keyword
https://read.qxmd.com/read/38536635/the-acetic-acid-produced-by-lactobacillus-species-regulates-immune-function-to-alleviate-pedv-infection-in-piglets
#1
JOURNAL ARTICLE
Ming-Jie Sun, Jun Hong Xing, Qing-Song Yan, Bo-Shi Zou, Ying-Jie Wang, Tian-Ming Niu, Tong Yu, Hai-Bin Huang, Di Zhang, Shu-Min Zhang, Wu-Sheng Sun, Ruo-Nan Zou, Chun-Feng Wang, Chun-Wei Shi
Porcine epidemic diarrhea virus (PEDV) infection results in significant mortality among newborn piglets, leading to substantial economic setbacks in the pig industry. Short-chain fatty acids (SCFA), the metabolites of intestinal probiotics, play pivotal roles in modulating intestinal function, enhancing the intestinal barrier, and bolstering immune responses through diverse mechanisms. The protective potential of Lactobacillus delbrueckii, Lactobacillus johnsonii, and Lactococcus lactis was first noted when administered to PEDV-infected piglets...
March 27, 2024: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/38536494/the-role-of-na-coupled-bicarbonate-transporters-ncbt-in-health-and-disease
#2
REVIEW
Shannon R Holmberg, Yohei Sakamoto, Akira Kato, Michael F Romero
Cellular and organism survival depends upon the regulation of pH, which is regulated by highly specialized cell membrane transporters, the solute carriers (SLC) (For a comprehensive list of the solute carrier family members, see: https://www.bioparadigms.org/slc/ ). The SLC4 family of bicarbonate (HCO3 - ) transporters consists of ten members, sorted by their coupling to either sodium (NBCe1, NBCe2, NBCn1, NBCn2, NDCBE), chloride (AE1, AE2, AE3), or borate (BTR1). The ionic coupling of SLC4A9 (AE4) remains controversial...
March 27, 2024: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/38534137/enhanced-alkaline-hydrogen-evolution-reaction-via-electronic-structure-regulation-activating-ptrh-with-rare-earth-tm-alloying
#3
JOURNAL ARTICLE
Qingqing Li, Botao Zhang, Chang Sun, Xiaolei Sun, Zhenxing Li, Yaping Du, Jin-Cheng Liu, Feng Luo
Developing high-performance electrocatalysts for alkaline hydrogen evolution reaction (HER) is crucial for producing green hydrogen, yet it remains challenging due to the sluggish kinetics in alkaline environments. Pt is located near the peak of HER volcano plot, owing to its exceptional performance in hydrogen adsorption and desorption, and Rh plays an important role in H2 O dissociation. Lanthanides (Ln) are commonly used to modulate the electronic structure of materials and further influence the adsorption/desorption of reactants, intermediates, and products, and noble metal-Ln alloys are recognized as effective platforms where Ln elements regulate the catalytic properties of noble metals...
March 27, 2024: Small
https://read.qxmd.com/read/38533975/cgmp-dependent-kinase-2-na-h-exchanger-nhe3-and-pdz-adaptor-nherf2-co-assemble-in-apical-membrane-microdomains
#4
JOURNAL ARTICLE
Min Luo, Yongjian Liu, Katerina Nikolovska, Brigitte Riederer, Enrico Patrucco, Franz Hofmann, Ursula Seidler
AIM: Trafficking, membrane retention, and signal-specific regulation of the Na+ /H+ exchanger 3 (NHE3) are modulated by the Na+ /H+ Exchanger Regulatory Factor (NHERF) family of PDZ-adapter proteins. This study explored the assembly of NHE3 and NHERF2 with the cGMP-dependent kinase II (cGKII) within detergent-resistant membrane microdomains (DRMs, "lipid rafts") during in vivo guanylate cycle C receptor (Gucy2c) activation in murine small intestine. METHODS: Small intestinal brush border membranes (siBBMs) were isolated from wild type, NHE3-deficient, cGMP-kinase II-deficient, and NHERF2-deficient mice, after oral application of the heat-stable Escherichia coli toxin (STa) analog linaclotide...
