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gestational thyroid disease

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https://www.readbyqxmd.com/read/29755326/transient-hypothyroidism-during-lactation-arrests-myelination-in-the-anterior-commissure-of-rats-a-magnetic-resonance-image-and-electron-microscope-study
#1
Federico S Lucia, Jesús Pacheco-Torres, Susana González-Granero, Santiago Canals, María-Jesús Obregón, José M García-Verdugo, Pere Berbel
Thyroid hormone deficiency at early postnatal ages affects the cytoarchitecture and function of neocortical and telencephalic limbic areas, leading to impaired associative memory and in a wide spectrum of neurological and mental diseases. Neocortical areas project interhemispheric axons mostly through the corpus callosum and to a lesser extent through the anterior commissure (AC), while limbic areas mostly project through the AC and hippocampal commissures. Functional magnetic resonance data from children with late diagnosed congenital hypothyroidism and abnormal verbal memory processing, suggest altered ipsilateral and contralateral telencephalic connections...
2018: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29707880/risk-factors-for-adverse-maternal-and-perinatal-outcomes-in-women-with-preeclampsia-analysis-of-1396-cases
#2
Xun Li, Weishe Zhang, Jianhua Lin, Huai Liu, Zujing Yang, Yincheng Teng, Si Duan, Xinxiu Lin, Yingming Xie, Yuanqiu Li, Liangqun Xie, Qiaozhen Peng, Lu Xia
Preeclampsia is a major cause of adverse maternal and perinatal outcomes, but how to identify women and fetuses at increased risk for later adverse events is a challenge. This study aimed to investigate the risk factors for adverse maternal and perinatal outcomes in women with preeclampsia. Data from 1396 women with preeclampsia were retrospectively collected and analyzed. Eighteen candidate risk factors and 12 adverse outcomes were investigated. The following factors were found to be significantly associated with at least one adverse outcome: maternal age 35 years or older, multiple birth, the usage of assisted reproductive technology, living in a rural area, history of pregnancy-induced hypertension, male fetus, multigravida, or having polycystic ovary syndrome, hemolysis, elevated liver enzymes, and low platelet count syndrome, intrahepatic cholestasis of pregnancy, cardiovascular disease, gestational diabetes mellitus, systemic lupus erythematosus, thyroid disease, or liver disease...
April 30, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29706030/preconception-management-of-thyroid-dysfunction
#3
Onyebuchi E Okosieme, Ishrat Khan, Peter N Taylor
Uncorrected thyroid dysfunction in pregnancy has well recognised deleterious effects on fetal and maternal health. The early gestation period is one of critical fetal vulnerability during which maternal thyroid dysfunction may have lasting repercussions. Accordingly, a pragmatic preconception strategy is key for ensuring optimal thyroid disease outcomes in pregnancy. Preconception planning in women with hypothyroidism should pre-empt and mirror the adaptive changes of the thyroid gland by careful levothyroxine dose adjustments to ensure adequate fetal thyroid hormone delivery in pregnancy...
April 29, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29699957/iodine-deficiency-in-pregnant-women-at-first-trimester-in-ankara
#4
Kazibe Koyuncu, Batuhan Turgay, Feride Söylemez
OBJECTIVE: Iodine deficiency in pregnant woman in Ankara was shown in previous studies. We aimed to conduct a study in a tertiary center to investigate for the need for iodine replacement in our population. MATERIAL AND METHODS: This was a single tertiary center, non-interventional, retrospective, cross-sectional study. Data were retrieved retrospectively from 440 women who had been in first trimester in gestational age. Maternal iodine status, TSH levels, T4 levels were examined...
April 27, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29644934/management-of-subclinical-hypothyroidism-in-pregnancy-a-comment-from-the-italian-society-of-endocrinology-sie-and-the-italian-thyroid-association-ait-to-the-2017-ata-guidelines-the-italian-way
#5
Mario Rotondi, Luca Chiovato, Furio Pacini, Luigi Bartalena, Paolo Vitti
The 2017 ATA Guidelines for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum were published six years after the previous ones. They provide comprehensive clinical recommendations for the whole spectrum of thyroid diseases as well as for optimal iodine intake during pregnancy, post-partum and lactation. The present position statement mainly regards the recommended flow-chart for therapeutic decision making in pregnant women being diagnosed with subclinical hypothyroidism. The major biochemical and clinical situations and the corresponding therapeutic indications will be commented...
