keyword
MENU ▼
Read by QxMD icon Read
search

D5

keyword
https://www.readbyqxmd.com/read/28092229/decamethylcyclopentasiloxane-d5
#1
(no author information available yet)
Decamethylcyclopentasiloxane (D5; CAS No. 541-02-6) is a precursor in the production of siloxane polymers for industry and medicine and is a carrier ingredient in many toiletries and cosmetics. D5 has a relatively low order of toxicity following acute administration via the oral, dermal, and inhalation routes of exposure. It is not considered to be a dermal or eye irritant or a dermal sensitizer. There is no appreciable dermal absorption of D5 based on results from in vivo and in vitro studies. It has not been shown to be genotoxic/mutagenic when tested in a number of short-term in vitro and in vivo assays and did not cause reproductive or developmental toxicity in rats...
January 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28088045/uhplc-ms-ms-method-for-the-quantitation-of-penicillin-g-and-metabolites-in-citrus-fruit-using-internal-standards
#2
Daniele Canzani, Kevin Hsieh, Matthew Standland, Walter Hammack, Fadi Aldeek
Penicillin G has been applied to citrus trees as a potential treatment in the fight against Huanglongbing (HLB). Here, we have developed and validated a method to identify and quantitate penicillin G and two of its metabolites, penillic acid and penilloic acid, in citrus fruit using ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). This method improves upon a previous method by incorporating isotopically labeled internal standards, namely, penillic acid-D5, and penilloic acid-D5...
January 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28077128/treatment-planning-comparison-of-impt-vmat-and-4%C3%AF-radiotherapy-for-prostate-cases
#3
Angelia Tran, Jingjing Zhang, Kaley Woods, Victoria Yu, Dan Nguyen, Gary Gustafson, Lane Rosen, Ke Sheng
BACKGROUND: Intensity-modulated proton therapy (IMPT), non-coplanar 4π intensity-modulated radiation therapy (IMRT), and volumetric-modulated arc therapy (VMAT) represent the most advanced treatment methods based on heavy ion and X-rays, respectively. Here we compare their performance for prostate cancer treatment. METHODS: Ten prostate patients were planned using IMPT with robustness optimization, VMAT, and 4π to an initial dose of 54 Gy to a clinical target volume (CTV) that encompassed the prostate and seminal vesicles, then a boost prescription dose of 25...
January 11, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28072925/impact-of-low-and-high-doses-of-marbofloxacin-on-the-selection-of-resistant-enterobacteriaceae-in-the-commensal-gut-flora-of-young-cattle-discussion-of-data-from-2-study-populations
#4
Guillaume Lhermie, Véronique Dupouy, Farid El Garch, Nadine Ravinet, Pierre-Louis Toutain, Alain Bousquet-Mélou, Henri Seegers, Sébastien Assié
In the context of requested decrease of antimicrobial use in veterinary medicine, our objective was to assess the impact of two doses of marbofloxacin administered on young bulls (YBs) and veal calves (VCs) treated for bovine respiratory disease, on the total population of Enterobacteriaceae in gut flora and on the emergence of resistant Enterobacteriaceae. In two independent experiments, 48 YBs from 6 commercial farms and 33 VCs previously colostrum deprived and exposed to cefquinome were randomly assigned to one of the three groups LOW, HIGH, and Control...
January 10, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28069281/-effect-of-donor-graft-characteristics-on-clinical-outcomes-in-descemet-stripping-automated-endothelial-keratoplasty-dsaek
#5
G Ho Wang Yin, M Sampo, S Soare, L Hoffart
INTRODUCTION: The purpose of our study was to evaluate the progression of lamellar corneal grafts after endothelial keratoplasty by Descemet stripping automated endothelial keratoplasty (DSAEK) and the effect of their characteristics on the clinical and functional results. MATERIALS AND METHODS: This was a prospective study in which 74 patients who had undergone endothelial keratoplasty by DSAEK were included. The corneal grafts were obtained from a French tissue bank and were delivered in a preservation medium containing a deturgescent agent (Corneajet(®) or Stemalpha 3(®))...
