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JOURNAL ARTICLE
Andrew N Dates, Daniel T D Jones, Jeffrey S Smith, Meredith A Skiba, Maria F Rich, Maggie M Burruss, Andrew C Kruse, Stephen C Blacklow
Adhesion G protein-coupled receptor (aGPCR) signaling influences development and homeostasis in a wide range of tissues. In the current model for aGPCR signaling, ligand binding liberates a conserved sequence that acts as an intramolecular, tethered agonist (TA), yet this model has not been evaluated systematically for all aGPCRs. Here, we assessed the TA-dependent activities of all 33 aGPCRs in a suite of transcriptional reporter, G protein activation, and β-arrestin recruitment assays using a new fusion protein platform...
April 4, 2024: Cell Chemical Biology
#22
JOURNAL ARTICLE
John H Lee, Jaes C Jones, Daniel S Lee, Jacob R Joseph
OBJECTIVE: Given the ubiquity and severity of postoperative pain following spine surgery, developing adequate pain management modalities is critical. Transcutaneous electrical nerve stimulation (TENS) is a promising noninvasive modality that is well studied for managing postoperative pain following a variety of surgeries, but data on using TENS for pain management in the acute postoperative period of spine surgery are limited. Therefore, this review aimed to recapitulate the existing evidence for the use of TENS in postoperative pain management for spine surgery and explore the potential of this modality moving forward...
April 12, 2024: Journal of Neurosurgery. Spine
#23
JOURNAL ARTICLE
Pierre-Gregoire Coulon, Swayam Prakash, Nisha R Dhanushkodi, Ruchi Srivastava, Latifa Zayou, Delia F Tifrea, Robert A Edwards, Cesar J Figueroa, Sebastian D Schubl, Lanny Hsieh, Anthony B Nesburn, Baruch D Kuppermann, Elmostafa Bahraoui, Hawa Vahed, Daniel Gil, Trevor M Jones, Jeffrey B Ulmer, Lbachir BenMohamed
BACKGROUND: Cross-reactive SARS-CoV-2-specific memory CD4+ and CD8+ T cells are present in up to 50% of unexposed, pre-pandemic, healthy individuals (UPPHIs). However, the characteristics of cross-reactive memory CD4+ and CD8+ T cells associated with subsequent protection of asymptomatic coronavirus disease 2019 (COVID-19) patients (i.e., unvaccinated individuals who never develop any COVID-19 symptoms despite being infected with SARS-CoV-2) remains to be fully elucidated. METHODS: This study compares the antigen specificity, frequency, phenotype, and function of cross-reactive memory CD4+ and CD8+ T cells between common cold coronaviruses (CCCs) and SARS-CoV-2...
2024: Frontiers in Immunology
#24
JOURNAL ARTICLE
Stéphanie Pascual, Brooklyn Noble, Nusreen Ahmad-Saeed, Catherine Aldridge, Simone Ambretti, Sharon Amit, Rachel Annett, Shaan Ashk O'Shea, Anna Maria Barbui, Gavin Barlow, Lucinda Barrett, Mario Berth, Alessandro Bondi, Nicola Boran, Sara E Boyd, Catarina Chaves, Martin Clauss, Peter Davies, Ileana T Dianzo-Delgado, Jaime Esteban, Stefan Fuchs, Lennart Friis-Hansen, Daniel Goldenberger, Andrej Golle, Juha O Groonroos, Ines Hoffmann, Tomer Hoffmann, Harriet Hughes, Marina Ivanova, Peter Jezek, Gwennan Jones, Zeynep Ceren Karahan, Cornelia Lass-Flörl, Frédéric Laurent, Laura Leach, Matilde Lee Horsbøll Pedersen, Caroline Loiez, Maureen Lynch, Robert J Maloney, Martin Marsh, Olivia Milburn, Shanine Mitchell, Luke S P Moore, Lynn Moffat, Marianna Murdjeva, Michael E Murphy, Deepa Nayar, Giacomo Nigrisoli, Fionnuala O'Sullivan, Büşra Öz, Teresa Peach, Christina Petridou, Mojgan Prinz, Mitja Rak, Niamh Reidy, Gian Maria Rossolini, Anne-Laure Roux, Patricia Ruiz-Garbajosa, Kordo Saeed, Llanos Salar-Vidal, Carlos Salas Venero, Mathyruban Selvaratnam, Eric Senneville, Peter Starzengruber, Ben Talbot, Vanessa Taylor, Rihard Trebše, Deborah Wearmouth, Birgit Willinger, Marjan Wouthuyzen-Bakker, Brianne Couturier, Florence Allantaz
Introduction : The BIOFIRE Joint Infection (JI) Panel is a diagnostic tool that uses multiplex-PCR testing to detect microorganisms in synovial fluid specimens from patients suspected of having septic arthritis (SA) on native joints or prosthetic joint infections (PJIs). Methods : A study was conducted across 34 clinical sites in 19 European and Middle Eastern countries from March 2021 to June 2022 to assess the effectiveness of the BIOFIRE JI Panel. Results : A total of 1527 samples were collected from patients suspected of SA or PJI, with an overall agreement of 88...
