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https://www.readbyqxmd.com/read/28945055/adjuvant-treatments-for-ependymomas
#1
E Alton Sartor, Patrick Y Wen
Ependymomas are rare primary central nervous system tumors occurring in children and young adults. They can be indolent or locally aggressive depending on location, histology, and extent of resection. Treatment involves maximal surgical resection and usually focal radiation therapy, depending on the presence of residual disease and tumor grade. Chemotherapy has been studied for both adults and children but do not have an established role in adjuvant therapy. In both age groups, treatment with mainly cisplatin based regimens can be considered in the setting of residual disease after surgery or for salvage therapy when surgery or further radiation is not indicated...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28945052/negative-influence-of-preoperative-tinnitus-on-hearing-preservation-in-vestibular-schwannoma-surgery
#2
Luciano Mastronardi, Guglielmo Cacciotti, Raffaellino Roperto, Ettore DI Scipio
BACKGROUNDS: Goals of vestibular schwannoma (VS) microsurgery are: maximal resection, facial nerve (FN) preservation and, in selected cases, hearing preservation (HP). Postoperative HP rates are related to clinical and radiographic factors: size of tumor, preoperative hearing, hypertension, diabetes, and presence or absence of preoperative tinnitus. In this retrospective review we evaluated the influence of preoperative tinnitus on HP after VS surgery in patients with preoperative socially useful hearing (SUH)...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28944995/comparative-analysis-of-serum-proteome-in-congenital-scoliosis-patients-with-tbx6-haploinsufficiency-a-first-report-pointing-to-lipid-metabolism
#3
Qiankun Zhu, Nan Wu, Gang Liu, Yangzhong Zhou, Sen Liu, Jun Chen, Jiaqi Liu, Yuzhi Zuo, Zhenlei Liu, Weisheng Chen, Yixin Chen, Jia Chen, Mao Lin, Yanxue Zhao, Yang Yang, Shensgru Wang, Xu Yang, Yufen Ma, Jian Wang, Xiaoli Chen, Jianguo Zhang, Jianxiong Shen, Zhihong Wu, Guixing Qiu
Congenital scoliosis (CS) is a three-dimensional deformity of the spine affecting quality of life. We have demonstrated TBX6 haploinsufficiency is the most important contributor to CS. However, the pathophysiology at the protein level remains unclear. Therefore, this study was to explore the differential proteome in serum of CS patients with TBX6 haploinsufficiency. Sera from nine CS patients with TBX6 haploinsufficiency and nine age- and gender-matched healthy controls were collected and analysed by isobaric tagged relative and absolute quantification (iTRAQ) labelling coupled with mass spectrometry (MS)...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28944990/children-concurrently-wasted-and-stunted-a-meta-analysis-of-prevalence-data-of-children-6-59%C3%A2-months-from-84-countries
#4
Tanya Khara, Martha Mwangome, Moses Ngari, Carmel Dolan
Children can be stunted and wasted at the same time. Having both deficits greatly elevates risk of mortality. The analysis aimed to estimate the prevalence and burden of children aged 6-59 months concurrently wasted and stunted. Data from demographic and health survey and Multi-indicator Cluster Surveys datasets from 84 countries were analysed. Overall prevalence for being wasted, stunted, concurrently wasted, and stunted among children 6 to 59 months was calculated. A pooled prevalence of concurrence was estimated and reported by gender, age, United Nations regions, and contextual categories...
September 25, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28944986/development-and-in-vitro-in-vivo-evaluation-of-a-novel-benznidazole-liquid-dosage-form-using-a-quality-by-design-approach
#5
Higo Fernando Santos Souza, Daniel Real, Darío Leonardi, Sandra Carla Rocha, Victoria Alonso, Esteban Serra, Ariel Mariano Silber, Claudio Javier Salomon
OBJECTIVES: To develop an alcohol-free solution suitable for children of benznidazole, the drug of choice for treatment of Chagas disease. METHODS: In a quality-by-design approach a systematic optimization procedure was carried out in order to estimate the values of the factors leading to the maximum drug concentration. The formulations were analyzed in terms of chemical and physical stability and drug content. The final preparation was subjected to an in-vivo palatability assay...
