keyword
https://read.qxmd.com/read/37821692/increased-anxiety-and-emotional-lability-in-a-patient-with-sdhb-gene-mutation-paraganglioma-a-call-to-multidisciplinary-approach
#21
JOURNAL ARTICLE
Joseph Allen White, James Rodriguez, Jagan Kandadai, Einas Kardas, Farrah Chohan, George Michel
Paragangliomas are neuroendocrine tumors that have the potential to secrete catecholamines. They have been linked to genetic mutations in the mitochondrial succinate dehydrogenase (SDH) complex. Patients can experience both physical symptoms and psychiatric symptoms like anxiety, depression, and psychosis. These symptoms can occur as paroxysmal episodes with periods of increased catecholamine secretion. We describe a patient with SDHB gene mutation, who has been diagnosed with a jugular paraganglioma, and was brought to the hospital under Baker Act for threats made online...
October 11, 2023: Endocrine
https://read.qxmd.com/read/37809158/implementing-an-interdisciplinary-procedure-curriculum
#22
JOURNAL ARTICLE
Bryce Montane, Abey Abraham, Sergio Bustamante, Tushar Vachharajani, Sabry Ayad, Jagan Devarajan, Dustin Thompson, Ran Lee, Penelope Rampersad, Brian Gage, Emily Reznicek, Chongliang Luo, Richard Wardrop
INTRODUCTION: This curriculum was designed to improve access to procedures for our internal medicine residents. METHODS: We created an interdisciplinary procedure course (IDPC) composed of two simulation sessions and a one-week procedural rotation supervised by multiple specialties including nephrology, cardiology, cardiothoracic anesthesiology, general anesthesiology, and interventional radiology. After the course, residents completed two surveys documenting the number of procedures and their level of confidence on a Likert scale (1 = very unconfident to 5 = very confident) prior to and after completing the curriculum...
September 2023: Curēus
https://read.qxmd.com/read/37797420/model-based-process-optimization-of-an-industrial-chromatographic-process-for-separation-of-lactoferrin-from-bovine-milk
#23
JOURNAL ARTICLE
Lukas Gerstweiler, Paulina Schad, Tatjana Trunzer, Lena Enghauser, Max Mayr, Jagan Billakanti
Model based process development using predictive mechanistic models is a powerful tool for in-silico downstream process development. It allows to obtain a thorough understanding of the process reducing experimental effort. While in pharma industry, mechanistic modeling becomes more common in the last years, it is rarely applied in food industry. This case study investigates risk ranking and possible optimization of the industrial process of purifying lactoferrin from bovine milk using SP Sepharose Big Beads with a resin particle diameter of 200 µm, based on a minimal number of lab-scale experiments combining traditional scale-down experiments with mechanistic modeling...
October 2, 2023: Journal of Chromatography. A
https://read.qxmd.com/read/37772688/aptabinding-of-tumor-necrosis-factor-%C3%AE-tnf%C3%AE-inhibits-its-proinflammatory-effects-and-alleviates-islet-inflammation
#24
JOURNAL ARTICLE
Roaa Mahmoud, Jagan Kalivarathan, Abdul J Castillo, Sasha Wang, Brian Fuglestad, Mazhar A Kanak, Soma Dhakal
Pancreatic islet cell transplantation (ICT) has emerged as an effective therapy for diabetic patients lacking endogenous insulin production. However, the islet graft function is compromised by a nonspecific inflammatory and thrombotic reaction known as the instant blood-meditated inflammatory reaction (IBMIR). Here, we report the characterization of four single-stranded DNA aptamers that bind specifically to TNFα - a pivotal cytokine that causes proinflammatory signaling during the IBMIR process - using single molecule binding analysis and functional assays as a means to assess the aptamers' ability in blocking TNFα activity and inhibiting the downstream proinflammatory gene expression in the islets...
