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https://www.readbyqxmd.com/read/28214075/asymmetric-total-synthesis-of-tetrahydroprotoberberine-derivatives-and-evaluation-of-their-binding-affinities-at-dopamine-receptors
#1
David Y W Lee, Jing Liu, Shuzhen Zhang, Peng Huang, Lee-Yuan Liu-Chen
Cocaine addiction remains a serious challenge for clinical and medical research because there is no effective pharmacological treatment. l-THP, a natural product isolated from Corydalis yanhusuo W.T. Wang, is one of the most frequently used traditional herbs to treat drug addiction in China. Our laboratory first reported that its demethylated metabolites l-ICP, l-CD, and l-CP had high affinity at dopamine D1, D2, and D5 receptors. Here we report the chemical synthesis of these metabolites and other derivatives and their binding affinities at dopamine receptors...
January 31, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28210467/diversity-and-distribution-of-culturable-lactic-acid-bacterial-species-in-indonesian-sayur-asin
#2
Wibowo Mangunwardoyo, Abinawanto, Andi Salamah, Endang Sukara, Sulistiani, Achmad Dinoto
BACKGROUND AND OBJECTIVES: Lactic acid bacteria (LAB) play important roles in processing of Sayur Asin (spontaneously fermented mustard). Unfortunately, information about LAB in Indonesian Sayur Asin, prepared by traditional manufactures which is important as baseline data for maintenance of food quality and safety, is unclear. The aim of this study was to describe the diversity and distribution of culturable lactic acid bacteria in Sayur Asin of Indonesia. MATERIALS AND METHODS: Four Sayur Asin samples (fermentation liquor and fermented mustard) were collected at harvesting times (3-7 days after fermentation) from two traditional manufactures in Tulung Agung (TA) and Kediri (KDR), East Java provinces, Indonesia...
August 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28208097/distribution-characteristics-of-volatile-methylsiloxanes-in-tokyo-bay-watershed-in-japan-analysis-of-surface-waters-by-purge-and-trap-method
#3
Yuichi Horii, Kotaro Minomo, Nobutoshi Ohtsuka, Mamoru Motegi, Kiyoshi Nojiri, Kurunthachalam Kannan
Surface waters including river water and effluent from sewage treatment plants (STPs) were collected from Tokyo Bay watershed, Japan, and analyzed for seven cyclic and linear volatile methylsiloxanes (VMSs), i.e., D3, D4, D5, D6, L3, L4, and L5 by an optimized purge and trap extraction method. The total concentrations of seven VMSs (ΣVMS) in river water ranged from <4.9 to 1700ng/L (mean: 220ng/L). The individual mean concentrations of cyclic VMSs in surface waters were; 10ng/L for D3, 13ng/L for D4, 180ng/L for D5, and 18ng/L for D6...
February 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28197204/effects-of-combined-simultaneous-and-sequential-endostar-and-cisplatin-treatment-in-a-mice-model-of-gastric-cancer-peritoneal-metastases
#4
Lin Jia, Shuguang Ren, Tao Li, Jianing Wu, Xinliang Zhou, Yan Zhang, Jianhua Wu, Wei Liu
Objective. Aimed to study the effects of endostar and cisplatin using an in vivo imaging system (IVIS) in a model of peritoneal metastasis of gastric cancer. Methods. NUGC-4 gastric cancer cells transfected with luciferase gene (NUGC-4-Luc) were injected i.p. into nude mice. One week later, mice were randomly injected i.p.: group 1, cisplatin (d1-3) + endostar (d4-7); group 2, endostar (d1-4) + cisplatin (d5-7); group 3, endostar + cisplatin d1, 4, and 7; group 4, saline for two weeks. One week after the final administration, mice were sacrificed...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28194093/effects-of-an-amylopectin-and-chromium-complex-on-the-anabolic-response-to-a-suboptimal-dose-of-whey-protein
#5
T N Ziegenfuss, H L Lopez, A Kedia, S M Habowski, J E Sandrock, B Raub, C M Kerksick, A A Ferrando