September 25, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28944985/ultrasound-characteristics-of-endometrial-cancer-as-defined-by-the-international-endometrial-tumor-analysis-ieta-consensus-nomenclature-a-prospective-multicenter-study
#6
Elisabeth Epstein, Daniela Fischerova, Lil Valentin, Antonia Carla Testa, Dorella Franchi, Povilas Sladkevicius, Frühauf Filip, Pelle G Lindqvist, Floriana Mascilini, Robert Fruscio, Lucia Anna Haak, Gina Opolskiene, Maria Angela Pascual, Juan Luis Alcazar, Valentina Chiappa, Stefano Guerriero, Joseph Carlson, Caroline Van Holsbeke, Francesco Paolo Giuseppe Leone, Bart De Moor, Tom Bourne, Ben van Calster, Arnaud Installe, Dirk Timmerman, Jan Y Verbakel, Thierry Van den Bosch
OBJECTIVES: To describe the sonographic features of endometrial cancer in relation to stage, grade, and histological type using the International Endometrial Tumor Analysis (IETA) terminology. METHODS: Prospective multicenter study on 1714 women with endometrial cancer undergoing a standardized transvaginal grayscale and Doppler ultrasound examination by an experienced ultrasound examiner using a high-end ultrasound system. Clinical and sonographic data were entered into a web-based protocol...
September 25, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28944976/obesity-and-frontal-striatal-brain-structures-in-offspring-of-individuals-with-bipolar-disorder-results-from-the-global-mood-and-brain-science-initiative
#7
Rodrigo B Mansur, Roger S McIntyre, Bo Cao, Yena Lee, Letícia Japiassú, Kun Chen, Rui Lu, Weicong Lu, Xiaodong Chen, Ting Li, Guiyun Xu, Kangguang Lin
OBJECTIVES: To compare frontal-striatal brain volumes between offspring of individuals with bipolar disorder (BD) and healthy controls; to investigate the associations of body mass index (BMI) and age with brain volumes; and to assess the moderating effects of BMI and age on the relationship between risk status and structural brain differences. METHODS: We cross-sectionally assessed structural regional and global brain volumes using magnetic resonance imaging and BMI among 53 BD offspring subjects, stratified by risk status, and 23 non-BD offspring controls (aged 8-28 years)...
September 25, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28944968/pediatric-vaccine-strain-herpes-zoster-a-case-series
#8
Sean Dreyer, Peera Hemarajata, Marcia Hogeling, Gregory P Henderson
BACKGROUND/OBJECTIVES: Herpes zoster (HZ) is caused by reactivation of the varicella zoster virus (VZV), and typically causes a painful, vesicular, dermatomal rash in adults over the age of fifty. However, HZ has been known to present in immunocompetent pediatric patients, which account for under 1% of total cases. Pediatric cases are typically caused by natural infection with VZV, but among vaccinated children up to half of cases can be due to vaccine-strain VZV. We present two such cases of vaccine-strain HZ in pediatric patients...
September 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28944952/bypassing-agent-prophylaxis-in-people-with-hemophilia-a-or-b-with-inhibitors
#9
REVIEW
Chatree Chai-Adisaksopha, Sarah J Nevitt, Mindy L Simpson, Maissaa Janbain, Barbara A Konkle
BACKGROUND: People with hemophilia A or B with inhibitors are at high risk of bleeding complications. Infusion of bypassing agents, such as recombinant activated FVII (rFVIIa) and plasma-derived activated prothrombin complex concentrate, are suggested as alternative therapies to factor VIII (haemophilia A) or IX (haemophilia B) for individuals who no longer respond to these treatments because they develop inhibitory antibodies. The ultimate goal of treatment is to preserve the individual's joints, otherwise destroyed by recurrent bleeds...
September 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28944938/-reverse-j-shaped-skin-flap-and-cranial-bone-groove-for-shunt-hardware-a-new-technique-in-patients-with-fragile-skin
#10
Murteza Cakir
INTRODUCTION: Shunt systems are not perfect devices and can cause severe complications. Complications may originate from problems related to the valve, the patient, or the surgery and more common in neonates, infants, especially preterm by reason of the special characteristics these patients owned. We therefore have succesfully developed useful and viable surgical technique in order to provide helpful aspects to surgical issues mentioned above. TECHNIQUE: This technique includes \"reverse J\" shaped skin incision with nonintersecting the shun's hardware and distal catheter and to be reduced the wound problems to the minimum rates by opening \"bone groove\"...
