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Jenna N Dietrich, Hasan Kazmi
BACKGROUND: The Impella manufacturer has changed its recommendation for the diluent of the heparinized purge solution from 20% dextrose (D20) to 5% dextrose (D5). This reduced viscosity may result in increased purge solution infusion rates and unfractionated heparin (UFH) exposure. Increased UFH exposure could potentially cause increased bleeding events and may necessitate reduction in UFH concentration in the purge solution. Our objective was to evaluate anticoagulation for patients on Impella pumps receiving heparinized purge solution with D20 or D5 diluents...
January 1, 2018: Journal of Pharmacy Practice
Maria C Vitor de Souza Brangioni, Danilo A Pereira, Aurore Thibaut, Felipe Fregni, Joaquim P Brasil-Neto, Raphael Boechat-Barros
Transcranial direct current stimulation (tDCS) applied over the dorsolateral prefrontal cortex (DLPFC) has been shown to reduce cravings in tobacco addiction; however, results have been somewhat mixed. In this study, we hypothesized that motivation to quit smoking is a critical factor of tDCS effects in smokers. Therefore, we conducted a double-blind, randomized clinical trial to evaluate the effects of both tDCS and motivation to quit on cigarette consumption and the relationship between these two factors...
2018: Frontiers in Pharmacology
Bart C H van der Nagel, Sophie Wassenaar, Soma Bahmany, Birgit C P Koch
BACKGROUND: Detection of alcohol consumption after a longer period of time can be useful in certain patient groups. To monitor chronic alcohol consumption, a novel analytical method for the quantification of phosphatidylethanols (PEth) was developed and validated using ultra performance convergence chromatography tandem mass spectrometry. METHODS: The main phosphatidylethanols -Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol (POPEth), 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanol (PLPEth), and 1,2-Dioleoyl-sn-glycero-3-phosphoethanol (DOPEth) were analyzed using a simple and fast sample preparation protocol followed by chromatographic separation using ultra performance convergence chromatography, a novel kind of supercritical fluid chromatography...
February 8, 2018: Therapeutic Drug Monitoring
Esfandiar Azadmarzabadi, Arvin Haghighatfard, Alireza Mohammadi
BACKGROUND: In stressful situations, a person's ability to appropriately complete tasks with minimal anxiety is known as stress resilience. Genetic variants in neuropeptide Y, Corticotropin releasing hormone receptor 1 (CRHR1), and serotonin transporter have been previously reported to be associated with low resilience, but the relationship between low resilience and the dopaminergic signalling pathway is not well understood. Here, we aimed to describe the association between comprehensive psychological characteristics and messenger RNA levels of dopamine receptor D1 (DRD1), dopamine receptor D2 (DRD2), dopamine receptor D3 (DRD3), dopamine receptor D4 (DRD4), dopamine receptor D5 (DRD5), COMT, Dopamine Beta-Hydroxylase (DBH), Tyrosine hydroxylase (TH), monoamine oxidase A (MAOM), dopa decarboxylase (DDC), dopamine transporter (DAT), serotonin transporter (5-HTT), brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) genes based on peripheral blood samples from 400 subjects who react differently to major life event stressors...
February 8, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Saif Aljabab, Balamurugan Vellayappan, Eric Vandervoort, Jamie Bahm, Robert Zohr, John Sinclair, Jean-Michel Caudrelier, Janos Szanto, Shawn Malone
PURPOSE: The aim of this study is to compare the dosimetric differences between four techniques for spine stereotactic body radiotherapy (SBRT): CyberKnife (CK), volumetric modulated arc therapy (VMAT), and helical tomotherapy (HT) with dynamic jaws (HT-D) and fixed jaws (HT-F). MATERIALS/METHODS: Data from 10 patients were utilized. All patients were planned for 24 Gy in two fractions, with the primary objectives being: (a) restricting the maximum dose to the cord to ≤ 17 Gy and/or cauda equina to ≤ 20 Gy, and (b) to maximize the clinical target volume (CTV) to receive the prescribed dose...
