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https://www.readbyqxmd.com/read/28646091/stress-specific-p38-map-kinase-activation-is-sufficient-to-drive-egf-receptor-endocytosis-but-not-nuclear-translocation
#1
Alejandra Tomas, Sylwia Jones, Simon O Vaughan, Daniel Hochhauser, Clare E Futter
P38 MAP kinase-dependent EGF receptor (EGFR) endocytosis is induced by stress. Ligand and stresses like X-rays, reportedly promote nuclear traffic of endocytosed EGFR for regulation of gene transcription and DNA repair. We fail to detect EGFR endocytosis or nuclear transport following X-ray treatment of HeLa or head and neck cancer cells, despite extensive DNA damage induction. Apparent nuclear staining with EGFR extracellular domain antibody remained present despite reduced/absent EGFR expression and so did not represent nuclear EGFR...
June 23, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28645770/the-association-between-sedentary-time-and-quality-of-life-from-the-osteoarthritis-initiative-who-might-benefit-most-from-treatment
#2
Daniel Pinto, Jing Song, Jungwha Lee, Rowland W Chang, Pamela A Semanik, Linda S Ehrlich-Jones, Christine A Pellegrini, Dorothy D Dunlop
OBJECTIVE: To investigate the relationship between sedentary behavior and quality adjusted life years (QALY) among participants in the Osteoarthritis Initiative (OAI). DESIGN: 1794 participants from a prospective multicenter, longitudinal cohort were classified into quantile groups based on average daily sedentary time (most sedentary Q1 >=11.6, 10.7<=Q2<11.6, 9.7<=Q3<10.7, least sedentary Q4<9.7 average daily sedentary hours). INTERVENTIONS: None...
June 20, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28644470/rapid-heteroatom-transfer-to-arylmetals-utilizing-multifunctional-reagent-scaffolds
#3
Hongyin Gao, Zhe Zhou, Doo-Hyun Kwon, James Coombs, Steven Jones, Nicole Erin Behnke, Daniel H Ess, László Kürti
Arylmetals are highly valuable carbon nucleophiles that are readily and inexpensively prepared from aryl halides or arenes and widely used on both laboratory and industrial scales to react directly with a wide range of electrophiles. Although C-C bond formation has been a staple of organic synthesis, the direct transfer of primary amino (-NH2) and hydroxyl (-OH) groups to arylmetals in a scalable and environmentally friendly fashion remains a formidable synthetic challenge because of the absence of suitable heteroatom-transfer reagents...
July 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28642612/active-removal-of-waste-dye-pollutants-using-ta3n5-w18o49-nanocomposite-fibres
#4
Daniel R Jones, Virginia Gomez, Joseph C Bear, Bertrand Rome, Francesco Mazzali, James D McGettrick, Aled R Lewis, Serena Margadonna, Waheed A Al-Masry, Charles W Dunnill
A scalable solvothermal technique is reported for the synthesis of a photocatalytic composite material consisting of orthorhombic Ta3N5 nanoparticles and WOx≤3 nanowires. Through X-ray diffraction and X-ray photoelectron spectroscopy, the as-grown tungsten(VI) sub-oxide was identified as monoclinic W18O49. The composite material catalysed the degradation of Rhodamine B at over double the rate of the Ta3N5 nanoparticles alone under illumination by white light, and continued to exhibit superior catalytic properties following recycling of the catalysts...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28640263/strong-constraints-on-aerosol-cloud-interactions-from-volcanic-eruptions
#5
Florent F Malavelle, Jim M Haywood, Andy Jones, Andrew Gettelman, Lieven Clarisse, Sophie Bauduin, Richard P Allan, Inger Helene H Karset, Jón Egill Kristjánsson, Lazaros Oreopoulos, Nayeong Cho, Dongmin Lee, Nicolas Bellouin, Olivier Boucher, Daniel P Grosvenor, Ken S Carslaw, Sandip Dhomse, Graham W Mann, Anja Schmidt, Hugh Coe, Margaret E Hartley, Mohit Dalvi, Adrian A Hill, Ben T Johnson, Colin E Johnson, Jeff R Knight, Fiona M O'Connor, Daniel G Partridge, Philip Stier, Gunnar Myhre, Steven Platnick, Graeme L Stephens, Hanii Takahashi, Thorvaldur Thordarson
Aerosols have a potentially large effect on climate, particularly through their interactions with clouds, but the magnitude of this effect is highly uncertain. Large volcanic eruptions produce sulfur dioxide, which in turn produces aerosols; these eruptions thus represent a natural experiment through which to quantify aerosol-cloud interactions. Here we show that the massive 2014-2015 fissure eruption in Holuhraun, Iceland, reduced the size of liquid cloud droplets-consistent with expectations-but had no discernible effect on other cloud properties...