January 6, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28065787/intestinal-farnesoid-x-receptor-controls-transintestinal-cholesterol-excretion-in-mice
#6
Jan Freark de Boer, Marleen Schonewille, Marije Boesjes, Henk Wolters, Vincent W Bloks, Trijnie Bos, Theo H van Dijk, Angelika Jurdzinski, Renze Boverhof, Justina C Wolters, Jan A Kuivenhoven, Jan M van Deursen, Ronald P J Oude Elferink, Antonio Moschetta, Claus Kremoser, Henkjan J Verkade, Folkert Kuipers, Albert K Groen
BACKGROUND & AIMS: The role of the intestine in the maintenance of cholesterol homeostasis is increasingly recognized. Fecal excretion of cholesterol is the last step in the atheroprotective reverse cholesterol transport pathway, to which biliary and transintestinal cholesterol excretion (TICE) contribute. The mechanisms controlling the flux of cholesterol through the TICE pathway are, however, poorly understood. We aimed to identify mechanisms that regulate and stimulate TICE. METHODS: We performed studies with C57Bl/6J mice, as well as mice with intestine-specific knockout of the farnesoid X receptor (FXR), mice that express an FXR transgene specifically in the intestine, and ABCG8-knockout mice...
January 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28065748/the-effects-of-early-life-stress-on-dopamine-system-function-in-adolescent-female-rats
#7
Iwona Majcher-Maślanka, Anna Solarz, Krzysztof Wędzony, Agnieszka Chocyk
During adolescence, many neural systems, including the dopamine system, undergo essential remodeling and maturation. It is well known that early-life stress (ELS) increases the risk for many psychopathologies during adolescence and adulthood. It is hypothesized that ELS interferes with the maturation of the dopamine system. There is a sex bias in the prevalence of stress-related mental disorders. Information regarding the effects of ELS on brain functioning in females is very limited. In the current study, maternal separation (MS) procedures were carried out to study the effects of ELS on dopamine system functioning in adolescent female rats...
January 5, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28060819/an-anti-human-lutheran-glycoprotein-phage-antibody-inhibits-cell-migration-on-laminin-511-epitope-mapping-of-the-antibody
#8
Yurie Enomoto-Okawa, Yuka Maeda, Nozomi Harashima, Yumika Sugawara, Fumihiko Katagiri, Kentaro Hozumi, Kam Man Hui, Motoyoshi Nomizu, Yuji Ito, Yamato Kikkawa
The Lutheran glycoprotein (Lu), also known as basal cell adhesion molecule (B-CAM), is an Ig superfamily (IgSF) transmembrane receptor for laminin α5. Although Lu is not present in normal hepatocytes, its expression is significantly increased in hepatocellular carcinoma (HCC). In this study, we isolated thirteen phage antibodies to Lu from a phage library of peripheral blood from HCC patients, suggesting that these patients produced autoantibodies against endogenous Lu. To characterize the phage antibodies, we determined the Lu domains they recognize...
2017: PloS One
https://www.readbyqxmd.com/read/28057080/combination-of-alpha-synuclein-immunotherapy-with-anti-inflammatory-treatment-in-a-transgenic-mouse-model-of-multiple-system-atrophy
#9
Elvira Valera, Brian Spencer, Jerel A Fields, Ivy Trinh, Anthony Adame, Michael Mante, Edward Rockenstein, Paula Desplats, Eliezer Masliah
Multiple system atrophy (MSA) is a fatal neurodegenerative disorder characterized by the pathological accumulation of alpha-synuclein (α-syn) in oligodendrocytes. Therapeutic efforts to stop or delay the progression of MSA have yielded suboptimal results in clinical trials, and there are no efficient treatments currently available for MSA patients. We hypothesize that combining therapies targeting different aspects of the disease may lead to better clinical outcomes. To test this hypothesis, we combined the use of a single-chain antibody targeting α-syn modified for improved central nervous system penetration (CD5-D5) with an unconventional anti-inflammatory treatment (lenalidomide) in the myelin basic protein (MBP)-α-syn transgenic mouse model of MSA...
