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https://www.readbyqxmd.com/read/27914279/identification-and-quantification-of-4-methylethcathinone-4-mec-and-3-4-methylenedioxypyrovalerone-mdpv-in-hair-by-lc-ms-ms-after-chronic-administration
#1
Jean Claude Alvarez, Isabelle Etting, Emuri Abe, Antoine Villa, Nicolas Fabresse
4-Methylethcathinone (4-MEC) and 3,4-methylenedioxypyrovalerone (MDPV) are synthetic cathinones. The objective of this study was to develop a method in order to measure these compounds in hair of a patient. After decontamination, 20mg of hair were grinded and incubated in phosphate buffer pH 5.0 in presence of 100ng of MDMA-d5 used as internal standard. Double basic liquid-liquid extraction was performed. Samples were separated on a 1.9μm Hypersil GOLD PFP column (100×2.1mm) using gradient elution. Compounds were detected by a LCQ TSQ Vantage XP triple-quadrupole mass spectrometer...
November 24, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27907016/direct-unequal-cleavages-embryo-developmental-competence-genetic-constitution-and-clinical-outcome
#2
Qiansheng Zhan, Zhen Ye, Robert Clarke, Zev Rosenwaks, Nikica Zaninovic
OBJECTIVE: To investigate the prevalence, developmental potential, chromosomal constitution and clinical outcome of embryos with direct unequal cleavages (DUC). DESIGN: A retrospective observational study. SETTING: Academic Institution. PARTICIPANT: 21,261 embryos from 3,155 cycles cultured in EmbryoScope®. RESULTS: The total incidence of DUCs per embryo occupying the first three cleavages were 26...
2016: PloS One
https://www.readbyqxmd.com/read/27897388/unprecedented-reaction-pathway-of-sterically-crowded-calcium-complexes-sequential-c-n-bond-cleavages-induced-by-c-h-bond-activations
#3
Yang Yang, Haobing Wang, Haiyan Ma
Five bis(quinolylmethyl)-(1H-indolylmethyl)amine (BQIA) compounds-{(quinol-8-yl-CH2)2NCH2(3-Br-1H-Indol-2-yl)} (L1H) and {[(8-R3-quinol-2-yl)CH2]2NCH(R2)[3-R1-1H-Indol-2-yl]} (L2-5H) (L2H: R1 = Br, R2 = H, R3 = H; L3H: R1 = Br, R2 = H, R3 = iPr; L4H: R1 = H, R2 = CH3, R3 = iPr; L5H: R1 = H, R2 = nBu, R3 = iPr)-have been synthesized and used to prepare calcium complexes. The reactions of L1-5H with silylamido calcium precursors (Ca[N(SiMe2R)2]2(THF)2, R = Me or H) at room temperature gave heteroleptic products (L1-2)CaN(SiMe3)2 (1, 2), (L3-4)CaN(SiHMe2)2 (3a, 4a) and homoleptic complexes (L3,5)2Ca (D3, D5)...
November 29, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27896287/enamel-ribbons-surface-nodules-and-octacalcium-phosphate-in-c57bl-6-amelx-mice-and-amelx-lyonization
#4
Yuanyuan Hu, Charles E Smith, Zhonghou Cai, Lorenza A-J Donnelly, Jie Yang, Jan C-C Hu, James P Simmer
BACKGROUND: Amelogenin is required for normal enamel formation and is the most abundant protein in developing enamel. METHODS: Amelx(+/+), Amelx(+/-) , and Amelx(-/-) molars and incisors from C57BL/6 mice were characterized using RT-PCR, Western blotting, dissecting and light microscopy, immunohistochemistry (IHC), transmission electron microscopy (TEM), scanning electron microscopy (SEM), backscattered SEM (bSEM), nanohardness testing, and X-ray diffraction. RESULTS: No amelogenin protein was detected by Western blot analyses of enamel extracts from Amelx(-/-) mice...