June 22, 2017: Nature
https://www.readbyqxmd.com/read/28638598/caregiver-burden-is-increased-in-parkinson-s-disease-with-mild-cognitive-impairment-pd-mci
#6
Ann J Jones, Roeline G Kuijer, Leslie Livingston, Daniel Myall, Kyla Horne, Michael MacAskill, Toni Pitcher, Paul T Barrett, Tim J Anderson, John C Dalrymple-Alford
BACKGROUND: There is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson's disease (PD-MCI) and the coping strategies used by these caregivers. METHODS: To investigate this relationship, we examined levels of burden, depression, anxiety, coping strategies and positive aspects of caregiving in the informal caregivers of 96 PD patients. The PD patients were classified using MDS-Task Force Level II criteria as showing either normal cognition (PD-N; n = 51), PD-MCI (n = 30) or with dementia (PDD; n = 15)...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28634631/sages-university-masters-program-a-structured-curriculum-for-deliberate-lifelong-learning
#7
Daniel B Jones, Dimitrios Stefanidis, James R Korndorffer, Justin B Dimick, Brian P Jacob, Linda Schultz, Daniel J Scott
BACKGROUND: Postgraduate training has been haphazard to date. Surgeons have relied on attendance to annual meetings and multiple choice study guides to demonstrate maintenance of certification and continuing medical education. METHODS: SAGES held a retreat to develop the concept and scope of the Masters Program. Surveys were sent to SAGES members to guide curriculum development and selection of anchoring operations. RESULTS: SAGES has developed an educational curriculum across eight domains (Acute Care, Biliary, Bariatric, Colorectal, Hernia, Foregut, Flex Endoscopy, and Robotic Surrey) incorporating SAGES educational materials and guidelines, social media, coaching and mentoring...
June 20, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28634241/psl-produced-by-mucoid-pseudomonas-aeruginosa-contributes-to-the-establishment-of-biofilms-and-immune-evasion
#8
Christopher J Jones, Daniel J Wozniak
Despite years of research and clinical advances, chronic pulmonary infections with mucoid Pseudomonas aeruginosa remain the primary concern for cystic fibrosis patients. Much of the research on these strains has focused on the contributions of the polysaccharide alginate; however, it is becoming evident that the neutral polysaccharide Psl also contributes to biofilm formation and the maintenance of chronic infections. Here, we demonstrate that Psl produced by mucoid strains has significant roles in biofilm structure and evasion of immune effectors...
June 20, 2017: MBio
https://www.readbyqxmd.com/read/28634037/clinical-benefit-of-drugs-targeting-mitochondrial-function-as-an-adjunct-to-reperfusion-in-st-segment-elevation-myocardial-infarction-a-meta-analysis-of-randomized-clinical-trials
#9
Gianluca Campo, Rita Pavasini, Giampaolo Morciano, A Michael Lincoff, C Michael Gibson, Masafumi Kitakaze, Jacob Lonborg, Amrita Ahluwalia, Hideki Ishii, Michael Frenneaux, Michel Ovize, Marcello Galvani, Dan Atar, Borja Ibanez, Giampaolo Cerisano, Simone Biscaglia, Brandon J Neil, Masanori Asakura, Thomas Engstrom, Daniel A Jones, Dana Dawson, Roberto Ferrari, Paolo Pinton, Filippo Ottani
AIMS: To perform a systematic review and meta-analysis of randomized clinical trials (RCT) comparing the effectiveness of drugs targeting mitochondrial function vs. placebo in patients with ST-segment elevation myocardial infarction (STEMI) undergoing mechanical coronary reperfusion. METHODS: Inclusion criteria: RCTs enrolling STEMI patients treated with primary percutaneous coronary intervention (PCI) and comparing drugs targeting mitochondrial function vs. placebo...
