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https://www.readbyqxmd.com/read/28712946/dissociation-between-decision-making-under-risk-and-decision-making-under-ambiguity-in-premanifest-and-manifest-huntington-s-disease
#1
Najia Adjeroud, Jeremy Besnard, Christophe Verny, Adriana Prundean, Clarisse Scherer, Bénédicte Gohier, Dominique Bonneau, Nicole El Massioui, Philippe Allain
We investigated decision-making under ambiguity (DM-UA) and decision making under risk (DM-UR) in individuals with premanifest and manifest Huntington's disease (HD). Twenty individuals with premanifest HD and 23 individuals with manifest HD, on one hand, and 39 healthy individuals divided into two control groups, on the other, undertook a modified version of the Iowa Gambling Task (IGT), an adaptation of a DM-UA task, and a modified version of the Game of Dice Task (GDT), an adaptation of a DM-UR task. Participants also filled in a questionnaire of impulsivity and responded to cognitive tests specifically designed to assess executive functions...
July 13, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28658719/patient-education-in-the-management-of-coronary-heart-disease
#2
REVIEW
Lindsey Anderson, James Pr Brown, Alexander M Clark, Hasnain Dalal, Henriette K Rossau, Charlene Bridges, Rod S Taylor
BACKGROUND: Coronary heart disease (CHD) is the single most common cause of death globally. However, with falling CHD mortality rates, an increasing number of people live with CHD and may need support to manage their symptoms and improve prognosis. Cardiac rehabilitation is a complex multifaceted intervention which aims to improve the health outcomes of people with CHD. Cardiac rehabilitation consists of three core modalities: education, exercise training and psychological support. This is an update of a Cochrane systematic review previously published in 2011, which aims to investigate the specific impact of the educational component of cardiac rehabilitation...
June 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28616213/postoperative-goal-directed-therapy-and-development-of-acute-kidney-injury-following-major-elective-noncardiac-surgery-post-hoc-analysis-of-pom-o-randomized-controlled-trial
#3
Amour Patel, John R Prowle, Gareth L Ackland
Background: The role of goal-directed therapy (GDT) in preventing creatinine rise following noncardiac surgery is unclear. We performed a post-hoc analysis of a randomized controlled trial to assess the relationship between postoperative optimization of oxygen delivery and development of acute kidney injury (AKI)/creatinine rise following noncardiac surgery. Methods: Patients were randomly assigned immediately postoperatively to receive either fluid and/or dobutamine therapy to maintain/restore their preoperative oxygen delivery, or protocolized standard care (oxygen delivery only recorded)...
June 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28605442/perioperative-goal-directed-therapy-with-uncalibrated-pulse-contour-methods-impact-on-fluid-management-and-postoperative-outcome
#4
F Michard, M T Giglio, N Brienza
Previous meta-analyses suggest that perioperative goal-directed therapy (GDT) is useful to decrease postoperative morbidity. Most GDT studies analysed were done with pulmonary artery catheters, oesophageal Doppler and calibrated pulse contour methods. Uncalibrated pulse contour (uPC) techniques are an appealing alternative but their accuracy has been questioned. The effects of GDT on fluid management (volumes and volume variability) remain unclear. We performed a meta-analysis of randomized controlled trials investigating the effects of GDT with uPC methods on postoperative outcome...
June 11, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28599813/google-dengue-trends-an-indicator-of-epidemic-behavior-the-venezuelan-case
#5
Ricardo A Strauss, Julio S Castro, Ralf Reintjes, Jaime R Torres
INTRODUCTION: Dengue Fever is a neglected increasing public health thread. Developing countries are facing surveillance system problems like delay and data loss. Lately, the access and the availability of health-related information on the internet have changed what people seek on the web. In 2004 Google developed Google Dengue Trends (GDT) based on the number of search terms related with the disease in a determined time and place. The goal of this review is to evaluate the accuracy of GDT in comparison with traditional surveillance systems in Venezuela...
August 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28598579/validation-of-protein-structure-models-using-network-similarity-score
#6
Sambit Ghosh, Vasundhara Gadiyaram, Saraswathi Vishveshwara
Accurate structural validation of proteins is of extreme importance in studies like protein structure prediction, analysis of molecular dynamic simulation trajectories and finding subtle changes in very similar structures. The benchmarks for today's structure validation are scoring methods like Global Distance Test-Total Structure (GDT-TS), TM-Score and Root Mean Square Deviations (RMSD). However, there is a lack of methods that look at both the protein backbone and side chain structures at the global connectivity level and provide information about the differences in connectivity...
June 9, 2017: Proteins
https://www.readbyqxmd.com/read/28593414/safety-and-effectiveness-of-day-surgery-laparoscopic-cholecystectomy-is-still-uncertain-meta-analysis-of-eight-randomized-controlled-trials-based-on-grade-approach
#7
Xiang-Yong Hao, Yan-Fei Shen, Yong-Gang Wei, Fei Liu, Hong-Yu Li, Bo Li
BACKGROUND: Currently, there is no consensus on whether laparoscopic cholecystectomy (LC) performed as day-surgery is safe and effective and can be considered as the standard for the management of symptomatic gallbladder disease. We conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the safety and effectiveness of this intervention based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. METHODS: We conducted a systematic search of several databases from their inception to November 10, 2016 for entries on the mortality, morbidity after discharge, readmission, postoperative morbidity, and patient satisfaction at 1 week of day-surgery LC...
