasticity-can-be-facilitated-by-sensori-motor-fusion-training-in-chronic-non-fluent-aphasia-a-case-report-study
#2
Célise Haldin, Audrey Acher, Louise Kauffmann, Thomas Hueber, Emilie Cousin, Pierre Badin, Pascal Perrier, Diandra Fabre, Dominic Perennou, Olivier Detante, Assia Jaillard, Hélène Lœvenbruck, Monica Baciu
The rehabilitation of speech disorders benefits from providing visual information which may improve speech motor plans in patients. We tested the proof of concept of a rehabilitation method (Sensori-Motor Fusion, SMF; Ultraspeech player) in one post-stroke patient presenting chronic non-fluent aphasia. SMF allows visualisation by the patient of target tongue and lips movements using high-speed ultrasound and video imaging. This can improve the patient's awareness of his/her own lingual and labial movements, which can, in turn, improve the representation of articulatory movements and increase the ability to coordinate and combine articulatory gestures...
November 17, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/29143411/spontaneous-neural-activity-differences-in-posttraumatic-stress-disorder-a-quantitative-resting-state-meta-analysis-and-fmri-validation
#3
Seth G Disner, Craig A Marquardt, Bryon A Mueller, Philip C Burton, Scott R Sponheim
Identifying the pathophysiology of posttraumatic stress disorder (PTSD) is a critical step toward reducing its debilitating impact. Spontaneous neural activity, measured at rest using various neuroimaging techniques (e.g., regional homogeneity [ReHo], amplitude of low frequency fluctuations [ALFF]), can provide insight about baseline neurobiological factors influencing sensory, cognitive, or behavioral processes associated with PTSD. The present study used activation likelihood estimation (ALE) to conduct the largest-to-date quantitative meta-analysis of spontaneous neural activity in PTSD, including 457 PTSD cases, 292 trauma-exposed controls (TECs), and 293 non-traumatized controls (NTCs) across 22 published studies...
November 15, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29135026/sensory-and-flavor-characteristics-of-tomato-juice-from-garden-gem-and-roma-tomatoes-with-comparison-to-commercial-tomato-juice
#4
Yaozhou Zhu, Charles A Sims, Harry J Klee, Paul J Sarnoski
The objective of this study was to characterize the flavor of a premium Florida tomato variety that has significant potential for producing a high quality processed juice product. A high-quality Florida plum tomato variety (Garden Gem), and a typical grocery-store plum tomato variety (Roma) were thermally processed into tomato juices without any additives. The 2 pilot products and a popular commercially available tomato juice (low sodium with sugar and flavor added) were compared using sensory evaluation and instrumental analysis...
November 14, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29131461/somatosensory-profile-of-patients-with-haemophilia
#5
S Krüger, M K Boettger, T Hilberg
INTRODUCTION: Patients with haemophilia (PwH) suffer from an enhanced pain sensitivity due to repetitive joint bleedings. A comprehensive, quantitative examination of the somatosensory system has not been performed in this population to date. MATERIAL AND METHODS: Thirty patients with moderate or severe haemophilia A or B and 30 healthy controls were examined by means of Quantitative Sensory Testing to assess the function of the somatosensory system. Detection (DT) and pain thresholds (PT) were determined, amounting to a total of 13 parameters...
November 13, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29128812/pharmacological-evidence-for-the-involvement-of-adenosine-triphosphate-sensitive-potassium-channels-in-chloroquine-induced-itch-in-mice
#6
Sattar Ostadhadi, Arash Foroutan, Nazgol-Sadat Haddadi, Abbas Norouzi-Javidan, Majid Momeny, Ghazaleh Zarrinrad, Seyed Hamid Ghaffari, Ahmad-Reza Dehpour
BACKGROUND: Chloroquine (CQ) evokes itch in human and scratching behavior in rodents through a histamine-independent pathway. Chloroquine directly excites peripheral sensory neurons which convey itch signals to the central nervous system. It has been revealed that ATP-sensitive potassium channels (KATP channels) are important in regulating neuronal excitability. Thus, we aimed to investigate the involvement of KATP channels in CQ-induced itch which may also reveal a linkage between metabolic state of cells and itch...
June 3, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29126222/lumbar-disc-herniation-the-association-between-quantitative-sensorial-test-and-magnetic-resonance-imaging-findings
#7
Serpil Canan Erbüyün, Gülgün Yilmaz Ovali, Beyhan Özyurt, E Alp Yentür
Objective: Quantitative sensorial tests (QST) are used for evaluating specific sensorial nerve function. In this study, QST and magnetic resonance imaging (MRI) findings are compared in lumbar disc herniation patients, and the accuracy of QST data was investigated. Material and Methods: Sixty-four patients between 18 and 70 years of age suffering from radicular pain with positive Lasegue's test were included in this study. Specific criteria included complaints due to L5 discopathy...