July 11, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944937/individual-development-and-potential-determinants-of-excess-weight-in-children-and-adolescents-a-longitudinal-study
#11
Alexandra Papandreou, Matthias Bopp, Julia Braun, Kaspar Staub, David Faeh
OBJECTIVES: Excess body weight is a major public health concern already at a young age. The aim of this study was to track weight status among pupils aged 6-14 years in the City of Zurich, to examine the association between sociodemographic and environmental factors and excess weight at school entry and excess weight gain thereafter. DESIGN: Longitudinal study. SETTING: Data were from the medical examinations routinely performed at public schools in Zurich, the largest city in Switzerland...
September 25, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28944936/smoking-cessation-in-workplace-settings-quit-rates-and-determinants-in-a-group-behaviour-therapy-programme
#12
Yann Hausherr, Carlos Quinto, Leticia Grize, Christian Schindler, Nicole Probst-Hensch
INTRODUCTION: To capitalise on the opportunities that the smoking ban legislation in Switzerland offers for the prevention of tobacco-related diseases, a smoking cessation programme in a workplace setting was developed and implemented in companies across the language and cultural regions of Switzerland. Our goal was to identify factors associated with relapse into smoking that may be overcome during training sessions or that should be considered for the optimisation of future interventions...
September 25, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28944926/upregulation-of-long-noncoding-rna-ap003419-16-predicts-high-risk-of-aging%C3%A2-associated-idiopathic-pulmonary-fibrosis
#13
Xiaoyan Hao, Yufeng Du, Li Qian, Dan Li, Xuejun Liu
Long noncoding RNAs (lncRNAs) are able to regulate adjacent genes and thus participate in the incidence in the present study has identified lncRNA AP003419.16, adjacent to the protein‑coding gene ribosomal protein S6 kinase B‑2 (RPS6KB2). RPS6KB2 is believed to be involved in the process of aging and idiopathic pulmonary fibrosis (IPF), due to its activation by growth factors and regulation by the protein kinase mTOR signaling pathway. The results of the present study indicated that the expression of AP003419...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944909/long-non%C3%A2-coding-rna-associated%C3%A2-competing-endogenous-rnas-are-induced-by-clusterin-in-retinal-pigment-epithelial-cells
#14
Zi Ye, Zhaohui Li, Shouzhi He
Age related macular degeneration is one of the most common causes of vision loss in the elderly. Long noncoding RNAs (lncRNAs) serve important roles in regulating gene expression by acting as competing endogenous RNAs (ceRNAs). However, the roles of specific lncRNAs and their associated ceRNA function induced by clusterin in cultured retinal pigment epithelial (RPE) cells remain to be fully elucidated. Based on high throughput sequencing data from RPE cells treated with or without clusterin, the present study identified differentially expressed mRNAs, lncRNAs and microRNAs (miRNAs)...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944893/pigment-epithelium%C3%A2-derived-factor-protects-human-glomerular-mesangial-cells-from-diabetes-via-noxo1%C3%A2-inos-suppression
#15
Ling Gao, Yingjie Hu, Jing Li
The authors previously reported that pigment epithelium‑derived factor (PEDF) protects the diabetic kidney from fibrosis via its anti‑oxidative effects. However, the underlying molecular mechanism has never been revealed. The present study aimed to investigate how PEDF protects mesangial cells from diabetes induced damage. Human mesangial cells were exposed to a diabetic environment [30 mmol/l glucose and 200 mg advanced glycation end products (AGEs)] in the absence or presence of PEDF (200 mg/l). The superoxide and peroxynitrite productions were measured by fluorescent assay...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944879/immunoreactivities-of-calbindin%C3%A2-d28k-calretinin-and-parvalbumin-in-the-somatosensory-cortex-of-rodents-during-normal-aging
#16
Ji Hyeon Ahn, Seongkweon Hong, Joon Ha Park, In Hye Kim, Jeong Hwi Cho, Tae-Kyeong Lee, Jae-Chul Lee, Bai Hui Chen, Bich-Na Shin, Eun Joo Bae, Yong Hwan Jeon, Young-Myeong Kim, Moo-Ho Won, Soo Young Choi
