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torch trial

Elijah Zhengyang Cai, Kalarani Sankaran, Monica Tan, Yiong Huak Chan, Thiam Chye Lim
INTRODUCTION: Our novel technique of pen torch transillumination (PTI) uses a cheap and easily available instrument (Penlite-LP212(®), Energizer(®), Missouri, USA) to visualize superficial veins invisible to the naked eye. We evaluate the efficacy of PTI in improving venepuncture success rate (SR) for patients with poor venous access. METHODS: This prospective randomized controlled trial looked at adult patients (n = 69) aged 21-90 with difficult venous access (history of ≥3 consecutive attempts required for successful cannulation during the current admission) requiring non-emergent venepuncture...
May 8, 2017: World Journal of Surgery
Lucia Kim, Mauro Saieg, Massimo Di Maio, Ciro Gallo, Charles Butts, Fortunato Ciardiello, Ronald Feld, Dengxiao Cheng, Vittorio Gebbia, Marco Angelo Burgio, Yasmin Alam, Simona Signoriello, Antonio Rossi, Natasha Leighl, Paolo Maione, Alessandro Morabito, Geoffrey Liu, Ming-Sound Tsao, Francesco Perrone, Cesare Gridelli
BACKGROUND: The TORCH phase III trial compared the efficacy of first-line erlotinib followed by chemotherapy at progression (experimental arm) with the reverse sequence (standard arm) in unselected advanced non-small cell lung cancer (NSCLC) patients. Here we report biomarker analyses. METHODS: EGFR and KRAS mutation, expression of EGFR family members and of cMET and PTEN and EGFR and ABCG2 germline polymorphisms were tested on tumor tissue or blood samples to either confirm previously proposed predictive role or describe it in an explorative setting...
February 25, 2017: Oncotarget
Martine Hoogendoorn, Talitha L Feenstra, Yumi Asukai, Andrew H Briggs, Ryan N Hansen, Reiner Leidl, Nancy Risebrough, Yevgeniy Samyshkin, Margarethe Wacker, Maureen P M H Rutten-van Mölken
OBJECTIVES: To validate outcomes of presently available chronic obstructive pulmonary disease (COPD) cost-effectiveness models against results of two large COPD trials-the 3-year TOwards a Revolution in COPD Health (TORCH) trial and the 4-year Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT) trial. METHODS: Participating COPD modeling groups simulated the outcomes for the placebo-treated groups of the TORCH and UPLIFT trials using baseline characteristics of the trial populations as input...
March 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Katelyn C Jelden, Shawn G Gibbs, Philip W Smith, Angela L Hewlett, Peter C Iwen, Kendra K Schmid, John J Lowe
An ultraviolet germicidal irradiation (UVGI) generator (the TORCH, ClorDiSys Solutions, Inc.) was used to compare the disinfection of surface coupons (plastic from a bedrail, stainless steel, and chrome-plated light switch cover) in a hospital room with walls coated with ultraviolet (UV)-reflective paint (Lumacept) or standard paint. Each surface coupon was inoculated with methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus faecalis (VRE), placed at 6 different sites within a hospital room coated with UV-reflective paint or standard paint, and treated by 10 min UVC exposure (UVC dose of 0-688 mJ/cm(2) between sites with standard paint and 0-553 mJ/cm(2) with UV-reflective paint) in 8 total trials...
June 2017: Journal of Occupational and Environmental Hygiene
Mahdi Eskandarlou, Mina Azimi, Soghra Rabiee, Mohammad Ali Seif Rabiee
BACKGROUND: Different methods for dressing of donor site of skin graft in burn patients have similarly pain, limitation of mobility of donor site and local complications such as infection and scar. Amniotic membrane has used for improvement of healing in some wounds. Accordingly in this study amnion was used as biologic dressing for donor site of skin graft to evaluate it's efficacy in improvement of pain, move score and the risk of local infection. METHODS: Study was done as clinical trial over 32 admitted patients in burn department of Beasat hospital...
January 2016: World Journal of Plastic Surgery
Giovanna Ghiani, Elisabetta Marongiu, Sergio Olla, Marco Pinna, Matteo Pusceddu, Girolamo Palazzolo, Irene Sanna, Silvana Roberto, Antonio Crisafulli, Filippo Tocco
BACKGROUND: We hypothesized that overnight fasting after a short dietary period, especially with carbohydrates, could allow performing breath-hold diving with no restraint for diaphragm excursion and blood shift and without any increase of metabolism, and in turn improve the diving response. METHODS: During two separate sessions, 8 divers carried out two trials: (A) a 30-m depth dive, three hours after a normal breakfast and (B) a dive to the same depth, but after following a diet and fasting overnight...