November 2016: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/27894942/-masson-s-haemangioma-an-unusual-cause-of-thoracic-compressive-myelopathy
#5
Bikash Ranjan Behera, Rabi Narayan Panda, Sanjib Mishra, Manmath Kumar Dhir
BACKGROUND: Masson's hemangioma is a rare pathological entity, featuring intravascular papillary endothelial hyperplasia. Although benign, this hemangioma grows to form an expansile compressing mass. This lesion is mostly seen in skin and subcutaneous tissue. Occurrence in neuraxis is rare for this pathological entity. Still rarer is the spinal location with only 5 case reports published till date in medical literature. CASE DESCRIPTION: Here we present a 26 year old male with paraplegia due to extradural compression at D4, D5 level...
November 25, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27886509/smooth-horizonless-geometries-deep-inside-the-black-hole-regime
#6
Iosif Bena, Stefano Giusto, Emil J Martinec, Rodolfo Russo, Masaki Shigemori, David Turton, Nicholas P Warner
We construct the first family of horizonless supergravity solutions that have the same mass, charges, and angular momenta as general supersymmetric rotating D1-D5-P black holes in five dimensions. This family includes solutions with arbitrarily small angular momenta, deep within the regime of quantum numbers and couplings for which a large classical black hole exists. These geometries are well approximated by the black-hole solution, and in particular exhibit the same near-horizon throat. Deep in this throat, the black-hole singularity is resolved into a smooth cap...
November 11, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27871757/an-approach-to-the-environmental-prioritisation-of-volatile-methylsiloxanes-in-several-matrices
#7
Vera Homem, Daniela Capela, José Avelino Silva, Alessandra Cincinelli, Lúcia Santos, Arminda Alves, Nuno Ratola
Siloxane-based compounds are widely used in personal care, pharmaceutical and household products as well as in industrial applications. Among the wide variety of these chemicals, special attention has been given to volatile methylsiloxanes (VMSs). These compounds have been extensively detected in several environmental compartments, as they are not effectively removed from wastewater and may migrate through different matrices and being lipophilic, bioaccumulate and biomagnify in living organisms. In this work, a prioritisation methodology for several VMSs in different environmental matrices was applied, estimating a hazard quotient by combining exposure evaluation through measured or predicted environmental concentrations (MEC or PEC) and effects using ecotoxicity data to establish no effect concentrations (PNEC)...
November 18, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27859445/quantification-of-furosemide-in-camel-plasma-by-high-resolution-mass-spectrometry-application-on-pharmacokinetics
#8
Ibrahim A Wasfi, Sayed A Wajid, B A Agha, Asmaa M Kamel, Nasreen A Al Biriki, Khaled M Al Neaimi, Waleed A Al Ali
We developed and validated a high resolution liquid chromatography mass spectrometry method for the quantification of furosemide in camel plasma which was used for a pharmacokinetic study in camels. Plasma samples were extracted by supported liquid extraction and furosemide and internal standard (furosemide-D5) were separated on a an Agilent Zorbax XDB C18 column (50 mm × 2.1 mm i.d., 3.5 µm). Data was acquired in full-scan mode over a mass range of 200-400 Da in negative electro spray mode at a resolution of 70,000...
November 18, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27858797/assessment-of-organic-micropollutants-occurrence-in-treated-wastewater-using-heat-shock-protein-47-stress-responses-in-chinese-hamster-ovary-cells-and-gc-ms-based-non-target-screening
#9
Selma Etteieb, Atsushi Kawachi, Junkyu Han, Foued Elayni, Jamila Tarhouni, Hiroko Isoda
Combining bioassays and analytical chemistry screening is a powerful approach to assess organic micropollutants which are the main contributors to toxic potential in complex mixtures of treated wastewater (TWW). The aim of this study was to perform a comprehensive toxicity assessment of treated effluents using stress response bioassays and then to assess the occurrence of the organic micropollutants which were responsible for this biological response using gas chromatography coupled with a mass spectrometry detector (GC/MS)...
November 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/27856039/impact-of-real-time-image-gating-on-spot-scanning-proton-therapy-for-lung-tumors-a%C3%A2-simulation-study
#10
Takahiro Kanehira, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Yoichi M Ito, Naoki Miyamoto, Tetsuya Inoue, Norio Katoh, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
PURPOSE: To investigate the effectiveness of real-time-image gated proton beam therapy for lung tumors and to establish a suitable size for the gating window (GW). METHODS AND MATERIALS: A proton beam gated by a fiducial marker entering a preassigned GW (as monitored by 2 fluoroscopy units) was used with 7 lung cancer patients. Seven treatment plans were generated: real-time-image gated proton beam therapy with GW sizes of ±1, 2, 3, 4, 5, and 8 mm and free-breathing proton therapy...
