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Quantitative sensorial

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https://www.readbyqxmd.com/read/29330349/pharmacologic-inhibition-of-phospholipase-c-in-the-brain-attenuates-early-memory-formation-in-the-honeybee-apis-mellifera-l
#1
Shota Suenami, Shiori Iino, Takeo Kubo
Although the molecular mechanisms involved in learning and memory in insects have been studied intensively, the intracellular signaling mechanisms involved in early memory formation are not fully understood. We previously demonstrated that phospholipase C epsilon (PLCe), whose product is involved in calcium signaling, is almost selectively expressed in the mushroom bodies, a brain structure important for learning and memory in the honeybee. Here, we pharmacologically examined the role of phospholipase C (PLC) in learning and memory in the honeybee...
January 12, 2018: Biology Open
https://www.readbyqxmd.com/read/29329103/analysis-of-anti-ganglioside-antibodies-by-a-line-immunoassay-in-patients-with-chronic-inflammatory-demyelinating-polyneuropathies-cidp
#2
Juliane Klehmet, Stefanie Märschenz, Klemens Ruprecht, Benjamin Wunderlich, Thomas Büttner, Rico Hiemann, Dirk Roggenbuck, Andreas Meisel
BACKGROUND: Unlike for acute immune-mediated neuropathies (IN), anti-ganglioside autoantibody (aGAAb) testing has been recommended for only a minority of chronic IN yet. Thus, we used a multiplex semi-quantitative line immunoassay (LIA) to search for aGAAb in chronic-inflammatory demyelinating polyneuropathy (CIDP) and its clinical variants. METHODS: Anti-GAAb to 11 gangliosides and sulfatide (SF) were investigated by LIA in 61 patients with IN (27 typical CIDP, 12 distal-acquired demyelinating polyneuropathy, 6 multifocal-acquired demyelinating sensory/motor polyneuropathy, 10 sensory CIDP, 1 focal CIDP and 5 multifocal-motoric neuropathy), 40 with other neuromuscular disorders (OND) (15 non-immune polyneuropathies, 25 myasthenia gravis), 29 with multiple sclerosis (MS) and 54 healthy controls (HC)...
January 12, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29324510/reliability-and-validity-of-computerized-force-platform-measures-of-balance-function-in-healthy-older-adults
#3
Cathy C Harro, Chelsea Garascia
BACKGROUND AND PURPOSE: Postural control declines with aging and is an independent risk factor for falls in older adults. Objective examination of balance function is warranted to direct fall prevention strategies. Force platform (FP) systems provide quantitative measures of postural control and analysis of different aspects of balance. The purpose of this study was to examine the reliability and validity of FP measures in healthy older adults. METHODS: This study enrolled 46 healthy elderly adults, mean age 67...
January 10, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29324082/sensory-dissociation-in-chronic-low-back-pain-two-case-reports
#4
Wacław M Adamczyk, Kerstin Luedtke, Oskar Saulicz, Edward Saulicz
Patients with chronic low back pain often report that they do not perceive their painful back accurately. Previous studies confirmed that sensory dissociation and/or discrepancy between perceived body image and actual size is one of the specific traits of patients with chronic pain. Current approaches for measuring sensory dissociation are limited to two-point-discrimination or rely on pain drawings not allowing for quantitative analysis. This case study reports the sensory dissociation of two cases with chronic low back pain using a recently published test (point-to-point-test (PTP)) and a newly developed test (two-point-estimation (TPE))...
January 11, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29317216/multisensory-temporal-binding-window-in-autism-spectrum-disorders-and-schizophrenia-spectrum-disorders-a-systematic-review-and-meta-analysis
#5
REVIEW
Han-Yu Zhou, Xin-Lu Cai, Michael Weigl, Peter Bang, Eric F C Cheung, Raymond C K Chan
Multisensory temporal integration could be compromised in both autism spectrum disorders (ASD) and schizophrenia spectrum disorders (SSD) and may play an important role in perceptual and cognitive impairment in these two disorders. This review aimed to quantitatively compare the sensory temporal acuity between healthy controls and the two clinical groups (ASD and SSD). Impairment of sensory temporal integration was robust and comparable in both patients with SSD (Hedges' g=0.91, 95%CI[0.62-1.19]; Z=6.21, p<...
