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Afreen Anwar, Solimar Ramis De Ayreflor Reyes, Aijaz Ahmad John, Erik Breiling, Abigail M O'Connor, Stephanie Reis, Jae-Hyuck Shim, Ali Asghar Shah, Jagan Srinivasan, Natalie G Farny
UNLABELLED: Lead (Pb(II)) is a pervasive heavy metal toxin with many well-established negative effects on human health. Lead toxicity arises from cumulative, repeated environmental exposures. Thus, prophylactic strategies to protect against the bioaccumulation of lead could reduce lead-associated human pathologies. Here we show that DNA and RNA aptamers protect C. elegans from toxic phenotypes caused by lead. Reproductive toxicity, as measured by brood size assays, is prevented by co-feeding of animals with DNA or RNA aptamers...
March 31, 2024: bioRxiv
#2
JOURNAL ARTICLE
Jean-Yves Ekra, Eliakunda Michael Mafie, Edouard K N'Goran, Dramane Kaba, Biégo Guillaume Gragnon, Jagan Srinivasan
The potential danger to livestock from African animal trypanosomiasis is well known. However, the trypanosome species circulating in cattle and their genetics are poorly understood. After different alignments according to three regions (ITS1, gGAPDH and rRNA gene) of the trypanosome genome, phylogenetic analyses were used to show the genetic diversity of the different species that were circulating in the cattle in three regions (Bagoue, Poro and Tchologo) of Côte d'Ivoire. These analyses were performed by alignment of ITS1; by alignment of partial 18S, ITS1, 5...
March 19, 2024: Pathogens
#3
JOURNAL ARTICLE
Mandla Rajashekhar, Banda Rajashekar, Thalla Prabhakar Reddy, Keerthi Manikyanahalli Chandrashekara, Kalisetti Vanisree, Kommagoni Ramakrishna, Vanam Sunitha, Ongolu Shaila, Eetela Sathyanarayana, Shahanaz, Somireddy Srinivasa Reddy, Adhi Shankar, Afifa Jahan, Padala Vinod Kumar, Maligi Jagan Mohan Reddy
Invasive alien species (IAS) pose a severe threat to global agriculture, with their impact projected to escalate due to climate change and expanding international trade. The fall armyworm (FAW), Spodoptera frugiperda (J. E. Smith), a native of the Americas, has rapidly spread across various continents, causing significant damage to several food crops, especially maize. Integrated pest management (IPM) programs are vital for sustainable FAW control, combining multiple strategies for sustainable results. Over three consecutive years, 2019-20, 2020-21 and 2021-22, the field demonstrations were conducted in semiarid regions of India, testing a four-component IPM approach viz...
March 26, 2024: Scientific Reports
#4
JOURNAL ARTICLE
Ken Sakaie, Katherine Koenig, Alan Lerner, Brian Appleby, Paula Ogrocki, Jagan A Pillai, Stephen Rao, James B Leverenz, Mark J Lowe
BACKGROUND AND PURPOSE: A substantial fraction of those who had Alzheimer's Disease (AD) pathology on autopsy did not have dementia in life. While biomarkers for AD pathology are well-developed, biomarkers specific to cognitive domains affected by early AD are lagging. Diffusion MRI (dMRI) of the fornix is a candidate biomarker for early AD-related cognitive changes but is susceptible to bias due to partial volume averaging (PVA) with cerebrospinal fluid. The purpose of this work is to leverage multi-shell dMRI to correct for PVA and to evaluate PVA-corrected dMRI measures in fornix as a biomarker for cognition in AD...
March 21, 2024: Magnetic Resonance Imaging
#5
JOURNAL ARTICLE
Gokul Sudhakaran, P Snega Priya, B Haridevamuthu, Raghul Murugan, Jagan Kannan, Mikhlid H Almutairi, Bader O Almutairi, Ajay Guru, Jesu Arockiaraj
This study investigates the individual and combined toxic effects of Bisphenol A (BPA) and Cadmium (Cd) in zebrafish, recognizing the complex mixture of pollutants organisms encounter in their natural environment. Examining developmental, neurobehavioral, reproductive, and physiological aspects, the study reveals significant adverse effects, particularly in combined exposures. Zebrafish embryos exposed to BPA + Cd exhibit synergistically increased mortality, delayed hatching, and morphological abnormalities, emphasizing the heightened toxicity of the combination...
