keyword
https://read.qxmd.com/read/38387749/microvascular-damage-neuroinflammation-and-extracellular-matrix-remodeling-in-col18a1-knockout-mice-as-a-model-for-early-cerebral-small-vessel-disease
#1
JOURNAL ARTICLE
Mahsima Khoshneviszadeh, Solveig Henneicke, Daniel Pirici, Akilashree Senthilnathan, Lorena Morton, Philipp Arndt, Rahul Kaushik, Oula Norman, Jari Jukkola, Ildiko Rita Dunay, Constanze Seidenbecher, Anne Heikkinen, Stefanie Schreiber, Alexander Dityatev
Collagen type XVIII (COL18) is an abundant heparan sulfate proteoglycan in vascular basement membranes. Here, we asked (i) if the loss of COL18 would result in blood-brain barrier (BBB) breakdown, pathological alterations of small arteries and capillaries and neuroinflammation as found in cerebral small vessel disease (CSVD) and (ii) if such changes may be associated with remodeling of synapses and neural extracellular matrix (ECM). We found that 5-month-old Col18a1-/- mice had elevated BBB permeability for mouse IgG in the deep gray matter, and intravascular erythrocyte accumulations were observed brain-wide in capillaries and arterioles...
February 20, 2024: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/37063869/application-of-weighted-gene-co-expression-network-and-immune-infiltration-for-explorations-of-key-genes-in-the-brain-of-elderly-covid-19-patients
#2
JOURNAL ARTICLE
Lixia Huang, Wei Qin, Zirui Guo, Xiaoyu Li, Fajiu Li, Xiang Wang
INTRODUCTION: Although many studies have demonstrated the existing neurological symptoms in COVID-19 patients, the mechanisms are not clear until now. This study aimed to figure out the critical molecular and immune infiltration situations in the brain of elderly COVID-19 patients. METHODS: GSE188847 was used for the differential analysis, WGCNA, and immune infiltration analysis. We also performed GO, KEGG, GSEA, and GSVA for the enrich analysis. RESULTS: 266 DEGs, obtained from the brain samples of COVID-19 and non-COVID-19 patients whose ages were over 70 years old, were identified...
2023: Frontiers in Immunology
https://read.qxmd.com/read/33579535/heroin-seeking-and-extinction-from-seeking-activate-matrix-metalloproteinases-at-synapses-on-distinct-subpopulations-of-accumbens-cells
#3
JOURNAL ARTICLE
Vivian C Chioma, Anna Kruyer, Ana-Clara Bobadilla, Ariana Angelis, Zachary Ellison, Ritchy Hodebourg, Michael D Scofield, Peter W Kalivas
BACKGROUND: Seeking addictive drugs is regulated by synaptic plasticity in the nucleus accumbens core and involves distinct plasticity in D1 and D2 receptor-expressing medium spiny neurons (D1/2-MSNs). However, it is unknown how differential plasticity between the two cell types is coordinated. Synaptic plasticity and seeking behavior induced by drug-paired cues depends not only on plasticity in the canonical pre- and postsynapse, but also on cue-induced changes in astrocytes and the extracellular matrix adjacent to the synapse...
May 15, 2021: Biological Psychiatry
https://read.qxmd.com/read/33396569/changes-in-gene-and-protein-expression-of-metalloproteinase-2-and-9-and-their-inhibitors-timp2-and-timp3-in-different-parts-of-fluoride-exposed-rat-brain
#4
JOURNAL ARTICLE
Agnieszka Łukomska, Irena Baranowska-Bosiacka, Karolina Dec, Anna Pilutin, Maciej Tarnowski, Karolina Jakubczyk, Wojciech Żwierełło, Marta Skórka-Majewicz, Dariusz Chlubek, Izabela Gutowska
Fluoride (F) exposure decreases brain receptor activity and neurotransmitter production. A recent study has shown that chronic fluoride exposure during childhood can affect cognitive function and decrease intelligence quotient, but the mechanism of this phenomenon is still incomplete. Extracellular matrix (ECM) and its enzymes are one of the key players of neuroplasticity which is essential for cognitive function development. Changes in the structure and the functioning of synapses are caused, among others, by ECM enzymes...
