keyword
MENU ▼
Read by QxMD icon Read
search

Metabolimics

keyword
https://www.readbyqxmd.com/read/27303373/microbiome-metabolome-responses-in-the-cecum-and-colon-of-pig-to-a-high-resistant-starch-diet
#1
Yue Sun, Yong Su, Weiyun Zhu
Currently, knowledge about the impact of long-term intake of high resistant starch diet on pig hindgut microbiota and metabolite profile is limited. In this study, a combination of the pyrosequencing and the mass spectrometry (MS)-based metabolomics techniques were used to investigate the effects of a raw potato starch (RPS, high in resistant starch) diet on microbial composition and microbial metabolites in the hindgut of pig. The results showed that Coprococcus, Ruminococcus, and Turicibacter increased significantly, while Sarcina and Clostridium decreased in relative abundances in the hindgut of pigs fed RPS...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26343413/a-metabolomic-perspective-of-griseofulvin-induced-liver-injury-in-mice
#2
Ke Liu, Jiong Yan, Madhav Sachar, Xinju Zhang, Ming Guan, Wen Xie, Xiaochao Ma
Griseofulvin (GSF) causes hepatic porphyria in mice, which mimics the liver injury associated with erythropoietic protoporphyria (EPP) in humans. The current study investigated the biochemical basis of GSF-induced liver injury in mice using a metabolimic approach. GSF treatment in mice resulted in significant accumulations of protoporphyrin IX (PPIX), N-methyl PPIX, bile acids, and glutathione (GSH) in the liver. Metabolomic analysis also revealed bioactivation pathways of GSF that contributed to the formation of GSF-PPIX, GSF-GSH and GSF-proline adducts...
December 1, 2015: Biochemical Pharmacology
https://www.readbyqxmd.com/read/25178933/integrative-analysis-of-transcriptomic-and-metabolomic-profiling-of-ascites-syndrome-in-broiler-chickens-induced-by-low-temperature
#3
Shourong Shi, Yiru Shen, Zhenhua Zhao, Zhuocheng Hou, Ying Yang, Huaijun Zhou, Jianmin Zou, Yuming Guo
Ascites syndrome (AS) still has an unacceptably high incidence rate in both humans and animals although there have been many studies on AS. To continue our previous pathological and biochemical investigation on the underlying mechanisms of AS incidence in broiler chickens, cutting-edge technologies including RNA-seq and metabolimics were used by directly comparing AS chickens and healthy controls. The RNA-seq analysis in the liver identified 390 differentially expressed genes (DEGs), among which 212 genes were up-regulated and 178 genes were down-regulated in the AS group compared to the control...
November 2014: Molecular BioSystems
https://www.readbyqxmd.com/read/24558881/-study-on-effect-of-artificial-csb-and-its-components-on-bile-acid-metabolism-in-rats-with-liver-fibrosis-and-its-mechanism
#4
Xing Zhang, Feng-Hua Li, Ping Liu, Jia Liu, Shuang Wang
Bile acid is a type of metabolite degraded from cholesterol in liver. Its accumulation in liver could cause liver diseases, liver damage and liver fibrosis. In this experiment, dimethyl nitrosamine (DMN) liver fibrosis was established in rats. The rats were delivered into the normal group, the model group and four treated groups. After the four-week modeling, the treated groups were orally administered with drugs for 2 weeks, whereas the model and normal groups were given equal amount of sterile water at the same time...
November 2013: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/22469869/ikk-nbd-peptide-inhibits-lps-induced-pulmonary-inflammation-and-alters-sphingolipid-metabolism-in-a-murine-model
#5
Philipp von Bismarck, Supandi Winoto-Morbach, Mona Herzberg, Ulrike Uhlig, Stefan Schütze, Ralph Lucius, Martin F Krause
Airway epithelial NF-κB is a key regulator of host defence in bacterial infections and has recently evolved as a target for therapeutical approaches. Evidence is accumulating that ceramide, generated by acid sphingomyelinase (aSMase), and sphingosine-1-phosphate (S1-P) are important mediators in host defence as well as in pathologic processes of acute lung injury. Little is known about the regulatory mechanisms of pulmonary sphingolipid metabolism in bacterial infections of the lung. The objective of this study was to evaluate the influence of NF-κB on sphingolipid metabolism in Pseudomonas aeruginosa LPS-induced pulmonary inflammation...