March 27, 2024: Acta Physiologica
https://read.qxmd.com/read/38533773/myricetin-oligomer-triggers-multi-receptor-mediated-penetration-and-autophagic-restoration-of-blood-brain-barrier-for-ischemic-stroke-treatment
#5
JOURNAL ARTICLE
Lei Liu, Zhifang Ma, Qiaoyi Han, Wei Meng, Haozheng Wang, Xinghua Guan, Qiang Shi
Restoration of blood-brain barrier (BBB) dysfunction, which drives worse outcomes of ischemic stroke, is a potential target for therapeutic opportunities, whereas a sealed BBB blocks the therapeutics entrance into the brain, making the BBB protection strategy paradoxical. Post ischemic stroke, hypoxia/hypoglycemia provokes the up-regulation of transmembrane glucose transporters and iron transporters due to multiple metabolic disorders, especially in brain endothelial cells. Herein, we develop a myricetin oligomer-derived nanostructure doped with Ce to bypass the BBB which is cointermediated by glucose transporters and iron transporters such as glucose transporters 1 (GLUT1), sodium/glucose cotransporters 1 (SGLT1), and transferrin(Tf) reporter (TfR)...
March 27, 2024: ACS Nano
https://read.qxmd.com/read/38533759/regulating-the-pore-structure-of-activated-carbon-by-pitch-for-high-performance-sodium-ion-storage
#6
JOURNAL ARTICLE
Yan-Ru Tian, Zong-Lin Yi, Fang-Yuan Su, Li-Jing Xie, Xu-Feng Zhang, Xiong-Fei Li, Jia-Yao Cheng, Jing-Peng Chen, Cheng-Meng Chen
The pore structure of carbon anodes plays a crucial role in enhancing the sodium storage capacity. Designing more confined pores in carbon anodes is accepted as an effective strategy. However, current design strategies for confined pores in carbon anodes fail to achieve both high capacity and initial Coulombic efficiency (ICE) simultaneously. Herein, we develop a strategy for utilizing the repeated impregnation and precarbonization method of liquid pitch to regulate the pore structure of the activated carbon (AC) material...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38530873/functional-polyphenol-based-nanoparticles-boosted-the-neuroprotective-effect-of-riluzole-for-acute-spinal-cord-injury
#7
JOURNAL ARTICLE
Taoyang Yuan, Tianyou Wang, Jianhua Zhang, Feng Ye, Zhipeng Gu, Yiwen Li, Jianguo Xu
Riluzole is commonly used as a neuroprotective agent for treating traumatic spinal cord injury (SCI), which works by blocking the influx of sodium and calcium ions and reducing glutamate activity. However, its clinical application is limited because of its poor solubility, short half-life, potential organ toxicity, and insufficient bioabilities toward upregulated inflammation and oxidative stress levels. To address this issue, epigallocatechin gallate (EGCG), a natural polyphenol, was employed to fabricate nanoparticles (NPs) with riluzole to enhance the neuroprotective effects...
March 26, 2024: Biomacromolecules
https://read.qxmd.com/read/38529844/a-whole-course-repair-system-based-on-ros-glucose-stimuli-responsive-egcg-release-and-tunable-mechanical-property-for-efficient-treatment-of-chronic-periodontitis-in-diabetic-rats
#8
JOURNAL ARTICLE
Qingchen Feng, Mei Zhang, Guanning Zhang, Hongxiang Mei, Chongying Su, Lisa Liu, Xiaoxia Wang, Ziqianhong Wan, Zhengyi Xu, Liangkui Hu, Yu Nie, Juan Li
Elevated glucose levels, multiple pro-inflammatory cytokines and the generation of excessive reactive oxygen species (ROS) are pivotal characteristics within the microenvironments of chronic periodontitis with diabetes mellitus (CPDM). Control of inflammation and modulation of immune system are required in the initial phase of CPDM treatment, while late severe periodontitis requires a suitable scaffold to promote osteogenesis, rebuild periodontal tissue and reduce alveolar bone resorption. Herein, a whole-course-repair system is introduced by an injectable hydrogel using phenylboronic acid functionalized oxidized sodium alginate (OSA-PBA) and carboxymethyl chitosan (CMC)...
