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https://www.readbyqxmd.com/read/29338729/computational-study-of-the-effects-of-arterial-bifurcation-on-the-temperature-distribution-during-cryosurgery
#1
Yong-Chang Zheng, Jun-Hong Wu, Zhi-Zhu He, Shao-Jiong Huang
BACKGROUND: Thermally significant blood flows into locally cooled diseased tissues and warm them during cryosurgery so that the iceball is often hard to cover the whole diseased volume. This paper is aimed at investigating the effects of large arterial bifurcation on the temperature distribution during cryosurgery through simulation method. METHODS: A parametric geometry model is introduced to construct a close-to-real arterial bifurcation. The three-dimensional transient conjugate heat transfer between bifurcated artery and solid tissues with phase change during cryosurgery is performed by finite volume method...
January 16, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29337367/correlation-of-simulation-finite-element-analysis-to-the-separation-of-intrinsically-magnetic-spores-and-red-blood-cells-using-a-microfluidic-magnetic-deposition-system
#2
Jianxin Sun, L Moore, Wei Xue, James Kim, Maciej Zborowski, Jeffrey J Chalmers
Magnetic separation of cells has been, and continues to be, widely used in a variety of applications, ranging from healthcare diagnostics to detection of food contamination. Typical, these technologies require cells labeled with antibody magnetic particle conjugate and a high magnetic energy gradient created in the flow containing the labeled cells (i.e. a column packed with magnetically inducible material), or dense packing of magnetic particles next to the flow cell. Such designs while creating high magnetic energy gradients, are not amenable to easy, highly detailed, mathematic characterization...
January 16, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29334079/first-heating-measurements-of-endovascular-stents-in-magnetic-particle-imaging
#3
Franz Wegner, Thomas Friedrich, Nikolaos Panagiotopoulos, Sarah Vaalma, Jan Peter Goltz, Florian M Vogt, Martin A Koch, Thorsten M Buzug, Joerg Barkhausen, Julian Haegele
Magnetic Particle Imaging (MPI) is a three-dimensional imaging method which visualizes the spatial distribution of Superparamagnetic Iron Oxide Nanoparticles (SPIOs) with oscillating and static magnetic fields. It is a quantitative method as the intensity of its signal is proportional to the concentration of the SPIOs. Due to its quantitativeness, high temporal resolution and kidney-safe tracers it is proposed to be a very promising noninvasive method for cardiovascular imaging. In this regard MPI in the presence of endovascular stents and assessment of stent patency with MPI has to be evaluated...
January 15, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29331052/flow-pattern-analysis-in-type-b-aortic-dissection-patients-after-stent-grafting-repair-comparison-between-complete-and-incomplete-false-lumen-thrombosis
#4
Wan Naimah Wan Ab Naim, Poo Balan Ganesan, Zhonghua Sun, Jing Lei, Shirley Jansen, Shahrul Amry Hashim, Teik Kok Ho, Einly Lim
Endovascular stent graft repair has become a common treatment for complicated Stanford Type B aortic dissection in order to restore true lumen flow and induce false lumen thrombosis. Using computational fluid dynamics, this study reports the differences in flow patterns and wall shear stress distribution in complicated Stanford Type B aortic dissection patients after endovascular stent graft repair. Five patients were included in this study: two having more than 80% false lumen thrombosis (Group 1), while three others had less than 80% false lumen thrombosis (Group 2) within one year following endovascular repair...
January 13, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29331029/characterization-of-cd34-hematopoietic-cells-in-systemic-mastocytosis-potential-role-in-disease-dissemination
#5
Andrea Mayado, Cristina Teodosio, Noelia Dasilva Freire, Maria Jara-Acevedo, Andrés C Garcia-Montero, Ivan Álvarez-Twose, Laura Sánchez-Muñoz, Almudena Matito, Carolina Caldas, Javier I Muñoz-González, Ana Henriques, José I Sánchez-Gallego, Luis Escribano, Alberto Orfao
BACKGROUND: Recent studies show that most systemic mastocytosis (SM) patients, including indolent SM (ISM) with (ISMs+) and without skin lesions (ISMs-), carry the KIT D816V mutation in PB leukocytes. We investigated the potential association between the degree of involvement of BM hematopoiesis by the KIT D816V mutation and the distribution of different maturation-associated compartments of bone marrow (BM) and peripheral blood (PB) CD34+ hematopoietic precursors (HPC) in ISM, and identified the specific PB cell compartments that carry this mutation...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29330837/computer-simulated-modeling-of-healthy-and-diseased-right-ventricular-and-pulmonary-circulation
#6
Jody Chou, Joseph B Rinehart
We have previously developed a simulated cardiovascular physiology model for in-silico testing and validation of novel closed-loop controllers. To date, a detailed model of the right heart and pulmonary circulation was not needed, as previous controllers were not intended for use in patients with cardiac or pulmonary pathology. With new development of controllers for vasopressors, and looking forward, for combined vasopressor-fluid controllers, modeling of right-sided and pulmonary pathology is now relevant to further in-silico validation, so we aimed to expand our existing simulation platform to include these elements...