June 2012: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/22381657/specialization-of-the-sting-venom-and-skin-mucus-of-cathorops-spixii-reveals-functional-diversification-of-the-toxins
#6
Anderson Daniel Ramos, Katia Conceição, Pedro Ismael Silva, Michael Richardson, Carla Lima, Mônica Lopes-Ferreira
Cathorops spixii is the most common venomous fish on the Brazilian coast. Apart from the involvement with defense against pathogens, the possible contribution of skin mucus components to the development of injuries caused by venomous fish species has not been investigated. Thus, the present study was conducted to gain a better understanding of the peptide and protein components of fish skin mucus and the sting venom from the catfish C. spixii. Our results show that sting venom and skin mucus have distinct constituents that distinguished them like structural proteins, chaperones, ion transport, carbohydrate metabolism, oxidoreductase, cell cycle and protein binding present in sting venom and like tropomyosin 3 isoform 2 and energy metabolim proteins in skin mucus...
May 2012: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/21710730/-metabolomics-study-of-anti-inflammatory-action-of-radix-paeoniae-rubra-and-radix-paeoniae-alba-by-ultraperformance-liquid-chromatography-mass-spectrometry
#7
Qiwei Yang, Li Yang, Aizhen Xiong, Lan Lu, Rui Wang, Zhengtao Wang
OBJECTIVE: To compare the anti-inflammatory effect of Radix Paeoniae Rubra and Radix Paeoniae Alba by animal experiment and metabolimic analysis. METHOD: To establish the rats model of toes swelling caused by carrageenan, study the anti-inflammatory effect of Radix Paeoniae Rubra and Radix Paeoniae Alba. The serum samples were analyzed by ultraperformance liquid chromatography-mass spectrometry (UPLC-MS), to find out the potential identification biomarker by PLS-DA...
March 2011: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/21609581/-genes-involved-in-folate-metabolim-and-neural-tube-defects
#8
REVIEW
Shuang Liang, Yun-yun Ren
No abstract text is available yet for this article.
April 2011: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/14581867/-hormonal-replacement-therapy-in-menopause-and-cancer-risk-an-update
#9
C La Vecchia, S Franceschi
The risk of breast cancer rises by about 2.3% per year of using estrogens and the risk is even higher in the case of combined therapy with estrogens and progestins; however the excess risk disappears 5 years after suspension of the treatment. The risk of endometrial tumour cancer is strongly associated with the use of estrogens but this increase is reduced or eliminated by the administration of progestinics for at least 12/14 days per month. The use of HRTs also seems to be directly associated with the risk of ovarian cancers, while they seem to exert a protective effect on colorectal neoplasms...
June 2003: Minerva Ginecologica
https://www.readbyqxmd.com/read/14065153/-action-of-adenosine-5-monophosphoric-acid-and-of-inosine-on-porphyrin-metabolims-in-experimental-saturnism
#10
L PECORA, R MOLE, A BALLETTA, E DANIELE, C PESARESI
No abstract text is available yet for this article.
May 1963: Folia Medica
https://www.readbyqxmd.com/read/12774390/-effects-of-soy-extract-on-energy-balance-in-ovariectomized-rats
#11
Ji-feng Wang, Hua Li, Jian-zhao Niu, Chi Zhang, Lian-qi Liou, Gong-yu Li, Hen-qing Tu
OBJECTIVE: In order to study on effects of soy extract on energy metabolims in ovariectomized rats. METHOD: 90 Wistar rats were randomly divided into 9 groups: control group, sham group, model group, estrogen group, soy isoflavone group of high dose, soy isoflavone of low dose, soy extract of high dose, soy extract of low dose, 10 rats each group. Beside of control and sham groups, the rest rats were ovariectomized. One week after operation, the rats were treatmented with different drugs, measument of body weigh and feed weigh each week...
February 2002: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/12774376/-effects-of-soy-extract-on-lipid-metabolism-in-ovariectomized-rats
#12
Ji-feng Wang, Jian-zhao Niu, Hua Li, Chi Zhang, Lian-qi Liu, Bao-hua Gao
OBJECTIVE: To study effects of soy extract on lipid metabolims in ovariectomized rats. METHOD: 90 Wistar rats were randomly divided into 9 groups: control group, sham group, model group, estrogen group, soy isoflavone group of high dose, soy isoflavone group of low dose, soy extract of high dose, soy extract of low dose, and soy polysaccharde group, 10 rats in each group. Except fer of control and sham groups, the test rats were ovariectomized. One week after operation, the rats were treated with different drugs...