September 29, 2023: Biotechnology Journal
https://read.qxmd.com/read/37740924/atn-cerebrospinal-fluid-biomarkers-in-dementia-with-lewy-bodies-initial-results-from-the-united-states-dementia-with-lewy-bodies-consortium
#25
JOURNAL ARTICLE
Lavanya Jain, Maria Khrestian, Shane Formica, Elizabeth D Tuason, Jagan A Pillai, Stephen Rao, Odinachi Oguh, Carol F Lippa, Oscar L Lopez, Sarah B Berman, Debby W Tsuang, Cyrus P Zabetian, David J Irwin, Douglas R Galasko, Irene Litvan, Karen S Marder, Lawrence S Honig, Jori E Fleisher, James E Galvin, Andrea C Bozoki, Angela S Taylor, Marwan N Sabbagh, James B Leverenz, Lynn M Bekris
INTRODUCTION: The National Institute on Aging - Alzheimer's Association (NIA-AA) ATN research framework proposes to use biomarkers for amyloid (A), tau (T), and neurodegeneration (N) to stage individuals with AD pathological features and track changes longitudinally. The overall aim was to utilize this framework to characterize pre-mortem ATN status longitudinally in a clinically diagnosed cohort of dementia with Lewy bodies (DLB) and to correlate it with the post mortem diagnosis. METHODS: The cohort was subtyped by cerebrospinal fluid (CSF) ATN category...
September 23, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/37732394/higher-order-dialectic-variation-and-syntactic-convergence-in-the-complex-warble-song-of-budgerigars
#26
JOURNAL ARTICLE
Abhinava Jagan Madabhushi, Nakul Wewhare, Priya Binwal, Vaishnavi Agarwal, Anand Krishnan
Dialectic signatures in animal acoustic signals are key in identification and association with group members. Complex vocal sequences may also convey information about behavioral state, and may thus vary according to social environment. Some bird species such as psittaciforms learn and modify their complex acoustic signals throughout their lives. However, the structure and function of vocal sequences in open-ended vocal learners remains understudied. Here, we examined vocal sequence variation in the warble song of budgerigars, and how these change upon contact between social groups...
September 21, 2023: Journal of Experimental Biology
https://read.qxmd.com/read/37716218/providencia-alcalifaciens-in-a-patient-with-a-staghorn-calculus-a-novel-presentation
#27
Joseph Allen White, Ameen Abdel Khalek, James Rodriguez, Jagan Kandadai, Mobashir Hosameddin, Saul Gonzalez
A member of the Enterobacteriaceae family, Providencia alcalifaciens is typically recognized as a source of gastrointestinal illness. Although its pathogenicity is not well known, many studies have suggested its mechanism of action involves the invasion of the intestinal mucosal layer. Although P. alcalifaciens is a urease producing microorganism, it has not been associated with the formation of a staghorn calculus in the setting of a urinary tract infection. This organism is neither commonly pursued in research or investigation nor is it commonly tested for in the clinical setting...
August 10, 2023: Diagnostic Microbiology and Infectious Disease
https://read.qxmd.com/read/37715695/orbital-sarcoidosis-with-invasion-of-the-lacrimal-gland
#28
JOURNAL ARTICLE
Spencer C Barbera, Triet M Do, Amy C Yu, Jagan D Gupta, Neel D Gupta, Enrique Palacios
No abstract text is available yet for this article.
September 16, 2023: Ear, Nose, & Throat Journal
https://read.qxmd.com/read/37714151/antigen-receptor-signaling-and-cell-death-resistance-controls-intestinal-humoral-response-zonation
#29
JOURNAL ARTICLE
Fiona Raso, Shuozhi Liu, Mikala J Simpson, Gregory M Barton, Christian T Mayer, Mridu Acharya, Jagan R Muppidi, Ann Marshak-Rothstein, Andrea Reboldi
Immunoglobulin A (IgA) maintains commensal communities in the intestine while preventing dysbiosis. IgA generated against intestinal microbes assures the simultaneous binding to multiple, diverse commensal-derived antigens. However, the exact mechanisms by which B cells mount broadly reactive IgA to the gut microbiome remains elusive. Here, we have shown that IgA B cell receptor (BCR) is required for B cell fitness during the germinal center (GC) reaction in Peyer's patches (PPs) and for generation of gut-homing plasma cells (PCs)...