January 12, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29326490/investigation-of-in-vitro-absorption-distribution-metabolism-and-excretion-and-in-vivo-pharmacokinetics-of-paromomycin-influence-on-oral-bioavailability
#7
M Jakir S K Pinjari, Rahul Somani, Ritu M Gilhotra
OBJECTIVE: The objective of this study is to investigate in vitro Caco2 permeability, metabolism and in vivo pharmacokinetic (PK) properties of paromomycin to develop an efficient dosage form with improved oral bioavailability. MATERIALS AND METHODS: For the purpose, Caco2 permeability assay, mouse microsomal stability assay and in vivo PKs in male BALB/c mice were performed. RESULTS: In Caco-2 permeability assay, paromomycin showed negligible permeability in the apical to basolateral (A-to-B) direction and vice versa (B-to-A)...
July 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29324813/increase-in-extraction-of-i-123-iomazenil-in-patients-with-chronic-cerebral-ischemia
#8
Hiroki Kato, Kayako Isohashi, Eku Shimosegawa, Jun Hatazawa
BACKGROUND: Cerebral extraction of diffusively distributed substances like oxygen has been suggested to change according to the cerebral blood flow (CBF) and status of the microvasculature. The relationships between the cerebral extraction of diffusively distributed lipophilic tracers and the severity of cerebral ischemia has not yet been clarified. In the present study, we attempted to elucidate the association between the extraction fraction of the lipophilic tracer I-123 iomazenil (IMZ) (IMZ-EF) and the oxygen extraction fraction (OEF) derived from O-15 PET in patients with chronic steno-occlusive disease of internal carotid artery (ICA) or middle cerebral artery (MCA)...
2018: PloS One
https://www.readbyqxmd.com/read/29313241/cd146-positive-human-dental-pulp-stem-cells-promote-regeneration-of-dentin-pulp-like-structures
#9
Mikiko Matsui, Tomoko Kobayashi, Takeo W Tsutsui
CD146 and STRO-1 are endothelial biomarkers that are co-expressed on the cellular membranes of blood vessels within human dental pulp tissue. This study characterized the percentage of dentin-like structures produced by CD146-positive (CD146+) human dental pulp stem cells (DPSCs), compared with their CD146-negative (CD146-) counterparts. DPSC populations were enriched using magnetic-activated cell sorting (MACS), yielding CD146+ and CD146- cells, as well as mixtures composed of 25% CD146+ cells and 75% CD146- cells (CD146+/-)...