January 5, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28050955/the-impact-of-male-age-on-embryo-quality-a-retrospective-study-using-time-lapse-imaging
#10
Guilherme R F Rosário, Diana S Vidal, Adriana V Silva, Antônio C C Franco
OBJECTIVE: This study aimed to correlate male age with embryo morphokinetic parameters on D3 considering the timing and the exact moment of embryo cleavage. METHODS: Time-lapse imaging was used to produce an ideal cleavage curve for the embryos analyzed. The percentage of embryos under the curve was analyzed and correlated with male age. RESULTS: 32.6% of the embryos from patients aged 28-33 years were under the curve; 36.2% of the embryos from patients aged 34-39 years were under the curve; 41...
December 1, 2016: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28048742/su-f-t-192-study-of-robustness-analysis-method-of-multiple-field-optimized-impt-plans-for-head-neck-patients
#11
Y Li, X Wang, H Li, J Wang, X Zhu, Y Li, S Frank, X Zhang
PURPOSE: Proton therapy is more sensitive to uncertainties than photon treatments due to protons' finite range depending on the tissue density. Worst case scenario (WCS) method originally proposed by Lomax has been adopted in our institute for robustness analysis of IMPT plans. This work demonstrates that WCS method is sufficient enough to take into account of the uncertainties which could be encountered during daily clinical treatment. METHODS: A fast and approximate dose calculation method is developed to calculate the dose for the IMPT plan under different setup and range uncertainties...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048681/mo-fg-campus-tep2-02-first-experiences-and-perspectives-in-using-direct-multicriteria-optimization-mco-on-volumetric-modulated-arc-therapy-vmat-for-head-and-neck-cancer
#12
Samantha Edgington, Christopher Cotter, Paul Busse, Bruce Crawford, Yi Wang
PURPOSE: To report the first experiences and perspectives in using direct multicriteria optimization (MCO) on volumetric-modulated arc therapy (VMAT) for head and neck (H&N) cancer. METHODS: Ten prior patients with tumors in representative H&N regions were selected to evaluate direct MCO-VMAT in RayStation v5.0 beta. The patients were previously treated by intensity-modulated radiation therapy (IMRT) with MCO on an Elekta linear accelerator with Agility multileaf collimator...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048619/su-f-t-382-volumetric-modulated-arc-therapy-vmat-beam-angle-optimization-in-pulsed-partial-brain-irradiation-ppbi-for-newly-diagnosed-glioblastoma
#13
J Zhou, Y Wang, X Ding, J Liang, D Yan, B Marples, J Dilworth
PURPOSE: To optimize VMAT beam parameters in PPBI to minimize treatment time. We investigate the coverage and organs at risk (OR) avoidance capability of shorter arcs with shorter treatment times. METHODS: We evaluated the treatment plans for eleven previously treated PPBI patients. Each patient received 46Gy (2Gy×23) to the initial target and an additional 14Gy (2Gy×7) as a sequential boost. Each daily 2-Gy fraction was delivered as ten 0.2-Gy pulses separated by 3-minute intervals using VMAT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048495/su-f-t-419-evaluation-of-planiq-feasibility-dvh-as-planning-objectives-for-skull-base-sbrt-patients
#14
W Jiang, H Wang, P Chi
PURPOSE: PlanIQ(Sun Nuclear Corporation) can provide feasibility measures on organs-at-risk(OARs) around the target based on depth, local anatomy density and energy of radiation beam used. This study is to test and evaluate PlanIQ feasibility DVHs as optimization objectives in the treatment planning process, and to investigate the potential to use them in routine clinical cases to improve planning efficiency. METHODS: Two to three arcs VMAT Treatment plans were generated in Pinnacle based on PlanIQ feasibility DVH for six skull base patients who previously treated with SBRT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048022/su-f-t-189-dosimetric-comparison-of-spot-scanning-proton-therapy-techniques-for-liver-tumors-close-to-the-skin-surface
#15
S Takao, T Matsuura, Y Matsuzaki, Y Fujii, T Fujii, N Katoh, S Shimizu, K Umegaki, H Shirato