April 2002: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/6836962/-effect-of-xidiphone-and-vitamin-e-on-lipid-metabolism-patterns-in-dyslipidemia-induced-by-cholesterol-loading
#13
Iu A Kniazev, T I Turkina, E A Iur'eva
Spectrum of lipids, their transport forms in blood serum and phospholipid composition in erythrocyte membranes were studied under conditions of dislipidemia induced by cholesterol loading after treatment with a mixture containing diphosphonate (xidiphone) and vitamin E as well as with the only vitamin E. Lypolytic reactions of metabolims were activated during simultaneous treatment with xidiphone and vitamin E: content of NEFA and triglycerides as well as of lipoprotein atherogenous fractions was decreased in blood, at the same time, decrease of lysophosphatidylcholine and phosphatidylcholine and increase of phosphatidylethanolamine were found in erythrocyte membranes...
January 1983: Voprosy Medit︠s︡inskoĭ Khimii
https://www.readbyqxmd.com/read/6448462/the-kinetics-of-inhibition-of-hepatic-drug-metabolism-by-prostaglandins-in-rabbits
#14
M Weiner
The in vitro effects of prostaglandin A1 and prostaglandin E1 on the hepatic microsomal metabolism of type I (aminopyrine) and type II (p-chloro-N-methylaniline and aniline) drug substrates in rabbits were investigated. Both prostaglandins competitively inhibited aminopyrine N-demethylation to the same extent with a 500 microM prostaglandin concentration decreasing metabolism by approximately 50 percent. Prostaglandin A1 and prostaglandin F1 decreased p-chloro-N-methylaniline biotransformation, and prostaglandin E1 depressed aniline metabolims, via mixed-inhibition kinetics...
September 1980: Research Communications in Chemical Pathology and Pharmacology
https://www.readbyqxmd.com/read/5669012/-studies-on-phosphorus-metabolim-in-patients-with-gastric-neoplasms
#15
J Oszacki, A Marczyńska, J Kulpa, K Szczygiel
No abstract text is available yet for this article.
January 1968: Nowotwory
https://www.readbyqxmd.com/read/5545960/effect-of-cortisone-on-vitamin-d-metabolim-in-rat-plasma
#16
D von Herrath, A Opitz, H U Koch, H Knoop, K Schaefer
No abstract text is available yet for this article.
January 1971: Klinische Wochenschrift
https://www.readbyqxmd.com/read/5049053/regulation-of-pyruvate-metabolim-in-rat-liver-mitochondria-by-adenine-nucleotides-and-fatty-acids
#17
J W Stucki, F Brawand, P Walter
No abstract text is available yet for this article.
May 1972: European Journal of Biochemistry
https://www.readbyqxmd.com/read/4478712/-metabolim-of-oleic-acid-125-i-influence-of-the-protein-isolated-from-soy-bean-glycinae-max
#18
N S Pereira, P Sawaya, S M Zucas, J C Barbério
No abstract text is available yet for this article.
January 1974: Revista de Farmácia e Bioquímica da Universidade de São Paulo
https://www.readbyqxmd.com/read/4100049/perinatal-metabolim-of-hemopexin-and-heme
#19
J D Ross, H H Liem, U Muller-Eberhard
No abstract text is available yet for this article.
January 1971: Proceedings of the Society for Experimental Biology and Medicine
https://www.readbyqxmd.com/read/871432/cobalamin-dependent-methionine-synthesis-and-methyl-folate-trap-in-human-vitamin-b12-deficiency
#20
H Sauer, W Wilmanns
The activity of methionine synthetase (MS) is important for the rapid growth of human haematopoietic cells and cultured lymphoblastoid cells. The MS reaction is the only known metabolic step in which both vitamin B12 and folate are essential in a single enzyme reaction. In vitamin B12 deficiency the MS activity in bone marrow cells is significantly lower than that in normal bone marrow. Free tetrahydrofolic acid (H4PteGlu) is normally liberated from its metabolically inactive storage form, 5-methyl-H4PteGlu (CH3H4PteGlu), in the cobalamin-dependent MS reaction...
June 1977: British Journal of Haematology
keyword
keyword
81955
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"