December 31, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/32471263/improvement-of-impaired-motor-functions-by-human-dental-exfoliated-deciduous-teeth-stem-cell-derived-factors-in-a-rat-model-of-parkinson-s-disease
#5
JOURNAL ARTICLE
Yong-Ren Chen, Pei-Lun Lai, Yueh Chien, Po-Hui Lee, Ying-Hsiu Lai, Hsin-I Ma, Chia-Yang Shiau, Kuo-Chuan Wang
Parkinson's disease (PD) is a long-term degenerative disease of the central nervous system (CNS) that primarily affects the motor system. So far there is no effective treatment for PD, only some drugs, surgery, and comprehensive treatment can alleviate the symptoms of PD. Stem cells derived from human exfoliated deciduous teeth (SHED), mesenchymal stem cells derived from dental pulp, may have promising potential in regenerative medicine. In this study, we examine the therapeutic effect of SHED-derived conditioned medium (SHED-CM) in a rotenone-induced PD rat model...
May 27, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/30656892/from-c-fos-to-mmp-9-in-control-of-synaptic-plasticity-to-produce-healthy-and-diseased-mind-a-personal-view
#6
JOURNAL ARTICLE
Leszek Kaczmarek
c-Fos is a component of AP-1 transcription factor. Three lines of evidence support pivotal role of c-Fos in learning and memory: (i) learning experience markedly enhances its expression; (ii) blocking od c-Fos impairs, while optogenetic activation of c-Fos expressing neurons supports learning and memory; (iii) c-Fos/AP-1 gene targets in activated neurons, encoding tissue inhibitor of metalloproteinases-1 (TIMP-1) and matrix metalloproteinase 9 (MMP- 9) play a major role in synaptic plasticity that underlies learning and memory...
October 15, 2018: Postepy Biochemii
https://read.qxmd.com/read/28576972/secreted-tissue-inhibitor-of-matrix-metalloproteinase-restricts-trans-synaptic-signaling-to-coordinate-synaptogenesis
#7
JOURNAL ARTICLE
Jarrod Shilts, Kendal Broadie
Synaptogenesis is coordinated by trans -synaptic signals that traverse the specialized synaptomatrix between presynaptic and postsynaptic cells. Matrix metalloproteinase (Mmp) activity sculpts this environment, balanced by secreted tissue inhibitors of Mmp (Timp). Here, we use the simplified Drosophila melanogaster matrix metalloproteome to test the consequences of eliminating all Timp regulatory control of Mmp activity at the neuromuscular junction (NMJ). Using in situ zymography, we find Timp limits Mmp activity at the NMJ terminal and shapes extracellular proteolytic dynamics surrounding individual synaptic boutons...
July 15, 2017: Journal of Cell Science
https://read.qxmd.com/read/27282248/transient-ecm-protease-activity-promotes-synaptic-plasticity
#8
JOURNAL ARTICLE
Marta Magnowska, Tomasz Gorkiewicz, Anna Suska, Marcin Wawrzyniak, Izabela Rutkowska-Wlodarczyk, Leszek Kaczmarek, Jakub Wlodarczyk
Activity-dependent proteolysis at a synapse has been recognized as a pivotal factor in controlling dynamic changes in dendritic spine shape and function; however, excessive proteolytic activity is detrimental to the cells. The exact mechanism of control of these seemingly contradictory outcomes of protease activity remains unknown. Here, we reveal that dendritic spine maturation is strictly controlled by the proteolytic activity, and its inhibition by the endogenous inhibitor (Tissue inhibitor of matrix metalloproteinases-1 - TIMP-1)...
June 10, 2016: Scientific Reports
https://read.qxmd.com/read/24005309/reward-learning-requires-activity-of-matrix-metalloproteinase-9-in-the-central-amygdala
#9
JOURNAL ARTICLE
Ewelina Knapska, Victoria Lioudyno, Anna Kiryk, Marta Mikosz, Tomasz Górkiewicz, Piotr Michaluk, Maciej Gawlak, Mayank Chaturvedi, Gabriela Mochol, Marcin Balcerzyk, Daniel K Wojcik, Grzegorz M Wilczynski, Leszek Kaczmarek
Learning how to avoid danger and pursue reward depends on negative emotions motivating aversive learning and positive emotions motivating appetitive learning. The amygdala is a key component of the brain emotional system; however, an understanding of how various emotions are differentially processed in the amygdala has yet to be achieved. We report that matrix metalloproteinase-9 (MMP-9, extracellularly operating enzyme) in the central nucleus of the amygdala (CeA) is crucial for appetitive, but not for aversive, learning in mice...
September 4, 2013: Journal of Neuroscience
https://read.qxmd.com/read/21669931/neural-circuit-architecture-defects-in-a-drosophila-model-of-fragile-x-syndrome-are-alleviated-by-minocycline-treatment-and-genetic-removal-of-matrix-metalloproteinase
#10
JOURNAL ARTICLE
Saul S Siller, Kendal Broadie
Fragile X syndrome (FXS), caused by loss of the fragile X mental retardation 1 (FMR1) product (FMRP), is the most common cause of inherited intellectual disability and autism spectrum disorders. FXS patients suffer multiple behavioral symptoms, including hyperactivity, disrupted circadian cycles, and learning and memory deficits. Recently, a study in the mouse FXS model showed that the tetracycline derivative minocycline effectively remediates the disease state via a proposed matrix metalloproteinase (MMP) inhibition mechanism...
