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https://www.readbyqxmd.com/read/28944882/evaluation-of-apoptosis-induced-by-exposure-to-antineoplastic-drugs-in-peripheral-blood-lymphocytes-of-nurses
#1
Heng Liao, Lijie Bi, Jun Wei, Xin Song
Cytostatic antineoplastic drugs are considered carcinogenic and mutagenic risk factors for health workers who are occupationally exposed to them; however, the molecular mechanisms underlying these effects remain to be elucidated. Therefore, the present study aimed to investigate the underlying mechanisms of antineoplastic drugs‑induced apoptosis of peripheral blood lymphocytes (PBLs) obtained from oncology nurses handling antineoplastic drugs. A microRNA (miRNA/miR) polymerase chain reaction (PCR) array was performed to analyze the expression levels of miRNAs in the PBLs from 3 trained nurses occupationally exposed to antineoplastic drugs...
September 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944871/shear-stress-induces-human-aortic-endothelial-cell-apoptosis-via-interleukin%C3%A2-1-receptor%C3%A2-associated-kinase-2%C3%A2-induced-endoplasmic-reticulum-stress
#2
Longfei Pan, Zhou Hong, Lei Yu, Yanxia Gao, Rui Zhang, Hui Feng, Lijuan Su, Gang Wang
Atherosclerosis is characterized by localized lesions distributed in the arterial tree due to the shear stress produced by blood flow. Endothelial cells are directly affected by alterations in blood flow. Dysfunction and injury to endothelial cells has been hypothesized to initiate the pathological processes of atherosclerosis. The present study aimed to investigate the mechanism of shear stress‑induced endothelial cellular apoptosis. Shear stress was generated using an artificial device to mimic the impact of disturbed blood flow on cultured human aortic endothelial cells (HAECs)...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944427/morphological-changes-in-the-thymus-composition-of-its-cells-and-subpopulations-of-peripheral-blood-lymphocytes-during-experimental-acute-ulcerative-colitis
#3
O V Makarova, E A Postovalova
Morphological changes in the thymus and composition of its cells and peripheral blood lymphocytes were studied in experiments on C57Bl/6 mice with sodium dextran sulfate-induced acute ulcerative colitis. Severe acute ulcerative colitis in rats was accompanied by stage III-IV accidental involution of the thymus. This state was characterized by inversion of the layers, death of thymocytes, and increase in the number and area of thymic corpuscles from CK19(+) epithelial cells. Flow cytofluorometry revealed an increase in the relative number of F4/80(+) macrophages in the thymus stroma and CD4(-)CD8(-)CD45(+)CD11c(+) dendritic cells and CD326(+)UEA(+)CD205(-) epithelial cells in the medulla...
September 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28944200/optical-coherence-tomography-angiography-of-optic-disc-perfusion-in-non-arteritic-anterior-ischemic-optic-neuropathy
#4
Jia-Wen Ling, Xue Yin, Qian-Yi Lu, Yi-Yi Chen, Pei-Rong Lu
AIM: To compare the optic disc blood flow of non-arteritic ischemic optic neuropathy (NAION) eyes with normal eyes. METHODS: The optic disc blood flow densities of diagnosed non-acute phase NAION eyes (21 eyes, 14 individuals) and normal eyes (19 eyes, 12 individuals) were detected via Optovue optical coherence tomography angiography (OCTA). The optic disc blood flow was measured via Image J software. Correlations between optic disc perfusion and visual function variables were assessed by linear regression analysis...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28943915/zoledronic-acid-inhibits-infiltration-of-tumor-associated-macrophages-and-angiogenesis-following-transcatheter-arterial-chemoembolization-in-rat-hepatocellular-carcinoma-models
#5
Da-Yong Zhou, Jie Qin, Jian Huang, Feng Wang, Guo-Peng Xu, Yan-Tian Lv, Ji-Bin Zhang, Li-Ming Shen