Calbindin‑D28k (CB), calretinin (CR) and parvalbumin (PV), which regulate cytosolic free Ca2+ concentrations in neurons, are chemically expressed in γ‑aminobutyric acid (GABA)ergic neurons that regulate the degree of glutamatergic excitation and output of projection neurons. The present study investigated age‑associated differences in CB, CR and PV immunoreactivities in the somatosensory cortex in three species (mice, rats and gerbils) of young (1 month), adult (6 months) and aged (24 months) rodents, using immunohistochemistry and western blotting...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944858/decreased-expression-of-hsa%C3%A2-mir%C3%A2-372-predicts-poor-prognosis-in-patients-with-gallbladder-cancer-by-affecting-chloride-intracellular-channel-1
#17
Ning Zhou, Wei Cheng, Chuang Peng, Yi Liu, Bo Jiang
It has been reported that hsa‑microRNA (miRNA/miR)‑372 functions as a tumor suppressor or oncogene in various digestive system tumors, however, its roles in gallbladder cancer (GBC) are yet to be established. The present study aimed to determine the expression and clinical relevance of hsa‑miR‑372 in GBC. The expression of hsa‑miR‑372 in 80 pairs of human GBC tissues and adjacent normal gallbladder tissues was measured by reverse transcription‑quantitative polymerase chain reaction. Subsequently, the associations between hsa‑miR‑372 expression levels and the clinicopathological characteristics of patients with GBC were determined using χ2 test...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944856/systemic-overexpression-of-the-11%C3%AE-%C3%A2-hsd1-promotes-endoplasmic-reticulum-stress-in-multiple-tissues-and-the-development-of-metabolic-syndrome-in-mice
#18
Chenxiao Li, Jihan Xia, Wenjuan Zhu, Leilei Xin, Cuiping An, Shulin Yang, Kui Li
Glucocorticoids are associated with lipid metabolism and their abnormal expression has an important function in the development of metabolic syndrome. The 11β‑hydroxysteroid dehydrogenase type 1 (11β‑HSD1) is a metabolic enzyme of glucocorticoids and may be a potential drug target for the treatment of metabolic syndrome. However, the association between the systemic expression of 11β‑HSD1 and metabolic syndrome remains to be elucidated. The present study used a cytomegalovirus promoter to obtain mice that systemically overexpressed the 11β‑HSD1 gene...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944849/celastrol-alleviates-angiotensin-ii%C3%A2-mediated-vascular-smooth-muscle-cell-senescence-via-induction-of-autophagy
#19
Xian-Jie Xu, Wei-Bo Zhao, Shi-Bin Feng, Cheng Sun, Qiang Chen, Bing Ni, Hou-Yuan Hu
Reactive oxygen species (ROS) production has been implicated in the promotion of cellular senescence. Celastrol, a quinone methide triterpenoid isolated from the Celastraceae family, exerts antioxidant effects and enhances autophagy in various cell types. Since autophagy serves an important role in regulating ROS, it was hypothesized that the antioxidant effect of celastrol is via enhanced autophagy, thus inhibiting cell senescence. Therefore, the present study used a Senescence β‑Galactosidase Staining kit, western blot analysis and cell cycle analysis to investigate whether celastrol alleviates angiotensin (Ang) II‑induced cellular senescence by upregulating autophagy in vascular smooth muscle cells (VSMCs)...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944802/subcellular-compartmentalisation-of-copper-iron-manganese-and-zinc-in-the-parkinson-s-disease-brain
#20
Sian Genoud, Blaine R Roberts, Adam P Gunn, Glenda M Halliday, Simon J G Lewis, Helen J Ball, Dominic J Hare, Kay L Double
Elevated iron and decreased copper levels are cardinal features of the degenerating substantia nigra pars compacta in the Parkinson's disease brain. Both of these redox-active metals, and fellow transition metals manganese and zinc, are found at high concentrations within the midbrain and participate in a range of unique biological reactions. We examined the total metal content and cellular compartmentalisation of manganese, iron, copper and zinc in the degenerating substantia nigra, disease-affected but non-degenerating fusiform gyrus, and unaffected occipital cortex in the post mortem Parkinson's disease brain compared with age-matched controls...
September 25, 2017: Metallomics: Integrated Biometal Science
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