2024: Journal of Bone and Joint Infection
#25
RANDOMIZED CONTROLLED TRIAL
Suzanne V Arnold, Philip G Jones, David J Maron, David J Cohen, Daniel B Mark, Harmony R Reynolds, Sripal Bangalore, Jiyan Chen, Jonathan D Newman, Robert A Harrington, Gregg W Stone, Judith S Hochman, John A Spertus
BACKGROUND: The ISCHEMIA trial found that patients with chronic coronary disease randomized to invasive strategy had better health status than those randomized to conservative strategy. It is unclear how best to translate these population-level results to individual patients. OBJECTIVES: The authors sought to identify patient characteristics associated with health status from invasive and conservative strategies, and develop a prediction algorithm for shared decision-making...
April 16, 2024: Journal of the American College of Cardiology
#26
JOURNAL ARTICLE
Nicholas Pohl, Parker Brush, Daren Aita, Justin Kistler, Christopher Jones, Rick Tosti, Daniel Fletcher
HYPOTHESIS: The purpose of this study was to compare inter-and intraobserver agreement of a novel intraoperative subluxation classification for patients undergoing ulnar nerve surgery at the elbow. We hypothesize there will be strong inter- and intraobserver agreement of the four-category classification system and reviewers will have substantial confidence while reviewing the classification system. METHODS: Four blinded fellowship-trained orthopedic hand surgeons reviewed 25 videos in total on two separate viewings, 21 days apart...
April 8, 2024: Journal of Shoulder and Elbow Surgery
#27
JOURNAL ARTICLE
Zachary A Kopelman, Chunqiao Tian, Jordyn Tumas, Neil T Phippen, Christopher M Tarney, Erica R Hope, Stuart S Winkler, Suzanne Jokajtys, Calen W Kucera, John K Chan, Michael T Richardson, Daniel S Kapp, Chad A Hamilton, Charles A Leath, Nathaniel L Jones, Rodney P Rocconi, John H Farley, Angeles Alvarez Secord, Casey M Cosgrove, Matthew A Powell, Ann Klopp, Joan L Walker, Gini F Fleming, Nicholas W Bateman, Thomas P Conrads, G Larry Maxwell, Kathleen M Darcy
OBJECTIVE: Investigate racial disparities in outcomes and molecular features in Black and White patients with endometrioid endometrial carcinoma (EEC). METHODS: Black and White patients diagnosed with EEC who underwent hysterectomy ± adjuvant treatment in SEER, National Cancer Database (NCDB), the Genomics Evidence Neoplasia Information Exchange (GENIE) project (v.13.0), and eight NCI-sponsored randomized phase III clinical trials (RCTs) were studied. Hazard ratio (HR) and 95% confidence interval (CI) were estimated for cancer-related death (CRD), non-cancer death (NCD), and all-cause death...
