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Y-Q Huang, Y Zou, R-J Zheng, X-D Ma
OBJECTIVE: Acute lymphocytic leukemia (ALL) is a multi-factorial blood disease with unknown pathogenesis. Histone H3K4 methylation was significantly reduced in ALL patients, whereas jumonji AT-rich interactive domain 1B (JARID1B) was the specific demethylase of H3K4me. This study explores the expression level of JARID1B in ALL patients and down-regulated JARID1B expression in ALL cells to explore the function of JARID1B in ALL. PATIENTS AND METHODS: JARID1B mRNA expression level in ALL patients was detected by Real-time PCR...
March 2018: European Review for Medical and Pharmacological Sciences
F-D Sun, P-C Wang, R-L Luan, S-H Zou, X Du
OBJECTIVE: Drug resistance has become an important factor that threatens the survival and prognosis of patients with breast cancer, especially in patients with advanced breast cancer. Several microRNAs have been proved to participate in the resistant process; however, the role of miR-574 in doxorubicin (Dox) resistant breast cancer is still unclear. PATIENTS AND METHODS: Quantitative Real-time poly chain reaction (qRT-PCR) was employed to detect the expression level of miR-574 in breast cancer Dox-resistant MCF-7/Adr cell line and parental MCF-7 cell line...
March 2018: European Review for Medical and Pharmacological Sciences
Evgeniya V Kaigorodova, Olga E Savelieva, Liubov A Tashireva, Natalia A Tarabanovskaya, Elena I Simolina, Evgeny V Denisov, Elena M Slonimskaya, Evgeny L Choynzonov, Vladimir M Perelmuter
The biological properties of circulating tumor cells (CTCs), and their dynamics during neoadjuvant chemotherapy are important, both for disease progression prediction and therapeutic target determination, with the aim of preventing disease progression. The aim of our study was to estimate of different CTC subsets in breast cancer during the NACT (neoadjuvant chemotherapy). The prospective study includes 27 patients with invasive breast cancer, T2-4N0-3M0, aged 32 to 60 years. Venous heparinized blood samples, taken before and after biopsy, after each courses of chemotherapy (on days 3-7), and before surgical intervention, served as the material for this study...
March 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Shazia Shah, Arshia, Nida Siraj Kazmi, Almas Jabeen, Aisha Faheem, Nida Dastagir, Tariq Ahmed, Khalid Mohammed Khan, Shakil Ahmed, Abeer Raza, Shahnaz Perveen
BACKGROUND: Inflammation is defined as the response of immune system cells to damaged or injured tissues The major symptoms of inflammation include increased blood flow, cellular influx, edema, elevated cellular metabolism, reactive oxygen species (ROS) nitric oxide (NO) and vasodilation. This normally protective mechanism against harmful agents when this normal mechanism becomes dysregulated that can cause serious illnesses including ulcerative colitis, Crohn's disease, rheumatoid arthritis, osteoarthritis, sepsis, and chronic pulmonary inflammation ...
March 21, 2018: Medicinal Chemistry
Emine Sekerdag, Ihsan Solaroglu, Yasemin Gursoy-Ozdemir
As a result of ischemia or hemorrhage, blood supply to neurons is disrupted which subsequently promotes a cascade of pathophysiological responses resulting in cell loss. Many mechanisms are involved solely or in combination in this disorder including excitotoxicity, mitochondrial death pathways, and the release of free radicals, protein misfolding, apoptosis, necrosis, autophagy and inflammation. Besides neuronal cell loss, damage to and loss of astrocytes as well as injury to white matter contributes also to cerebral injury...
March 20, 2018: Current Neuropharmacology
Yu-Qing Zhou, Lindsay S Cahill, John G Sled
Genetically engineered mice have been widely used for studying cardiovascular development, physiology and diseases. In the past decade, high frequency ultrasound imaging technology has been significantly advanced and applied to observe the cardiovascular structure, function, and blood flow dynamics with high spatial and temporal resolution in mice. This noninvasive imaging approach has made possible longitudinal studies of the mouse embryo/fetus in utero. In this chapter, we describe detailed methods for: (1) the assessment of the structure, function, and flow dynamics of the developing heart of the mouse embryo during middle gestation (E10...
2018: Methods in Molecular Biology
U Hassan, R Zhu, R Bashir
Sepsis, as a leading cause of death worldwide, relies on systemic inflammatory response syndrome (SIRS) criteria for its diagnosis. SIRS is highly non-specific as it relies on monitoring of patients' vitals for sepsis diagnosis, which are known to change with many confounding factors. Changes in leukocyte counts and CD64 expression levels are known specific biomarkers of pro-inflammatory host response at the onset of sepsis. Recently, we have developed a biosensor chip that can enumerate the leukocyte counts and quantify the neutrophil CD64 expression levels from a drop of blood...