March 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38529803/releasing-free-radicals-in-precursor-triggers-the-formation-of-closed-pores-in-hard-carbon-for-sodium-ion-batteries
#9
JOURNAL ARTICLE
Yilin Wang, Zonglin Yi, Lijing Xie, Yixuan Mao, Wenjun Ji, Zhanjun Liu, Xianxian Wei, Fangyuan Su, Cheng-Meng Chen
Increasing closed pore volume in hard carbon is considered to be the most effective way to enhance the electrochemical performance in sodium-ion batteries. However, there lack of systematic insights into the formation mechanisms of closed pores at molecular level. In this study, a regulation strategy of closed pores via adjustment of the content of free radicals is reported. Sufficient free radicals are exposed by part delignification of bamboo, which is related to the formation of well-developed carbon layers and rich closed pores...
March 26, 2024: Advanced Materials
https://read.qxmd.com/read/38529713/mechanistic-insights-into-sodium-ion-mediated-ligand-binding-affinity-and-modulation-of-5-ht2b-gpcr-activity-implications-for-drug-discovery-and-development
#10
JOURNAL ARTICLE
Arushi Chauhan, Jitender Singh, Namrata Sangwan, Pramod K Avti
PURPOSE: The G-protein coupled receptor (GPCR) family, implicated in neurological disorders and drug targets, includes the sensitive serotonin receptor subtype, 5-HT2B. The influence of sodium ions on ligand binding at the receptor's allosteric region is being increasingly studied for its impact on receptor structure. METHODS: High-throughput virtual screening of three libraries, specifically the Asinex-GPCR library, which contains 8,532 compounds and FDA-approved (2466 compounds) and investigational compounds (2731)) against the modeled receptor [4IB4-5HT2B RM ] using the standard agonist/antagonist (Ergotamine/Methysergide), as previously selected from our studies based on ADMET profiling, and further on basis of binding free energy a single compound - dihydroergotamine is chosen...
March 26, 2024: Journal of Receptor and Signal Transduction Research
https://read.qxmd.com/read/38529272/mannose-enhances-intestinal-immune-barrier-function-and-dextran-sulfate-sodium-salt-induced-colitis-in-mice-by-regulating-intestinal-microbiota
#11
JOURNAL ARTICLE
Yi Yang, Qiming Ma, Qingyu Wang, Lifeng Zhao, Hengshan Liu, Yanjun Chen
BACKGROUND: Inflammatory bowel disease (IBD) greatly affects human quality of life. Mannose has been reported to be used to treat IBD, but the mechanism is currently unknown. METHODS: C57/BL mice were used as research subjects, and the mouse acute colitis model was induced using dextran sulfate sodium salt (DSS). After oral administration of mannose, the body weights and disease activity index (DAI) scores of the mice were observed. The colon lengths, histopathological sections, fecal content microbial sequencing, colon epithelial inflammatory genes, and tight junction protein Occludin-1 expression levels were measured...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38529186/chinese-bayberry-myrica-rubra-sieb-et-zucc-leaves-proanthocyanidins-inhibit-intestinal-glucose-transport-in-human-caco-2-cells
#12
JOURNAL ARTICLE
Mengting Wang, Haiguang Mao, Zhijian Ke, Jianchu Chen, Lili Qi, Jinbo Wang
Background: The hypoglycemic effects of Chinese bayberry leaves proanthocyanidins (BLPs) have been demonstrated. It is unclear, nevertheless, whether BLPs reduced postprandial blood glucose levels by regulating glucose uptake and glucose transport. Method: This study investigated the effect of BLPs (25, 50, and 100 μg/mL) on glucose uptake and glucose transport in human intestinal epithelial cells (Caco-2 cells). The uptake of 2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl) amino]-D-glucose (2-NBDG) and disaccharidases activity in Caco-2 cells were measured...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38529063/transcriptome-and-co-expression-network-revealed-molecular-mechanism-underlying-selenium-response-of-foxtail-millet-setaria-italica
