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https://www.readbyqxmd.com/read/28301911/the-prevalence-and-clinical-relevance-of-asa-nonresponse-after-cardiac-surgery
#1
Saskia Wand, Elisabeth Hannah Adam, Anna Julienne Wetz, Patrick Meybohm, Nils Kunze-Szikszay, Kai Zacharowski, Aron Frederick Popov, Anton Moritz, Lisa Moldenhauer, Julia Kaiser, Martin Bauer, Christian Friedrich Weber
We aimed to identify the prevalence of acetylsalicylic acid (ASA) nonresponse in patients after coronary artery bypass graft (CABG) surgery and the possible consequences for the rate of major cardiovascular events. This prospective, observational, bicentric cohort study was conducted in two German University hospitals. A total of 400 patients (200 in each study center) undergoing elective CABG surgery were enrolled after written informed consent. Platelet function was analyzed on day 3 (d3) and day 5 (d5) postoperatively following stimulation with arachidonic acid (ASPItest) and with thrombin receptor-activating peptide 6 (TRAPtest) using multiple electrode aggregometry (Multiplate)...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28297424/dosimetric-impact-of-cylinder-size-in-high-dose-rate-vaginal-cuff-brachytherapy-vcbt-for-primary-endometrial-cancer
#2
Hualin Zhang, Mahesh Gopalakrishnan, Plato Lee, Zhuang Kang, Vythialingam Sathiaseelan
The purpose of this study was to evaluate the dosimetric impact of cylinder size in high-dose-rate (HDR) vaginal cuff brachytherapy (VCBT). Sample plans of HDR VCBT in a list of cylinders ranging from 2.5 to 4 cm in diameter at 0.5 cm increment were created and analyzed. The doses were prescribed either at the 0.5 cm depth with 5.5 Gy for 4 fractions or at the cylinder surface with 8.8 Gy for 4 fractions, in various treatment lengths. A 0.5 cm shell volume called PTV_Eval was contoured for each plan and served as the target volume for dosimetric evaluation...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296314/effect-of-the-normalized-prescription-isodose-line-on-the-magnitude-of-monte-carlo-vs-pencil-beam-target-dose-differences-for-lung-stereotactic-body-radiotherapy
#3
Dandan Zheng, Qinghui Zhang, Xiaoying Liang, Xiaofeng Zhu, Vivek Verma, Shuo Wang, Sumin Zhou
In lung stereotactic body radiotherapy (SBRT) cases, the pencil beam (PB) dose calculation algorithm is known to overestimate target dose as compared to the more accurate Monte Carlo (MC) algorithm. We investigated whether changing the normalized prescription isodose line affected the magnitude of MC vs. PB target dose differences. Forty-eight patient plans and twenty virtual-tumor phantom plans were studied. For patient plans, four alternative plans prescribed to 60%, 70%, 80%, and 90% isodose lines were each created for 12 patients who previously received lung SBRT treatments...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28294977/phosphoinositides-major-actors-in-membrane-trafficking-and-lipid-signaling-pathways
#4
REVIEW
Johan-Owen De Craene, Dimitri L Bertazzi, Séverine Bär, Sylvie Friant
Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids between the different compartments of eukaryotic cells. They act by recruiting and/or activating effector proteins and thus are involved in regulating various cellular functions, such as vesicular budding, membrane fusion and cytoskeleton dynamics. Although detected in small concentrations in membranes, their role is essential to cell function, since imbalance in their concentrations is a hallmark of many cancers. Their synthesis involves phosphorylating/dephosphorylating positions D3, D4 and/or D5 of their inositol ring by specific lipid kinases and phosphatases...
