keyword
MENU ▼
Read by QxMD icon Read
search

D5

keyword
https://www.readbyqxmd.com/read/28635614/advanced-treatment-planning-using-direct-4d-optimisation-for-pencil-beam-scanned-particle-therapy
#1
Kinga Bernatowicz, Ye Zhang, Rosalind Lucy Perrin, Damien Charles Weber, Antony John Lomax
We report on development of a new four-dimensional (4D) optimisation approach for scanned proton beams, which incorporates both irregular motion patterns and the delivery dynamics of the treatment machine into the plan optimiser. Furthermore, we assess the effectiveness of this technique to reduce dose to critical structures in proximity to moving targets, while maintaining effective target dose homogeneity and coverage. The proposed approach has been tested using both a simulated phantom and a clinical liver cancer case, and allows for realistic 4D calculations and optimisation using irregular breathing patterns extracted from e...
June 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28627430/kinetic-of-eosinophil-count-during-bacterial-infection-revisiting-an-old-marker-to-assess-the-efficacy-of-antimicrobial-therapy
#2
B Davido, S Makhloufi, M Matt, R Calin, O Senard, C Perronne, A Dinh, J Salomon
INTRODUCTION: Eosinopenia has been in the centre of debates for decades as a criterion of sepsis. Depending on authors, different cut-off values are proposed. METHODS: We conducted a prospective study, from February to August 2016, of hospitalized adults suffering from bacterial infection with eosinopenia defined by an eosinophil count <100/mm(3). Patients were divided into 2 groups considering the first day of effective antimicrobial therapy. They were observed during 5days (D) in order to evaluate whether recovery from eosinopenia was predictive of an appropriate antibiotic regimen...
June 13, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28613975/activation-of-drd5-dopamine-receptor-d5-inhibits-tumor-growth-by-autophagic-cell-death
#3
Zhi Gen Leng, Shao Jian Lin, Ze Rui Wu, Yu Hang Guo, Lin Cai, Han Bing Shang, Hao Tang, Ya Jun Xue, Mei Qing Lou, Wenxiu Zhao, Wei-Dong Le, Wei Guo Zhao, Xun Zhang, Zhe Bao Wu
Dopamine agonists such as bromocriptine and cabergoline have been successfully used in the treatment of pituitary prolactinomas and other neuroendocrine tumors. However, their therapeutic mechanisms are not fully understood. In this study we demonstrated that DRD5 (dopamine receptor D5) agonists were potent inhibitors of pituitary tumor growth. We further found that DRD5 activation increased production of reactive oxygen species (ROS), inhibited the MTOR pathway, induced macroautophagy/autophagy, and led to autophagic cell death (ACD) in vitro and in vivo...
June 14, 2017: Autophagy
https://www.readbyqxmd.com/read/28595643/planning-strategies-for-inter-fractional-robustness-in-pancreatic-patients-treated-with-scanned-carbon-therapy
#4
Vania Batista, Daniel Richter, Stephanie E Combs, Oliver Jäkel
BACKGROUND: Managing inter-fractional anatomy changes is a challenging task in radiotherapy of pancreatic tumors, especially in scanned carbon-ion delivery. This treatment planning study aims to focus on clinically feasible solutions, such as the beam angle selection and margin design to increase the robustness against inter-fractional uncertainties. METHODS: This study included 10 patients with weekly 3D-CT imaging and physician-approved Clinical Target Volume (CTV)...