BACKGROUND: Previous research has demonstrated the permissive effect of insulin on muscle protein kinetics, and the enhanced insulin sensitizing effect of chromium. In the presence of adequate whole protein and/or essential amino acids (EAA), insulin has a stimulatory effect on muscle protein synthesis, whereas in conditions of lower blood EAA concentrations, insulin has an inhibitory effect on protein breakdown. In this study, we determined the effect of an amylopectin/chromium (ACr) complex on changes in plasma concentrations of EAA, insulin, glucose, and the fractional rate of muscle protein synthesis (FSR)...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28187377/simultaneous-quantification-of-reparixin-and-paclitaxel-in-plasma-and-urine-using-ultra-performance-liquid-chromatography-tandem-mass-spectroscopy-uhplc-ms-ms-application-to-a-preclinical-pharmacokinetic-study-in-rats
#6
Sarandeep Malhi, Nicholas Stesco, Samaa Alrushaid, Ted M Lakowski, Neal M Davies, Xiaochen Gu
A liquid chromatography-tandem mass spectroscopy (LC-MS/MS) assay was developed and validated to simultaneously quantify anticancer drugs reparixin and paclitaxel in this study. The compounds were extracted from plasma and urine samples by protein precipitation with acetone (supplemented with 0.1% formic acid). Chromatographic separation was achieved using a C18 column, and drug molecules were ionized using dual ion source electrospray and atmospheric pressure chemical ionization (DUIS: ESI-APCI). Reparixin and paclitaxel were quantified using negative and positive multiple reaction monitoring (MRM) mode, respectively...
February 3, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28187145/a-new-sythetic-hybrid-a1d5-between-gossypium-herbaceum-and-g-raimondii-and-its-morphological-cytogenetic-molecular-characterization
#7
Yuxiang Wu, Di Chen, Shuijin Zhu, Lufei Zhang, Lingjiao Li
The diploid species G. herbaceum (A1) and G. raimondii (D5) are the progenitors of allotetraploid cotton, respectively. However, hybrids between G. herbaceum and G. raimondii haven't been reported. In the present study, hybridization between G. herbaceum and G. raimondii was explored. Morphological, cytogenetic and molecular analyses were used to assess the hybridity. The interspecific hybrid plants were successfully obtained. Most of the morphological characteristics of the hybrids were intermediate between G...
2017: PloS One
https://www.readbyqxmd.com/read/28164671/urinary-intestine-fatty-acid-binding-protein-is-associated-with-poor-outcome-of-pneumonia-patients-in-intensive-care-unit
#8
Sai-Wai Ho, Shi-Chuan Chang, Lee-Wei Chen
BACKGROUND: Urinary intestine fatty acid binding protein (U-IFABP) is a biomarker for gut injury. Previous studies showed that enterocyte damage in critically ill patients was common and appeared to be associated with poor prognosis. However, the impact of enterocyte damage on the outcome of critically ill patients with pneumonia has not yet been well investigated. The aim of the study is to evaluate the prognostic value of U-IFABP in critically ill patients with pneumonia. METHODS: A prospective observational study was performed in the intensive care unit (ICU) from September 1, 2013 to April 30, 2014...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28162594/-354-dopamine-d1-d5-receptor-mediated-mechanisms-in-the-maintenance-of-pathological-pain-plasticity
#9
S Megat
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28161596/polygoni-multiflori-radix-derived-anthraquinones-alter-bile-acid-disposition-in-sandwich-cultured-rat-hepatocytes
#10
Li Kang, Luqin Si, Jing Rao, Dan Li, Ya Wu, Sanlan Wu, Minghui Wu, Sijie He, Wenwen Zhu, Yang Wu, Jiaqiang Xu, Gao Li, Jiangeng Huang
Hepatic adverse reaction associated with Polygoni Multiflori Radix (PMR) has been frequently reported in recent years. Highly-enriched anthraquinones (AQs) in PMR, such as emodin, chrysophanol and physcion, have been found to be hepatotoxic. In the present study, sandwich-cultured rat hepatocytes (SCRHs) were employed to investigate the effect of individual and combined AQs on the disposition of endogenous bile acids (BAs) and exogenous probe substrates including deuterium-labeled taurocholate (d5-TCA), glycochenodeoxycholic acid (d4-GCDCA) and 5 (and 6)-carboxy-2,7'dichlorofluorescein (CDF)...