June 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28584204/decision-making-impairments-in-primary-angle-closure-glaucoma-patients
#8
Hui Pu, Yong Wang, Qiang Wei, Hui-Juan Ma, Pan-Pan Hu, Shou-Ling Li, Hong-Bo Pang, Yang-Hua Tian, Kai Wang
BACKGROUND: Primary angle-closure glaucoma (PACG) is a common eye disease and a common cause of blindness. Inappropriate medical decisions severely affect the prognosis. This study investigated decision-making under risk in PACG patients. METHODS: Thirty patients with first acute attack of PACG before surgery and thirty healthy controls were included in the study. Decision-making under risk was evaluated with the game of dice task (GDT). The results of Eysenck Personality Questionnaire (EPQ) and GDT between PACG patients and healthy controls were compared...
June 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28575331/oesophageal-doppler-guided-goal-directed-haemodynamic-therapy-in-thoracic-surgery-a-single-centre-randomized-parallel-arm-trial
#9
K B Kaufmann, L Stein, L Bogatyreva, F Ulbrich, J T Kaifi, D Hauschke, T Loop, U Goebel
Background: Postoperative pulmonary and renal complications are frequent in patients undergoing lung surgery. Hyper- and hypovolaemia may contribute to these complications. We hypothesized that goal-directed haemodynamic management based on oesophageal Doppler monitoring would reduce postoperative pulmonary complications in a randomized clinical parallel-arm trial. Methods: One hundred patients scheduled for thoracic surgery were randomly assigned to either standard haemodynamic management (control group) or goal-directed therapy (GDT group) guided by an oesophageal Doppler monitoring-based algorithm...
June 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28545390/mqaprank-improved-global-protein-model-quality-assessment-by-learning-to-rank
#10
Xiaoyang Jing, Qiwen Dong
BACKGROUND: Protein structure prediction has achieved a lot of progress during the last few decades and a greater number of models for a certain sequence can be predicted. Consequently, assessing the qualities of predicted protein models in perspective is one of the key components of successful protein structure prediction. Over the past years, a number of methods have been developed to address this issue, which could be roughly divided into three categories: single methods, quasi-single methods and clustering (or consensus) methods...
May 25, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28483253/the-effects-of-postnatal-phthalate-exposure-on-the-development-of-auditory-temporal-processing-in-rats
#11
Bong Jik Kim, Jungyoon Kim, Vanhnansy Keoboutdy, Ho-Jang Kwon, Seung-Ha Oh, Jae Yun Jung, Il Yong Park, Ki Chung Paik
OBJECTIVE: The central auditory pathway is known to continue its development during the postnatal critical periods and is shaped by experience and sensory inputs. Phthalate, a known neurotoxic material, has been reported to be associated with attention deficits in children, impacting many infant neurobehaviors. The objective of this study was to investigate the potential effects of neonatal phthalate exposure on the development of auditory temporal processing. METHODS: Neonatal Sprague-Dawley rats were randomly assigned into two groups: The phthalate group (n = 6), and the control group (n = 6)...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28474098/reasoning-and-mathematical-skills-contribute-to-normatively-superior-decision-making-under-risk-evidence-from-the-game-of-dice-task
#12
Marie-Theres Pertl, Laura Zamarian, Margarete Delazer
In this study, we assessed to what extent reasoning improves performance in decision making under risk in a laboratory gambling task (Game of Dice Task-Double, GDT-D). We also investigated to what degree individuals with above average mathematical competence decide better than those with average mathematical competence. Eighty-five participants performed the GDT-D and several numerical tasks. Forty-two individuals were asked to calculate the probabilities and the outcomes associated with the different options of the GDT-D before performing it...
May 4, 2017: Cognitive Processing
https://www.readbyqxmd.com/read/28430836/test-retest-reliability-of-common-behavioral-decision-making-tasks
#13
Melissa T Buelow, Wesley R Barnhart
Objective: To examine test-retest reliability of common behavioral decision making tasks. Method: A total of 98 undergraduate students completed two administrations of the Iowa Gambling Task (IGT), Balloon Analogue Risk Task (BART), Columbia Card Task (CCT), and Game of Dice Task (GDT), three weeks apart. Results: The BART, CCT, and GDT showed moderately strong correlations across time. On the IGT, no correlations were seen between Time 1 Trials 1-40 and Time 2 performance; however, weak correlations were observed between Time 1 Trials 41-100 and Time 2 performance...