June 13, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28625816/a-prospective-multicenter-study-evaluating-learning-curves-and-competence-in-endoscopic-ultrasound-and-endoscopic-retrograde-cholangiopancreatography-among-advanced-endoscopy-trainees-the-rapid-assessment-of-trainee-endoscopy-skills-rates-study
#10
Sachin Wani, Rajesh Keswani, Matt Hall, Samuel Han, Meer Akbar Ali, Brian Brauer, Linda Carlin, Amitabh Chak, Dan Collins, Gregory A Cote, David L Diehl, Christopher J DiMaio, Andrew Dries, Ihab El-Hajj, Swan Ellert, Kimberley Fairley, Ashley Faulx, Larissa Fujii-Lau, Srinivas Gaddam, Seng-Ian Gan, Jonathan P Gaspar, Chitiki Gautamy, Stuart Gordon, Cynthia Harris, Sarah Hyder, Ross Jones, Stephen Kim, Srinadh Komanduri, Ryan Law, Linda Lee, Rawad Mounzer, Daniel Mullady, V Raman Muthusamy, Mojtaba Olyaee, Patrick Pfau, Shreyas Saligram, Cyrus Piraka, Amit Rastogi, Laura Rosenkranz, Fadi Rzouq, Aditi Saxena, Raj J Shah, Violette C Simon, Aaron Small, Jayaprakash Sreenarasimhaiah, Andrew Walker, Andrew Y Wang, Rabindra R Watson, Robert H Wilson, Patrick Yachimski, Dennis Yang, Steven Edmundowicz, Dayna S Early
BACKGROUND AND AIMS: Based on the Next Accreditation System, trainee assessment should occur on a continuous basis with individualized feedback. We aimed to validate endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) learning curves among advanced endoscopy trainees (AETs) using a large national sample of training programs and to develop a centralized database that allows assessment of performance in relation to peers. METHODS: ASGE recognized training programs were invited to participate and AETs were graded on ERCP and EUS exams using a validated competency assessment tool that assesses technical and cognitive competence in a continuous fashion...
June 15, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28625591/prognostic-significance-of-a-negative-confirmatory-biopsy-on-reclassification-among-men-on-active-surveillance
#11
Vishnu Ganesan, Charles Dai, Yaw A Nyame, Daniel J Greene, Nima Almassi, Daniel Hettel, Joseph Zabell, Hans Arora, Samuel Haywood, Alice Crane, Chad Reichard, Anna Zampini, Ahmed Elshafei, Robert J Stein, Khaled Fareed, J Stephen Jones, Michael Gong, Andrew J Stephenson, Eric A Klein, Ryan K Berglund
OBJECTIVE: To examine the association between absence of disease on confirmatory biopsy and risk of pathologic reclassification in men on active surveillance (AS). METHODS: Men with grade groups 1 and 2 disease on AS between 2002 and 2015 were identified who received a confirmatory biopsy within 1 year of diagnosis and ≥3 biopsies overall. The primary outcomes were pathologic reclassification by grade (any increase in primary Gleason pattern or Gleason score) or volume (>33% of sampled cores involved or increase in the number of cores with >50% involvement)...