January 6, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29316895/daily-repetitive-sensory-stimulation-of-the-paretic-hand-for-the-treatment-of-sensorimotor-deficits-in-patients-with-subacute-stroke-reset-a-randomized-sham-controlled-trial
#6
Jan C Kattenstroth, Tobias Kalisch, Matthias Sczesny-Kaiser, Wolfgang Greulich, Martin Tegenthoff, Hubert R Dinse
BACKGROUND: Repetitive sensory stimulation (RSS) adapts the timing of stimulation protocols used in cellular studies to induce synaptic plasticity. In healthy subjects, RSS leads to widespread sensorimotor cortical reorganization paralleled by improved sensorimotor behavior. Here, we investigated whether RSS reduces sensorimotor upper limb impairment in patients with subacute stroke more effectively than conventional therapy. METHODS: A single-blinded sham-controlled clinical trial assessed the effectiveness of RSS in treating sensorimotor deficits of the upper limbs...
January 9, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29306634/an-automated-gas-chromatographic-mass-spectrometric-method-for-the-quantitative-analysis-of-the-odor-active-molecules-present-in-the-vapors-emanated-from-wine
#7
Yan Wen, Ricardo Lopez, Vicente Ferreira
An automated dynamic headspace (DHS) method combined with thermal desorption (TD) and gas chromatography-mass spectrometry (GC-MS) has been developed and applied to characterize the composition of the vapors emanating from wine during its consumption. The method provides a snapshot of the contents in the wine vapors of up to 40 relevant aroma compounds, including methanethiol, sulfur dioxide, aldehydes, fusel alcohols or volatile phenols. Leaving aside methanethiol, method repeatability was better than 15%, and better than 11% in 30 cases...
December 28, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29298304/the-vienna-psychosocial-assessment-procedure-for-bionic-reconstruction-in-patients-with-global-brachial-plexus-injuries
#8
Laura Antonia Hruby, Anna Pittermann, Agnes Sturma, Oskar Christian Aszmann
BACKGROUND: Global brachial plexopathies cause major sensory and motor deficits in the affected arm and hand. Many patients report of psychosocial consequences including chronic pain, decreased self-sufficiency, and poor body image. Bionic reconstruction, which includes the amputation and prosthetic replacement of the functionless limb, has been shown to restore hand function in patients where classic reconstructions have failed. Patient selection and psychological evaluation before such a life-changing procedure are crucial for optimal functional outcomes...
2018: PloS One
https://www.readbyqxmd.com/read/29296629/alterations-in-neurovascular-coupling-following-acute-traumatic-brain-injury
#9
Hyounguk Jang, Stanley Huang, Daniel X Hammer, Lin Wang, Harmain Rafi, Meijun Ye, Cristin G Welle, Jonathan A N Fisher
Following acute traumatic brain injury (TBI), timely transport to a hospital can significantly improve the prognosis for recovery. There is, however, a dearth of quantitative biomarkers for brain injury that can be rapidly acquired and interpreted in active, field environments in which TBIs are frequently incurred. We explored potential functional indicators for TBI that can be noninvasively obtained through portable detection modalities, namely optical and electrophysiological approaches. By combining diffuse correlation spectroscopy with colocalized electrophysiological measurements in a mouse model of TBI, we observed concomitant alterations in sensory-evoked cerebral blood flow (CBF) and electrical potentials following controlled cortical impact...
October 2017: Neurophotonics
https://www.readbyqxmd.com/read/29288083/poly-ethylene-co-vinyl-alcohol-is-a-suitable-substrate-for-human-olfactory-neuroepithelial-cell-differentiation-in-vitro-through-a-defined-regulatory-pathway
#10
Sheng-Tien Li, Tai-Horng Young, Tsung-Wei Huang
Olfactory dysfunction significantly influences patients' life quality, but currently has no adequate treatment. Poly (ethylene-co-vinyl alcohol) (EVAL) mediates cell adhesion, growth and modulates differentiation of neural stem cells. However, whether EVAL is a suitable substrate to establish an in vitro culture system that can promote development and differentiation of human olfactory neuroepithelial cells (HONCs) remains unexplored. This study isolates and cultures HONCs on controls and EVAL films for 21 days...