#13
JOURNAL ARTICLE
Yinyuan Wen, Liuna Cheng, Zeya Zhao, Mengyao An, Shixue Zhou, Juan Zhao, Shuqi Dong, Xiangyang Yuan, Meiqiang Yin
INTRODUCTION: Selenium-enriched foxtail millet ( Setaria italica ) represents a functional cereal with significant health benefits for humans. This study endeavors to examine the impact of foliar application of sodium selenite (Na2 SeO4 ) on foxtail millet, specifically focusing on selenium (Se) accumulation and transportation within various plant tissues. METHODS: To unravel the molecular mechanisms governing selenium accumulation and transportation in foxtail millet, we conducted a comprehensive analysis of selenium content and transcriptome responses in foxtail millet spikelets across different days (3, 5, 7, and 12) under Na2 SeO4 treatment (200 μmol/L)...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38528736/nonextractable-polyphenols-from-fu-brick-tea-alleviates-ulcerative-colitis-by-controlling-colon-microbiota-targeted-release-to-inhibit-intestinal-inflammation-in-mice
#14
JOURNAL ARTICLE
Chengcheng Yang, Wuqi Yang, Yu Wang, Yao Du, Tong Zhao, Hongjun Shao, Daoyuan Ren, Xingbin Yang
This study was designed to elucidate the colon microbiota-targeted release of nonextractable bound polyphenols (NEPs) derived from Fu brick tea and to further identify the possible anti-inflammatory mechanism in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) mice. 1.5% DSS drinking water-induced C57BL/6J mice were fed rodent chow supplemented with or without 8% NEPs or dietary fibers (DFs) for 37 days. The bound p -hydroxybenzoic acid and quercetin in NEPs were liberated up to 590.5 ± 70...
March 25, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38528561/transcriptome-and-open-chromatin-analysis-reveals-the-process-of-myocardial-cell-development-and-key-pathogenic-target-proteins-in-long-qt-syndrome-type-7
#15
JOURNAL ARTICLE
Peipei Chen, Junyu Long, Tianrui Hua, Zhifa Zheng, Ying Xiao, Lianfeng Chen, Kang Yu, Wei Wu, Shuyang Zhang
OBJECTIVE: Long QT syndrome type 7 (Andersen-Tawil syndrome, ATS), which is caused by KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal malformations. The development, differentiation and electrophysiological maturation of cardiomyocytes (CMs) changes promote the pathophysiology of Long QT syndrome type 7(LQT7). We aimed to specifically reproduce the ATS disease phenotype and study the pathogenic mechanism. METHODS AND RESULTS: We established a cardiac cell model derived from human induced pluripotent stem cells (hiPSCs) to the phenotypes and electrophysiological function, and the establishment of a human myocardial cell model that specifically reproduces the symptoms of ATS provides a reliable platform for exploring the mechanism of this disease or potential drugs...
March 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38528541/protective-effect-of-synbiotic-combination-of-lactobacillus-plantarum-sc-5-and-olive-oil-extract-tyrosol-in-a-murine-model-of-ulcerative-colitis
#16
JOURNAL ARTICLE
Fazheng Yu, Xueyu Hu, HongLin Ren, Xiaoxu Wang, Ruoran Shi, Jian Guo, Jiang Chang, Xiaoshi Zhou, Yuanyuan Jin, Yansong Li, Zengshan Liu, Pan Hu
BACKGROUND: Ulcerative colitisis (UC) classified as a form of inflammatory bowel diseases (IBD) characterized by chronic, nonspecific, and recurrent symptoms with a poor prognosis. Common clinical manifestations of UC include diarrhea, fecal bleeding, and abdominal pain. Even though anti-inflammatory drugs can help alleviate symptoms of IBD, their long-term use is limited due to potential side effects. Therefore, alternative approaches for the treatment and prevention of inflammation in UC are crucial...