September 2011: Disease Models & Mechanisms
https://read.qxmd.com/read/21084591/metzincin-proteases-and-their-inhibitors-foes-or-friends-in-nervous-system-physiology
#11
REVIEW
Santiago Rivera, Michel Khrestchatisky, Leszek Kaczmarek, Gary A Rosenberg, Diane M Jaworski
Members of the metzincin family of metalloproteinases have long been considered merely degradative enzymes for extracellular matrix molecules. Recently, however, there has been growing appreciation for these proteinases and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), as fine modulators of nervous system physiology and pathology. Present all along the phylogenetic tree, in all neural cell types, from the nucleus to the synapse and in the extracellular space, metalloproteinases exhibit a complex spatiotemporal profile of expression in the nervous parenchyma and at the neurovascular interface...
November 17, 2010: Journal of Neuroscience
https://read.qxmd.com/read/16254495/axotomy-of-sympathetic-neurons-activates-the-metalloproteinase-2-enzymatic-pathway
#12
COMPARATIVE STUDY
Lucia Leone, M Egle De Stefano, Arianna Del Signore, Tamara C Petrucci, Paola Paggi
We have previously shown that intraganglionic synapse disassembly consequent on superior cervical ganglion (SCG) neuron axotomy was preceded by the loss of the dystroglycan beta subunit (beta-DG) localized at the postsynaptic specializations. Because DG, a transmembrane molecular complex bridging the extracellular matrix to the cortical cytoskeleton, could be a physiological target of metalloproteinases (MMPs) 2 and 9, we investigated their possible involvement in the injury-induced intraganglionic synapse disassembly...
November 2005: Journal of Neuropathology and Experimental Neurology
https://read.qxmd.com/read/16052496/a-disintegrin-and-metalloprotease-21-adam21-is-associated-with-neurogenesis-and-axonal-growth-in-developing-and-adult-rodent-cns
#13
COMPARATIVE STUDY
Peng Yang, K Adam Baker, Theo Hagg
We have reported that alpha6beta1 integrin regulates the directed migration of neuroblasts from the adult rodent subventricular zone (SVZ) through the rostral migratory stream (RMS). ADAM (a disintegrin and metalloprotease) proteins bind integrins. Here, we show that ADAM21, but not ADAM2, -3, -9, -10, -12, -15, or -17, is expressed in adult rats and mice by ependyma and SVZ cells with long basal processes, and in radial glia at early postnatal times. ADAM21-positive processes projected into the RMS, contacted blood vessels, and were present within the RMS intermingled with neuroblasts up to where neuroblasts start their radial migration and differentiation in the olfactory bulb...
September 19, 2005: Journal of Comparative Neurology
https://read.qxmd.com/read/10366632/spatiotemporal-expression-patterns-of-metalloproteinases-and-their-inhibitors-in-the-postnatal-developing-rat-cerebellum
#14
JOURNAL ARTICLE
C Vaillant, M Didier-Bazès, A Hutter, M F Belin, N Thomasset
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade the components of the extracellular matrix (ECM). The balance between MMPs and their inhibitors [tissue inhibitors of metalloproteinases (TIMPs)] in the pericellular environment determines the most significant proteolytic events in tissue remodeling. In vitro evidence is accumulating that these molecules may be crucial in the maturation of neural cells. Here, we investigated the in vivo expression of MMPs 2, 3, and 9 and TIMPs 1, 2, and 3 in the developing and adult rat cerebellum using immunohistochemistry and in situ hybridization...
June 15, 1999: Journal of Neuroscience
https://read.qxmd.com/read/6087987/is-gamma-aminobutyric-acid-the-neurotransmitter-of-barnacle-photoreceptors
#15
COMPARATIVE STUDY
L C Timpe, A E Stuart
The hypothesis that gamma-aminobutyric acid (GABA) is the neurotransmitter of barnacle photoreceptors was tested by studying the effect of GABA on the membrane of the cell directly postsynaptic to the photoreceptor, by testing the ability of GABA antagonists to block transmission at this synapse, and by estimating the free GABA content of the photoreceptor. The results of these experiments suggest that GABA is not the photoreceptor's neurotransmitter.
July 30, 1984: Brain Research
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