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https://www.readbyqxmd.com/read/29042272/effect-of-dietary-nitrate-on-respiratory-physiology-at-high-altitude-results-from-the-xtreme-alps-study
#1
Andrew Cumpstey, Philip J Hennis, Edward T Gilbert-Kawai, Bernadette O Fernandez, Matthieu Poudevigne, Alexandra Cobb, Paula Meale, Kay Mitchell, Helen Moyses, Helmut Pöhnl, Monty G Mythen, Michael P W Grocott, Martin Feelisch, Daniel S Martin
Nitric oxide (NO) production plays a central role in conferring tolerance to hypoxia. Tibetan highlanders, successful high-altitude dwellers for millennia, have higher circulating nitrate and exhaled NO (ENO) levels than native lowlanders. Since nitrate itself can reduce the oxygen cost of exercise in normoxia it may confer additional benefits at high altitude. Xtreme Alps was a double-blinded randomised placebo-controlled trial to investigate how dietary nitrate supplementation affects physiological responses to hypoxia in 28 healthy adult volunteers resident at 4559 m for 1 week; 14 receiving a beetroot-based high-nitrate supplement and 14 receiving a low-nitrate 'placebo' of matching appearance/taste...
October 14, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29039274/different-escherichia-coli-b2-st131-clades-b-and-c-producing-extended-spectrum-%C3%AE-lactamases-esbl-colonizing-residents-of-portuguese-nursing-homes
#2
C Rodrigues, E Machado, S Fernandes, L Peixe, Â Novais
ESBL-producing Enterobacteriaceae and particularly Escherichia coli ST131 isolates producing CTX-M enzymes are commonly found colonizing the intestine of nursing home (NH) residents, but ST131 subclonal structure has been scarcely explored in this vulnerable population. Our goal was to perform a pilot study to assess the faecal carriage rate and epidemiological features of ESBL- and/or carbapenemase-producing Enterobacteriaceae (ESBL-E and CPE, respectively) among NH residents. For this purpose, faecal samples from residents at 4 different NHs in the North of Portugal (representing 9·5% of the residents' population, July 2014) were screened for ESBL-E and/or CPE by phenotypic and genotypic methods...
October 17, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29030444/common-presence-of-aerobic-anoxygenic-photosynthesis-within-the-genus-limnohabitans
#3
Vojtěch Kasalický, Yonghui Zeng, Kasia Piwosz, Karel Šimek, Hana Kratochvilová, Michal Koblížek
The genus Limnohabitans (Comamonadaceae, Betaproteobacteria) is a common and a highly active component of freshwater bacterioplankton communities. So far, the genus has been considered to contain only heterotrophic species. In this study, we detected photosynthesis genes pufLM and bchY in 28 out of 46 strains from three Limnohabitans lineages. The obtained pufM sequences are very closely related to environmental pufM sequences detected in various freshwater habitats, indicating ubiquity and potential importance of photoheterotrophic Limnohabitans in nature...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29022336/methylsiloxanes-release-from-one-landfill-through-yearly-cycle-and-their-removal-mechanisms-especially-hydroxylation-in-leachates
#4
Lin Xu, Shihe Xu, Liqin Zhi, Xudan He, Chunhui Zhang, Yaqi Cai
In one yearly cycle (2016), D4 and D5 were detected in biogas samples (n = 36, 0.105-2.33 mg/m(3)) from a Chinese municipal landfill, while D4-D6 were detected in influents/effluents of leachate storage pond (n = 72, < LOQ-30.5 μg/L). Mass loads of cVMS in both biogas (591-6575 mg/d) and leachate influents (659-5760 mg/d) increased from January to July (summer), and then decreased from July to December (winter). Removal experiments indicated that 1) hydrolysis and volatilization were predominant removal mechanism for D4 and D5, respectively, in leachate storage pond, responsible for their more significant removal (94...
October 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29019030/cloning-and-upscale-production-of-monoamine-oxidase-n-mao-n-d5-by-pichia-pastoris
#5
Kristína Markošová, Andrea Camattari, Michal Rosenberg, Anton Glieder, Nicholas J Turner, Martin Rebroš
OBJECTIVE: To clone monoamine oxidase N, that catalyses the selective oxidative deamination or deracemisation of amines into imines, in Pichia pastoris and prove the importance of choosing the proper expression system for its recombinant production. RESULTS: Monoamine oxidase, originating from Aspergillus niger and subjected to directed evolution (MAO-N D5), was cloned and expressed in Pichia pastoris CBS7435 Mut(S) strain for the first time. Various transformants were screened at microscale level...