June 8, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28585489/evaluation-of-the-radiation-dose-volume-effects-of-optic-nerves-and-chiasm-by-psychophysical-electrophysiologic-tests-and-optical-coherence-tomography-in-nasopharyngeal-carcinoma
#5
Ozlem Ozkaya Akagunduz, Suzan Guven Yilmaz, Deniz Yalman, Berna Yuce, Elif Demirkilinc Biler, Filiz Afrashi, Mustafa Esassolak
PURPOSE: To evaluate the radiation dose-volume effects of optic nerves and chiasm by visual psychophysical, electrophysiologic tests, and optical coherence tomography in patients with locally advanced nasopharyngeal carcinoma. MATERIALS AND METHODS: A series of visual tests including visual acuity, visual field, contrast sensitivity, visual evoked potential, and optical coherence tomography were administered to 20 patients with locally advanced (T3-T4) nasopharyngeal carcinoma who were treated with definitive chemoradiotherapy...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28580949/upregulated-energy-metabolism-in-the-drosophila-mushroom-body-is-the-trigger-for-long-term-memory
#6
Pierre-Yves Plaçais, Éloïse de Tredern, Lisa Scheunemann, Séverine Trannoy, Valérie Goguel, Kyung-An Han, Guillaume Isabel, Thomas Preat
Efficient energy use has constrained the evolution of nervous systems. However, it is unresolved whether energy metabolism may resultantly regulate major brain functions. Our observation that Drosophila flies double their sucrose intake at an early stage of long-term memory formation initiated the investigation of how energy metabolism intervenes in this process. Cellular-resolution imaging of energy metabolism reveals a concurrent elevation of energy consumption in neurons of the mushroom body, the fly's major memory centre...
June 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/28578920/clinical-factors-and-dosimetry-associated-with-the-development-of-prostate-brachytherapy-related-urethral-strictures-a-matched-case-control-study
#7
Sandeep Singhal, Muhammad F Jamaluddin, Emma Lee, Ronald S Sloboda, Matthew Parliament, Nawaid Usmani
PURPOSE: Urethral strictures are a rare complication of prostate brachytherapy (BXT), with prior studies showing radiation dose to the bulbomembranous urethra as being associated with stricture formation. This retrospective case-control study explored clinical and dosimetric parameters associated with the development of BXT-related urethral strictures. METHODS AND MATERIALS: A cohort of 34 patients developed urethral strictures after BXT at our institution for the period of 2008-2014...
May 31, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28577194/genome-wide-characterization-of-the-rab-gene-family-in-gossypium-by-comparative-analysis
#8
Peng Li, Wangzhen Guo
BACKGROUND: Rab protein family is the largest subfamily of small G protein family. As one of the most important families in plant, Rab family plays an important role in the process of plant growth and development. So far, the identification of 57 members of the Rab family in Arabidopsis has been completed. In cotton, the relevant family has not been reported. RESULTS: Here, we identified 87, 169, 136, 80 Rabs in the four sequenced cotton species, G. raimondii (D5), G...
December 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28576677/impact-of-different-dilution-techniques-on-boar-sperm-quality-and-sperm-distribution-of-the-extended-ejaculate
#9
M Schulze, C Ammon, J Schaefer, A-M Luther, M Jung, D Waberski
The dilution of ejaculates is a fundamental step for the production of liquid-preserved boar semen. For a long time, it has been recommended to add the extender to the ejaculate. The aim of the present study was to first compare the effect of the position ('center' vs. 'wall') where the extender is added to the semen-mixing cylinder (height 32.5cm; diameter 12.7cm) using an automatic dispenser (n=11). In experiment 2 (n=30), we analyzed the two main dilution methods (extender to the semen ('control') vs. 'reverse')...