March 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28291587/comparison-of-sedation-and-mechanical-antinociception-induced-by-intravenous-administration-of-acepromazine-and-four-dose-rates-of-dexmedetomidine-in-donkeys
#5
Ignacio Lizarraga, Fernanda Castillo-Alcala, Lauren S Robinson
OBJECTIVE: To assess and compare the sedative and antinociceptive effects of four dosages of dexmedetomidine in donkeys. STUDY DESIGN: Randomized, controlled, crossover, Latin-square, blinded study. ANIMALS: Six healthy, castrated, adult, standard donkeys. METHODS: Dexmedetomidine (2, 3, 4 and 5 μg kg(-1); D2, D3, D4 and D5), acepromazine (0.1 mg kg(-1)) and saline were administered intravenously to each donkey and a 1 week interval was allowed between successive trials on each animal...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28289281/oxytocin-by-intranasal-and-intravenous-routes-reaches-the-cerebrospinal-fluid-in-rhesus-macaques-determination-using-a-novel-oxytocin-assay
#6
M R Lee, K B Scheidweiler, X X Diao, F Akhlaghi, A Cummins, M A Huestis, L Leggio, B B Averbeck
Oxytocin (OT) is a potential treatment for multiple neuropsychiatric disorders. As OT is a peptide, delivery by the intranasal (IN) route is the preferred method in clinical studies. Although studies have shown increased cerebrospinal fluid (CSF) OT levels following IN administration, this does not unequivocably demonstrate that the peripherally administered OT is entering the CSF. For example, it has been suggested that peripheral delivery of OT could lead to central release of endogenous OT. It is also unknown whether the IN route provides for more efficient entry of the peptide into the CSF compared to the intravenous (IV) route, which requires blood-brain barrier penetration...
March 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28289242/acupuncture-attenuated-vascular-dementia-induced-hippocampal-long-term-potentiation-impairments-via-activation-of-d1-d5-receptors
#7
Yang Ye, Hui Li, Jing-Wen Yang, Xue-Rui Wang, Guang-Xia Shi, Chao-Qun Yan, Si-Ming Ma, Wen Zhu, Qian-Qian Li, Tian-Ran Li, Ling-Yong Xiao, Cun-Zhi Liu
BACKGROUND AND PURPOSE: Emerging evidence suggests that acupuncture could improve cognitive impairment in vascular dementia by enhancing synaptic plasticity in the hippocampus. The purpose of this study is to investigate whether dopamine, a key mediator of synaptic plasticity, is involved in this cognitive improvement. METHODS: Vascular dementia model was established by bilateral common carotid arteries occlusion in male Wistar rats. Three days after the operation, animals received acupuncture treatment for 2 weeks, once daily...
March 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28286707/molecular-phylogenies-confirm-the-presence-of-two-cryptic-hemimycale-species-in-the-mediterranean-and-reveal-the-polyphyly-of-the-genera-crella-and-hemimycale-demospongiae-poecilosclerida
#8
Maria J Uriz, Leire Garate, Gemma Agell
BACKGROUND: Sponges are particularly prone to hiding cryptic species as their paradigmatic plasticity often favors species phenotypic convergence as a result of adaptation to similar habitat conditions. Hemimycale is a sponge genus (Family Hymedesmiidae, Order Poecilosclerida) with four formally described species, from which only Hemimycale columella has been recorded in the Atlanto-Mediterranean basin, on shallow to 80 m deep bottoms. Contrasting biological features between shallow and deep individuals of Hemimycale columella suggested larger genetic differences than those expected between sponge populations...
2017: PeerJ
https://www.readbyqxmd.com/read/28279967/ezetimibe-increases-endogenous-cholesterol-excretion-in-humans
#9
Xiaobo Lin, Susan B Racette, Lina Ma, Michael Wallendorf, Richard E Ostlund
OBJECTIVE: Ezetimibe improves cardiovascular outcomes when added to optimum statin treatment. It lowers low-density lipoprotein cholesterol and percent intestinal cholesterol absorption, but the exact cardioprotective mechanism is unknown. We tested the hypothesis that the dominant effect of ezetimibe is to increase the reverse transport of cholesterol from rapidly mixing endogenous cholesterol pool into the stool. APPROACH AND RESULTS: In a randomized, placebo-controlled, double-blind parallel trial in 24 healthy subjects with low-density lipoprotein cholesterol 100 to 200 mg/dL, we measured cholesterol metabolism before and after a 6-week treatment period with ezetimibe 10 mg/d or placebo...
March 9, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28278125/laboratory-validation-of-an-lc-ms-ms-method-for-the-detection-of-ractopamine-clenbuterol-and-salbutamol-in-bovine-and-swine-muscle-at-sub-%C3%AE-g-kg-regulatory-limits
#10
Rodrigo H M M Granja, Karine V G Reche, Fabio M Giannotti, João K G de Souza, Sarita P G Ferrari, André Danioti Dos Santos, Amarylis C B A Wanschel, Alessandro G Salerno
Ractopamine (RAC), is a β-adrenergic agonist increasingly used in the swine and cattle industry. This compound redirects nutrients to favor leanness rather than fat deposition, improves growth and carcass traits gaining higher economic benefit to producers. Countries around the world are split over whether to allow the use of RAC, in meat production. Clenbuterol (CLB) and Salbutamol (SLB) are anillinic and phenolic β-agonists, respectively, with the same capacity of producing economic benefits for the meat sector...