April 8, 2024: Gynecologic Oncology
#28
JOURNAL ARTICLE
Pei Li, Yajie Liu, Julia N Faraone, Cheng Chih Hsu, Michelle Chamblee, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Jeffrey C Horowitz, Rama K Mallampalli, Linda J Saif, Eugene M Oltz, Daniel Jones, Jianrong Li, Richard J Gumina, Shan-Lu Liu
UNLABELLED: The rapid evolution of SARS-CoV-2 variants presents a constant challenge to the global vaccination effort. In this study, we conducted a comprehensive investigation into two newly emerged variants, BA.2.87.1 and JN.1, focusing on their neutralization resistance, infectivity, antigenicity, cell-cell fusion, and spike processing. Neutralizing antibody (nAb) titers were assessed in diverse cohorts, including individuals who received a bivalent mRNA vaccine booster, patients infected during the BA...
April 9, 2024: MBio
#29
REVIEW
Marianne Leruez-Ville, Christos Chatzakis, Daniele Lilleri, Daniel Blazquez-Gamero, Ana Alarcon, Nicolas Bourgon, Ina Foulon, Jacques Fourgeaud, Anna Gonce, Christine E Jones, Paul Klapper, André Krom, Tiziana Lazzarotto, Hermione Lyall, Paulo Paixao, Vassiliki Papaevangelou, Elisabeth Puchhammer, George Sourvinos, Pamela Vallely, Yves Ville, Ann Vossen
Congenital cytomegalovirus (cCMV) infection carries a significant burden with a 0.64% global prevalence and a 17-20% chance of serious long-term effects in children. Since the last guidelines, our understanding, particularly regarding primary maternal infections, has improved. A cCMV guidelines group was convened under the patronage of the European Society of Clinical Virology in April 2023 to refine these insights. The quality and validity of selected studies were assessed for potential biases and the GRADE framework was employed to evaluate quality of evidence across key domains...
May 2024: The Lancet regional health. Europe
#30
JOURNAL ARTICLE
Felicity Liew, Claudia Efstathiou, Sara Fontanella, Matthew Richardson, Ruth Saunders, Dawid Swieboda, Jasmin K Sidhu, Stephanie Ascough, Shona C Moore, Noura Mohamed, Jose Nunag, Clara King, Olivia C Leavy, Omer Elneima, Hamish J C McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Victoria C Harris, Linzy Houchen-Wolloff, Neil J Greening, Nazir I Lone, Matthew Thorpe, A A Roger Thompson, Sarah L Rowland-Jones, Annemarie B Docherty, James D Chalmers, Ling-Pei Ho, Alexander Horsley, Betty Raman, Krisnah Poinasamy, Michael Marks, Onn Min Kon, Luke S Howard, Daniel G Wootton, Jennifer K Quint, Thushan I de Silva, Antonia Ho, Christopher Chiu, Ewen M Harrison, William Greenhalf, J Kenneth Baillie, Malcolm G Semple, Lance Turtle, Rachael A Evans, Louise V Wain, Christopher Brightling, Ryan S Thwaites, Peter J M Openshaw
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1 . Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment...
April 2024: Nature Immunology
#31
JOURNAL ARTICLE
J Guillermo Sanchez, Scott Rankin, Emily Paul, Heather A McCauley, Daniel O Kechele, Jacob R Enriquez, Nana-Hawa Jones, Siri A W Greeley, Lisa Letourneau-Friedberg, Aaron M Zorn, Mansa Krishnamurthy, James M Wells
The gastrointestinal tract is complex and consists of multiple organs with unique functions. Rare gene mutations can cause congenital malformations of the human GI tract, although the molecular basis of these has been poorly studied. We identified a patient with compound-heterozygous mutations in RFX6 presenting with duodenal mal-rotation and atresia, implicating RFX6 in development of the proximal intestine. To identify how mutations in RFX6 impact intestinal patterning and function, we derived iPSCs from this patient to generate human intestinal organoids (HIOs)...