April 20, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28419290/svmqa-support-vector-machine-based-protein-single-model-quality-assessment
#14
Balachandran Manavalan, Jooyoung Lee
Motivation: The accurate ranking of predicted structural models and selecting the best model from a given candidate pool remain as open problems in the field of structural bioinformatics. The quality assessment (QA) methods used to address these problems can be grouped into two categories: consensus methods and single-model methods. Consensus methods in general perform better and attain higher correlation between predicted and true quality measures. However, these methods frequently fail to generate proper quality scores for native-like structures which are distinct from the rest of the pool...
April 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28374872/influence-of-temporal-resolution-skills-in-speech-discrimination-abilities-of-older-subjects
#15
P G Nair, B M Basheer
Compromised temporal resolving power of the auditory system can be one of the main factors contributing to poor speech perception skills in the elderly. Very few of the earlier studies have systematically examined this aspect. Hence, the current study was designed with the following objectives: 1) To establish normative database of Gaps in Noise (GIN) test in elderly population in an Indian context. 2) To determine the relationship between speech discrimination skills and temporal resolution abilities in elderly individuals with normal hearing sensitivity...
February 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28358552/determinants-of-risk-taking-in-hiv-associated-neurocognitive-disorders
#16
Daniela Gomez, Christopher Power, M John Gill, Esther Fujiwara
OBJECTIVE: Decision-making involves fronto-striatal brain areas that are particularly vulnerable to the effects of HIV infection. Some studies report impaired decision-making in people with HIV/AIDS with past or present addictions and/or accompanying HIV-associated neurocognitive disorders (HAND). The authors investigated risk-based decision-making in HIV/AIDS, separating individuals with or without accompanying HAND. METHOD: A total of 288 HIV-infected persons underwent standardized neuropsychological testing...
March 30, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28253353/effect-of-goal-directed-therapy-on-outcome-after-esophageal-surgery-a-quality-improvement-study
#17
Denise P Veelo, Mark I van Berge Henegouwen, Kirsten S Ouwehand, Bart F Geerts, Maarten C J Anderegg, Susan van Dieren, Benedikt Preckel, Jan M Binnekade, Suzanne S Gisbertz, Markus W Hollmann
BACKGROUND: Goal-directed therapy (GDT) can reduce postoperative complications in high-risk surgery patients. It is uncertain whether GDT has the same benefits in patients undergoing esophageal surgery. Goal of this Quality Improvement study was to evaluate the effects of a stroke volume guided GDT on post-operative outcome. METHODS AND FINDINGS: We compared the postoperative outcome of patients undergoing esophagectomy before (99 patients) and after (100 patients) implementation of GDT...
2017: PloS One
https://www.readbyqxmd.com/read/28178363/ranolazine-for-stable-angina-pectoris
#18
REVIEW
Carlos A Salazar, Juan E Basilio Flores, Liz E Veramendi Espinoza, Jhon W Mejia Dolores, Diego E Rey Rodriguez, César Loza Munárriz
BACKGROUND: Stable angina pectoris is a chronic medical condition with significant impact on mortality and quality of life; it can be macrovascular or microvascular in origin. Ranolazine is a second-line anti-anginal drug approved for use in people with stable angina. However, the effects of ranolazine for people with angina are considered to be modest, with uncertain clinical relevance. OBJECTIVES: To assess the effects of ranolazine on cardiovascular and non-cardiovascular mortality, all-cause mortality, quality of life, acute myocardial infarction incidence, angina episodes frequency and adverse events incidence in stable angina patients, used either as monotherapy or as add-on therapy, and compared to placebo or any other anti-anginal agent...
February 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28113294/topological-analysis-and-gaussian-decision-tree-effective-representation-and-classification-of-biosignals-of-small-sample-size
#19
Zhifei Zhang, Yang Song, Haochen Cui, Jayne Wu, Fernando Schwartz, Hairong Qi
GOAL: Bucking the trend of big data, in microdevice engineering, small sample size is common, especially when the device is still at the proof-of-concept stage. The small sample size, small inter-class variation, and large intra-class variation, have brought biosignal analysis new challenges. Novel representation and classification approaches need to be developed to effectively recognize targets of interests with the absence of a large training set. METHODS: Moving away from the traditional signal analysis in the spatiotemporal domain, we exploit the biosignal representation in the topological domain that would reveal the intrinsic structure of point clouds generated from the biosignal...
December 2, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28108318/response-inhibition-set-shifting-and-complex-executive-function-in-patients-with-chronic-lower-back-pain
#20
Rytis Masiliūnas, Dalia Vitkutė, Edgaras Stankevičius, Vaidas Matijošaitis, Kęstutis Petrikonis
OBJECTIVE: The aim of our study was to evaluate how response inhibition, set shifting, and complex executive function (represented by risky decision-making) are altered in chronic lower back pain patients. MATERIALS AND METHODS: A total of 29 patients with chronic lower back pain (CLBP >6 months) aged 49-69 years and 30 healthy volunteers matched for age, gender, and education were enrolled in a case-control study. The study was conducted in the Departments of Neurology and Neurosurgery of Panevėžys Regional Hospital, Lithuania...
January 2, 2017: Medicina
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