February 28, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28274007/facial-dysmorphism-an-unreported-teratogenicity-with-levetiracetam
#11
Jyotsana Gupta, Sandhya Jain, Shalini Rajaram, Neerja Goel, Bindiya Gupta
Levetiracetam (LEV) is a relatively newer anticonvulsant drug used to treat epilepsy and is approved by United States Food and Drugs Administration (USFDA). The drug binds to a synaptic vesicle glycoprotein and inhibits presynaptic calcium channels, thus reducing neurotransmitter release. Commonly reported side effects include drowsiness, weakness, unsteady gait, mood changes and loss of appetite. Like most other antiepileptics, it is a Category C drug in pregnancy. We report the first case of facial dysmorphism in the neonate of a mother taking LEV antenatally...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28265619/influence-of-ph-and-mg-ii-on-the-catalytic-core-domain-5-of-a-bacterial-group-ii-intron
#12
M Pechlaner, A Dominguez-Martin, R K O Sigel
RNA molecules fold into complex structures that allow them to perform specific functions. To compensate the relative lack of diversity of functional groups within nucleotides, metal ions work as crucial co-factors. In addition, shifted pKas are observed in RNA, enabling acid-base reactions at ambient pH. The central catalytic domain 5 (D5) hairpin of the Azotobacter vinelandii group II intron undergoes both metal ion binding and pH dependence, presumably playing an important functional role in the ribozyme's reaction...
March 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28259582/development-of-passive-samplers-for-in-situ-measurement-of-pyrethroid-insecticides-in-surface-water
#13
Jiaying Xue, Chunyang Liao, Jie Wang, Zachary Cryder, Tianbo Xu, Fengmao Liu, Jay Gan
Pyrethroid insecticides are widely used in urban environments, and their occurrence has been recently associated with aquatic toxicity in urban surface streams. Synthetic pyrethroids are strongly hydrophobic compounds, highlighting the importance of the freely dissolved concentration (Cfree), rather than the total chemical concentration, for better prediction of potential effects in aquatic ecosystems. The goal of this study was to develop a simple, robust and field-applicable passive sampling methodology that may be used for in situ monitoring of trace levels of pyrethroids in surface water...
March 1, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28253287/platelet-gpiib-supports-initial-pulmonary-retention-but-inhibits-subsequent-proliferation-of-melanoma-cells-during-hematogenic-metastasis
#14
Katrin Echtler, Ildiko Konrad, Michael Lorenz, Simon Schneider, Sebastian Hofmaier, Florian Plenagl, Konstantin Stark, Thomas Czermak, Anca Tirniceriu, Martin Eichhorn, Axel Walch, Georg Enders, Steffen Massberg, Christian Schulz
Platelets modulate the process of cancer metastasis. However, current knowledge on the direct interaction of platelets and tumor cells is mostly based on findings obtained in vitro. We addressed the role of the platelet fibrinogen receptor glycoprotein IIb (integrin αIIb) for experimental melanoma metastasis in vivo. Highly metastatic B16-D5 melanoma cells were injected intravenously into GPIIb-deficient (GPIIb-/-) or wildtype (WT) mice. Acute accumulation of tumor cells in the pulmonary vasculature was assessed in real-time by confocal videofluorescence microscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28251860/time-weighted-average-concentration-monitoring-based-on-thin-film-solid-phase-microextraction
#15
Fardin Ahmadi, Chris Sparham, Ezel Boyaci, Janusz Pawliszyn
Time weighted average (TWA) passive sampling with thin film solid phase microextraction (TF-SPME) and liquid chromatography tandem mass spectrometry (LC-MS/MS) was used for collection, identification, and quantification of benzophenone-3, benzophenone-4, 2-phenylbenzimidazole-5-sulphonic acid, octocrylene, and triclosan in the aquatic environment. Two types of TF-SPME passive samplers, including a retracted thin film device using a hydrophilic lipophilic balance (HLB) coating, and an open bed configuration with an octadecyl silica-based (C18) coating, were evaluated in an aqueous standard generation (ASG) system...