Hepatic transcatheter arterial chemoembolization (TACE), a minimally invasive procedure to block the blood supply of tumors and release of cytotoxic agents, is preferentially applied to patients with hepatocellular carcinoma (HCC) who are not able to receive radical treatments. However, the long-term effects of TACE are unsatisfactory, as the microenvironment following procedure stimulates tumor angiogenesis, which promotes recurrence and metastasis of residual tumors. Tumor associated macrophages (TAMs) have been revealed to stimulate tumor growth and angiogenesis associated with poor prognosis in HCC...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943879/plasma-cxcl13-but-not-b-cell-frequencies-in-acute-hiv-infection-predicts-emergence-of-cross-neutralizing-antibodies
#6
Jenniffer M Mabuka, Anne-Sophie Dugast, Daniel M Muema, Tarylee Reddy, Yathisha Ramlakhan, Zelda Euler, Nasreen Ismail, Amber Moodley, Krista L Dong, Lynn Morris, Bruce D Walker, Galit Alter, Thumbi Ndung'u
Immunological events in acute HIV-1 infection before peak viremia (hyperacute phase) may contribute to the development of broadly cross-neutralizing antibodies. Here, we used pre-infection and acute-infection peripheral blood mononuclear cells and plasma samples from 22 women, including 10 who initiated antiretroviral treatment in Fiebig stages I-V of acute infection to study B cell subsets and B-cell associated cytokines (BAFF and CXCL13) kinetics for up to ~90 days post detection of plasma viremia. Frequencies of B cell subsets were defined by flow cytometry while plasma cytokine levels were measured by ELISA...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28943539/leptomeningeal-collaterals-strongly-correlate-with-reduced-cerebrovascular-reactivity-measured-by-acetazolamide-challenged-single-photon-emission-computed-tomography-using-a-stereotactic-extraction-estimation-analysis-in-patients-with-unilateral-internal-carotid
#7
Takenobu Kunieda, Kosuke Miyake, Hiroki Sakamoto, Yuko Iwasaki, Shin Iida, Satoshi Morise, Kengo Fujita, Masataka Nakamura, Satoshi Kaneko, Hirofumi Kusaka
Objective To assess the correlation between the angiographic appearance of cerebral collateral pathways or the degree of internal carotid artery stenosis (ICAS) and reduced cerebrovascular reactivity (CVR) estimated by single-photon emission computed tomography (SPECT) image analysis in patients with unilateral ICAS. Methods A retrospective analysis was performed in 42 patients with unilateral ICAS who underwent cerebral angiography and acetazolamide-challenged SPECT of the brain. Cerebral blood flow quantitation was performed using the quantitative SPECT/dual-table autoradiography method...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943532/relationship-between-bacteremia-and-hemorrhagic-stroke-in-patients-with-continuous-flow-left-ventricular-assist-device
#8
Daisuke Yoshioka, Ryoto Sakaniwa, Koichi Toda, Takaaki Samura, Shunsuke Saito, Noriyuki Kashiyama, Shuhei Okazaki, Keitaro Domae, Yasushi Yoshikawa, Shigeru Miyagawa, Hiroyasu Iso, Yasushi Sakata, Yoshiki Sawa
BACKGROUND: Blood stream infection is thought to increase the risk of hemorrhagic stroke, a major adverse event with devastating outcome, in patients with continuous-flow left ventricular assist devices (LVADs). We analyzed the risk factors of hemorrhagic stroke in LVAD patients, as well as the time relationship between systemic bacteremia and hemorrhagic stroke.Methods and Results:We evaluated the incidence of systemic bacteremia and stroke in 164 patients who underwent continuous-flow LVAD implantation between 2005 and 2016...
September 23, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28943261/retinal-microcirculation-imaging-in-sickle-cell-disease-patients
#9
W Birkhoff, J de Vries, G Dent, A Verma, J L Kerkhoffs, A H F van Meurs, M de Kam, M Moerland, J Burggraaf
OBJECTIVES: To explore the feasibility of a new quantitative method for microvascular function: non-invasive retinal function imaging (RFI). in sickle cell disease (SCD) patients and healthy controls and have it benchmarked against Laser Speckle Contrast Imaging (LSCI) measurements. METHODS: The variability of Microvascular measurements was assessed in 8 SCD patients and 8 healthy matched controls. Measurements were conducted twice on two different study days. RFI was performed for assessment of arterial and venous retinal blood flow...