April 12, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29607233/preterm-parturient-with-polyhydramnios-and-pancreatitis-primary-presentation-of-hyperparathyroidism
#6
Esther S Han, Katherine Fritton, Phoebe Bacon, Martin K Slodzinski, Cynthia Argani
Objective: To report a case of severe hypercalcemia secondary to primary hyperparathyroidism in a late-preterm pregnant patient and review medical and surgical treatments as well as obstetric and neonatal outcomes. Background: Diagnosis of parathyroid disease during pregnancy can be difficult due to nonspecific presentation. Management decisions are complex and require multidisciplinary collaboration. Case: A 29-year-old G2P1001 woman at 35 weeks and 3 days' gestation presented with preterm contractions, polyhydramnios, pancreatitis, and severe hypercalcemia...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29422016/malignancy-during-pregnancy-in-japan-an-exceptional-opportunity-for-early-diagnosis
#7
Masayuki Sekine, Yoshiyuki Kobayashi, Tsutomu Tabata, Tamotsu Sudo, Ryuichiro Nishimura, Koji Matsuo, Brendan H Grubbs, Takayuki Enomoto, Tomoaki Ikeda
BACKGROUND: Malignancy during pregnancy has become a significant cause of maternal death in developed countries, likely due to both an older pregnant population, and increases of cervical cancer in younger women. Our aim is to investigate the clinical aspects of malignancy during pregnancy in Japan and to use this information to identify opportunities for earlier detection and treatment. METHODS: We provided a questionnaire to 1508 secondary or tertiary care hospitals in Japan...
February 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29409959/ahr-and-cyp1a2-genotypes-both-affect-susceptibility-to-motor-deficits-following-gestational-and-lactational-exposure-to-polychlorinated-biphenyls
#8
Breann T Colter, Helen Frances Garber, Sheila M Fleming, Jocelyn Phillips Fowler, Gregory D Harding, Molly Kromme Hooven, Amy Ashworth Howes, Smitha Krishnan Infante, Anna L Lang, Melinda Curran MacDougall, Melinda Stegman, Kelsey Rae Taylor, Christine Perdan Curran
Polychlorinated biphenyls (PCBs) are persistent organic pollutants known to cause adverse health effects and linked to neurological deficits in both human and animal studies. Children born to exposed mothers are at highest risk of learning and memory and motor deficits. We developed a mouse model that mimics human variation in the aryl hydrocarbon receptor and cytochrome P450 1A2 (CYP1A2) to determine if genetic variation increases susceptibility to developmental PCB exposure. In our previous studies, we found that high-affinity Ahrb Cyp1a2(-/-) and poor-affinity Ahrd Cyp1a2(-/-) knockout mice were most susceptible to learning and memory deficits following developmental PCB exposure compared with Ahrb Cyp1a2(+/+) wild type mice (C57BL/6J strain)...
March 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29396862/maternal-thyroid-stimulating-hormone-reference-ranges-for-first-trimester-screening-from-11-to-14-weeks-of-gestation
#9
Tomáš Šálek, Ishraq Dhaifalah, Dagmar Langova, Jana Havalová
BACKGROUND: To establish maternal thyroid-stimulating hormone (TSH) reference ranges for first trimester screening from 11 + 0 to 13 + 6 weeks of gestation. METHODS: A total of 10 592 singleton and 201 twin consecutive Caucasian pregnant women who underwent simultaneously prenatal first trimester Down's syndrome screening and thyroid function screening from January 2010 to November 2017 were included in the study. Women with positive antithyroid peroxidase antibody (TPOAb) and positive personal history of thyroid disease were previously excluded...
February 3, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29395867/oncological-management-and-obstetric-and-neonatal-outcomes-for-women-diagnosed-with-cancer-during-pregnancy-a-20-year-international-cohort-study-of-1170-patients
#10
Jorine de Haan, Magali Verheecke, Kristel Van Calsteren, Ben Van Calster, Roman G Shmakov, Mina Mhallem Gziri, Michael J Halaska, Robert Fruscio, Christianne A R Lok, Ingrid A Boere, Paolo Zola, Petronella B Ottevanger, Christianne J M de Groot, Fedro A Peccatori, Karina Dahl Steffensen, Elyce H Cardonick, Evgeniya Polushkina, Lukas Rob, Lorenzo Ceppi, Gennady T Sukhikh, Sileny N Han, Frédéric Amant
BACKGROUND: Awareness is growing that cancer can be treated during pregnancy, but the effect of this change on maternal and neonatal outcomes is unknown. The International Network on Cancer, Infertility and Pregnancy (INCIP) registers the incidence and maternal, obstetric, oncological, and neonatal outcomes of cancer occurring during pregnancy. We aimed to describe the oncological management and obstetric and neonatal outcomes of patients registered in INCIP and treated in the past 20 years, and assess associations between cancer type or treatment modality and obstetric and neonatal outcomes...
