keyword
MENU ▼
Read by QxMD icon Read
search

Sodium homeostasis

keyword
https://www.readbyqxmd.com/read/29154907/an-integrated-mathematical-epithelial-cell-model-for-airway-surface-liquid-regulation-by-mechanical-forces
#1
Dan Wu, Richard C Boucher, Brian Button, Timothy Elston, Ching-Long Lin
A robust method based on reverse engineering was utilized to construct the ion-channel conductance functions for airway epithelial sodium channels (ENaC), the cystic fibrosis transmembrane conductance regulator (CFTR), and calcium-activated chloride channels (CaCC). The ion-channel conductance models for both normal (NL) and cystic fibrosis (CF) airway epithelia were developed and then coupled to an adenosine triphosphate (ATP) metabolism model and a fluid transport model (collectively called the integrated cell model) to investigate airway surface liquid (ASL) volume regulation and hence mucus concentration, by mechanical forces in NL and CF human airways...
November 15, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29150514/sinorhizobium-meliloti-glutathione-reductase-is-required-for-both-redox-homeostasis-and-symbiosis
#2
Guirong Tang, Ningning Li, Yumin Liu, Liangliang Yu, Junhui Yan, Li Luo
Glutathione (L-γ-glutamyl-L-cysteinylglycine; GSH), one of the key antioxidants in Sinorhizobium meliloti, is required for the development of alfalfa (Medicago sativa) nitrogen-fixing nodules. Glutathione exists either in a reduced form (GSH) or an oxidized form (GSSG), and its content is regulated by two pathways in S. meliloti The first pathway is the de novo synthesis of glutathione from its constituent amino acids, namely, Glu, Cys, and Gly, catalyzed by γ-glutamyl cysteine synthetase (GshA) and glutathione synthetase (GshB)...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29144825/salt-hypertension-and-immunity
#3
A Justin Rucker, Nathan P Rudemiller, Steven D Crowley
The link between inappropriate salt retention in the kidney and hypertension is well recognized. However, growing evidence suggests that the immune system can play surprising roles in sodium homeostasis, such that the study of inflammatory cells and their secreted effectors has provided important insights into salt sensitivity. As part of the innate immune system, myeloid cells have diverse roles in blood pressure regulation, ranging from prohypertensive actions in the kidney, vasculature, and brain, to effects in the skin that attenuate blood pressure elevation...
November 16, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/29134970/circadian-potassium-excretion-is-unaffected-following-furosemide-induced-increase-in-sodium-delivery-to-the-distal-nephron
#4
B P Ilenwabor, E O Asowata, L F Obika
The mineralocorticoid aldosterone is widely accepted as a key regulator of K+ balance as well as urinary K+excretion. However, recent evidence suggests that the circadian control of K+ excretion is independent of aldosterone. Thedelivery of Na+ to the distal nephron is known to be an important determinant of aldosterone mediated secretion of K+ in thissegment of the nephron. Examining the link between distal Na+ delivery and K+ excretion; and how this link affect circadianK+ excretion will advance what is currently known about the maintenance of K+ homeostasis...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29130489/angiotensin-1-7-modulates-electrophysiological-characteristics-and-calcium-homeostasis-in-pulmonary-veins-cardiomyocytes-via-mas-pi3k-enos-signaling-pathway
#5
Yen-Yu Lu, Wen-Shiann Wu, Yung-Kuo Lin, Chen-Chuan Cheng, Yao-Chang Chen, Shih-Ann Chen, Yi-Jen Chen
BACKGROUND: Atrial fibrillation (AF) is the most common sustained arrhythmia, and pulmonary veins (PVs) play a critical role in triggering AF. Angiotensin (Ang)-(1-7) regulates calcium (Ca(2+) ) homeostasis and also plays a critical role in cardiovascular pathophysiology. However, the role of Ang-(1-7) in PV arrhythmogenesis remains unclear. MATERIALS AND METHODS: Conventional microelectrodes, whole-cell patch-clamp, and the Fluo-3 fluorimetric ratio technique were used to record ionic currents and intracellular Ca(2+) in isolated rabbit PV preparations, and in single isolated PV cardiomyocytes, before and after administration of Ang-(1-7)...