October 10, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28993595/optimization-of-analytical-conditions-for-a-rapid-determination-of-aniline-in-environmental-water-by-liquid-chromatography-tandem-mass-spectrometry
#6
Koji Furukawa, Makoto Hashimoto, Satoshi Kaneco
A rapid determination of aniline in environmental water was examined based on liquid chromatography/tandem mass spectrometry (LC/MS/MS). Environmental water samples were diluted 20-fold with Mill-Q water and measured by LC/MS/MS after adding a surrogate substance (aniline-d5). In the results of the present study, the calibration curve of aniline showed good linearity in the range of 0.05 - 2.0 μg/L. Since the RSD (repeatability) by measuring repeatedly an aniline standard solution (0.05 μg/L, n = 7) was 3...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28988490/the-measurement-of-functioning-using-the-international-classification-of-functioning-disability-and-health-comparing-qualifier-ratings-with-existing-health-status-instruments
#7
Birgit Prodinger, Gerold Stucki, Michaela Coenen, Alan Tennant
BACKGROUND: The International Classification of Functioning, Disability and Health is the international standard for describing and monitoring functioning. While the categories, the units of the classification, were not designed with measurement in mind, the hierarchical structure of the classification lends itself to the possibility of summating categories into some higher order domain. Focusing on the chapters of d4 Mobility, d5 Self-Care and d6 Domestic Life, this study seeks to ascertain if qualifiers rating of categories (0-No problem to 4-Complete problem) within those chapters can be summated, and whether such derived measurement is consistent with estimates obtained from well-known instruments which purport to measure the same constructs...
October 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28985546/ovulation-induction-and-controlled-ovarian-stimulation-using-letrozole-gonadotropin-combination-a-single-center-retrospective-cohort-study
#8
Sushila Arya, Sanja Kupesic-Plavsic, Zuber D Mulla, Alok K Dwivedi, Zeni Crisp, Jisha Jose, Luis S Noble
OBJECTIVE: To assess the effect of letrozole in combination with low dose gonadotropins for ovulation induction in anovulatory infertility from polycystic ovary syndrome (PCOS) and controlled ovarian stimulation for endometriosis, and unexplained infertility patients. STUDY DESIGN: Retrospective cohort study in a setting of private Reproductive Endocrinology and Infertility Clinic affiliated with the University. Three hundred couples (650 cycles) requiring OI/COS for PCOS (92 patients, 195 cycles), endometriosis (89 patients, 217 cycles), and unexplained infertility (119 patients, 238 cycles)...
September 23, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28982667/endogenous-cholesterol-excretion-is-negatively-associated-with-carotid-intima-media-thickness-in-humans
#9
Xiaobo Lin, Susan B Racette, Lina Ma, Michael Wallendorf, Victor G Dávila-Román, Richard E Ostlund
OBJECTIVE: Epidemiological studies strongly suggest that lipid factors independent of low-density lipoprotein cholesterol contribute significantly to cardiovascular disease risk. Because circulating lipoproteins comprise only a small fraction of total body cholesterol, the mobilization and excretion of cholesterol from plasma and tissue pools may be an important determinant of cardiovascular disease risk. Our hypothesis is that fecal excretion of endogenous cholesterol is protective against atherosclerosis...
October 5, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28980809/elucidating-the-behavior-of-cyclic-volatile-methylsiloxanes-in-a-subarctic-freshwater-food-web-a-modeled-and-measured-approach
#10
Ingjerd Sunde Krogseth, Emma Maria Undeman, Anita Evenset, Guttorm N Christensen, Mick J Whelan, Knut Breivik, Nicholas A Warner
Cyclic volatile methylsiloxanes (cVMS) are used in personal care products and emitted to aquatic environments through wastewater effluents, and their bioaccumulation potential is debated. Here, a new bentho-pelagic version of the ACC-HUMAN model was evaluated for polychlorinated biphenyls (PCBs) and applied to cVMS in combination with measurements to explore their bioaccumulation behavior in a subarctic lake. Predictions agreed better with measured PCB concentrations in Arctic char (Salvelinus alpinus) and brown trout (Salmo trutta) when the benthic link was included than in the pelagic-only model...