March 22, 2018: Lab on a Chip
Noelia Grande Gutierrez, Andrew Kahn, Jane C Burns, Alison L Marsden
No abstract text is available yet for this article.
October 31, 2017: Global Cardiology Science & Practice
Elsayed Ibraheem Elsayed Massoud
AIM: To investigate that the increased intracapsular pressure, during the delay period, can interrupt the blood flow to the femoral head. METHODS: An observational retrospective study included a group of 17 patients with traumatic hip dislocation, their ages at time of injury averaged 26 (range from 3 to 70) years. Outcomes were assessed clinically and radiographically at a period averaged 11.5 (range from 4 to 20) years. RESULTS: Minor trauma caused dislocation in seven and severe trauma in ten patients...
March 18, 2018: World Journal of Orthopedics
Jeong Hee Lee, Eung Do Kim, Eun Jung Jun, Hyoung Sun Yoo, Joon Woo Lee
Background: The purpose of this paper is to provide technology trends and information regarding market and prospects in stents used for human blood vessels in Korea and the world.A stent is a medical device in the form of a cylindrical metal net used to normalize flow when blood or other bodily fluids such as biliary fluids are obstructed in blood vessels, gastrointestinal tracts, etc. by inserting the stent into a narrowed or clogged area. Stents are classified into vascular and non-vascular stents...
2018: Biomaterials Research
Ana Aires, Maria Dos Anjos Teixeira, Catarina Lau, Cláudia Moreira, Ana Spínola, Alexandra Mota, Inês Freitas, Jorge Coutinho, Margarida Lima
Background: Immunophenotypic analysis of the bone marrow (BM) cells has proven to be helpful in the diagnosis of Myelodysplastic Syndromes (MDS). However, the usefulness of flow cytometry (FCM) for the detection of myelodysplasia in the peripheral blood (PB) still needs to be investigated. The aim of this pilot study was to evaluate the value of FCM-based PB neutrophil and monocyte immunophenotyping for the diagnosis of lower risk MDS (LR-MDS). Methods: We evaluated by 8-color FCM the expression of multiple cell surface molecules (CD10, CD11b, CD11c, CD13, CD14, CD15, CD16, CD34, CD45, CD56, CD64 and HLA-DR) in PB neutrophils and monocytes from a series of 14 adult LR-MDS patients versus 14 normal individuals...
2018: BMC Hematology
Fangbin Zhou, Yaying Zhou, Ming Yang, Jinli Wen, Jun Dong, Wenyong Tan
Background: Circulating endothelial cells (CECs) and their subpopulations could be potential novel biomarkers for various malignancies. However, reliable enumerable methods are warranted to further improve their clinical utility. This study aimed to optimize a flow cytometric method (FCM) assay for CECs and subpopulations in peripheral blood for patients with solid cancers. Patients and methods: An FCM assay was used to detect and identify CECs. A panel of 60 blood samples, including 44 metastatic cancer patients and 16 healthy controls, were used in this study...
2018: Cancer Management and Research
Hao Wan, Jingying Yue, Shoujun Zhu, Takaaki Uno, Xiaodong Zhang, Qinglai Yang, Kuai Yu, Guosong Hong, Junying Wang, Lulin Li, Zhuoran Ma, Hongpeng Gao, Yeteng Zhong, Jessica Su, Alexander L Antaris, Yan Xia, Jian Luo, Yongye Liang, Hongjie Dai
Fluorescence imaging of biological systems in the second near-infrared (NIR-II, 1000-1700 nm) window has shown promise of high spatial resolution, low background, and deep tissue penetration owing to low autofluorescence and suppressed scattering of long wavelength photons. Here we develop a bright organic nanofluorophore (named p-FE) for high-performance biological imaging in the NIR-II window. The bright NIR-II >1100 nm fluorescence emission from p-FE affords non-invasive in vivo tracking of blood flow in mouse brain vessels...