October 10, 2023: Immunity
https://read.qxmd.com/read/37690597/ddd-028-a-potent-neuroprotective-non-opioid-compound-for-the-treatment-of-diabetic-neuropathy
#30
JOURNAL ARTICLE
Laura Micheli, Jagan Rajamoni, Lorenzo Di Cesare Mannelli, Parthasarathi Rajagopalan, Carla Ghelardini, Raghavan Rajagopalan
Diabetic neuropathy (DN) is a painful, chronic ailment that affects a large segment of diabetic population worldwide. Current medications such as pregabalin or duloxetine treat only the pain symptom associated with DN, but not the underlying nerve damage. DDD-028 (1) is a small molecule that displays potent pain-relieving activity in streptozotocin (STZ)-induced rodent model of DN. Combined with other studies indicating that DDD-028 suppresses astrogliosis and nerve damage induced by the anti-cancer drug, paclitaxel, the present study suggests that DDD-028 would be useful as a disease modifying therapeutic in the treatment of DN...
September 9, 2023: Bioorganic & Medicinal Chemistry Letters
https://read.qxmd.com/read/37659482/bioresorbable-films-of-polycaprolactone-blended-with-poly-lactic-acid-or-poly-lactic-co-glycolic-acid
#31
JOURNAL ARTICLE
Jagan Mohan Dodda, Mina Ghafouri Azar, Petr Bělský, Miroslav Šlouf, Veronika Gajdošová, Phanindra Babu Kasi, Luis Oliveros Anerillas, Tomáš Kovářík
Recent complications on the use of polypropylene meshes for hernia repair has led to the development of meshes or films, which were based on resorbable polymers such as polycaprolactone (PCL), polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA). These materials are able to create suitable bioactive environment for the growth and development of cells. In this research, we mainly focused on the relations among structure, mechanical performance and biocompatiblity of PCL/PLA and PCL/PLGA and blends prepared by solution casting...
August 31, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37659443/network-analysis-of-behavioral-approach-inhibition-systems-and-brain-volume-in-individuals-with-and-without-major-depressive-disorder-or-social-anxiety-disorder
#32
JOURNAL ARTICLE
Qimin Liu, Delaney Davey, Jagan Jimmy, Olusola Ajilore, Heide Klumpp
BACKGROUND: Social anxiety disorder (SAD) and major depressive disorder (MDD) are characterized by behavioral abnormalities in motivational systems, namely, the behavioral inhibition system (BIS) and behavioral activation system (BAS). Limited studies indicate brain volume in regions that support emotion, learning/memory, reward, and cognitive functions relate to BIS/BAS. To increase understanding of BIS/BAS, the current study used a network approach. METHODS: Patients with SAD (n=59), MDD (n=64) and healthy controls (n=36) completed a BIS/BAS questionnaire and structural MRI scans; volumetric regions of interest comprised cortical and limbic structures based on previous BIS/BAS studies...
August 31, 2023: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/37568816/chemoprevention-of-colon-cancer-by-dfmo-sulindac-and-no-sulindac-administered-individually-or-in-combinations-in-f344-rats
#33
JOURNAL ARTICLE
Venkateshwar Madka, Jagan M R Patlolla, Karthikkumar Venkatachalam, Yuting Zhang, Gopal Pathuri, Nicole Stratton, Stanley Lightfoot, Naveena B Janakiram, Altaf Mohammed, Chinthalapally V Rao
Non-steroidal anti-inflammatory drugs (NSAIDs) are promising colorectal cancer (CRC) chemopreventive drugs; however, to overcome NSAIDs' associated side effects, there is a need to develop safer and efficacious approaches. The present study was designed to evaluate (i) the efficacy of nitric-oxide releasing (NO)-Sulindac as compared to Sulindac; (ii) whether NO-Sulindac is superior to Sulindac in enhancing low-dose difluoromethylornithine (DFMO)-induced chemopreventive efficacy, and (iii) assessing the key biomarkers associated with colon tumor inhibition by these combinations...