October 5, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28977407/high-throughput-uplc%C3%A2-msms-method-for-the-analysis-of-phosphatidylethanol-peth-16-0-18-1-a-specific-biomarker-for-alcohol-consumption-in-whole-blood
#11
Trine Naalsund Andreassen, Hilde Havnen, Olav Spigset, Berit Margrethe Hasle Falch, Ragnhild Bergene Skråstad
Phosphatidylethanol (PEth) is an alcohol biomarker formed in the presence of ethanol in the body. Both due to its specificity and because it has a detection window of up to several weeks after alcohol intake, its application potential is broader than for other ethanol biomarkers. The aim of this study was to develop and validate a robust method for PEth in whole blood with fast and efficient sample extraction and a short analytical runtime, suitable for high throughput routine purposes. A validated ultra-performance liquid chromatography tandem mass spectrometry (UPLC®-MSMS) method for quantification of PEth 16:0/18:1 in the range 0...
September 4, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28975698/dopamine-d4-receptor-activation-restores-ca1-ltp-in-hippocampal-slices-from-aged-mice
#12
Fangli Guo, Jianhua Zhao, Dandan Zhao, Jiangang Wang, Xiaofang Wang, Zhiwei Feng, Martin Vreugdenhil, Chengbiao Lu
Normal aging is characterized with a decline in hippocampal memory functions that is associated with changes in long-term potentiation (LTP) of the CA3-to-CA1 synapse. Age-related deficit of the dopaminergic system may contribute to impairment of CA1 LTP. Here we assessed how the modulation of CA1 LTP by dopamine is affected by aging and how it is dependent on the Ca(2+) source. In slices from adult mice, the initial slope of the field potential showed strong LTP, but in slices from aged mice LTP was impaired...
October 3, 2017: Aging Cell
https://www.readbyqxmd.com/read/28955227/stress-induced-reduction-of-dorsal-striatal-d2-dopamine-receptors-prevents-retention-of-a-newly-acquired-adaptive-coping-strategy
#13
Paolo Campus, Sonia Canterini, Cristina Orsini, Maria Teresa Fiorenza, Stefano Puglisi-Allegra, Simona Cabib
The inability to learn an adaptive coping strategy in a novel stressful condition leads to dysfunctional stress coping, a marker of mental disturbances. This study tested the involvement of dorsal striatal dopamine receptors in the dysfunctional coping with the Forced Swim test fostered by a previous experience of reduced food availability. Adult male mice were submitted to a temporary (12 days) reduction of food availability [food-restricted (FR)] or continuously free-fed (FF). Different groups of FF and FR mice were used to evaluate: (1) dorsal striatal mRNA levels of the two isoforms of the dopamine D2 receptor (D2S, D2L)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28950781/blockade-of-dopamine-d1-family-receptors-attenuates-the-mania-like-hyperactive-risk-preferring-and-high-motivation-behavioral-profile-of-mice-with-low-dopamine-transporter-levels
#14
Morgane Milienne-Petiot, Lucianne Groenink, Arpi Minassian, Jared W Young
BACKGROUND: Patients with bipolar disorder mania exhibit poor cognition, impulsivity, risk-taking, and goal-directed activity that negatively impact their quality of life. To date, existing treatments for bipolar disorder do not adequately remediate cognitive dysfunction. Reducing dopamine transporter expression recreates many bipolar disorder mania-relevant behaviors (i.e. hyperactivity and risk-taking). The current study investigated whether dopamine D1-family receptor blockade would attenuate the risk-taking, hypermotivation, and hyperactivity of dopamine transporter knockdown mice...
October 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28950743/expression-of-matrix-metalloproteinases-in-the-mouse-uterus-and-human-myometrium-during-pregnancy-labor-and-preterm-labor
#15
Annalia Lombardi, Sofia Makieva, Sara F Rinaldi, Felice Arcuri, Felice Petraglia, Jane E Norman
BACKGROUND: Uterine extracellular matrix (ECM) remodeling occurs throughout pregnancy and at parturition. Imbalanced availability of key mediators in ECM degradation, namely, matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), is implicated in the pathogenesis of preterm labor (PTL). OBJECTIVES: Examine the expression of MMPs and their inhibitors TIMPs in (a) the mouse uterus throughout normal gestation, at labor, and during inflammation-induced PTL and (b) the human term and preterm myometrium...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28940477/camp-levels-in-lymphocytes-and-cd4-regulatory-t-cell-functions-are-affected-by-dopamine-receptor-gene-polymorphisms
#16
Marco Cosentino, Natasa Kustrimovic, Marco Ferrari, Emanuela Rasini, Franca Marino
The neurotransmitter dopamine (DA) has prominent effects in the immune system and between the immune cells, CD4+ regulatory T lymphocytes (Treg), a specialized T cell subsets crucial for the control of immune homeostasis, are especially sensitive to DA. Dopaminergic receptors (DR) are grouped into two families according to their pharmacological profile and main second messenger coupling: the D1 -like (D1 and D5 ) which activate adenylate cyclase and the D2 -like (D2 , D3 and D4 ) which inhibit adenylate cyclase and exist in several variants, which have been associated to clinical conditions such as schizophrenia, bipolar disorder, substance abuse and addiction...