February 7, 2018: Journal of Applied Clinical Medical Physics
Sang-Yoon Lee, Sunggyu Lee, Minkyu Choi, Kurunthachalam Kannan, Hyo-Bang Moon
Environmental contamination by siloxanes is a matter of concern due to their widespread consumption in personal care as well as industrial products and potential toxicity. Nevertheless, methods for simultaneous determination of cyclic and linear siloxanes in sediment are lacking. In this study, we developed an optimized analytical method to determine cyclic and linear siloxanes based on gas chromatography coupled to tandem mass spectrometry (GC-MS/MS). This method was applied to determine concentrations of 19 siloxane compounds in surface and core sediments from industrialized bays in Korea to assess contamination status, spatial distribution, and historical trends...
January 27, 2018: Environmental Pollution
Celine Defaix, Audrey Solgadi, Thu Ha Pham, Alain M Gardier, Pierre Chaminade, Laurent Tritschler
In vivo measurement of multiple neurotransmitters is highly interesting but remains challenging in the field of neuroscience. GABA and l-glutamic acid are the major inhibitory and excitatory neurotransmitters, respectively, in the central nervous system, and their changes are related to a variety of diseases such as anxiety and major depressive disorder. This study described a simple method allowing the simultaneous LC-MS/MS quantification of l-glutamic acid, glutamine and GABA. Analytes were acquired from samples of the prefrontal cortex by microdialysis technique in freely moving mice...
January 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
Matteo Moretti, Luisa Andrello, Silvia Visonà, Claudia Vignali, Angelo Groppi, Francesca Freni, Antonio Osculati, Luca Tajana, Luca Morini
The study aims the development and validation of a LC-MS/MS method for the identification and quantification of benzodiazepines and zolpidem in nails as alternative keratinized matrix to hair in long-term monitoring of anxiolytic and hypnotic drugs. Both fingernail and toenail samples (1-2 mm) were collected by clipping the excess overhang of the nail from volunteers and from postmortem cases. They were washed twice with organic solvents, dried under nitrogen stream, pulverized, immersed in a methanol solution (internal standard: diazepam-D5) and sonicated up to two hours...
January 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
Shun Mizuno, Xiao-Pen Lee, Masaya Fujishiro, Takaaki Matsuyama, Miho Yamada, Yuki Sakamoto, Maiko Kusano, Kei Zaitsu, Chika Hasegawa, Iwao Hasegawa, Takeshi Kumazawa, Akira Ishii, Keizo Sato
A new high-throughput method was developed for analysis of valproate in human plasma samples by QuEChERS extraction and gas chromatography-tandem mass spectrometry (GC-MS/MS). Plasma samples (0.2 ml) spiked with valproate and secobarbital-d5 (internal standard) were diluted with 1.3 ml of distilled water. Acetonitrile (1 ml) was added followed by 0.4 g MgSO4 and 0.1 g NaOAC. After a centrifugation step (2000 g for 10 min), 1 ml of the supernatant was transferred to a dispersive-solid phase extraction (dSPE) tube containing 150 mg MgSO4 and 50 mg C18...
February 3, 2018: Legal Medicine
Arnaud Hocquelet, Thibaut Auriac, Cynthia Perier, Clarisse Dromain, Marie Meyer, Jean-Baptiste Pinaquy, Alban Denys, Hervé Trillaud, Baudouin Denis De Senneville, Véronique Vendrely
AIM: To assess regular MRI findings and tumour texture features on pre-CRT imaging as potential predictive factors of event-free survival (disease progression or death) after chemoradiotherapy (CRT) for anal squamous cell carcinoma (ASCC) without metastasis. MATERIALS AND METHODS: We retrospectively included 28 patients treated by CRT for pathologically proven ASCC with a pre-CRT MRI. Texture analysis was carried out with axial T2W images by delineating a 3D region of interest around the entire tumour volume...