March 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29378479/preimplantation-genetic-diagnosis-of-multiple-endocrine-neoplasia-type-2a-using-informative-markers-identified-by-targeted-sequencing
#11
Songchang Chen, Shuyuan Li, Junyu Zhang, Lanlan Zhang, Yiyao Chen, Li Wang, Li Jin, Yuting Hu, Xiaoping Qi, Hefeng Huang, Chenming Xu
BACKGROUND: The revised guidelines for the management of medullary thyroid carcinoma recommend that genetic counseling regarding reproductive options, including preimplantation genetic diagnosis (PGD), be considered for all RET mutation carriers of reproductive age to avoid the transmission of multiple endocrine neoplasia type 2 (MEN2). However, the high complexity and cost of PGD have hindered its widespread use. Thus, it is necessary to establish a simple and relatively inexpensive method to facilitate the PGD of MEN2...
March 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29284889/anaesthetic-implications-of-severe-hyperthyroidism-secondary-to-molar-pregnancy-a-case-report-and-review-of-literature
#12
Srinivasan Swaminathan, Roshin Ann James, Rashmi Chandran, Reesha Joshi
Pregnant women with gestational trophoblastic disease have an increased likelihood to develop hyperthyroidism secondary to increased secretion of human chorionic gonadotropin. Most of these cases of hyperthyroidism remain undiagnosed and may present as a thyrotoxic crisis during the perioperative period. Pregnant patients with gestational trophoblastic disease should be always evaluated for hyperthyroidism, and in cases of severe hyperthyroidism, antithyroid treatment should be initiated before evacuation of the mole...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29166819/pregnancy-outcomes-among-women-with-asthma
#13
Haitham Baghlaf, Andrea R Spence, Nicholas Czuzoj-Shulman, Haim Arie Abenhaim
PURPOSE: The purpose of this study is to examine the association between maternal asthma and pregnancy, delivery and neonatal outcomes. MATERIALS AND METHODS: We carried out a retrospective cohort study using the Health Care Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) database from 2003 to 2011. Among women who delivered during this time period, we compared pregnancy, delivery, and neonatal outcomes in asthmatics versus non-asthmatics. Multivariate logistic regression was used to estimate adjusted odds ratios and 95% confidence intervals...
November 22, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29120650/-thyroid-screening-in-pregnancy-guideline-in-practice
#14
Patrícia Páleníková, Iveta Kalafutová, Zdenka Horníková, Juraj Payer
Thyroid diseases may adversely affect the conception, maintain pregnancy. They increase the risk of complications in pregnancy and may have a negative effect on the fetus. Therefore it is necessary to capture thyroid diseases in the population of pregnant women, in the early stage of pregnancy. In Slovakia, since 2009, the Expert Guideline of the Ministry of Health of the Slovak Republic for the diagnosis and treatment of autoimmune thyroid diseases in women during pregnancy has been in force. In our patient cohort, we monitored 666 pregnant patients, the timeliness of screening, thyroid parameters, the number of pregnancies and their complications, the need for levothyroxine treatment...