January 8, 2018: Human Cell
https://www.readbyqxmd.com/read/29312587/tumour-microenvironmental-blood-flow-determines-a-metabolomic-signature-identifying-lysophospholipids-and-resolvin-d-as-biomarkers-in-endometrial-cancer-patients
#10
Núria Eritja, Mariona Jové, Kristine Eldevik Fasmer, Sònia Gatius, Manuel Portero-Otin, Jone Trovik, Camilla Krakstad, Joaquim Sol, Reinald Pamplona, Ingfrid S Haldorsen, Xavier Matias-Guiu
Purpose: We aimed to study the potential influence of tumour blood flow -obtained from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)- in the metabolomic profiles of endometrial tumours. Methods: Liquid chromatography coupled to mass spectrometry established the metabolomic profile of endometrial cancer lesions exhibiting high (n=12) or low (n=14) tumour blood flow at DCE-MRI. Univariate and multivariate statistics (ortho-PLS-DA, a random forest (RF) classifier and hierarchical clustering) and receiver operating characteristic (ROC) curves were used to establish a panel for potentially discriminating tumours with high versus low blood flow...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29311033/lesion-specific-and-vessel-related-determinants-of-fractional-flow-reserve-beyond-coronary-artery-stenosis
#11
Amir Ahmadi, Jonathon Leipsic, Kristian A Øvrehus, Sara Gaur, Emilia Bagiella, Brian Ko, Damini Dey, Gina LaRocca, Jesper M Jensen, Hans Erik Bøtker, Stephan Achenbach, Bernard De Bruyne, Bjarne L Nørgaard, Jagat Narula
OBJECTIVES: The aims of the present study were: 1) to investigate the contribution of the extent of luminal stenosis and other lesion composition-related factors in predicting invasive fractional flow reserve (FFR); and 2) to explore the distribution of various combinations of morphological characteristics and the severity of stenosis among lesions demonstrating normal and abnormal FFR. BACKGROUND: In patients with stable ischemic heart disease, FFR-guided revascularization, as compared with medical therapy alone, is reported to improve outcomes...
January 2, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29310150/noninvasive-vascular-assessment-of-lower-extremity-wounds-in-diabetics-are-we-able-to-predict-perfusion-deficits
#12
Iram Naz, Elliot Walters, Cameron M Akbari, Christopher E Attinger, Paul J Kim
Vascular assessment of the lower extremity is a critical step in any patient presenting with lower extremity chronic wounds to predict the likelihood of healing and risk of amputation. This concept is vital in patients with diabetes due to their complex vascular anatomy and disease distribution. Three arteries supply the six angiosomes of the lower extremity (i.e., three-dimensional blocks of tissue fed by a "source" artery in the foot and ankle). In diabetic patients, assessment of adequate blood flow to the lower extremities is complicated by the presence of arterial calcification, associated neuropathy, and inflammation...
October 12, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29305878/study-of-microvascular-non-newtonian-blood-flow-modulated-by-electroosmosis
#13
Dharmendra Tripathi, Ashu Yadav, O Anwar Bég, Rakesh Kumar
An analytical study of microvascular non-Newtonian blood flow is investigated in presence of electro-osmosis phenomenon. Blood is considered as a Bingham rheological aqueous ionic solutions. An externally applied static axial electrical field is imposed on the system. The Poisson-Boltzmann equation for electric potential distribution is implemented to accommodate the electrical double layer in the microvascular. With long wavelength, lubrication and Debye-Hückel approximations, the boundary value problem is rendered non-dimensional...
January 3, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29305613/optimized-time-resolved-echo-piv-ptv-measurements-elucidate-blood-flow-in-patients-with-left-ventricular-thrombus
#14
Kaushik Sampath, Thura T Harfi, Ricard/T George, Joseph Katz
Contrast ultrasound is a widely used clinical tool to obtain real-time qualitative blood flow assessments in the heart, liver, etc. Echocardiographic particle image velocimetry (echo-PIV) is a technique for obtaining quantitative velocity maps from contrast ultrasound images. However, unlike optical PIV, routine echo images are prone to non-uniform spatiotemporal variations in tracer distribution, making analysis difficult for standard PIV algorithms. This study introduces optimized procedures that integrate image enhancement, PIV and particle tracking velocimetry (PTV) to obtain reliable time-resolved 2D velocity distributions...
January 5, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29301706/an-experimental-study-and-finite-element-modeling-of-head-and-neck-cooling-for-brain-hypothermia
#15
Hui Li, Roland K Chen, Yong Tang, William Meurer, Albert J Shih
Reducing brain temperature by head and neck cooling is likely to be the protective treatment for humans when subjects to sudden cardiac arrest. This study develops the experimental validation model and finite element modeling (FEM) to study the head and neck cooling separately, which can induce therapeutic hypothermia focused on the brain. Anatomically accurate geometries based on CT images of the skull and carotid artery are utilized to find the 3D geometry for FEM to analyze the temperature distributions and 3D-printing to build the physical model for experiment...