November 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29116415/a-microfluidic-device-for-quantitative-investigation-of-zebrafish-larvae-s-rheotaxis
#8
Amir Reza Peimani, Georg Zoidl, Pouya Rezai
Zebrafish is a model organism for various sensory-motor biological studies. Rheotaxis, or the ability of zebrafish to orient and swim against the water stream, is a common behavior that involves multiple sensory-motor processes such as their lateral line and visual systems. Due to the lack of a controllable and easy-to-use assay, zebrafish rheotaxis at larval stages is not well-understood. In this paper, we report a microfluidic device that can be used to apply the flow stimulus precisely and repeatedly along the longitudinal axis of individual zebrafish larvae to study their coaxial rheotaxis...
November 7, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/29109238/extensive-tonotopic-mapping-across-auditory-cortex-is-recapitulated-by-spectrally-directed-attention-and-systematically-related-to-cortical-myeloarchitecture
#9
Frederic K Dick, Matt I Lehet, Martina F Callaghan, Tim A Keller, Martin I Sereno, Lori L Holt
Auditory selective attention is vital in natural soundscapes. But, it is unclear how attentional focus on the primary dimension of auditory representation - acoustic frequency - might modulate basic auditory functional topography during active listening. In contrast to visual selective attention, which is supported by motor-mediated optimization of input across saccades and pupil dilation, the primate auditory system has fewer means of differentially sampling the world. This makes spectrally-directed endogenous attention a particularly crucial aspect of auditory attention...
November 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29107771/overlapping-frontoparietal-networks-for-tactile-and-visual-parametric-working-memory-representations
#10
Yuan-Hao Wu, Işıl Uluç, Timo Torsten Schmidt, Kathrin Tertel, Evgeniya Kirilina, Felix Blankenburg
Previous working memory (WM) research based on non-human primate electrophysiology and human EEG has shown that frontal brain regions maintain frequencies of flutter stimulation across different sensory modalities by means of a supramodal parametric WM code. These findings imply that frontal regions encode the memorized frequencies in a sensory-unspecific, quantitative format. Here, we explored which brain regions maintain information about frequencies provided by different sensory modalities at the level of activity pattern across fMRI voxel populations...
October 28, 2017: NeuroImage
https://www.readbyqxmd.com/read/29106408/cell-type-specific-metabolic-labeling-of-nascent-proteomes-in-vivo
#11
Beatriz Alvarez-Castelao, Christoph T Schanzenbächer, Cyril Hanus, Caspar Glock, Susanne Tom Dieck, Aline R Dörrbaum, Ina Bartnik, Belquis Nassim-Assir, Elena Ciirdaeva, Anke Mueller, Daniela C Dieterich, David A Tirrell, Julian D Langer, Erin M Schuman
Although advances in protein labeling methods have made it possible to measure the proteome of mixed cell populations, it has not been possible to isolate cell-type-specific proteomes in vivo. This is because the existing methods for metabolic protein labeling in vivo access all cell types. We report the development of a transgenic mouse line where Cre-recombinase-induced expression of a mutant methionyl-tRNA synthetase (L274G) enables the cell-type-specific labeling of nascent proteins with a non-canonical amino-acid and click chemistry...
November 6, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/29105897/chronic-intensive-care-related-pain-exploratory-analysis-on-predictors-and-influence-on-health-related-quality-of-life
#12
P Baumbach, T Götz, A Günther, T Weiss, W Meissner
BACKGROUND: There is growing evidence for the development of chronic pain after intensive care. Nonetheless, there is only limited knowledge about factors leading to chronic intensive care-related pain (CIRP). Thus, the primary objective was the identification of predictors of CIRP. Moreover, we aimed to assess the impact of CIRP on patients' health-related quality of Life (HRQOL). METHODS: Comprehensive information on patients' pain before ICU admission and present pain was collected longitudinally by means of the German Pain Questionnaire 6 and 12 months after ICU discharge (ICUDC )...
November 5, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29099662/local-oxygen-homeostasis-during-various-neuronal-network-activity-states-in-the-mouse-hippocampus
#13
Justus Schneider, Nikolaus Berndt, Ismini E Papageorgiou, Jana Maurer, Sascha Bulik, Martin Both, Andreas Draguhn, Hermann-Georg Holzhütter, Oliver Kann
Cortical information processing comprises various activity states emerging from timed synaptic excitation and inhibition. However, the underlying energy metabolism is widely unknown. We determined the cerebral metabolic rate of oxygen (CMRO2) along a tissue depth of <0.3 mm in the hippocampal CA3 region during various network activities, including gamma oscillations and sharp wave-ripples that occur during wakefulness and sleep. These physiological states associate with sensory perception and memory formation, and critically depend on perisomatic GABA inhibition...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29098015/parents-perceptions-of-dental-care-challenges-in-male-children-with-autism-spectrum-disorder-an-initial-qualitative-exploration
#14
Leah I Stein Duker, Benjamin F Henwood, Ricky N Bluthenthal, Emma Juhlin, José C Polido, Sharon A Cermak
Background: Many children with autism spectrum disorders (ASD) experience barriers to oral care in the dental office setting. The purpose of this study was to provide an increased understanding of these challenges experienced during oral care in the dental office by children with ASD. Method: This study was part of a larger mixed methods design and builds on quantitative results from a survey of parents of children with ASD ages 2-18 in which parents reported difficulties with access to care, sensory processing, and uncooperative behaviors...