2016: Journal of the International Society of Sports Nutrition
Yogesh Suresh Punekar, Graeme Roberts, Afisi Ismaila, Martin O'Leary
BACKGROUND: The cost-effectiveness of umeclidinium bromide-vilanterol (UMEC/VI) versus tiotropium monotherapy in the UK was assessed using a UMEC/VI treatment-specific economic model based on a chronic obstructive pulmonary disease (COPD) disease-progression model. METHODS: The model was implemented as a linked-equation model to estimate COPD progression and associated health service costs, and its impact on quality-adjusted life years (QALYs) and survival. Statistical risk equations for clinical endpoints and resource use were derived from the ECLIPSE and TORCH studies, respectively...
2015: Cost Effectiveness and Resource Allocation: C/E
Vivek Choudhury, Sanjiv B Amin, Asha Agarwal, L M Srivastava, Arun Soni, Satish Saluja
BACKGROUND: In utero latent iron deficiency has been associated with abnormal neurodevelopmental outcomes during childhood. Its concomitant effect on auditory neural maturation has not been well studied in late preterm and term infants. OBJECTIVE: The objective was to determine whether in utero iron status is associated with auditory neural maturation in late preterm and term infants. DESIGN: This prospective cohort study was performed at Sir Ganga Ram Hospital, New Delhi, India...
November 2015: American Journal of Clinical Nutrition
Ana M López-Sabirón, Kristina Fleiger, Stefan Schäfer, Javier Antoñanzas, Ane Irazustabarrena, Alfonso Aranda-Usón, Germán A Ferreira
Plasma torch gasification (PTG) is currently researched as a technology for solid waste recovery. However, scientific studies based on evaluating its environmental implications considering the life cycle assessment (LCA) methodology are lacking. Therefore, this work is focused on comparing the environmental effect of the emissions of syngas combustion produced by refuse derived fuel (RDF) and PTG as alternative fuels, with that related to fossil fuel combustion in the cement industry. To obtain real data, a semi-industrial scale pilot plant was used to perform experimental trials on RDF-PTG...
August 2015: Waste Management & Research
Alan P Skarbnik, Anthony J Olszanski
No abstract text is available yet for this article.
February 2013: Translational Lung Cancer Research
Louise Rosalyn Carter, Raffaele Califano
No abstract text is available yet for this article.
December 2012: Translational Lung Cancer Research
David Niederseer, Sabine A M Richter, Daniel Neunhäuserer, Bernd Lamprecht, Sonia A Buist, Michael Studnicka, Josef Niebauer
PURPOSE: Evidence-based medicine promotes the current best evidence from clinical trials to guide decisions for individual patients. We assessed whether chronic obstructive pulmonary disease (COPD) patients included in exercise training studies and pharmacologic trials match those from a non-selected COPD target population sample. METHODS: Exercise training studies were identified in a literature search. Towards a Revolution in COPD Health (TORCH) and Understanding Potential Long-Term Impacts on Function with Tiotropium (UPLIFT) were chosen to represent pharmacologic trials...
September 2015: Sleep & Breathing, Schlaf & Atmung
Zohra S Lassi, Ayesha M Imam, Sohni V Dean, Zulfiqar A Bhutta
INTRODUCTION: Infections can impact the reproductive health of women and hence may influence pregnancy related outcomes for both the mother and the child. These infections range from sexually transmitted infections (STIs) to TORCHS infections to periodontal disease to systemic infections and may be transmitted to the fetus during pregnancy, labor, delivery or breastfeeding. METHODS: A systematic review and meta-analysis of the evidence was conducted to ascertain the possible impact of preconception care for adolescents, women and couples of reproductive age on MNCH outcomes...
September 26, 2014: Reproductive Health
Rajesh Zacharias, Michael Colancecco, Ryan Shipe, Stephen Summers, Paulo Oliveira, Bruce Greenberg, Andrew Fischer
SESSION TITLE: Miscellaneous Cases ISESSION TYPE: Affiliate Case Report SlidePRESENTED ON: Sunday, October 26, 2014 at 10:45 AM - 12:00 PMINTRODUCTION: We present a case of hydrocarbon pneumonitis secondary to aspiration of tiki torch fluid. CASE PRESENTATION: A 19 year old healthy female presented with dyspnea,pleurisy & drenching night sweats,post ingestion of "tiki" (flame) torch fluid,while inebriated at a party.Physical exam showed a room air oxyhemoglobin saturation of 88% & diminished bibasilar breath sounds...