March 13, 2024: Science of the Total Environment
#6
JOURNAL ARTICLE
Andrea J Radtke, Ekaterina Postovalova, Arina Varlamova, Alexander Bagaev, Maria Sorokina, Olga Kudryashova, Mark Meerson, Margarita Polyakova, Ilia Galkin, Viktor Svekolkin, Sergey Isaev, Daniil Wiebe, Anna Sharun, Alexander Sarachakov, Grigory Perelman, Yaroslav Lozinsky, Ziv Yaniv, Bradley C Lowekamp, Emily Speranza, Li Yao, Stefania Pittaluga, Arthur L Shaffer, Danny Jonigk, James D Phelan, Theresa Davies-Hill, Da Wei Huang, Pavel Ovcharov, Krystle Nomie, Ekaterina Nuzhdina, Nikita Kotlov, Ravshan Ataullakhanov, Nathan Fowler, Michael Kelly, Jagan Muppidi, Jeremy L Davis, Jonathan M Hernandez, Wyndham H Wilson, Elaine S Jaffe, Louis M Staudt, Mark Roschewski, Ronald N Germain
Follicular lymphoma (FL) is a generally incurable malignancy that evolves from developmentally blocked germinal center (GC) B cells. To promote survival and immune escape, tumor B cells undergo significant genetic changes and extensively remodel the lymphoid microenvironment. Dynamic interactions between tumor B cells and the tumor microenvironment (TME) are hypothesized to contribute to the broad spectrum of clinical behaviors observed among FL patients. Despite the urgent need, existing clinical tools do not reliably predict disease behavior...
March 11, 2024: Cancer Cell
#7
JOURNAL ARTICLE
Jagan Nath Adhikari, Bishnu Prasad Bhattarai, Tej Bahadur Thapa
Crop damage, predation on domestic animals and human attacks are often associated with human-wildlife conflict. The abundance and encounter rate of wild mammals are often associated with human wildlife conflict. Crop damage, livestock depredation and human injury and their relation with environmental factors and encounter rate of the mammals was evaluated in the central region of Chitwan Annapurna Landscape. The abundance and the encounter rate of large mammals were determined by dividing the study area into four different study blocks (A, B, C and D) based on river course and topography...
February 29, 2024: Heliyon
#8
JOURNAL ARTICLE
Prathab Balaji Saravanan, Jagan Kalivarathan, Kaeden McClintock, Shujauddin Mohammed, Elijah Burch, Christiane Morecock, Jinze Liu, Aamir Khan, Marlon F Levy, Mazhar A Kanak
Islets experience enormous stress during the isolation process, leading to suboptimal endocrine function after total pancreatectomy with islet autotransplantation (TPIAT). Our investigation focused on inducing isolation stress in islets ex vivo, where proinflammatory cytokines and hypoxia prompted the release of stress exosomes (exoS ) sized between 50 and 200 nm. Mass spectrometry analysis revealed 3 distinct subgroups of immunogenic proteins within these exoS : damage-associated molecular patterns (DAMPs), chaperones, and autoantigens...
February 15, 2024: American Journal of Transplantation
#9
JOURNAL ARTICLE
Jagan A Pillai, James Bena, Babak Tousi, Kasia Rothenberg, C Dirk Keene, James B Leverenz
INTRODUCTION: Cerebral amyloid angiopathy (CAA) often accompanies dementia-associated pathologies and is important in the context of anti-amyloid monoclonal therapies and risk of hemorrhage. METHODS: We conducted a retrospective neuropathology-confirmed study of 2384 participants in the National Alzheimer Coordinating Center cohort (Alzheimer's disease [AD], n = 1175; Lewy body pathology [LBP], n = 316; and mixed AD and LBP [AD-LBP], n = 893)...