February 1, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28153252/a-novel-method-for-the-determination-of-glycidyl-and-3-monochloropropanediol-esters-in-fish-oil-by-gas-chromatography-tandem-mass-spectrometry
#11
A Garballo-Rubio, J Soto-Chinchilla, A Moreno, A Zafra-Gómez
Today, food security is one of the most important global issues with food quality control and identification of contaminants in foods and beverages, being crucial for human health and safety. In this paper, a novel single-step method for the simultaneous determination of 3-monochloropropanediol (3-MCPD) and glycidyl esters in samples of winterized and non-winterized fish oil by using gas chromatography tandem mass spectrometry (GC-MS/MS) is validated. The method is based on alkaline hydrolysis of esters at room temperature, using only 3-MCPD-d5 as internal standard, and a derivatization step with phenylboronic acid (PBA) at 90°C...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28150727/development-of-a-multilocus-based-approach-for-sponge-phylum-porifera-identification-refinement-and-limitations
#12
Qi Yang, Christopher M M Franco, Shirley J Sorokin, Wei Zhang
For sponges (phylum Porifera), there is no reliable molecular protocol available for species identification. To address this gap, we developed a multilocus-based Sponge Identification Protocol (SIP) validated by a sample of 37 sponge species belonging to 10 orders from South Australia. The universal barcode COI mtDNA, 28S rRNA gene (D3-D5), and the nuclear ITS1-5.8S-ITS2 region were evaluated for their suitability and capacity for sponge identification. The highest Bit Score was applied to infer the identity...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28144113/clinical-implications-of-eclipse-analytical-anisotropic-algorithm-and-acuros-xb-algorithm-for-the-treatment-of-lung-cancer
#13
Gangarapu Sri Krishna, Vuppu Srinivas, Palreddy Yadagiri Reddy
The aim of the present study was to investigate the dose-volume variations of planning target volume (PTV) and organs at risks (OARs) in 15 left lung cancer patients comparing analytical anisotropic algorithm (AAA) versus Acuros XB algorithm. Originally, all plans were created using AAA with a template of dose constraints and optimization parameters, and the patients were treated using intensity modulated radiotherapy. In addition, another set of plans was created by performing only dose calculations using Acuros algorithm without doing any reoptimization...
October 2016: Journal of Medical Physics
https://www.readbyqxmd.com/read/28143399/expansion-and-stress-responses-of-the-ap2-erebp-superfamily-in-cotton
#14
Chunxiao Liu, Tianzhen Zhang
BACKGROUND: The allotetraploid cotton originated from one hybridization event between an extant progenitor of Gosssypium herbaceum (A1) or G. arboreum (A2) and another progenitor, G. raimondii Ulbrich (D5) 1-1.5 million years ago (Mya). The APETALA2/ethylene-responsive element binding protein (AP2/EREBP) transcription factors constitute one of the largest and most conserved gene families in plants. They are characterized by their AP2 domain, which comprises 60-70 amino acids, and are classified into four main subfamilies: the APETALA2 (AP2), Related to ABI3/VP1 (RAV), Dehydration-Responsive Element Binding protein (DREB) and Ethylene-Responsive Factor (ERF) subfamilies...
January 31, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28142338/toxicity-assessment-of-molindone-hydrochloride-a-dopamine-d2-d5-receptor-antagonist-in-juvenile-and-adult-rats
#15
Gopala Krishna, Gopa Gopalakrishnan, Saryu Goel
Neuroleptic drug molindone hydrochloride is a dopamine D2/D5 receptor antagonist and it is in late stage development for the treatment of impulsive aggression in children and adolescents who have attention deficient/hyperactivity disorder (ADHD). This new indication for this drug would expand the target population to include younger patients, and therefore, toxicity assessments in juvenile animals were undertaken in order to determine susceptibility differences, if any, between this age group and the adult rats...