September 21, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28942939/relation-of-coronary-flow-reserve-to-other-findings-on-positron-emission-tomography-myocardial-perfusion-imaging-and-left-heart-catheterization-in-patients-with-end-stage-renal-disease-being-evaluated-for-kidney-transplant
#10
Yehuda Paz, Rachelle Morgenstern, Richard Weinberg, Mariana Chiles, Navdeep Bhatti, Ziad Ali, Sumit Mohan, Sabahat Bokhari
Cardiovascular disease is the leading cause of death in patients with end-stage renal disease (ESRD) and often goes undetected. Abnormal coronary flow reserve (CFR), which predicts increased risk of cardiac death, may be present in patients with ESRD without other evidence of coronary artery disease (CAD). We prospectively studied 131 patients who had rest and dipyridamole pharmacologic stress N(13)-ammonia positron emission tomography myocardial perfusion imaging (PET MPI) for kidney transplant evaluation...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28942476/predicting-early-pregnancy-in-egyptian-buffalo-cows-via-measuring-uterine-and-luteal-blood-flows-and-serum-and-saliva-progesterone
#11
Mohamed E Lasheen, Hussein M Badr, Mohamed M M Kandiel, Amal M Abo El-Maaty, Haney Samir, Mohamed Farouk, Mohamed H Eldawy
Various methods are being employed to detect early pregnancy in domestic animals. This study aimed to predict early pregnancy in buffaloes via measuring the corpus luteum (CL) diameter, the luteal blood flow (LBF) area, the uterine blood flow (UBF) vascularization area, and progesterones in saliva and serum for non-pregnant (NPBs, N = 12) and pregnant (PBs, N = 12) buffaloes. The results revealed that the CL diameter and the luteal color blood flow blue and red (P = 0.0001) areas of the pregnant animals kept increasing from day 1 to day 35 of the gestation period, but it decreased in NPBs on day 21 after reaching a peak from ovulation to day 18...
September 23, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28942100/doppler-ultrasonography-can-be-useful-to-determine-the-etiology-of-idiopathic-sudden-sensorineural-hearing-loss
#12
Ahmet Mutlu, Isa Cam, Sinem Dasli, Murat Topdag
OBJECTIVE: This study aims to evaluate clinical features of both carotid and vertebral arteries in the idiopathic sudden sensorineural hearing loss (ISSNHL) patients and healthy individuals to contribute additional knowledge on vascular compromise theory. METHODS: This study was designed as a retrospective case control study in a tertiary referral center. 55 patients for ISSNHL and 35 healthy participants (70 ears) are involved to the study. All of the patients were evaluated for the systemic disorders and excluded other possible causes (autoimmune diseases, acoustic schwannoma, drug toxicity, etc) of ISSNHL...
September 20, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28942094/effects-of-n-3-fatty-acid-treatment-on-monocyte-pheno-types-in-humans-with-hypertriglyceridemia
#13
Xiao-Yuan Dai Perrard, Zeqin Lian, George Bobotas, Mary R Dicklin, Kevin C Maki, Huaizhu Wu
BACKGROUND: Hypertriglyceridemia increases risk for atherosclerotic cardiovascular disease and may contribute to atherosclerosis by changing circulating monocyte phenotypes. High-dose n-3 polyunsaturated fatty acids reduce blood triglyceride levels. Effects of triglyceride-lowering therapy on monocyte phenotypes are not well known. OBJECTIVE: We examined effects of n-3 polyunsaturated fatty acid treatments (eicosapentaenoic acid [EPA] plus docosapentaenoic acid [MAT9001] vs EPA ethyl esters [EPA-EE]) on monocyte phenotypes in individuals with hypertriglyceridemia...
August 26, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28942075/clinical-and-in-vitro-evidence-that-subclinical-hemolysis-contributes-to-lvad-thrombosis
#14
Carlo R Bartoli, David Zhang, Jooeun Kang, Samson Hennessy-Strahs, David Restle, Jessica Howard, Gretchen Redline, Christian Bermudez, Pavan Atluri, Michael A Acker
BACKGROUND: Recent data suggest that hemolysis contributes to left ventricular assist device (LVAD) thrombosis, but the mechanism is unknown. In a clinical study, we measured plasma free hemoglobin (pfHgb) and the incidence of LVAD thrombosis. In an in vitro study, we examined biophysical relationships between shear stress, pfHgb and von Willebrand factor (vWF) metabolism toward understanding mechanisms of LVAD thrombosis. METHODS: In the clinical study, blood samples were obtained from continuous-flow LVAD patients (n = 30)...
September 21, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28941934/effects-of-dietary-nitrate-supplementation-on-the-response-to-extremity-cooling-and-endothelial-function-in-individuals-with-cold-sensitivity-a-double-blind-placebo-controlled-crossover-randomised-control-trial
#15
Clare M Eglin, Joseph T Costello, Stephen J Bailey, Mark Gilchrist, Heather Massey, Anthony I Shepherd
Individuals with cold sensitivity have low peripheral skin blood flow and skin temperature possibly due to reduced nitric oxide (NO•) bioavailability. Beetroot has a high concentration of inorganic nitrate and may increase NO-mediated vasodilation. Using a placebo-controlled, double blind, randomised, crossover design, this study tested the hypotheses that acute beetroot supplementation would increase the rate of cutaneous rewarming following a local cold challenge and augment endothelium-dependent vasodilation in cold sensitive individuals...