February 5, 2018: European Radiology
Dhiraj M Rathod, Keyur R Patel, Hiren N Mistri, Arvind G Jangid, Pranav S Shrivastav, Mallika Sanyal
A highly sensitive and selective high performance liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of alverine (ALV) and its active metabolite, para hydroxy alverine (PHA), in human plasma. For sample preparation, solid phase extraction of analytes was performed on Phenomenex Strata-X cartridges using alverine-d5 as the internal standard. The analytes were separated on Symmetry Shield RP18 (150 mm×3.9 mm, 5 µm) column with a mobile phase consisting of acetonitrile and 10 mM ammonium formate (65:35, v/v)...
April 2017: Journal of Pharmaceutical Analysis
S Proksch, J Brossart, K Vach, E Hellwig, M J Altenburger, L Karygianni
AIM: To investigate if a combination of mineral trioxide aggregate (MTA) and fluoride compounds affects bone cells. METHODOLOGY: MTA discs (ProRoot® , Dentsply Sirona, Ballaigues, Switzerland) with and without addition of 0.1%, 0.25%, and 0.5% sodium fluoride were characterized for their surface roughness by laser scanning microscopy and for the adhesion of human alveolar osteoblasts by scanning electron microscopy. Using eluates from fluoride-enriched MTA discs, the cell proliferation was measured by monitoring the DNA incorporation of 5-bromo-2'-deoxyuridine...
February 3, 2018: International Endodontic Journal
Mark A Smith, Gaylen E Fronk, Jean M Abel, Ryan T Lacy, Sarah E Bills, Wendy J Lynch
RATIONALE: Preclinical studies consistently report that aerobic exercise decreases drug self-administration and other forms of drug-seeking behavior; however, relatively few studies have examined other types of physical activity. OBJECTIVES: The purpose of the present study was to examine the effects of resistance exercise (i.e., strength training) on heroin self-administration and mRNA expression of genes known to mediate opioid reinforcement and addictive behavior in the nucleus accumbens (NAc) of heroin-exposed rats...
February 2, 2018: Psychopharmacology
Lucile Ferreux, Mathilde Bourdon, Amira Sallem, Pietro Santulli, Virginie Barraud-Lange, Nathalie Le Foll, Chloé Maignien, Charles Chapron, Dominique de Ziegler, Jean-Philippe Wolf, Khaled Pocate-Cheriet
STUDY QUESTION: The aim of this study was to evaluate the live birth rate (LBR) after frozen-thawed Day 5 (D5) and Day 6 (D6) blastocyst transfers. SUMMARY ANSWER: LBR following frozen-thawed blastocyst transfer is significantly lower with D6 than with D5 blastocyst regardless of embryo quality. WHAT IS KNOWN ALREADY: During fresh embryo transfer cycles, pregnancy rates (PR) are significantly higher when transferring blastocysts expanded on D5 compared with slow developing blastocysts (D6)...
February 2, 2018: Human Reproduction
Guillermo Tarazona, Gonzalo Benedit, Rogelio Fernández, Marta Pérez, Jaime Rodríguez, Carlos Jiménez, Carmen Cuevas
QM/NMR-DFT (quantum mechanics combined with nuclear magnetic resonance parameters calculated by density functional theory approximations) studies allowed us to link two stereoclusters separated by two methylene groups present in the new meroditerpenes halioxepine B (2) and halioxepine C (3) and the known halioxepine (1), isolated from two Indonesian sponges of the genus Haliclona (Reniera). DP4 and DP4+ probabilities were used to discriminate the two diastereotopic arrangements of the two stereoclusters, whose unconnected relative configurations were determined by ROESY and J-based configurational analysis...