September 28, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27845160/opinion-of-the-scientific-committee-on-consumer-safety-sccs-final-version-of-the-opinion-on-decamethylcyclopentasiloxane-cyclopentasiloxane-d5-in-cosmetic-products
#11
Dr Christophe Rousselle
No abstract text is available yet for this article.
November 12, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27827491/extensive-h-atom-abstraction-from-benzoate-by-oh-radicals-at-the-air-water-interface
#12
Shinichi Enami, Michael R Hoffmann, Agustín J Colussi
Much is known about OH-radical chemistry in the gas-phase and bulk water. Important atmospheric and biological processes, however, involve little investigated OH-radical reactions at aqueous interfaces with hydrophobic media. Here, we report the online mass-specific identification of the products and intermediates generated on the surface of aqueous (H2O, D2O) benzoate-h5 and -d5 microjets by ∼8 ns ˙OH(g) pulses in air at 1 atm. Isotopic labeling lets us unambiguously identify the phenylperoxyl radicals that ensue H-abstraction from the aromatic ring and establish a lower bound (>26%) to this process as it takes place in the interfacial water nanolayers probed by our experiments...
November 9, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27825952/adenovirus-36-antibody-detection-improving-the-standard-serum-neutralization-assay
#13
Cynthia L Chappell, Mary Dickerson, R Sue Day, Olga Dubuisson, Nikhil V Dhurandhar
Adenovirus 36 (AdV36) causes weight gain in animal models, including non-human primates. In humans, AdV36-neutralizing antibodies are associated with adiposity; however, longitudinal studies in large populations are needed to clarify AdV36's contribution. The current gold standard for detection of AdV36-specific antibody is the serum neutralization assay (SNA), which requires long incubation times and highly trained personnel. The standard SNA was modified using an immunocytochemical (ICC) approach, which allows for a more rapid and objective assessment of AdV36 antibodies...
January 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/27825624/quantification-of-suvorexant-in-urine-using-gas-chromatography-mass-spectrometry
#14
Mariah Carson, Sarah Kerrigan
Suvorexant (Belsomra(®)) is a novel sedative hypnotic drug that is prescribed to promote sleep in patients with insomnia. It is the first of a new class of drugs classified as dual orexin receptor antagonists (DORAs). Sedative hypnotics with central nervous system depressant effects feature prominently in forensic toxicology investigations. For this reason, a new analytical method was developed to identify suvorexant in urine using liquid-liquid extraction (LLE) and gas chromatography/mass spectrometry (GC/MS)...
November 2, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27825364/mid-regional-pro-adrenomedullin-mr-proadm-a-marker-of-positive-fluid-balance-in-critically-ill-patients-results-of-the-envol-study
#15
Bernard Vigué, Pierre-Etienne Leblanc, Frédérique Moati, Eric Pussard, Hussam Foufa, Aurore Rodrigues, Samy Figueiredo, Anatole Harrois, Jean-Xavier Mazoit, Homa Rafi, Jacques Duranteau
BACKGROUND: The optimal control of blood volume without fluid overload is a main challenge in the daily care of intensive care unit (ICU) patients. Accordingly this study focused on the identification of biomarkers to help characterize fluid overload status. METHODS: Sixty-seven patients were studied from ICU admission to day 7 (D7). Blood and urine samples were taken daily and sodium and water balance strictly calculated resulting in a total cumulative assessment of ∆Na(+) and ∆H2O...
November 9, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27817026/the-inhibition-of-dopamine-synthesis-in-fetuses-changes-the-pattern-of-t-lymphocyte-maturation-in-the-thymus-of-adult-rats
#16
N V Lifantseva, Ts O Koneeva, S N Voronova, L A Zakharova, V I Melnikova
The mRNA for dopamine receptors of type D1, D3, D5, but not type D2, was detected in the thymus of rats starting from day 16 of embryonic development (E16). Dopamine at concentrations of 10(-8)-10(‒6) M inhibited fetus thymocyte response to mitogen, confirming the functionality of the receptors and the possibility of a direct effect of dopamine on the developing thymus. Pharmacological inhibition of catecholamine synthesis in the crucial period of thymus development leads to long-term changes in the T-system immunity due to increased production of natural regulatory T-lymphocytes...