March 2, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28249560/a-genome-wide-analysis-of-the-lysophosphatidate-acyltransferase-lpaat-gene-family-in-cotton-organization-expression-sequence-variation-and-association-with-seed-oil-content-and-fiber-quality
#16
Nuohan Wang, Jianjiang Ma, Wenfeng Pei, Man Wu, Haijing Li, Xingli Li, Shuxun Yu, Jinfa Zhang, Jiwen Yu
BACKGROUND: Lysophosphatidic acid acyltransferase (LPAAT) encoded by a multigene family is a rate-limiting enzyme in the Kennedy pathway in higher plants. Cotton is the most important natural fiber crop and one of the most important oilseed crops. However, little is known on genes coding for LPAATs involved in oil biosynthesis with regard to its genome organization, diversity, expression, natural genetic variation, and association with fiber development and oil content in cotton. RESULTS: In this study, a comprehensive genome-wide analysis in four Gossypium species with genome sequences, i...
March 1, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28249037/effects-of-a-skin-massaging-device-on-the-ex-vivo-expression-of-human-dermis-proteins-and-in-vivo-facial-wrinkles
#17
Elisa Caberlotto, Laetitia Ruiz, Zane Miller, Mickael Poletti, Lauri Tadlock
Mechanical and geometrical cues influence cell behaviour. At the tissue level, almost all organs exhibit immediate mechanical responsiveness, in particular by increasing their stiffness in direct proportion to an applied mechanical stress. It was recently shown in cultured-cell models, in particular with fibroblasts, that the frequency of the applied stress is a fundamental stimulating parameter. However, the influence of the stimulus frequency at the tissue level has remained elusive. Using a device to deliver an oscillating torque that generates cyclic strain at different frequencies, we studied the effect(s) of mild skin massage in an ex vivo model and in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28235506/effective-volumes-of-1-5-mepivacaine-with-different-sodium-concentration-for-ultrasound-guided-popliteal-block
#18
Mercedes López, Miguel Calvo, Azahara Sancho, Nicolas Brogly, Emilia Guasch, Fernando Gilsanz
STUDY OBJECTIVE: To determine if a solution of 1.5% mepivacaine diluted with 5% dextrose, which decreases the sodium concentration by 30%, results in reduced volume requirements for a complete sensory block, in the case of an ultrasound guided popliteal nerve block. DESIGN: A randomized controlled study. SETTING: Operating room. PATIENTS: We included seventy ASA 1-3 patients, undergoing unilateral "hallux valgus" repair under ultrasound guided popliteal nerve block...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28228791/two-cases-of-pregnancy-and-lactation-associated-osteoporosis-successfully-treated-with-denosumab
#19
Ariel Sánchez, María Belén Zanchetta, Karina Danilowicz
Case 1. A 35-year-old woman in the 8(th) month of her first pregnancy suffered acute lumbar pain that persisted for 4 months. In the 5(th) month postpartum an acute increase in the low back pain led to a MRI which showed recent deformity in L1 and deformities of undetermined time of evolution in L2, L4, and L5. Laboratory evaluation did not reveal metabolic derangements. She had low bone mineral density (BMD, DXA) and severe deterioration of the microarchitecture of distal appendicular bone (HR-pQCT). Kyphoplasty of all 4 vertebrae was performed in 2 stages, and treatment with subcutaneous denosumab, 60 mg every 6 months, was begun...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28226279/roles-of-steady-state-and-dynamic-models-for-regulation-of-hydrophobic-chemicals-in-aquatic-systems-a-case-study-of-decamethylcyclopentasiloxane-d5-and-pcb-180-in-three-diverse-ecosystems
#20
Jaeshin Kim, Donald Mackay, David E Powell
We seek to contribute to the improved regulatory use of mass balance models to complement environmental monitoring data by applying the steady-state Quantitative Water Air Sediment Interactive model (QWASI) and a novel unsteady-state QWASI model. A steady-state model can yield not only a useful simulation of chemical fate under near steady-state conditions, but it can provide insights into the likely influences of increasing or decreasing emission rates, temperature changes, and unexpectedly high sensitivities to model parameters that may require additional investigation...
May 2017: Chemosphere
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