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Olaparib pancrea

Paul M Wilkerson, Konstantin J Dedes, Daniel Wetterskog, Alan Mackay, Maryou B Lambros, Marthe Mansour, Jessica Frankum, Christopher J Lord, Rachael Natrajan, Alan Ashworth, Jorge S Reis-Filho
The 11q13-q14 locus is frequently amplified in human cancers, with a complex structure harbouring multiple potential oncogenic drivers. The EMSY gene has been proposed as a driver of the third core of the 11q13-q14 amplicon. This gene encodes a protein reported to be a BRCA2-binding partner, which when over-expressed would lead to impairment of BRCA2 functions and could constitute a mechanism for BRCA2 inactivation in non-hereditary breast and ovarian cancers. We hypothesized that if EMSY amplification abrogates BRCA2 functions, cells harbouring this aberration would be unable to elicit competent homologous recombination DNA repair and, therefore, may have increased sensitivity to genotoxic therapies and potent PARP inhibitors...
September 2011: Journal of Pathology
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