June 15, 2017: Urology
https://www.readbyqxmd.com/read/28623408/plexiform-neurofibroma-causing-an-ossifying-subperiosteal-haematoma-a-rare-case-in-the-tibia-of-an-11-year-old-girl
#12
Anton Lavell, Christopher W Jones, Daniel Wong, Peter Counsel, Richard Carey-Smith
Ossifying subperiosteal haematoma is an exceedingly rare manifestation of Neurofibromatosis type 1 (NF-1). We report an interesting case of plexiform neurofibroma causing a rapidly growing tibial mass as a result of subperiosteal haemorrhage, in an 11-year-old girl with previously undiagnosed NF-1. This reflects a precursor of the more mature periosteal ossification seen in cases traditionally termed "subperiosteal cysts". A previously well young girl was referred by her general practitioner with an increasingly large, mildly tender, soft lump on the anterior aspect of her right tibia...
June 16, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28621574/endovascular-plug-for-internal-carotid-artery-occlusion-in-the-management-of-a-cavernous-pseudoaneurysm-with-bifrontal-subdural-empyema-technical-note
#13
Sunil Manjila, Gagandeep Singh, Obinna Ndubuizu, Zoe Jones, Daniel P Hsu, Alan R Cohen
The authors demonstrate the use of an endovascular plug in securing a carotid artery pseudoaneurysm in an emergent setting requiring craniotomy for a concurrent subdural empyema. They describe the case of a 14-year-old boy with sinusitis and bifrontal subdural empyema who underwent transsphenoidal exploration at an outside hospital. An injury to the right cavernous segment of the ICA caused torrential epistaxis. Bleeding was successfully controlled by inflating a Foley balloon catheter within the sphenoid sinus, and the patient was transferred to the authors' institution...
June 16, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28609690/what-do-we-know-about-child-abuse-and-neglect-patterns-of-co-occurrence-a-systematic-review-of-profiling-studies-and-recommendations-for-future-research
#14
REVIEW
Agata Debowska, Dominic Willmott, Daniel Boduszek, Adele D Jones
Latent class (LCA) and latent profile (LPA) analysis represent methodological approaches to identify subgroups of maltreated individuals. Although research examining child abuse and neglect (CAN) profiles is still rare, the application of person-centered techniques to clarify CAN types co-occurrence has substantially increased in recent years. Therefore, the aim of the present study was to provide a summary and critical evaluation of the findings of LCA/LPA child maltreatment research to: (a) systemize the current understanding of patterns of maltreatment across populations and (b) elucidate interactive effects of CAN types on psychosocial functioning...
June 10, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28607128/relationship-of-hypertension-to-coronary-atherosclerosis-and-cardiac-events-in-patients-with-coronary-computed-tomographic-angiography
#15
Rine Nakanishi, Lohendran Baskaran, Heidi Gransar, Matthew J Budoff, Stephan Achenbach, Mouaz Al-Mallah, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J W Chow, Augustin DeLago, Martin Hadamitzky, Joerg Hausleiter, Ricardo Cury, Gudrun Feuchtner, Yong-Jin Kim, Jonathon Leipsic, Philipp A Kaufmann, Erica Maffei, Gilbert Raff, Leslee J Shaw, Todd C Villines, Allison Dunning, Hugo Marques, Gianluca Pontone, Daniele Andreini, Ronen Rubinshtein, Jeroen Bax, Erica Jones, Niree Hindoyan, Millie Gomez, Fay Y Lin, James K Min, Daniel S Berman
Hypertension is an atherosclerosis factor and is associated with cardiovascular risk. We investigated the relationship between hypertension and the presence, extent, and severity of coronary atherosclerosis in coronary computed tomographic angiography and cardiac events risk. Of 17 181 patients enrolled in the CONFIRM registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) who underwent ≥64-detector row coronary computed tomographic angiography, we identified 14 803 patients without known coronary artery disease...
June 12, 2017: Hypertension
https://www.readbyqxmd.com/read/28600313/novel-microbial-assemblages-dominate-weathered-sulfide-bearing-rock-from-copper-nickel-deposits-in-the-duluth-complex-minnesota-usa
#16
Daniel S Jones, Kim A Lapakko, Zachary J Wenz, Michael C Olson, Elizabeth W Roepke, Michael J Sadowsky, Paige J Novak, Jake V Bailey
The Duluth Complex in northeastern Minnesota hosts economically-significant deposits of copper, nickel, and platinum group elements (PGEs). The primary sulfide mineralogy of these deposits includes the minerals pyrrhotite, chalcopyrite, pentlandite, and cubanite, and weathering experiments show that most sulfide-bearing rock from the Duluth Complex generates moderately acidic leachate (pH 4-6). Microorganisms are important catalysts for metal sulfide oxidation and could influence water quality from mines in the Duluth Complex...