November 12, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29129281/the-essential-roles-of-metal-ions-in-insect-homeostasis-and-physiology
#6
REVIEW
Julian At Dow
Metal ions play distinct roles in living organisms, including insects. Some, like sodium and potassium, are central players in osmoregulation and 'blood and guts' transport physiology, and have been implicated in cold adaptation. Calcium is a key player as a second messenger, and as a structural element. Other metals, particularly those with multiple redox states, can be cofactors in many metalloenzymes, but can contribute to toxic oxidative stress on the organism in excess. This short review selects some examples where classical knowledge has been supplemented with recent advances, in order to emphasize the importance of metals as essential nutrients for insect survival...
October 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/29128492/expression-of-potassium-dependent-sodium-calcium-exchanger-in-the-murine-lens
#7
Alicia De Maria, Haiqing Zhao, Steven Bassnett
Loss of intracellular calcium homeostasis may contribute to the opacification of lens tissue during cortical cataract formation. In healthy lenses, the concentration of intracellular calcium is maintained at levels far below electrochemical equilibrium but the identity of the calcium extrusion mechanism in lens fiber cells has remained elusive. Previous studies focused on the role of plasma membrane calcium ATPases and sodium-calcium exchangers. Here, we examined the expression of mRNA transcripts encoding potassium-dependent sodium-calcium exchangers (Nckx's, encoded by the Slc24 gene family) in the mouse lens...
November 9, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29101357/microrna-27a-regulates-hepatic-lipid-metabolism-and-alleviates-nafld-via-repressing-fas-and-scd1
#8
Meiyuan Zhang, Weilan Sun, Minghao Zhou, Yan Tang
MicroRNAs are implicated as crucial mediators in metabolic diseases including obesity, diabetes, and non-alcoholic fatty liver diseases (NAFLD). Here, we show miR-27a attenuated hepatic de novo lipogenesis and alleviated obesity-initiated NAFLD through inhibiting Fasn and Scd1 in liver. Hepatic levels of miR-27a were significantly augmented in HFD-fed and ob/ob mice. Further studies demonstrated that miR-27a directly interacted with 3' untranslated region (3'-UTR) of hepatic Fasn and Scd1 mRNAs and reduced their expression levels in mice...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29095946/endoplasmic-reticulum-stress-inhibits-expression-of-genes-involved-in-thyroid-hormone-synthesis-and-their-key-transcriptional-regulators-in-frtl-5-thyrocytes
#9
Gaiping Wen, Robert Ringseis, Klaus Eder
Endoplasmic reticulum (ER) stress is characterized by the accumulation of misfolded proteins due to an impairment of ER quality control pathways leading to the activation of a defense system, called unfolded protein response (UPR). While thyrocytes are supposed to be highly susceptible to environmental conditions that cause ER stress due to the synthesis of large amounts of secretory proteins required for thyroid hormone synthesis, systematic investigations on the effect of ER stress on expression of key genes of thyroid hormone synthesis and their transcriptional regulators are lacking...
2017: PloS One
https://www.readbyqxmd.com/read/29092848/intrarenal-activation-of-endothelin-type-b-receptors-improves-kidney-oxygenation-in-type-1-diabetic-rats
#10
Stephanie Franzén, Liselotte Pihl, Angelica Fasching, Fredrik Palm
About one third of patients with type 1 diabetes develops kidney disease. The mechanism is largely unknown, but intrarenal hypoxia has been proposed as a unifying mechanism for chronic kidney disease including diabetic nephropathy. The endothelin system has recently been demonstrated to regulate oxygen availability in the diabetic kidney via a pathway involving endothelin type A receptors (ETA-R). These receptors mainly mediate vasoconstriction and tubular sodium retention, and inhibition of ETA-R improves intrarenal oxygenation in the diabetic kidney...
November 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29092635/hydrogen-sulfide-ameliorates-zinc-induced-cell-death-in-neuroblastoma-sh-sy5y-cells
#11
Megumi Shimoji, Hirokazu Hara, Tetsuro Kamiya, Kensuke Okuda, Tetsuo Adachi
Previous reports have demonstrated that excess zinc (Zn(2+)) released from nerve terminals following cerebral ischemia causes brain injury. Therefore, disturbance of Zn(2+) homeostasis in the brain is thought to be closely linked to neurotoxicity. Recently, hydrogen sulfide (H2S), a gaseous mediator, has been reported to ameliorate ischemic brain injury. However, its mechanism is not fully understood. In this study, we examined whether sodium hydrogen sulfide (NaHS), an H2S donor, protects against Zn(2+) cytotoxicity using human neuroblastoma SH-SY5Y cells...