March 21, 2018: Nature Communications
Tatsuya Tsuchitani, Yoshihiro Maeda, Masahiko Oda, Takuya Enoki, Yoshiyuki Takahashi, Chiemi Mitsuie, Masao Tanooka, Noriko Kotoura, Kazuhiro Kitajima
The QSPECT dual table autoradiography (DTARG) method can be used for quantitative determination of cerebral blood flow. We verified the influence on quantitative values obtained for cerebral blood flow in the case when usual acquisition was impossible and evaluated those values. Results obtained with an acquisition time of 30 min were considered to be true values, and the correlation and consistency with results of other times were evaluated. Values obtained with a shortened acquisition time showed a high correlation with the true value...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
Chenguang Li, Yi Shen, Rende Xu, Yuxiang Dai, Shufu Chang, Hao Lu, Lei Ge, Jianying Ma, Juying Qian, Junbo Ge
The safety and efficacy of bivalirudin during percutaneous coronary intervention (PCI) in high bleeding risk patients with chronic total occlusion lesions (CTO) has not been studied till date. The use of bivalirudin may increase the thrombotic events during CTO-PCI.Between May 2013 and April 2014, a total of 117 high bleeding risk patients with CTOs underwent PCI. Bivalirudin was used in 89 cases with different strategies, including standard usage, combination of heparin, and additional bolus of bivalirudin on the basis of standard usage...
March 20, 2018: International Heart Journal
Gang Chen, Lingmin Wu, Lihui Zheng, Ligang Ding, Tom Wong, Shu Zhang, Yan Yao
This study aimed to prospectively evaluate the safety and efficacy of a new developed method that uses percutaneous ultrasound-guided hematoma aspiration followed by targeted localized manual compression for treatment of femoral artery pseudoaneurysm after cardiac catheterization, which obviates thrombin use, surgery, and long-time compression.From January 2007 to July 2014, 32 patients (17 women; mean age, 55.3 ± 11.5 years) out of 8,725 consecutive cases undergoing cardiac catheterization via femoral access developed one pseudoaneurysm each ranging in size from 21 × 11 mm to 72 × 39 mm...
March 20, 2018: International Heart Journal
Tatiana A Karakasheva, George A Dominguez, Ayumi Hashimoto, Eric W Lin, Christopher Chiu, Kate Sasser, Jae W Lee, Gregory L Beatty, Dmitry I Gabrilovich, Anil K Rustgi
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a population of immature immune cells with several protumorigenic functions. CD38 is a transmembrane receptor-ectoenzyme expressed by MDSCs in murine models of esophageal cancer. We hypothesized that CD38 could be expressed on MDSCs in human colorectal cancer (CRC), which might allow for a new perspective on therapeutic targeting of human MDSCs with anti-CD38 monoclonal antibodies in this cancer. METHODS: Blood samples were collected from 41 CRC patients and 8 healthy donors, followed by peripheral blood mononuclear cell (PBMC) separation...
March 22, 2018: JCI Insight
Abdullah Aljurayyan, Suttida Puksuriwong, Muhammad Ahmed, Ravi Sharma, Madhan Krishnan, Salil Sood, Katherine Davies, Devika Rajashekar, Sam Leong, Paul S McNamara, Stephen Gordon, Qibo Zhang
There is increasing interest recently in developing intranasal vaccines against respiratory tract infections. Antibody response is critical in vaccine-induced protection and TFH is considered important in mediating antibody response. Most data supporting the role for TFH in antibody response are from animal studies, and direct evidence from humans is limited, apart from TFH -like cells in blood. We studied activation and induction of TFH and its role on anti-influenza antibody response by live-attenuated influenza vaccine(LAIV) in human nasopharynx-associated lymphoid tissue(NALT)...
March 21, 2018: Journal of Virology
Iain Parsons, E J Hutley, I Gibb, J Lentaigne, D Wilson, A T Cox
INTRODUCTION: The role of the military physician in Deployed Hospital Care involves the diagnosis and management of a wide variety of disease states. Broad clinical skills need to be complemented by judicious use of a limited array of investigations. No study has specifically quantified what investigations physicians use on operations. METHODS: A retrospective cross-sectional study was performed to ascertain what investigations were undertaken on all patients managed by the General Internal Medicine teams over a 14 month period during a recent enduring operation in Afghanistan...
March 21, 2018: Journal of the Royal Army Medical Corps
Takuya Kurazumi, Yojiro Ogawa, Ryo Yanagida, Hiroshi Morisaki, Ken-Ichi Iwasaki
BACKGROUND: Exposure to carbon dioxide (CO2) and cephalad fluid shift are considered factors that affect intracranial pressure (ICP) during spaceflight. Increases in ICP were reported during cephalad fluid shift induced by head-down tilt (HDT), while little is known regarding the effect of additional CO2 during HDT on ICP. Therefore, we tested the hypothesis that this combination increases ICP more than HDT alone. METHODS: There were 15 healthy male volunteers who underwent 4 types of 10-min interventions consisting of Placebo/Supine (air and supine), CO2/Supine (3% CO2 and supine, CO2 alone), Placebo/HDT (air and -10° HDT, HDT alone), and CO2/HDT (3% CO2 and -10° HDT, combination)...
April 1, 2018: Aerospace Medicine and Human Performance
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