June 9, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28599608/a-brain-electrical-activity-eeg-based-biomarker-of-functional-impairment-in-traumatic-head-injury-a-multisite-validation-trial
#17
Daniel Hanley, Leslie S Prichep, Neeraj Badjatia, Jeff Bazarian, RIchard P Chiacchierini, Kenneth C Curley, John S Garrett, Elizabeth B Jones, Rosanne Naunheim, Brian J O'Neil, John O'Neill, Wright David, J Stephen Huff
The potential clinical utility of a novel quantitative EEG-based Brain Function Index (BFI) as a measure of the presence and severity of functional brain injury was studied as part of an independent prospective validation trial. The BFI was derived using EEG features associated with functional brain impairment reflecting current consensus on the physiology of concussive injury. 720 adult patients (18-85 years) evaluated within 72 hours of sustaining a closed head injury were enrolled at 11 US Emergency Departments...
June 9, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28599198/hypoalbuminemia-systemic-inflammatory-response-syndrome-and-functional-outcome-in-intracerebral-hemorrhage
#18
Mario Di Napoli, Réza Behrouz, Christopher H Topel, Vivek Misra, Fulvio Pomero, Alessia Giraudo, Paolo Pennati, Luca Masotti, Floris H B M Schreuder, Julie Staals, Catharina J M Klijn, Craig J Smith, Adrian R Parry-Jones, Mark A Slevin, Brian Silver, Joshua Z Willey, Mahmoud R Azarpazhooh, Jaime Masjuán Vallejo, Hipólito Nzwalo, Aurel Popa-Wagner, Daniel A Godoy
PURPOSE: Hypoalbuminemia and systemic inflammatory response syndrome (SIRS) are reported in critically-ill patients, but their relationship is unclear. We sought to determine the association of admission serum albumin and SIRS with outcomes in patients with intracerebral hemorrhage (ICH). METHODS: We used a multicenter, multinational registry of ICH patients to select patients in whom SIRS parameters and serum albumin levels had been determined on admission. Hypoalbuminemia was defined as the lowest standardized quartile of albumin; SIRS according to standard criteria...
June 1, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28598926/enhancing-feedback-on-professionalism-and-communication-skills-in-anesthesia-residency-programs
#19
John D Mitchell, Cindy Ku, Carol Ann B Diachun, Amy DiLorenzo, Daniel E Lee, Suzanne Karan, Vanessa Wong, Randall M Schell, Marek Brzezinski, Stephanie B Jones
BACKGROUND: Despite its importance, training faculty to provide feedback to residents remains challenging. We hypothesized that, overall, at 4 institutions, a faculty development program on providing feedback on professionalism and communication skills would lead to (1) an improvement in the quantity, quality, and utility of feedback and (2) an increase in feedback containing negative/constructive feedback and pertaining to professionalism/communication. As secondary analyses, we explored these outcomes at the individual institutions...
June 7, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28598583/ring-opening-1-amino-3-aminomethylation-of-donor-acceptor-cyclopropanes-via-1-3-diazepanes
#20
Daniel B Werz, Lennart K B Garve, Peter G Jones
The first ring-opening reaction of donor-acceptor cyclopropanes leading to diamines is reported. For this a 1,3-bisfunctionalization was developed using cyclopropanes, triazinanes, and Sc(OTf)3 as catalyst, followed by treatment with acid. The reaction proceeds under very mild conditions and tolerates many functional groups. Moreover, a library of various 1,3-diazepanes is synthesized arising as intermediates of the first formal aza-[4+3]-cycloaddition reaction with donor-acceptor cyclopropanes.
June 9, 2017: Angewandte Chemie
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