March 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38527888/iodine-enrichment-in-the-groundwater-in-south-china-and-its-hydrogeochemical-control
#17
JOURNAL ARTICLE
Fengping Zhou, Qianting Xu, Yuyun Chen, Weihua Zhang, Rongliang Qiu
In North China, iodine-rich groundwater has been extensively studied, but few in South China. This study aimed to investigate the characteristics of iodine-rich groundwater in South China and identify potential contamination sources. The results revealed that the average concentration of iodine in groundwater was 890 µg/L, with a maximum concentration of 6350 µg/L, exceeding the permitted levels recommended by the World Health Organization (5-300 µg/L). Notably, the enrichment of iodide occurred in acidic conditions (pH = 6...
August 2024: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/38527677/colon-targeted-hydroxyethyl-starch-curcumin-microspheres-with-high-loading-capacity-ameliorate-ulcerative-colitis-via-alleviating-oxidative-stress-regulating-inflammation-and-modulating-gut-microbiota
#18
JOURNAL ARTICLE
Da Huang, Yongming Wang, Chenlan Xu, Minglang Zou, Yangcan Ming, Fang Luo, Zhenjin Xu, Ying Miao, Na Wang, Zhenyu Lin, Zuquan Weng
Curcumin (CUR) is a natural polyphenol that holds promise for treating ulcerative colitis (UC), yet oral administration of CUR exhibits limited bioavailability and existing formulations for oral delivery of CUR often suffer from unsatisfactory loading capacity. This study presents hydroxyethyl starch-curcumin microspheres (HC-MSs) with excellent CUR loading capacity (54.52 %), and the HC-MSs can further encapsulate anti-inflammatory drugs dexamethasone (DEX) to obtain a combination formulation (DHC-MSs) with high DEX loading capacity (19...
March 23, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38526674/morphology-development-and-pigment-production-of-talaromyces-marneffei-are-diversely-modulated-under-physiologically-relevant-growth-conditions
#19
JOURNAL ARTICLE
Yuan Nong, Fang Wang, Feifei Shuai, Shi Chen
Talaromyces marneffei is an opportunistic pathogenic fungus that mainly affects HIV-positive individuals endemic to Southeast Asia and China. Increasing efforts have been made in the pathogenic mechanism and host interactions understanding of this pathogen in the last two decades; however, there are still no conclusions on how T. marneffei was transmitted from the donor bamboo rats to humans. A perception that the failure of fungus isolation from soil was attributed to the low salt tolerance of T. marneffei...
March 25, 2024: Current Microbiology
https://read.qxmd.com/read/38525223/development-of-a-method-for-the-determination-of-sedatives-in-bovine-and-porcine-urine-and-kidneys-by-liquid-chromatography-tandem-mass-spectrometry
#20
JOURNAL ARTICLE
Tomasz Śniegocki, Elżbieta Samorek, Bartosz Sell, Weronika Krajewska
INTRODUCTION: Sedatives have been used for a long time as animal tranquillisers to prevent stress and weight loss during their transportation. The proper determination of these substances in food of animal origin is essential for consumer safety. MATERIAL AND METHODS: A 1 g portion of pig or cow urine or homogenised kidney was mixed with acetonitrile, sodium chloride was added, and the solution was further mixed and then centrifuged. The supernatant was transferred to a new centrifuge tube with primary and secondary amine, octadecylsilane and ZrO2 , and mixed rapidly...
March 2024: Journal of Veterinary Research
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