December 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29286627/incorporating-electron-deficient-bipyridinium-chromorphores-to-make-multiresponsive-metal-organic-frameworks
#11
Ning-Ning Yang, Jia-Jia Fang, Qi Sui, En-Qing Gao
Metal-organic frameworks (MOFs) are versatile platforms to design switchable and sensory materials responsive to external stimulus. Copuling the electron-deficient bipyridinium chromorphore with the pore structures of MOFs is a nice strategy to design multiresponsive MOFs. Here we present a proof-of-concept study. Postsynthetic N,N'-cycloalkylation of UiO-67-bpy (bpy = 2,2'-bipyridyl) leads to a novel ionic MOF (UiO-67-DQ) functionalized by the electron-deficient diquat (DQ) chromophore. The combination of porosity, cationic character and electron deficiency imparts UiO-67-DQ with versatile responsive properties...
December 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29285568/characterization-of-migraineurs-presenting-interictal-widespread-pressure-hyperalgesia-identified-using-a-tender-point-count-a-cross-sectional-study
#12
Toshihide Toriyama, Tetsuyoshi Horiuchi, Kazuhiro Hongo
BACKGROUND: Migraineurs exhibit pain hypersensitivity throughout the body during and between migraine headaches. Migraine is classified as a central sensitivity syndrome, typified by fibromyalgia showing widespread pressure hyperalgesia determined by a tender point. This study was performed to examine whether: 1) there is a subgroup of episodic migraineurs with widespread pressure hyperalgesia during and between attacks; 2) if such a subgroup exists, what is the prevalence and what is the difference between groups with interictal widespread hyperalgesia and acute allodynia regarding the demographic and clinical characteristics of migraine...
December 28, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29278602/ethnic-differences-identified-by-pain-sensitivity-questionnaire-correlate-with-clinical-pain-responses
#13
Brooke A Bell, Ruth Ruscheweyh, Bernard Joseph Kelley, Timothy J Ness, Thomas R Vetter, Alethia Baldwin Sellers
BACKGROUND AND OBJECTIVES: The Pain Sensitivity Questionnaire, English version (PSQ-E), is predictive of pain-related responses to experimental stimuli. Ethnic differences have been noted in experimental measures of pain sensation using quantitative sensory testing. The present study sought to determine if the PSQ-E also identified similar ethnic differences. METHODS: Fifty-seven subjects who self-identified as African Americans (AAs) and who were scheduled to undergo a low-back interventional procedure completed the PSQ-E and other questionnaires...
December 22, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29261728/using-thermal-scanning-assays-to-test-protein-protein-interactions-of-inner-ear-cadherins
#14
Deepanshu Choudhary, Anusha Kumar, Thomas J Magliery, Marcos Sotomayor
Protein-protein interactions play a crucial role in biological processes such as cell-cell adhesion, immune system-pathogen interactions, and sensory perception. Understanding the structural determinants of protein-protein complex formation and obtaining quantitative estimates of their dissociation constant (KD) are essential for the study of these interactions and for the discovery of new therapeutics. At the same time, it is equally important to characterize protein-protein interactions in a high-throughput fashion...
2017: PloS One
https://www.readbyqxmd.com/read/29241189/lord-adrian-md-prs-om
#15
John M S Pearce
Edgar Douglas Adrian was an outstandingly brilliant, Nobel prize-winning neurophysiologist. He is remembered for developing the all-or-none principle of muscle contraction, and for explaining the minutiae of motor and sensory nerve transmission. He showed that the afferent effect in a neuron depends on the pattern in time of the impulses travelling in it, thereby providing a quantitative basis of nervous behaviour. With Sir Charles Sherrington, he was awarded the Nobel Prize in 1932 for discoveries on the functions of the neurons...