January 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29300458/protein-profiling-and-sizing-of-extracellular-vesicles-from-colorectal-cancer-patients-via-flow-cytometry
#16
Ye Tian, Ling Ma, Manfei Gong, Guoqiang Su, Shaobin Zhu, Wenqiang Zhang, Shuo Wang, Zhibin Li, Chaoxiang Chen, Lihong Li, Lina Wu, Xiaomei Yan
Extracellular vesicles (EVs) have stimulated considerable scientific and clinical interest, yet protein profiling and sizing of individual EVs remains challenging due to their small particle size, low abundance of proteins, and overall heterogeneity. Building upon a laboratory-built high-sensitivity flow cytometer (HSFCM), we report here a rapid approach for quantitative multiparameter analysis of single EVs down to 40 nm with an analysis rate up to 10,000 particles per minute. Statistically robust particle size distribution was acquired in minutes with a resolution and profile well matched with those of cryo-TEM measurements...
January 4, 2018: ACS Nano
https://www.readbyqxmd.com/read/29296635/proinflammatory-b-cell-profile-in-the-early-phases-of-ms-predicts-an-active-disease
#17
Thomas Guerrier, Myriam Labalette, David Launay, Catalina Lee-Chang, Olivier Outteryck, Guillaume Lefèvre, Patrick Vermersch, Sylvain Dubucquoi, Hélène Zéphir
Objective: To assess whether any alteration of B-cell subset distribution and/or the cytokine production capacities of B cells could be associated with any stage of MS and could be predictive of MS evolution. Methods: We prospectively enrolled radiologically isolated syndrome (RIS), clinically isolated syndrome (CIS), naive patients with relapsing remitting MS (RRMS) of any disease modifying drug, and healthy controls (HCs). Peripheral blood B-cell subset distributions and the interleukin (IL)-6/IL-10-producing B-cell ratio were assessed by flow cytometry to evaluate their proinflammatory and anti-inflammatory functional properties...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29296499/momentum-transfer-monte-carlo-for-the-simulation-of-laser-speckle-imaging-and-its-application-in-the-skin
#18
Caitlin Regan, Carole Hayakawa, Bernard Choi
Due to its simplicity and low cost, laser speckle imaging (LSI) has achieved widespread use in biomedical applications. However, interpretation of the blood-flow maps remains ambiguous, as LSI enables only limited visualization of vasculature below scattering layers such as the epidermis and skull. Here, we describe a computational model that enables flexible in-silico study of the impact of these factors on LSI measurements. The model uses Monte Carlo methods to simulate light and momentum transport in a heterogeneous tissue geometry...
December 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29287129/new-advances-in-fetal-cardiovascular-magnetic-resonance-imaging-for-quantifying-the-distribution-of-blood-flow-and-oxygen-transport-potential-applications-in-fetal-cardiovascular-disease-diagnosis-and-therapy
#19
REVIEW
Liqun Sun, Christopher K Macgowan, Sharon Portnoy, John G Sled, Shi-Joon Yoo, Lars Grosse-Wortmann, Edgar Jaeggi, John Kingdom, Mike Seed
Until recently, our modern understanding of fetal circulatory physiology has been largely based on invasive measurements made in fetal sheep. However, new MRI technology developed by our group has provided equivalent information about the distribution of blood flow and oxygen transport noninvasively. The initial findings largely confirm prior estimates about the human fetal circulation extrapolated from fetal sheep data and human ultrasound data. Here we describe the hemodynamics of the normal late gestation human fetal circulation by MRI and speculate about what the advent of this technology might mean in terms of the management of fetuses affected by placental insufficiency and congenital heart disease...
December 2017: Echocardiography
https://www.readbyqxmd.com/read/29285082/molecular-mechanisms-in-vascular-injury-induced-by-hypertension-expression-and-role-of-microrna-34a
#20
Siguan Liu, Fanfan Yi, Wenwei Cheng, Xin Qu, Chunting Wang
The aim of the present study was to investigate the expression and function of microRNA (miR)-34a in patients with primary hypertension. The expression of miR-34a was measured in the peripheral blood of 50 patients with primary hypertension and 28 normal controls by reverse transcription quantitative polymerase chain reaction. In addition, human umbilical vein endothelial cells (HUVECs) were transfected with an miR-34a inhibitor to suppress the expression of miR-34a, and the proliferation, migration and cell cycle distribution of HUVECs were measured by Cell Counting Kit-8, Transwell and flow cytometry assays...
December 2017: Experimental and Therapeutic Medicine
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