September 2016: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27811173/an-allosteric-potentiator-of-the-dopamine-d1-receptor-increases-locomotor-activity-in-human-d1-knock-in-mice-without-causing-stereotypy-or-tachyphylaxis
#17
Kjell A Svensson, Beverly A Heinz, John M Schaus, James P Beck, Junliang Hao, Joseph H Krushinski, Matthew R Reinhard, Michael P Cohen, Sarah L Hellman, Brian G Getman, Xushan Wang, Michelle M Menezes, Deanna L Maren, Julie F Falcone, Wesley H Anderson, Rebecca A Wright, S Michelle Morin, Kelly L Knopp, Benjamin L Adams, Borys Rogovoy, Ilya Okun, Todd M Suter, Michael A Statnick, Donald R Gehlert, David L Nelson, Virginia L Lucaites, Renee Emkey, Neil W DeLapp, Todd R Wiernicki, Jeffrey W Cramer, Charles R Yang, Robert F Bruns
Allosteric potentiators amplify the sensitivity of physiological control circuits, a mode of action that could provide therapeutic advantages. This hypothesis was tested with the dopamine D1 receptor potentiator DETQ. In HEK293 cells expressing the human D1 receptor, DETQ induced a 21-fold leftward shift in the cAMP response to dopamine, with a Kb of 26 nM. The maximum response to DETQ alone was ~12% of the maximum response to dopamine, suggesting weak allosteric agonist activity. DETQ was ~30-fold less potent at rat and mouse D1 receptors and was inactive at the human D5 receptor...
November 3, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27802918/high-throughput-assay-for-quantification-of-the-plasma-concentrations-of-thiopental-using-automated-solid-phase-extraction-spe-directly-coupled-to-lc-ms-ms-instrumentation
#18
Seyed Mojtaba Moosavi, Kiran Shekar, John Fraser, Maree T Smith, Sussan Ghassabian
Most previous assays for thiopental are time-consuming due to laborious sample extraction steps prior to analysis using gas chromatography or high pressure liquid chromatography. Here, we describe the first high-throughput liquid chromatography - tandem mass spectrometry (LC-MS/MS) method for quantification of thiopental concentrations in samples of human plasma. Robotic on-line solid phase extraction (SPE) was used to elute the analytes of interest from samples of human plasma (50μL) loaded onto C18 SPE cartridges to which were added aliquots (50μL) of internal standard solution (thiopental-d5 100ng/mL) and 0...
October 27, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27796643/identification-of-candidate-genes-from-the-sad-gene-family-in-cotton-for-determination-of-cottonseed-oil-composition
#19
Xiaoguang Shang, Chaoze Cheng, Jian Ding, Wangzhen Guo
Cotton is an economically important crop grown for natural fiber and seed oil production. Cottonseed oil ranks third after soybean oil and colza oil in terms of edible oilseed tonnage worldwide. The fatty acid composition of cottonseed oil determines its industrial application and nutritional values. However, little progress has been made in understanding cottonseed oil biogenesis. Stearoyl-acyl carrier protein desaturase (SAD), the only known enzyme to convert saturated fatty acids into unsaturated fatty acids in plants, plays key roles in determining the fatty acid composition of cottonseed oil...
October 28, 2016: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/27793671/antiferroptotic-activity-of-non-oxidative-dopamine
#20
Ding Wang, Yingpeng Peng, Yangchun Xie, Borong Zhou, Xiaofang Sun, Rui Kang, Daolin Tang
Dopamine is a neurotransmitter that has many functions in the nervous and immune systems. Ferroptosis is a non-apoptotic form of regulated cell death that is involved in cancer and neurodegenerative diseases. However, the role of dopamine in ferroptosis remains unidentified. Here, we show that the non-oxidative form of dopamine is a strong inhibitor of ferroptotic cell death. Dopamine dose-dependently blocked ferroptosis in cancer (PANC1 and HEY) and non-cancer (MEF and HEK293) cells following treatment with erastin, a small molecule ferroptosis inducer...
October 25, 2016: Biochemical and Biophysical Research Communications
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