PURPOSE: Spot-scanning technique has been utilized to achieve conformal dose distribution to large and complicated tumors. This technique generally does not require patient-specific devices such as aperture and compensator. The commercially available spot-scanning proton therapy (SSPT) systems, however, cannot deliver proton beams to the region shallower than 4 g/cm2. Therefore some range compensation device is required to treat superficial tumors with SSPT. This study shows dosimetric comparison of the following treatment techniques: (i) with a tabletop bolus, (ii) with a nozzle-mounted applicator, and (iii) without any devices and using intensity-modulated proton therapy (IMPT) technique...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047787/th-ab-bra-02-automated-triplet-beam-orientation-optimization-for-mri-guided-co-60-radiotherapy
#16
D Nguyen, D Thomas, M Cao, D O'Connor, J Lamb, K Sheng
PURPOSE: MRI guided Co-60 provides daily and intrafractional MRI soft tissue imaging for improved target tracking and adaptive radiotherapy. To remedy the low output limitation, the system uses three Co-60 sources at 120° apart, but using all three sources in planning is considerably unintuitive. We automate the beam orientation optimization using column generation, and then solve a novel fluence map optimization (FMO) problem while regularizing the number of MLC segments. METHODS: Three patients-1 prostate (PRT), 1 lung (LNG), and 1 head-and-neck boost plan (H&NBoost)-were evaluated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047221/we-ab-209-08-novel-beam-specific-adaptive-margins-for-reducing-organ-at-risk-doses
#17
H Tsang, C P Kamerling, P Ziegenhein, S Nill, U Oelfke
PURPOSE: Current practice of using 3D margins in radiotherapy with high-energy photon beams provides larger-than-required target coverage. According to the photon depth-dose curve, target displacements in beam direction result in minute changes in dose delivered. We exploit this behavior by generating margins on a per-beam basis which simultaneously account for the relative distance of the target and adjacent organs-at-risk (OARs). METHODS: For each beam, we consider only geometrical uncertainties of the target location perpendicular to beam direction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047056/th-ef-brb-03-significant-cord-and-esophagus-dose-reduction-by-4%C3%AF-non-coplanar-spine-stereotactic-body-radiation-therapy-and-stereotactic-radiosurgery
#18
V Yu, A Tran, D Nguyen, K Woods, M Cao, T Kaprealian, R Chin, D Low, K Sheng
PURPOSE: To demonstrate significant organ-at-risk (OAR) sparing achievable with 4π non-coplanar radiotherapy on spine SBRT and SRS patients. METHODS: Twenty-five stereotactic spine cases previously treated with VMAT (n = 23) or IMRT (n = 2) were included in this study. A computer-aided-design model of a Linac with a 3D-scanned human surface was utilized to determine the feasible beam space throughout the 4π steradian and beam specific source-to-target-distances (STD) required for collision avoidance...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046924/th-cd-209-11-simulation-study-of-real-time-image-gating-on-spot-scanning-proton-therapy-for-lung-tumors
#19
T Kanehira, T Matsuura, S Takao, Y Matsuzaki, Y Fujii, T Fujii, N Miyamoto, T Inoue, N Katoh, S Shimizu, K Umegaki, H Shirato
PURPOSE: To study the impact of a real-time-image gating on spot scanning proton therapy for lung tumors and to examine the suitable size of the gating window (GW). METHODS: We investigated a real-time-image gated proton therapy (RGPT), in which two fluoroscopic units monitor a gold sphere fiducial in real-time, and the proton beam is irradiated only when the marker enters within the pre-assigned GW. We designed 5 treatment plans for 7 lung cancer patients: RGPT with a GW of ±1, 2, 5, and 8 mm and free-breathing proton therapy (FBPT) using the end-exhale and average images of 4-dimensional (4D) CT, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046762/su-f-j-162-is-bulky-electron-density-assignment-appropriatefor-mri-only-based-treatment-planning-for-lung-cancer
#20
P Prior, X Chen, C Johnstone, E Gore, X Li
PURPOSE: To assess the appropriateness of bulky electron density assisment for MRI-only treatment planning for lung cancer via comparing dosimetric difference between MRI- and CT-based plans. METHODS: Planning 4DCTs acquired for six representative lung cancer patients were used to generate CT-based IMRT plans. To avoid the effect of anatomic difference between CT and MRI, MRI-based plans were generated using CTs by forcing the relative electron density (rED) of organ specific values from ICRU report 46 and using the mean rED value of the internal target volume (ITV) of the patient for the ITV...
June 2016: Medical Physics
keyword
keyword
81965
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"