August 7, 2023: Cancers
https://read.qxmd.com/read/37546268/insights-into-mechanisms-of-seed-longevity-in-soybean-a-review
#34
REVIEW
Polneni Jagan Mohan Rao, Mandalapu Pallavi, Yarasi Bharathi, P Bindu Priya, Patta Sujatha, Kona Prabhavathi
Soybean, a crop of international importance, is challenged with the problem of seed longevity mainly due to its genetic composition and associated environmental cues. Soybean's fragile seed coat coupled with poor DNA integrity, ribosomal dysfunction, lipid peroxidation and poor antioxidant system constitute the rationale for fast deterioration. Variability among the genotypes for sensitivity to field weathering contributed to their differential seed longevity. Proportion and density of seed coat, glassy state of cells, calcium and lignin content, pore number, space between seed coat and cotyledon are some seed related traits that are strongly correlated to longevity...
2023: Frontiers in Plant Science
https://read.qxmd.com/read/37538946/placebo-hypoalgesic-and-nocebo-hyperalgesic-effects-in-post-extraction-patients-a-cross-sectional-study
#35
JOURNAL ARTICLE
Suchithra Sampath Kumar, Sidra Bano, Jagan P
BACKGROUND AND OBJECTIVES: Pain is an unpleasant sensory and emotional experience that affects people's physical, mental, and social health. Patients at times present with postoperative pain with no clinical signs after the surgical dental procedures and adequate pharmacological management. This can be due to the amplified emotional component of the individual in their postoperative period. Hence, this study aimed to estimate the association between placebo, nocebo effects, and postoperative pain associated with tooth extraction procedures...
August 2023: British Journal of Pain
https://read.qxmd.com/read/37533145/costal-margin-injuries-and-trans-diaphragmatic-intercostal-hernia-presentation-management-and-outcomes-according-to-the-sheffield-classification
#36
JOURNAL ARTICLE
Jonathan L Byers, Jagan N Rao, Laura Socci, David N Hopkinson, Sara Tenconi, John G Edwards
BACKGROUND: Costal margin rupture (CMR) injuries are under-diagnosed and inconsistently managed, whilst carrying significant symptomatic burden. We hypothesised that the Sheffield Classification system of CMR injuries would relate to injury patterns and management options. METHODS: Data were collected prospectively between 2006 and 2023 at a Major Trauma Centre in the United Kingdom. CT scans were interrogated and injuries were categorised according to the Sheffield Classification...
August 3, 2023: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/37484416/community-dynamics-of-bumblebee-across-elevation-gradients-and-habitat-mosaics-in-chitwan-annapurna-landscape-nepal
#37
JOURNAL ARTICLE
Kishor Chandra Ghimire, Anjeela Pandey, Ichha Roka, Jagan Nath Adhikari, Daya Ram Bhusal
The species composition of bumblebees ( Bombus species) across the elevation gradients in Chitwan-Annapurna Landscape (CHAL) was studied from April to November 2019. We performed opportunistic surveys to collect the bumblebee specimens. The walking transects were followed in the accessible places along the Kaligandaki, Marshyandi, and Budhigandaki river basins in different habitats (e.g., agricultural, forest, grassland and home garden). We identified 16 Bombus species from the sampling areas. The highest relative abundance was of B...