November 1, 2017: Free Radical Research
https://www.readbyqxmd.com/read/29081083/ionotropic-receptor-76b-is-required-for-gustatory-aversion-to-excessive-na-in-drosophila
#12
Min Jung Lee, Ha Yeon Sung, HyunJi Jo, Hyung-Wook Kim, Min Sung Choi, Jae Young Kwon, KyeongJin Kang
Avoiding ingestion of excessively salty food is essential for cation homeostasis that underlies various physiological processes in organisms. The molecular and cellular basis of the aversive salt taste, however, remains elusive. Through a behavioral reverse genetic screening, we discover that feeding suppression by Na(+)-rich food requires Ionotropic Receptor 76b (Ir76b) in Drosophila labellar gustatory receptor neurons (GRNs). Concentrated sodium solutions with various anions caused feeding suppression dependent on Ir76b...
October 2017: Molecules and Cells
https://www.readbyqxmd.com/read/29079724/ca-2-protein-alpha-1d-of-cav1-3-regulates-intracellular-calcium-concentration-and-migration-of-colon-cancer-cells-through-a-non-canonical-activity
#13
Yann Fourbon, Maxime Guéguinou, Romain Félix, Bruno Constantin, Arnaud Uguen, Gaëlle Fromont, Laurie Lajoie, Christophe Magaud, Thierry Lecomte, Emmanuel Chamorey, Aurélien Chatelier, Olivier Mignen, Marie Potier-Cartereau, Aurélie Chantôme, Patrick Bois, Christophe Vandier
It is generally accepted that voltage-gated Ca(2+) channels, CaV, regulate Ca(2+) homeostasis in excitable cells following plasma membrane depolarization. Here, we show that the Ca(2+) protein α1D of CaV1.3 channel is overexpressed in colorectal cancer biopsies compared to normal tissues. Gene silencing experiments targeting α1D reduced the migration and the basal cytosolic Ca(2+) concentration of HCT116 colon cancer cell line and modified the cytosolic Ca(2+) oscillations induced by the sodium/calcium exchanger NCX1/3 working in its reverse mode...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29076168/pleiotropic-effects-of-enhancing-vacuolar-k-h-exchange-in-tomato
#14
Anna De Luca, José M Pardo, Eduardo O Leidi
Cation antiporters of the NHX family are widely regarded as determinants of salt tolerance due to their capacity to drive sodium (Na) and sequester it into vacuoles. Recent work shows however that NHX transporters are primarily involved in vacuolar potassium (K) storage. Over-expression of the K/H antiporter AtNHX1 in tomato increases K accumulation into vacuoles and plant sensitivity to K deprivation. Here we show that the appearance of early leaf symptoms of K deficiency was associated with higher concentration of polyamines...
October 27, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/29068000/%C3%AE-glucans-in-food-modify-colonic-microflora-by-inducing-antimicrobial-protein-calprotectin-in-a-dectin-1-induced-il-17f-dependent-manner
#15
T Kamiya, C Tang, M Kadoki, K Oshima, M Hattori, S Saijo, Y Adachi, N Ohno, Y Iwakura
Dectin-1 (gene symbol: Clec7a) is a receptor for β-glucans that play an important role for the host defense against fungi. Recently, we showed that Clec7a(-/-) mice are resistant against dextran sodium sulfate (DSS)-induced colitis because of regulatory T-cell population expansion in the colon. The regulatory T-cell expansion is caused by expansion of commensal Lactobacillus murinus whose growth is suppressed by an antimicrobial protein, calprotectin S100A8/A9. In this report, we showed that S100A8 was mainly produced by mouse colonic epithelial cells...