December 14, 2017: European Neurology
https://www.readbyqxmd.com/read/29233604/axonal-excitability-changes-and-acute-symptoms-of-oxaliplatin-treatment-in-vivo-evidence-for-slowed-sodium-channel-inactivation
#16
Rikke Heide, Hugh Bostock, Lise Ventzel, Peter Grafe, Joseph Bergmans, Anders Fuglsang-Frederiksen, Nanna B Finnerup, Hatice Tankisi
OBJECTIVE: Neurotoxicity is the most frequent dose-limiting side effect of the anti-cancer agent oxaliplatin, but the mechanisms are not well understood. This study used nerve excitability testing to investigate the pathophysiology of the acute neurotoxicity. METHODS: Questionnaires, quantitative sensory tests, nerve conduction studies and nerve excitability testing were undertaken in 12 patients with high-risk colorectal cancer treated with adjuvant oxaliplatin and in 16 sex- and age-matched healthy controls...
November 26, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29233061/inter-and-intra-tester-reliability-of-sensibility-testing-in-healthy-individuals
#17
Tugrul Bulut, Mesut Tahta, Ufuk Sener, Muhittin Sener
Static two-point discrimination (S2PD) and Semmes-Weinstein monofilament (SWM) tests are the most widely used tests for evaluation of sensory deterioration. It is a necessity to know the inter- and intra-tester reliability of these tests to determine the suitability of method. Another important point in evaluation of sensory deterioration is whether or not there is a reference point which can be compared with the test results. So, it is important to know the reliability of sensory evaluation tests on the healthy extremities...
December 12, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/29229984/molecular-and-functional-variation-in-ipsc-derived-sensory-neurons
#18
Jeremy Schwartzentruber, Stefanie Foskolou, Helena Kilpinen, Julia Rodrigues, Kaur Alasoo, Andrew J Knights, Minal Patel, Angela Goncalves, Rita Ferreira, Caroline Louise Benn, Anna Wilbrey, Magda Bictash, Emma Impey, Lishuang Cao, Sergio Lainez, Alexandre Julien Loucif, Paul John Whiting, Alex Gutteridge, Daniel J Gaffney
Induced pluripotent stem cells (iPSCs), and cells derived from them, have become key tools for modeling biological processes, particularly in cell types that are difficult to obtain from living donors. Here we present a map of regulatory variants in iPSC-derived neurons, based on 123 differentiations of iPSCs to a sensory neuronal fate. Gene expression was more variable across cultures than in primary dorsal root ganglion, particularly for genes related to nervous system development. Using single-cell RNA-sequencing, we found that the number of neuronal versus contaminating cells was influenced by iPSC culture conditions before differentiation...
December 11, 2017: Nature Genetics
https://www.readbyqxmd.com/read/29225027/evolution-of-the-sauropterygian-labyrinth-with-increasingly-pelagic-lifestyles
#19
James M Neenan, Tobias Reich, Serjoscha W Evers, Patrick S Druckenmiller, Dennis F A E Voeten, Jonah N Choiniere, Paul M Barrett, Stephanie E Pierce, Roger B J Benson
Sauropterygia, a successful clade of marine reptiles abundant in aquatic ecosystems of the Mesozoic, inhabited nearshore to pelagic habitats over >180 million years of evolutionary history [1]. Aquatic vertebrates experience strong buoyancy forces that allow movement in a three-dimensional environment, resulting in structural convergences such as flippers and fish-like bauplans [2, 3], as well as convergences in the sensory systems. We used computed tomographic scans of 19 sauropterygian species to determine how the transition to pelagic lifestyles influenced the evolution of the endosseous labyrinth, which houses the vestibular sensory organ of balance and orientation [4]...
December 18, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29222932/a-fibers-mediate-cold-hyperalgesia-in-patients-with-oxaliplatin-induced-neuropathy
#20
Julia Forstenpointner, Violetta C Oberlojer, Dennis Naleschinski, Johanna Höper, Stephanie M Helfert, Andreas Binder, Janne Gierthmühlen, Ralf Baron
Cold hyperalgesia is a common side effect of oxaliplatin treatment; still the pathophysiological and molecular mechanisms as well as the contribution of different primary afferent fiber systems are unclear. Therefore, patients with oxaliplatin-induced acute neuropathy with (n=6) and without (n=7) cold hyperalgesia were tested by applying a preferential blockade of peripheral myelinated A-fiber afferents in combination with quantitative sensory testing. Additionally, an interview-based questionnaire assessed the severity of symptoms and the impact on daily activities...
December 9, 2017: Pain Practice: the Official Journal of World Institute of Pain
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