January 31, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28131091/lipophilicity-is-a-key-factor-to-increase-the-antiviral-activity-of-hiv-neutralizing-antibodies
#16
Marcelo T Augusto, Axel Hollmann, Fulvia Troise, Ana S Veiga, Antonello Pessi, Nuno C Santos
The HIV broadly neutralizing antibody 2F5 targets the transiently exposed epitope in the membrane proximal external region (MPER) of HIV-1 gp41, by a two-step mechanism involving the viral membrane and this viral glycoprotein. It was recently shown that 2F5 conjugation with a cholesterol moiety outside of the antibody paratope substantially increases its antiviral activity. Additionally, the antiviral activity of D5, a human antibody that binds to the N-terminal heptad repeat (NHR) of gp41 and lacks membrane binding, was boosted by the same cholesterol conjugation...
January 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28127421/pre-operative-anaemia-is-associated-with-total-morbidity-burden-on-days-3-and-5-after-cardiac-surgery-a-cohort-study
#17
Julie Sanders, Jackie A Cooper, Daniel Farrar, Simon Braithwaite, Updeshbir Sandhu, Michael G Mythen, Hugh E Montgomery
BACKGROUND: Pre-operative anaemia is associated with mortality and red blood cell (RBC) transfusion requirement after cardiac surgery. However, the effect on post-operative total morbidity burden (TMB) is unknown. We explored the effect of pre-operative anaemia on post-operative TMB. METHODS: Data were drawn from the Cardiac Post-Operative Morbidity Score (C-POMS) development study (n = 442). C-POMS describes and quantifies (0-13) TMB after cardiac surgery by noting the presence/absence of 13 morbidity domains on days 3 (D3), 5 (D5), 8 (D8) and 15 (D15)...
2017: Perioperative Medicine
https://www.readbyqxmd.com/read/28126308/large-scale-retrospective-monte-carlo-dosimetric-study-for-permanent-implant-prostate-brachytherapy
#18
Nelson Miksys, Eric Vigneault, Andre-Guy Martin, Luc Beaulieu, Rowan M Thomson
PURPOSE: To retrospectively compare water-based and full tissue model Monte Carlo dose calculations in a large cohort of patients undergoing (125)I permanent implant prostate brachytherapy. METHODS AND MATERIALS: For 613 patients, EGSnrc BrachyDose dose calculations were performed in 2 virtual patient models: TG43sim (simulated American Association of Physicists in Medicine Task Group Report 43 conditions) and MCref (computed tomography-derived heterogeneous tissue model with interseed effects)...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28122284/periodic-elevation-of-regulatory-t-cells-on-the-day-of-embryo-transfer-is-associated-with-better-in-vitro-fertilization-outcome
#19
Wen-Juan Wang, Fu-Jun Liu, Xia Zhang, Xue-Mei Liu, Qing-Lan Qu, Feng-Hua Li, Li-Li Zhuang, Xiao-Xiao Li, Cui-Fang Hao
Treg cells have been shown to be important in maintaining maternofetal tolerance, but the expression of Tregs in assisted reproductive technology (ART) in women on the day of embryo transfer (D0), 5days (D5) and 14days after ET (D14); the related factors influencing the expression levels of Tregs; the proliferation ability and the relevant cytokine epression by Tregs on D14 have not been investigated. In this study, 124 women undergoing in vitro fertilization-intracytoplasmic sperm injection (IVF/ICSI) were enrolled...
January 19, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28121989/reduced-ectopic-pregnancy-rate-on-day-5-embryo-transfer-compared-with-day-3-a-meta-analysis
#20
Bingqian Zhang, Linlin Cui, Rong Tang, Lingling Ding, Lei Yan, Zi-Jiang Chen
OBJECTIVE: To compare the risk of ectopic pregnancy (EP) after embryo transfer on day 3(D3-ET) and day 5(D5-ET). DESIGN: Meta-analysis. PATIENTS: Women with pregnancy resulting from in vitro undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). RESULT(S): Twenty-two studies were identified through research conducted using the PubMed, Embase, and Cochrane databases and ClinicalTrials.gov...
2017: PloS One
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