June 2023: Heliyon
https://read.qxmd.com/read/37461624/multi-ancestry-genome-wide-meta-analysis-of-56-241-individuals-identifies-lrrc4c-lhx5-as1-and-nominates-ancestry-specific-loci-ptprk-grb14-and-kiaa0825-as-novel-risk-loci-for-alzheimer-s-disease-the-alzheimer-s-disease-genetics-consortium
#38
Farid Rajabli, Penelope Benchek, Giuseppe Tosto, Nicholas Kushch, Jin Sha, Katrina Bazemore, Congcong Zhu, Wan-Ping Lee, Jacob Haut, Kara L Hamilton-Nelson, Nicholas R Wheeler, Yi Zhao, John J Farrell, Michelle A Grunin, Yuk Yee Leung, Pavel P Kuksa, Donghe Li, Eder Lucio da Fonseca, Jesse B Mez, Ellen L Palmer, Jagan Pillai, Richard M Sherva, Yeunjoo E Song, Xiaoling Zhang, Taha Iqbal, Omkar Pathak, Otto Valladares, Amanda B Kuzma, Erin Abner, Perrie M Adams, Alyssa Aguirre, Marilyn S Albert, Roger L Albin, Mariet Allen, Lisa Alvarez, Liana G Apostolova, Steven E Arnold, Sanjay Asthana, Craig S Atwood, Gayle Ayres, Clinton T Baldwin, Robert C Barber, Lisa L Barnes, Sandra Barral, Thomas G Beach, James T Becker, Gary W Beecham, Duane Beekly, Bruno A Benitez, David Bennett, John Bertelson, Thomas D Bird, Deborah Blacker, Bradley F Boeve, James D Bowen, Adam Boxer, James Brewer, James R Burke, Jeffrey M Burns, Joseph D Buxbaum, Nigel J Cairns, Laura B Cantwell, Chuanhai Cao, Christopher S Carlson, Cynthia M Carlsson, Regina M Carney, Minerva M Carrasquillo, Scott Chasse, Marie-Francoise Chesselet, Nathaniel A Chin, Helena C Chui, Jaeyoon Chung, Suzanne Craft, Paul K Crane, David H Cribbs, Elizabeth A Crocco, Carlos Cruchaga, Michael L Cuccaro, Munro Cullum, Eveleen Darby, Barbara Davis, Philip L De Jager, Charles DeCarli, John DeToledo, Malcolm Dick, Dennis W Dickson, Beth A Dombroski, Rachelle S Doody, Ranjan Duara, NIlüfer Ertekin-Taner, Denis A Evans, Kelley M Faber, Thomas J Fairchild, Kenneth B Fallon, David W Fardo, Martin R Farlow, Victoria Fernandez-Hernandez, Steven Ferris, Tatiana M Foroud, Matthew P Frosch, Brian Fulton-Howard, Douglas R Galasko, Adriana Gamboa, Marla Gearing, Daniel H Geschwind, Bernardino Ghetti, John R Gilbert, Alison M Goate, Thomas J Grabowski, Neill R Graff-Radford, Robert C Green, John H Growdon, Hakon Hakonarson, James Hall, Ronald L Hamilton, Oscar Harari, John Hardy, Lindy E Harrell, Elizabeth Head, Victor W Henderson, Michelle Hernandez, Timothy Hohman, Lawrence S Honig, Ryan M Huebinger, Matthew J Huentelman, Christine M Hulette, Bradley T Hyman, Linda S Hynan, Laura Ibanez, Gail P Jarvik, Suman Jayadev, Lee-Way Jin, Kim Johnson, Leigh Johnson, M Ilyas Kamboh, Anna M Karydas, Mindy J Katz, John S Kauwe, Jeffrey A Kaye, C Dirk Keene, Aisha Khaleeq, Ronald Kim, Janice Knebl, Neil W Kowall, Joel H Kramer, Walter A Kukull, Frank M LaFerla, James J Lah, Eric B Larson, Alan Lerner, James B Leverenz, Allan I Levey, Andrew P Lieberman, Richard B Lipton, Mark Logue, Oscar L Lopez, Kathryn L Lunetta, Constantine G Lyketsos, Douglas Mains, Flanagan E Margaret, Daniel C Marson, Eden R R Martin, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Paul Massman, Arjun Masurkar, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Stefan McDonough, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, Thomas J Montine, Edwin S Monuki, John C Morris, Shubhabrata Mukherjee, Amanda J Myers, Trung Nguyen, Sid O'Bryant, John M Olichney, Marcia Ory, Raymond Palmer, Joseph E Parisi, Henry L Paulson, Valory