December 0: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29072060/risk-factors-for-hydatidiform-mole-is-husband%C3%A2-s-job-a-major-risk-factor
#15
Hourieh Shamshiri Milani, Morteza Abdollahi, Sara Torbati, Taha Asbaghi, Eznollah Azargashb
Background: The hydatidiform mole (HM) is a precancerous placenta considered as a gestational trophoblastic disease (GTD). It may convert to more invasive forms of gestational trophoblastic neoplasia (GTN), endangering women’s health by more severe complications. Most GTN cases originate from HM, which is associated with uterine bleeding, preeclampsia and thyroid problems. Its etiology has not been adequately explored, but some risk factors have been reported. The aim of the present study was to assess any relationships between molar pregnancy and factors including mothers’ and husbands’ occupations...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29067240/benign-thyroid-disease-in-pregnancy-a-state-of-the-art-review
#16
REVIEW
Efterpi Tingi, Akheel A Syed, Alexis Kyriacou, George Mastorakos, Angelos Kyriacou
Thyroid dysfunction is the commonest endocrine disorder in pregnancy apart from diabetes. Thyroid hormones are essential for fetal brain development in the embryonic phase. Maternal thyroid dysfunction during pregnancy may have significant adverse maternal and fetal outcomes such as preterm delivery, preeclampsia, miscarriage and low birth weight. In this review we discuss the effect of thyroid disease on pregnancy and the current evidence on the management of different thyroid conditions in pregnancy and postpartum to improve fetal and neonatal outcomes, with special reference to existing guidelines on the topic which we dissect, critique and compare with each other...
December 2016: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29026609/ketosis-prone-diabetes-and-sle-co-presenting-in-an-african-lady-with-previous-gestational-diabetes
#17
S Hussain, S Keat, S V Gelding
We describe the case of an African woman who was diagnosed with ketosis-prone diabetes with diabetes-associated autoantibodies, after being admitted for diabetic ketoacidosis (DKA) precipitated by her first presentation of systemic lupus erythematosus (SLE). She had a seven-year history of recurrent gestational diabetes (GDM) not requiring insulin therapy, with return to normoglycaemia after each pregnancy. This might have suggested that she had now developed type 2 diabetes (T2D). However, the diagnosis of SLE prompted testing for an autoimmune aetiology for the diabetes, and she was found to have a very high titre of GAD antibodies...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28989870/prepregnancy-hypothyroidism-versus-gestational-hypothyroidism-a-comparative-study
#18
Prashant Ulhas Kaduskar, Mala Dharmalingam, Pramila Kalra
INTRODUCTION: Hypothyroidism managed inadequately in pregnancy may have grave outcomes for both mother and baby. Understanding pregnancy outcomes in our country with low awareness about thyroid diseases is important. OBJECTIVES: The objectives of the study were to evaluate demographic features and biochemical parameters in patients with prepregnancy hypothyroidism versus patients diagnosed to have primary hypothyroidism during pregnancy and to assess pregnancy outcomes...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28982017/incidence-of-subclinical-hypothyroidism-and-hypothyroidism-in-early-pregnancy
#19
Frida Hosseini Akram, Bengt Johansson, Gunnar Möllerström, Britt-Marie Landgren, Anneli Stavreus-Evers, Lottie Skjöldebrand-Sparre
BACKGROUND: Untreated and subclinical hypothyroidism (SCH) has been associated with adverse pregnancy complications such as increased risk of miscarriage, hypertension, preeclampsia, and preterm delivery. However, in Sweden, screening for thyroid dysfunction during pregnancy is only recommended for women with a high risk of thyroid disease. Therefore, the aim of this study was to determine the incidence of clinical and SCH in women in the first trimester of pregnancy. MATERIALS AND METHODS: In this prospective study, 1298 pregnant women were divided into three groups: one unselected general screening group (n = 611), one low-risk group comprising women without risk factors for thyroid disorder (n = 511), and one high-risk group comprising women with an inheritance or suspicion of thyroid disease or undergoing treatment for thyroid disease (n = 88)...
November 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28965575/severe-selenium-deficits-in-pregnant-women-irrespective-of-autoimmune-thyroid-disease-in-an-area-with-marginal-selenium-intake
#20
Urszula Ambroziak, Sandra Hybsier, Urszula Shahnazaryan, Małgorzata Krasnodębska-Kiljańska, Eddy Rijntjes, Zbigniew Bartoszewicz, Tomasz Bednarczuk, Lutz Schomburg
OBJECTIVES: Selenium (Se) deficiency is related to an increased risk of preterm labor, miscarriage, preeclampsia, gestational diabetes, and other obstetric complications. As the Se status declines during pregnancy, we hypothesized that the decline may be exacerbated in women with autoimmune thyroid disease (AITD). MATERIAL AND METHODS: Pregnant women (n=74; 30 [23-38] years) were consecutively recruited from the district of Warsaw, Poland, and divided into healthy subjects (HS, n=45), and women with a diagnosis of AITD (AITD, n=29)...
December 2017: Journal of Trace Elements in Medicine and Biology
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