April 8, 2024: Development
#32
JOURNAL ARTICLE
Shannon C White, John M Ruiz, Matthew Allison, Bert N Uchino, Timothy W Smith, Daniel J Taylor, Dusti R Jones, Michael A Russell, Emily B Ansell, Joshua M Smyth
This study examined the cardiovascular disease (CVD) risk profiles of male law enforcement officers (LEOs) and civilians. CVD risk profiles were based on data collected using traditional objective (e.g., resting BP, cholesterol), novel objective (e.g., ambulatory BP) and self-report measures (e.g., EMA social vigilance). A subset of male LEOs ( n = 30, M age = 41.47, SD = 8.03) and male civilians ( n = 120, M age = 40.73, SD = 13.52) from a larger study were included in analyses. Results indicated LEOs had significantly higher body mass index [BMI], 31...
2024: Health Psychology Open
#33
JOURNAL ARTICLE
Daniel Upmann, Dirk Bockfeld, Peter G Jones, Eliza Târcoveanu
The structures of ten phosphane chalcogenide complexes of gold(III) halides, with general formula R 1 3- n R 2 n P E Au X 3 ( R 1 = t -butyl; R 2 = i -propyl; n = 0 to 3; E = S or Se; X = Cl or Br) are presented. The eight possible chlorido derivatives are: 9a , n = 3, E = S; 10a , n = 2, E = S; 11a , n = 1, E = S; 12a , n = 0, E = S; 13a , n = 3, E = Se; 14a , n = 2, E = Se; 15a , n = 1, E = Se; and 16a , n = 0, E = Se, and the corresponding bromido derivatives are 9b - 16b in the same order. Structures were obtained for 9a , 10a (and a second polymorph 10aa ), 11a (and its deutero-chloro-form monosolvate 11aa ), 12a (as its di-chloro-methane monosolvate), 14a , 15a (as its deutero-chloro-form monosolvate 15aa , in which the solvent mol-ecule is disordered over two positions), 9b , 11b , 13b and 15b ...
March 1, 2024: Acta Crystallographica. Section E, Crystallographic Communications
#34
JOURNAL ARTICLE
Elie Massaad, William J Smith, Joseph Bradley, Eric Esposito, Mihir Gupta, Evan Burns, Ryan Burns, José K Velarde, Inka K Berglar, Rajiv Gupta, Maria Martinez-Lage, Jorg Dietrich, Jochen K Lennerz, Gavin P Dunn, Pamela S Jones, Bryan D Choi, Albert E Kim, Matthew Frosch, Fred G Barker, William T Curry, Bob S Carter, Brian V Nahed, Daniel P Cahill, Ganesh M Shankar
BACKGROUND: Survival is variable in patients with glioblastoma IDH wild-type (GBM), even after comparable surgical resection of radiographically-detectable disease, highlighting the limitations of radiographic assessment of infiltrative tumor anatomy. The majority of post-surgical progressive events are failures within 2cm of the resection margin, motivating supramaximal resection strategies to improve local control. However, which patients benefit from such radical resections remains unknown...
April 6, 2024: Neuro-oncology
#35
John Sharp, Daniel Jones, Julia Rotow, Panos Fidias, Erin Bertino, Dwight Owen
No abstract text is available yet for this article.
April 5, 2024: Journal of the National Comprehensive Cancer Network: JNCCN
#36
JOURNAL ARTICLE
Christopher M Callahan, Amy Carter, Hannah S Carty, Daniel O Clark, Tedd Grain, Seth L Grant, Kimberly McElroy-Jones, Deanna Reinoso, Lisa E Harris
A recent National Academies report recommended that health systems invest in new infrastructure to integrate social and medical care. Although many health systems routinely screen patients for social concerns, few health systems achieve the recommended model of integration. In this critical case study in an urban safety net health system, we describe the human capital, operational redesign, and financial investment needed to implement the National Academy recommendations. Using data from this case study, we estimate that other health systems seeking to build and maintain this infrastructure would need to invest $1 million to $3 million per year...