Pavlik, David Paydarfar, Victoria Perez, Elaine Peskind, Ronald C Petersen, Aimee Pierce, Marsha Polk, Wayne W Poon, Huntington Potter, Liming Qu, Mary Quiceno, Joseph F Quinn, Ashok Raj, Murray Raskind, Eric M Reiman, Barry Reisberg, Joan S Reisch, John M Ringman, Erik D Roberson, Monica Rodriguear, Ekaterina Rogaeva, Howard J Rosen, Roger N Rosenberg, Donald R Royall, Mark A Sager, Mary Sano, Andrew J Saykin, Julie A Schneider, Lon S Schneider, William W Seeley, Susan H Slifer, Scott Small, Amanda G Smith, Janet P Smith, Joshua A Sonnen, Salvatore Spina, Peter St George-Hyslop, Robert A Stern, Alan B Stevens, Stephen M Strittmatter, David Sultzer, Russell H Swerdlow, Rudolph E Tanzi, Jeffrey L Tilson, John Q Trojanowski, Juan C Troncoso, Debby W Tsuang, Vivianna M Van Deerlin, Linda J van Eldik, Jeffery M Vance, Badri N Vardarajan, Robert Vassar, Harry V Vinters, Jean-Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Patrice L Whitehead, Ellen M Wijsman, Kirk C Wilhelmsen, Benjamin Williams, Jennifer Williamson, Henrik Wilms, Thomas S Wingo, Thomas Wisniewski, Randall L Woltjer, Martin Woon, Clinton B Wright, Chuang-Kuo Wu, Steven G Younkin, Chang-En Yu, Lei Yu, Xiongwei Zhu, Brian W Kunkle, William S Bush, Li-San Wang, Lindsay A Farrer, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Gerard D Schellenberg, Gyungah R Jun, Christiane Reitz, Adam C Naj
Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset in the Alzheimer's Disease (AD) Genetics Consortium (ADGC) to test for novel shared and ancestry-specific AD susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6,728 African American, 8,899 Hispanic (HIS), and 3,232 East Asian individuals, performing within-ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis...
July 8, 2023: medRxiv
https://read.qxmd.com/read/37397580/primary-lung-adenocarcinoma-in-transplanted-lung-in-post-bilateral-lung-transplantation
#39
Fathima Shafra Mubarak, Sanjay Agrawal, Jagan Rao
KEY CLINICAL MESSAGE: Primary lung cancer was reported by a bilateral lung transplant patient without any risk factors. Single lung transplantation should be contemplated instead of double lung transplantation as it has been shown to increase the risk of lung cancers. ABSTRACT: This is a case report of a 37-year-old woman, with no history of smoking, who developed adenocarcinoma in her transplanted lung 17 years post transplantation. The development of lung cancer 17 years after transplantation is considered as a rare finding in this case report...
July 2023: Clinical Case Reports
https://read.qxmd.com/read/37396794/the-architect-of-neurotransmission-in-c-elegans-how-flp-3-neuropeptides-structures-direct-their-function
#40
JOURNAL ARTICLE
Rehab Salama, Elizabeth DiLoreto, Jagan Srinivasan
Neuropeptides direct functions in the nervous, endocrine, and immune systems of all animals by altering the activity at neural synapses. A single neuropeptide gene can be post-translationally modified to create multiple active peptides. These individual active peptides can have unique functions and drive discrete binding partners. We have previously shown that specific peptides encoded by the C. elegans neuropeptide gene, flp- 3, have sex-specific roles in response to a pheromone released by hermaphrodite C...
2023: microPublication. Biology
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