May 29, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28572626/a-randomised-cross-over-study-assessing-the-blue-pyjama-syndrome-in-major-depressive-episode
#10
Hélèna Delmas, Jean-Marie Batail, Bruno Falissard, Gabriel Robert, Maxence Rangé, Stéphane Brousse, Jacques Soulabaille, Dominique Drapier, Florian Naudet
This paper introduces a "blue pyjama syndrome" (whereby wearing hospital pyjamas results in an exaggerated impression of severity). We performed a 5-day, prospective, randomized, cross-over study in a French mood disorder unit for inpatients. At Day 1 (D1) and Day 5 (D5), two 5-minute video interviews were recorded with patients in pyjamas or in day clothes (the sequence was randomly allocated). Psychiatrists unaware of the study objective assessed the videos and scored their clinical global impressions (CGI, with scores ranging from 1 to 7)...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28571237/dexmedetomidine-as-an-additive-to-spinal-anaesthesia-in-orthopaedic-patients-undergoing-lower-limb-surgeries-a-randomized-clinical-trial-comparing-two-different-doses-of-dexmedetomidine
#11
Arati Rai, Meyong Pincho Bhutia
INTRODUCTION: Use of dexmedetomidine as an additive to spinal anaesthesia is gaining popularity; but there seems to be no clear consensus on the ideal dose to be used. Because of dose related prolongation of duration of motor blockade along with increase in the incidence of side effects of dexmedetomidine namely hypotension and bradycardia, use of higher doses is not recommended. AIM: To evaluate the efficacy of two different doses of dexmedetomidine (3 μg and 5 μg) given in combination with 0...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28557623/developmental-competence-and-epigenetic-profile-of-porcine-embryos-produced-by-two-different-cloning-methods
#12
Ying Liu, Andrea Lucas-Hahn, Bjoern Petersen, Rong Li, Doris Hermann, Petra Hassel, Maren Ziegler, Knud Larsen, Heiner Niemann, Henrik Callesen
The "Dolly" based cloning (classical nuclear transfer, [CNT]) and the handmade cloning (HMC) are methods that are nowadays routinely used for somatic cloning of large domestic species. Both cloning protocols share several similarities, but differ with regard to the required in vitro culture, which in turn results in different time intervals until embryo transfer. It is not yet known whether the differences between cloned embryos from the two protocols are due to the cloning methods themselves or the in vitro culture, as some studies have shown detrimental effects of in vitro culture on conventionally produced embryos...
June 2017: Cellular Reprogramming
https://www.readbyqxmd.com/read/28545167/synthesis-of-s-2-s-3-4-chlorophenyl-n-4-chlorophenyl-sulfonyl-4-phenyl-4-5-dihydro-1h-pyrazole-1-carboximidamido-3-methyl-d3-butanamide-d5-octa-deuterated-jd5037
#13
Malliga R Iyer, Resat Cinar, Nathan J Coffey, Robert J Chorvat, George Kunos
JD5037 (1) is a potent and selective, peripherally acting inverse agonist of the cannabinoid (CB1 R) receptor. Peripheral CB1 receptor antagonists/inverse agonists have great potential in the treatment of metabolic disorders like type 2 diabetes, obesity and NASH. We report the synthesis of octa-deuterated [(2) H8 ]-JD5037 (S, S) (8) along with its (S, R) diastereomer (13) from commercially available L-valine-d8 starting material. The [(2) H8 ]-JD5037 compound will be used to quantitate unlabeled JD5037 during clinical ADME studies and will be used as an LC-MS/MS bioanalytical standard...
May 25, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28542386/correlation-between-plasma-endothelin-1-levels-and-severity-of-septic-liver-failure-quantified-by-maximal-liver-function-capacity-limax-test-a-prospective-study
#14
Magnus F Kaffarnik, Navid Ahmadi, Johan F Lock, Tilo Wuensch, Johann Pratschke, Martin Stockmann, Maciej Malinowski
AIM: To investigate the relationship between the degree of liver dysfunction, quantified by maximal liver function capacity (LiMAx test) and endothelin-1, TNF-α and IL-6 in septic surgical patients. METHODS: 28 septic patients (8 female, 20 male, age range 35-80y) were prospectively investigated on a surgical intensive care unit. Liver function, defined by LiMAx test, and measurements of plasma levels of endothelin-1, TNF-α and IL-6 were carried out within the first 24 hours after onset of septic symptoms, followed by day 2, 5 and 10...
2017: PloS One
https://www.readbyqxmd.com/read/28537724/palladium-catalyzed-enantioselective-arylation-of-aryl-sulfenate-anions-a-combined-experimental-and-computational-study
#15
Tiezheng Jia, Mengnan Zhang, Samuel P McCollom, Ana Bellomo, Sonia Montel, Jianyou Mao, Spencer D Dreher, Christopher J Welch, Erik L Regalado, R Thomas Williamson, Brian C Manor, Neil C Tomson, Patrick J Walsh
A novel approach to produce chiral diaryl sulfoxides from aryl benzyl sulfoxides and aryl bromides via an enantioselective arylation of aryl sulfenate anions is reported. A (JosiPhos)Pd-based catalyst successfully promotes the asymmetric arylation reaction with good functional group compatibility. A wide range of enantioenriched diaryl, aryl heteroaryl, and even diheteroaryl sulfoxides were generated. Many of the sulfoxides prepared herein would be difficult to prepare via classic enantioselective oxidation of sulfides, including Ph(Ph-d5)SO (90% ee, 95% yield)...