October 25, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/29066772/transcription-factor-tfeb-cell-autonomously-modulates-susceptibility-to-intestinal-epithelial-cell-injury-in-vivo
#16
Tatsuro Murano, Mehran Najibi, Geraldine L C Paulus, Fatemeh Adiliaghdam, Aida Valencia-Guerrero, Martin Selig, Xiaofei Wang, Kate Jeffrey, Ramnik J Xavier, Kara G Lassen, Javier E Irazoqui
Understanding the transcription factors that modulate epithelial resistance to injury is necessary for understanding intestinal homeostasis and injury repair processes. Recently, transcription factor EB (TFEB) was implicated in expression of autophagy and host defense genes in nematodes and mammalian cells. However, the in vivo roles of TFEB in the mammalian intestinal epithelium were not known. Here, we used mice with a conditional deletion of Tfeb in the intestinal epithelium (Tfeb (ΔIEC)) to examine its importance in defense against injury...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29066445/collecting-duct-nitric-oxide-synthase-1%C3%A3-activation-maintains-sodium-homeostasis-during-high-sodium-intake-through-suppression-of-aldosterone-and-renal-angiotensin-ii-pathways
#17
Kelly A Hyndman, Elena V Mironova, Jorge F Giani, Courtney Dugas, Jessika Collins, Alicia A McDonough, James D Stockand, Jennifer S Pollock
BACKGROUND: During high sodium intake, the renin-angiotensin-aldosterone system is downregulated and nitric oxide signaling is upregulated in order to remain in sodium balance. Recently, we showed that collecting duct nitric oxide synthase 1β is critical for fluid-electrolyte balance and subsequently blood pressure regulation during high sodium feeding. The current study tested the hypothesis that high sodium activation of the collecting duct nitric oxide synthase 1β pathway is critical for maintaining sodium homeostasis and for the downregulation of the renin-angiotensin-aldosterone system-epithelial sodium channel axis...
October 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29066441/endoplasmic-reticulum-stress-is-associated-with-autophagy-and-cardiomyocyte-remodeling-in-experimental-and-human-atrial-fibrillation
#18
Marit Wiersma, Roelien A M Meijering, Xiao-Yan Qi, Deli Zhang, Tao Liu, Femke Hoogstra-Berends, Ody C M Sibon, Robert H Henning, Stanley Nattel, Bianca J J M Brundel
BACKGROUND: Derailment of proteostasis, the homeostasis of production, function, and breakdown of proteins, contributes importantly to the self-perpetuating nature of atrial fibrillation (AF), the most common heart rhythm disorder in humans. Autophagy plays an important role in proteostasis by degrading aberrant proteins and organelles. Herein, we investigated the role of autophagy and its activation pathway in experimental and clinical AF. METHODS AND RESULTS: Tachypacing of HL-1 atrial cardiomyocytes causes a gradual and significant activation of autophagy, as evidenced by enhanced LC3B-II expression, autophagic flux and autophagosome formation, and degradation of p62, resulting in reduction of Ca(2+) amplitude...
October 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29056513/metformin-alters-upper-small-intestinal-microbiota-that-impact-a-glucose-sglt1-sensing-glucoregulatory-pathway
#19
Paige V Bauer, Frank A Duca, T M Zaved Waise, Brittany A Rasmussen, Mona A Abraham, Helen J Dranse, Akshita Puri, Catherine A O'Brien, Tony K T Lam
The gut microbiota alters energy homeostasis. In parallel, metformin regulates upper small intestinal sodium glucose cotransporter-1 (SGLT1), but whether changes of the microbiota or SGLT1-dependent pathways in the upper small intestine mediate metformin action is unknown. Here we report that upper small intestinal glucose sensing triggers an SGLT1-dependent pathway to lower glucose production in rodents. High-fat diet (HFD) feeding reduces glucose sensing and SGLT1 expression in the upper small intestine. Upper small intestinal metformin treatment restores SGLT1 expression and glucose sensing while shifting the upper small intestinal microbiota partly by increasing the abundance of Lactobacillus...
October 17, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/29045337/blood-pressure-regulation-by-the-angiotensin-type-1-receptor-in-the-proximal-tubule
#20
Marloes C van Haaster, Alicia A McDonough, Susan B Gurley
PURPOSE OF REVIEW: The renin-angiotensin system (RAS) plays a critical role in the pathogenesis of hypertension. Homeostatic actions of the RAS, such as increasing blood pressure (BP) and vasoconstriction, are mediated via type 1 (AT1) receptors for angiotensin II. All components of the RAS are present in the renal proximal tubule, which reabsorbs the bulk of the glomerular filtrate, making this segment of the nephron a location of great interest for solute handling under RAS influence...
October 16, 2017: Current Opinion in Nephrology and Hypertension
keyword
keyword
81976
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"