September 20, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28941609/association-of-apolipoproteins-b-and-a-1-with-markers-of-vascular-health-or-cardiovascular-events
#16
Yiming M Zhu, Subodh Verma, Marinda Fung, Matthew J McQueen, Todd J Anderson, Eva M Lonn
BACKGROUND: Apolipoprotein B (apoB) and apolipoprotein A-1 (apoA-1) are markers of lipoprotein metabolism. Although their relationship to cardiovascular disease has been well documented, little is known regarding their correlation to measures of vascular structure and function. This study was conducted to investigate the relationship between apoA-1, apoB, and measures of vascular function, as well their relationship to adverse cardiovascular events. Moreover, we evaluated whether apoB or the apoB/apoA-1 ratio was more closely related to vascular markers than was low-density lipoprotein cholesterol (LDL-C) or non-high-density lipoprotein cholesterol (non-HDL-C)...
October 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28941496/quinacrine-suppresses-tumor-necrosis-factor-%C3%AE-and-ifn-%C3%AE-in-dermatomyositis-and%C3%A2-cutaneous-lupus-erythematosus
#17
REVIEW
Paul Alves, Muhammad M Bashir, Maria Wysocka, Majid Zeidi, Rui Feng, Victoria P Werth
Antimalarials are used to treat dermatomyositis (DM) and cutaneous lupus erythematosus (CLE). Although hydroxychloroquine (HCQ) is frequently used, addition of quinacrine (QC) has shown additional clinical effects when combined with HCQ. To quantify the effects of HCQ versus QC in suppressing secretion of tumor necrosis factor-α (TNF-α) and IFN-α from the peripheral blood mononuclear cells of DM and CLE patients, lipopolysaccharide-stimulated and control peripheral blood mononuclear cells from DM and CLE patients and control subjects were analyzed for the effect of HCQ and QC on TNF-α and IFN-α production using ELISA testing...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941232/engineering-cardiovascular-implant-surfaces-to-create-a-vascular-endothelial-growth-microenvironment
#18
Jingan Li, Kun Zhang, Nan Huang
Cardiovascular disease is generally accepted as the leading cause of morbidity and mortality worldwide, and an increasing number of patients suffer from atherosclerosis and thrombosis annually. To treat these disorders and prolong the sufferers' life, several cardiovascular implants have been developed and applied clinically. Nevertheless, thrombosis and hyperplasia at the site of cardiovascular implants are recognized as long-term problems in the practice of interventional cardiology. Here, we start this review from the clinical requirement of the implants, such as anti-hyperplasia, anti-thrombosis and pro-endothelialization, wherein particularly focus on the natural factors which influence functional endothelialization in situ, including the healthy smooth muscle cells (SMCs) environment, blood flow shear stress (BFSS) and the extracellular matrix (ECM) microenvironment...
September 23, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28941171/roles-of-mitochondrial-dynamics-modulators-in-cardiac-ischaemia-reperfusion-injury
#19
REVIEW
Chayodom Maneechote, Siripong Palee, Siriporn C Chattipakorn, Nipon Chattipakorn
The current therapeutic strategy for the management of acute myocardial infarction (AMI) is to return blood flow into the occluded coronary artery of the heart, a process defined as reperfusion. However, reperfusion itself can increase mortality rates in AMI patients because of cardiac tissue damage and dysfunction, which is termed 'ischaemia/reperfusion (I/R) injury'. Mitochondria play an important role in myocardial I/R injury as disturbance of mitochondrial dynamics, especially excessive mitochondrial fission, is a predominant cause of cardiac dysfunction...
September 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28941170/imaging-flow-cytometry-assays-for-quantifying-pigment-grade-titanium-dioxide-particle-internalization-and-interactions-with-immune-cells-in-whole-blood
#20
Rachel E Hewitt, Bradley Vis, Laetitia C Pele, Nuno Faria, Jonathan J Powell
Pigment grade titanium dioxide is composed of sub-micron sized particles, including a nanofraction, and is widely utilized in food, cosmetic, pharmaceutical, and biomedical industries. Oral exposure to pigment grade titanium dioxide results in at least some material entering the circulation in humans, although subsequent interactions with blood immune cells are unknown. Pigment grade titanium dioxide is employed for its strong light scattering properties, and this work exploited that attribute to determine whether single cell-particle associations could be determined in immune cells of human whole blood at "real life" concentrations...
September 20, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
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