July 2017: Research in Autism Spectrum Disorders
https://www.readbyqxmd.com/read/29097193/women-s-sense-of-coherence-and-its-association-with-early-weaning
#15
Fernando M Cortelo, Sérgio T M Marba, Karine L Cortellazzi, Glaucia M B Ambrosano, Luciane M Guerra, Ana Cláudia G Almeida, Scott L Tomar, Margarete Ribeiro da Silva, Rosana F Possobon
OBJECTIVE: To investigate whether there is an association between sense of coherence levels and early weaning. METHOD: This study had a quantitative nature and a cross-sectional design. Factors associated with early weaning (interruption of maternal breastfeeding) were investigated in a sample of 425 women older than 18 years, mothers of children up to 36 months of age who were not twins, with no sensory or motor deficiencies, without distinction of ethnicity or social class...
October 30, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/29095376/circulating-lipids-and-acute-pain-sensitization-an-exploratory-analysis
#16
Angela Starkweather, Thomas Julian, Divya Ramesh, Amy Heineman, Jamie Sturgill, Susan G Dorsey, Debra E Lyon, Dayanjan Shanaka Wijesinghe
BACKGROUND: In individuals with low back pain, higher lipid levels have been documented and were associated with increased risk for chronic low back pain. OBJECTIVES: The purpose of this research was to identify plasma lipids that discriminate participants with acute low back pain with or without pain sensitization as measured by quantitative sensory testing. METHODS: This exploratory study was conducted as part of a larger parent randomized controlled trial...
November 2017: Nursing Research
https://www.readbyqxmd.com/read/29093170/locus-coeruleus-phasic-discharge-is-essential-for-stimulus-induced-gamma-oscillations-in-the-prefrontal-cortex
#17
Ricardo M Neves, Silvia van Keulen, Mingyu Yang, Nikos K Logothetis, Oxana Eschenko
The Locus Coeruleus (LC) noradrenergic (NE) neuromodulatory system is critically involved in regulation of neural excitability via its diffuse ascending projections. Tonic NE release in the forebrain is essential for maintenance of vigilant states and increases the signal-to-noise ratio of cortical sensory responses. The impact of phasic NE release on cortical activity and sensory processing is less explored. We have previously reported that LC microstimulation caused a transient desynchronization of the population activity in the medial prefrontal cortex (mPFC), similar to noxious somatosensory stimuli...
November 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29091435/time-resolved-gravimetric-method-to-assess-degassing-of-roasted-coffee
#18
Samo Smrke, Marco Wellinger, Tomonori Suzuki, Franz Balsiger, Sebastian E W Opitz, Chahan Yeretzian
During the roasting of coffee, thermally driven chemical reactions lead to the formation of gases, of which a large fraction is carbon dioxide (CO2). Part of these gases is released during roasting while part is retained inside the porous structure of the roasted beans and is steadily released during storage or more abruptly during grinding and extraction. The release of CO2 during the various phases from roasting to consumption is linked to many important properties and characteristics of coffee. It is an indicator for freshness, plays an important role in shelf life and in packaging, impacts the extraction process, is involved in crema formation, and may affect the sensory profile in the cup...
November 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29089923/sensory-alterations-in-patients-with-isolated-idiopathic-dystonia-an-exploratory-quantitative-sensory-testing-analysis
#19
Lejla Paracka, Florian Wegner, Christian Blahak, Mahmoud Abdallat, Assel Saryyeva, Dirk Dressler, Matthias Karst, Joachim K Krauss
Abnormalities in the somatosensory system are increasingly being recognized in patients with dystonia. The aim of this study was to investigate whether sensory abnormalities are confined to the dystonic body segments or whether there is a wider involvement in patients with idiopathic dystonia. For this purpose, we recruited 20 patients, 8 had generalized, 5 had segmental dystonia with upper extremity involvement, and 7 had cervical dystonia. In total, there were 13 patients with upper extremity involvement...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29089757/identification-of-lncrnas-involved-in-biological-regulation-in-early-age-related-macular-degeneration
#20
Wei Zhu, Yi-Fang Meng, Qian Xing, Jian-Jun Tao, Jiong Lu, Yan Wu
BACKGROUND: Age-related macular degeneration (AMD) is one of the most common causes of adult blindness in developed countries. However, the role of long noncoding RNAs (lncRNAs) in the development and progression of early AMD is unclear. METHODS: We established the lncRNA profile of early AMD by reannotation of microarrays from the gene expression omnibus database. Quantitative real-time polymerase chain reaction was used to determine the expression of selected lncRNAs...
2017: International Journal of Nanomedicine
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