June 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28534606/standardized-reporting-of-functioning-information-on-icf-based-common-metrics
#16
Birgit Prodinger, Alan Tennant, Gerold Stucki
BACKGROUND: In clinical practice and research a variety of clinical data collection tools are used to collect information on people's functioning for clinical practise and research and National Health Information Systems. Reporting on ICF-based common metrics enables standardized documentation of functioning information in national health information systems. OBJECTIVE: The objective of this methodological note on applying the ICF in rehabilitation is to demonstrate how to report functioning information collected with a data collection tool on ICF-based common metrics...
May 23, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28530752/active-metal-template-synthesis-of-a-neutral-indolocarbazole-containing-2-rotaxane-host-system-for-selective-oxoanion-recognition
#17
Asha Brown, Thomas Lang, Kathleen M Mullen, Paul D Beer
An active metal template strategy was used to synthesise a neutral indolocarbazole containing [2]rotaxane anion host system. (1)H NMR anion binding investigations reveal that the [2]rotaxane recognises a range of monoanions in acetone-d5 : D2O 95 : 5 with an unusual interlocked host selectivity for acetate and dihydrogenphosphate oxoanions over halides. The rotaxane displays an overall selectivity for the sulfate dianion, favouring a 2 : 1 host : guest binding stoichiometry at low sulfate concentration and a 1 : 1 stoichiometry in the presence of excess sulfate...
May 31, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28521812/radiotherapy-improves-serum-fatty-acids-and-lipid-profile-in-breast-cancer
#18
Sana Shaikh, Naseem Aslam Channa, Farha Naz Talpur, Muhammad Younis, Naila Tabassum
BACKGROUND: Breast cancer is a disease with diverse clinical symptoms, molecular profiles, and its nature to response its therapeutic treatments. Radiotherapy (RT), along with surgery and chemotherapy is a part of treatment in breast cancer. The aim of present study was to investigate pre and post treatment effects of radiotherapy in serum fatty acids and its lipids profile in patients with breast cancer. METHODS: In this comparative as well as follow up study, Serum fatty acids were performed by gas chromatography to investigate fatty acids and Microlab for analysis of lipid profile...
May 18, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28520922/gc-ms-method-for-quantification-of-mephedrone-in-human-blood-sample
#19
Khaled M Mohamed
Abuse of mephedrone (4-methylmethcathinone) has emerged among the last few years. Intoxication and fatality associated with mephedrone have been reported in the literature. The present work describes a simple and rapid gas chromatography-mass spectrometry (GC-MS) method for detection and quantification of mephedrone in human blood samples using GC-MS. Blood was deproteinated with acetonitrile and the supernatant was derivatized and extracted in a single step with ethyl chloroformate and ethyl acetate. Methamphetamine-d5 was used as an internal standard (IS)...
May 18, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28515379/alternative-internal-standard-calibration-of-an-indirect-enzymatic-analytical-method-for-2-mcpd-fatty-acid-esters
#20
Kazuo Koyama, Kinuko Miyazaki, Kousuke Abe, Yoshitsugu Egawa, Toru Fukazawa, Tadashi Kitta, Takashi Miyashita, Toru Nezu, Hidenori Nohara, Takashi Sano, Yukinari Takahashi, Hideji Taniguchi, Hiroshi Yada, Kumiko Yamazaki, Yomi Watanabe
An indirect enzymatic analysis method for the quantification of fatty acid esters of 2-/3-monochloro-1,2-propanediol (2/3-MCPD) and glycidol was developed, using the deuterated internal standard of each free-form component. A statistical method for calibration and quantification of 2-MCPD-d5, which is difficult to obtain, is substituted by 3-MCPD-d5 used for calculation of 3-MCPD. Using data from a previous collaborative study, the current method for the determination of 2-MCPD content using 2-MCPD-d5 was compared to three alternative new methods using 3-MCPD-d5...
May 17, 2017: Journal of Oleo Science
keyword
keyword
81965
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"