September 20, 2017: Immunology
https://www.readbyqxmd.com/read/28938734/hyperspectral-microscopy-can-detect-metabolic-heterogeneity-within-bovine-post-compaction-embryos-incubated-under-two-oxygen-concentrations-7-versus-20
#17
Melanie L Sutton-McDowall, Martin Gosnell, Ayad G Anwer, Melissa White, Malcolm Purdey, Andrew D Abell, Ewa M Goldys, Jeremy G Thompson
STUDY QUESTION: Can we separate embryos cultured under either 7% or 20% oxygen atmospheres by measuring their metabolic heterogeneity? SUMMARY ANSWER: Metabolic heterogeneity and changes in metabolic profiles in morula exposed to two different oxygen concentrations were not detectable using traditional fluorophore and two-channel autofluorescence but were detectable using hyperspectral microscopy. WHAT IS KNOWN ALREADY: Increased genetic and morphological blastomere heterogeneity is associated with compromised developmental competence of embryos and currently forms the basis for embryo scoring within the clinic...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28935873/whole-genome-sequencing-molecular-typing-and-in-vivo-virulence-of-oxa-48-producing-escherichia-coli-isolates-including-st131-h30-rx-h22-and-h41-subclones
#18
María de Toro, Javier Fernández, Vanesa García, Azucena Mora, Jorge Blanco, Fernando de la Cruz, M Rosario Rodicio
Carbapenem-resistant Enterobacteriaceae, including the increasingly reported OXA-48 Escherichia coli producers, are an emerging public health threat worldwide. Due to their alarming detection in our healthcare setting and their possible presence in the community, seven OXA-48-producing, extraintestinal pathogenic E. coli were analysed by whole genome sequencing as well as conventional tools, and tested for in vivo virulence. As a result, five E. coli OXA-48-producing subclones were detected (O25:H4-ST131/PST43-fimH30-virotype E; O25:H4-ST131/PST9-fimH22-virotype D5, O16:H5-ST131/PST506-fimH41; O25:H5-ST83/PST207 and O9:H25-ST58/PST24)...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28926567/critical-developmental-windows-for-morphology-and-hematology-revealed-by-intermittent-and-continuous-hypoxic-incubation-in-embryos-of-quail-coturnix-coturnix
#19
Warren W Burggren, Nourhan A Elmonoufy
Hypoxia during embryonic growth in embryos is frequently a powerful determinant of development, but at least in avian embryos the effects appear to show considerable intra- and inter-specific variation. We hypothesized that some of this variation may arise from different protocols that may or may not result in exposure during the embryo's critical window for hypoxic effects. To test this hypothesis, quail embryos (Coturnix coturnix) in the intact egg were exposed to hypoxia (~15% O2) during "early" (Day 0 through Day 5, abbreviated as D0-D5), "middle" (D6-D10) or "late" (D11-D15) incubation or for their entire 16-18 day incubation ("continuous hypoxia") to determine critical windows for viability and growth...
2017: PloS One
https://www.readbyqxmd.com/read/28922709/non-drainage-versus-drainage-in-tourniquet-free-knee-arthroplasty-a-prospective-trial
#20
Kai Zhou, Haoyang Wang, Jinglong Li, Duan Wang, Zongke Zhou, Fuxing Pei
BACKGROUND: It is still unknown whether drainage is necessary and non-drainage is safe and acceptable after tourniquet-free total knee arthroplasty (TKA). We aim to investigate whether non-drainage use is accepted in TKA that is performed without a tourniquet. METHODS: Clinical data of 80 adult patients who did or did not receive drainage in our centres from August 2015 to December 2015 were prospective investigated. RESULTS: The drainage group exhibited reduced hidden blood loss (47...
September 18, 2017: ANZ Journal of Surgery
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