April 4, 2024: American Journal of Public Health
#37
JOURNAL ARTICLE
Katie Tunks Leach, Daniel Demant, Paul Simpson, Joanne Lewis, Tracy Levett-Jones
Ambulance staff wellbeing programs aim to support the bio-psycho-social and sometimes spiritual needs of paramedics. While evidence demonstrates strong connections between spirituality and/or religion to wellbeing outcomes, little is known about spiritual care in ambulance services or its impact. The aim of this study was to investigate paramedics' perspectives on the role and value of Australian ambulance chaplains. A cross-sectional online study of registered paramedics in Australia was conducted between November and December 2022...
April 4, 2024: Journal of Health Care Chaplaincy
#38
JOURNAL ARTICLE
Laura Vang Rasmussen, Ingo Grass, Zia Mehrabi, Olivia M Smith, Rachel Bezner-Kerr, Jennifer Blesh, Lucas Alejandro Garibaldi, Marney E Isaac, Christina M Kennedy, Hannah Wittman, Péter Batáry, Damayanti Buchori, Rolando Cerda, Julián Chará, David W Crowder, Kevin Darras, Kathryn DeMaster, Karina Garcia, Manuel Gómez, David Gonthier, Purnama Hidayat, Juliana Hipólito, Mark Hirons, Lesli Hoey, Dana James, Innocensia John, Andrew D Jones, Daniel S Karp, Yodit Kebede, Carmen Bezner Kerr, Susanna Klassen, Martyna Kotowska, Holger Kreft, Ramiro Llanque, Christian Levers, Diego J Lizcano, Adrian Lu, Sidney Madsen, Rosebelly Nunes Marques, Pedro Buss Martins, America Melo, Hanson Nyantakyi-Frimpong, Elissa M Olimpi, Jeb P Owen, Heiber Pantevez, Matin Qaim, Sarah Redlich, Christoph Scherber, Amber R Sciligo, Sieglinde Snapp, William E Snyder, Ingolf Steffan-Dewenter, Anne Elise Stratton, Joseph M Taylor, Teja Tscharntke, Vivian Valencia, Cassandra Vogel, Claire Kremen
Agricultural simplification continues to expand at the expense of more diverse forms of agriculture. This simplification, for example, in the form of intensively managed monocultures, poses a risk to keeping the world within safe and just Earth system boundaries. Here, we estimated how agricultural diversification simultaneously affects social and environmental outcomes. Drawing from 24 studies in 11 countries across 2655 farms, we show how five diversification strategies focusing on livestock, crops, soils, noncrop plantings, and water conservation benefit social (e...
April 5, 2024: Science
#39
Joseph L Witztum, Daniel Gaudet, Marcello Arca, Alan Jones, Handrean Soran, Ioanna Gouni-Berthold, Erik S G Stroes, Veronica J Alexander, Richard Jones, Lynnetta Watts, Shuting Xia, Sotirios Tsimikas
No abstract text is available yet for this article.
October 13, 2023: Journal of Clinical Lipidology
#40
JOURNAL ARTICLE
Jason R Thomas, Claude Shelton, Jason Murphy, Scott Brittain, Mark-Anthony Bray, Peter Aspesi, John Concannon, Frederick J King, Robert J Ihry, Daniel J Ho, Martin Henault, Andrea Hadjikyriacou, Marilisa Neri, Frederic D Sigoillot, Helen T Pham, Matthew Shum, Louise Barys, Michael D Jones, Eric J Martin, Anke Blechschmidt, Sébastien Rieffel, Thomas J Troxler, Felipa A Mapa, Jeremy L Jenkins, Rishi K Jain, Peter S Kutchukian, Markus Schirle, Steffen Renner
Phenotypic assays have become an established approach to drug discovery. Greater disease relevance is often achieved through cellular models with increased complexity and more detailed readouts, such as gene expression or advanced imaging. However, the intricate nature and cost of these assays impose limitations on their screening capacity, often restricting screens to well-characterized small compound sets such as chemogenomics libraries. Here, we outline a cheminformatics approach to identify a small set of compounds with likely novel mechanisms of action (MoAs), expanding the MoA search space for throughput limited phenotypic assays...
April 2, 2024: ACS Chemical Biology
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