February 2, 2018: Journal of Natural Products
Bárbara Socas-Rodríguez, Javier Hernández-Borges, Antonio V Herrera-Herrera, Miguel Ángel Rodríguez-Delgado
In this work, the suitability of Fe3O4 nanoparticles coated with polydopamine was evaluated as sorbent for the extraction of a group of 21 compounds with oestrogenic activity including seven phytoestrogens, six mycotoxins as well as four synthetic and four natural oestrogens from different types of milk, including sheep milk, in which the evaluation of oestrogenic compounds have never been developed before. Extraction was carried out using magnetic micro-dispersive solid-phase extraction after a previous deproteinisation step...
February 1, 2018: Analytical and Bioanalytical Chemistry
Lihua Lyu, Qiufeng Wang, Shujie Song, Liyan Li, Huaibin Zhou, Ming Li, ZhiYing Jiang, Chen Zhou, Guorong Chen, Jianxin Lyu, Yidong Bai
Oncocytic tumors are composed of oncocytes characterized by acidophilic granular and reticular cytoplasm. Such features have been attributed to the distinctive aggregation of abnormal mitochondria. Sporadic mitochondrial DNA (mtDNA) mutations, particularly those in complex I subunit genes, have been identified as one of the most noticeable alterations. We reviewed 11,051 cases of patients with thyroid tumors who visited the first affiliated hospital of Wenzhou Medical University from January 2011 to August 2017, and we were able to identify 123 cases as oncocytic tumors...
January 28, 2018: Mitochondrion
Luiz Sergio F Carvalho, Lauro Afonso C Bogniotti, Osorio Luis Rangel de Almeida, Jose C Quinaglia E Silva, Wilson Nadruz, Otavio Rizzi Coelho, Andrei C Sposito
OBJECTIVE: In ST-elevation myocardial infarction, 7-15% of patients admitted as Killip I will develop symptomatic heart failure or decreased ejection fraction. However, available clinical scores do not predict the risk of severe outcomes well, such as heart failure, recurrent myocardial infarction, and sudden death in these Killip I individuals. Therefore, we evaluated whether one vs two measurements of BNP would improve prediction of adverse outcomes in addition to the GRACE score in ST-elevation myocardial infarction/Killip I individuals...
January 1, 2018: European Heart Journal. Acute Cardiovascular Care
Romain A Colas, Anthony W Ashton, Shankar Mukherjee, Jesmond Dalli, Oscar B Akide-Ndunge, Huan Huang, Mahalia S Desruisseaux, Fangxia Guan, Linda A Jelicks, Fabiane Matos Dos Santos, Jyothi Nagajyothi, Michael Zingman, Jinet Reyes, Louis M Weiss, Charles N Serhan, Herbert B Tanowitz
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease (CD). CD is a persistent, life-long infection affecting many organs, most notably the heart where it may result in acute myocarditis and chronic cardiomyopathy. The pathological features include myocardial inflammation and fibrosis. In the Brazil-strain infected CD-1 mouse that recapitulates many of the features of human infection, we found increased plasma levels of resolvin D1 (RvD1), a specialized pro-resolving mediator of inflammation, both during the acute and chronic phases of the infection (>100 days post infection) as determined by ELISA...
January 22, 2018: Infection and Immunity
Lirong Zhao, Weimin Ye, Munawar Maria, Majid Pedram, Jianfeng Gu
Xiphinema japonicum n. sp., isolated in Ningbo, China, from the rhizosphere of Podocarpus macrophyllus (Thunb.) imported from Japan is described. The new species belongs to Xiphinema non-americanum group 7 and is characterized by medium body length (3.0-3.7 mm), total stylet length 190-201 μm, vulva located anteriorly (V = 30.5%-35.3%), two equally developed female genital branches without uterine differentiation (no Z or pseudo-Z organ and/or spines in the uteri), short tail, convex-conoid with subdigitate peg in terminus, and absence of males...
December 2017: Journal of Nematology
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