October 1, 2014: Chest
David Price, Dorothy Keininger, Madlaina Costa-Scharplatz, Karen Mezzi, Maria Dimova, Yumi Asukai, Björn Ställberg
BACKGROUND: Indacaterol/glycopyrronium (IND/GLY) is a once-daily inhaled fixed-dose combination of indacaterol (IND), a long-acting β2-adrenergic agonist (LABA), and glycopyrronium (GLY), a long-acting muscarinic antagonist (LAMA) for use as maintenance treatment to relieve symptoms of chronic obstructive pulmonary disease (COPD) in adults. OBJECTIVE: To determine the economic benefits of IND/GLY compared with the free combination of indacaterol and glycopyrronium (IND + GLY), and with the fixed-dose combination of salmeterol/fluticasone (SFC), in a moderate-to-severe COPD population with low-exacerbation risk...
December 2014: Respiratory Medicine
Khumbo Kalua, Michael Gichangi, Ernest Barassa, Edson Eliah, Susan Lewallen, Paul Courtright
BACKGROUND: Knowledge and skills of primary health care workers (PHCWs) in primary eye care have been demonstrated to be inadequate in several districts of Kenya, Malawi, and Tanzania. We tested whether enhanced supervision, focused on improving practical skills over two years, would raise the scores of these workers on a test of basic knowledge and skills. METHODS: This was a randomised controlled trial. All primary health care (PHC) facilities within two districts of each country were enrolled and randomly assigned by district (Kenya, Malawi) or by health care facility (Tanzania) to receive quarterly skills-based supervision by a district eye coordinator or to continue existing routine supervision...
2014: BMC Health Services Research
Gourav Goyal, Jayantee Kalita, Usha K Misra
Psychogenic non epileptic seizure (PNES) can be induced by several induction tests but their relative usefulness has not been evaluated. In this study, we report the sensitivity and specificity of various induction tests in the diagnosis of PNES and assess their discomfort level. The induction tests were: (a) compression of temple region (CTR), (b) verbal suggestion (VS), (c) tuning fork application (TFA), (d) moist swab application (MSA), (e) torch light stimulation (TLS) and (f) saline injection (SI). Up to 3 trials were done for each test except for normal saline injection which was given once...
August 2014: Epilepsy Research
Ali Salehi, Solmaz Jabarzare, Mohammadreza Neurmohamadi, Soleiman Kheiri, Mahmoud Rafieian-Kopaei
Purpose. This trial was designed to evaluate the efficacy and safety of topical honey eye drops in patients with diagnosed VKC. Methods. This clinical trial was conducted on 60 patients with diagnosed VKC. The patients were selected and randomly allocated between two groups of 30. Patients in two groups received honey eye drop (60% in artificial tear) or placebo, other than cromolyn and fluorometholone 1% eye drops, to be used topically in each eye, four times per day. The patients were examined with slit lamp and torch at baseline and the follow-up visits on the 1st, 3rd, and 6th months of the study for redness, limbal papillae, and intraocular pressure...
2014: Evidence-based Complementary and Alternative Medicine: ECAM
Annemarije L Kruis, Björn Ställberg, Rupert C M Jones, Ioanna G Tsiligianni, Karin Lisspers, Thys van der Molen, Jan Willem H Kocks, Niels H Chavannes
BACKGROUND: Guideline recommendations for chronic obstructive pulmonary disease (COPD) are based on the results of large pharmaceutically-sponsored COPD studies (LPCS). There is a paucity of data on disease characteristics at the primary care level, while the majority of COPD patients are treated in primary care. OBJECTIVE: We aimed to evaluate the external validity of six LPCS (ISOLDE, TRISTAN, TORCH, UPLIFT, ECLIPSE, POET-COPD) on which current guidelines are based, in relation to primary care COPD patients, in order to inform future clinical practice guidelines and trials...
2014: PloS One
Luis Javier Nannini, Phillippa Poole, Stephen J Milan, Rebecca Holmes, Rebecca Normansell
BACKGROUND: Both long-acting beta2-agonists (LABA) and inhaled corticosteroids (ICS) have been recommended in guidelines for the treatment of chronic obstructive pulmonary disease (COPD). Their coadministration in a combination inhaler may facilitate adherence to medication regimens and improve efficacy. OBJECTIVES: To determine the efficacy and safety of combined ICS and LABA for stable COPD in comparison with placebo. SEARCH METHODS: We searched the Cochrane Airways Group Specialised Register of trials, reference lists of included studies and manufacturers' trial registries...
2013: Cochrane Database of Systematic Reviews
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