February 14, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#10
REVIEW
Kusuma Betha Cahaya Imani, Jagan Mohan Dodda, Jinhwan Yoon, Fernando G Torres, Abu Bin Imran, G Roshan Deen, Renad Al-Ansari
Conductive hydrogels (CHs) have received significant attention for use in wearable devices because they retain their softness and flexibility while maintaining high conductivity. CHs are well suited for applications in skin-contact electronics and biomedical devices owing to their high biocompatibility and conformality. Although highly conductive hydrogels for smart wearable devices are extensively researched, a detailed summary of the outstanding results of CHs is required for a comprehensive understanding...
January 19, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
#11
JOURNAL ARTICLE
Yeonji Yea, S S D Elanchezhiyan, R Saravanakumar, Govindan Jagan, Jong Uk Choi, Karunamoorthy Saravanakumar, Chang Min Park
The fabrication of all-solid-state Z-scheme sonophotocatalysts is vital for improving the transfer rate of photogenerated electrons to remove antibiotics present in wastewater. Herein, a novel indirect Z-scheme ZnFe-layered double hydroxide (LDH)/reduced graphene oxide (rGO)/graphitic carbon nitride (g-C3 N5 ) heterojunction was synthesized using a simple strategy. The ZnFe-LDH/rGO/g-C3 N5 (ZF@rGCN) ternary composites were systematically characterized using different techniques. Results revealed that the 15%ZF@rGCN catalyst achieved a ciprofloxacin (CIP) degradation efficiency of 95...
January 16, 2024: Environmental Research
#12
JOURNAL ARTICLE
Therapeutic Potential of Benzimidazoisoquinoline Derivatives in Alleviating Murine Hepatic Fibrosis.
Sowmya Mekala, Sukumar Genji, Shilpa Chawla, Ramasatyaveni Geesala, Jupally Prashanth, B Jagan Mohan Reddy, Prathama Mainkar, Amitava Das
Hepatic fibrosis is a pathological condition of liver disease with an increasing number of cases worldwide. Therapeutic strategies are warranted to target the activated hepatic stellate cells (HSCs), the collagen-producing cells, an effective strategy for controlling the disease progression. Benzimidazoisoquinoline derivatives were synthesized as hybrid molecules by the combination of benzimidazoles and isoquinolines to evaluate their anti-fibrotic potential using an in-vitro and in-vivo model of hepatic fibrosis...
January 14, 2024: Chemistry & Biodiversity
#13
Shrinivas Venkatesh, Arun Ramdas Menon, Vivek Patel, Jagan Murugan, Anand Raja
No abstract text is available yet for this article.
December 2023: Indian Journal of Surgical Oncology
#14
JOURNAL ARTICLE
Jun Sang Choi, Jagan Singh Meena, Su Bin Choi, Seung-Boo Jung, Jong-Woong Kim
MXenes, with their remarkable attributes, stand at the forefront of diverse applications. However, the challenge remains in sustaining their performance, especially concerning Ti3 C2 Tx MXene electrodes. Current self-healing techniques, although promising, often rely heavily on adjacent organic materials. This study illuminates a pioneering water-initiated self-healing mechanism tailored specifically for standalone MXene electrodes. Here, both water and select organic solvents seamlessly mend impaired regions...
December 28, 2023: Small
#15
JOURNAL ARTICLE
Francesca Spirito, Pier Paolo Claudio, Candace M Howard, Jagan Valluri, Krista L Denning, Lorenzo Lo Muzio, Antonio Cortese
INTRODUCTION: Ineffective anticancer therapy can result in unnecessary toxicity and the development of resistant clones. Many types of solid tumors, including head and neck squamous cell carcinoma, have been found to contain a small population of cancer stem cells (CSCs) that contribute to tumor propagation, maintenance, and treatment resistance. MATERIALS AND METHODS: Selectively enriched CSCs from primary cancer cell cultures can be used in a chemosensitivity assay for a functional test (ChemoID) that uses patients' live tumor cells to indicate which chemotherapy agent (or "combinations") will kill not only the bulk of tumor cells but also the CSCs that are known to cause cancer to recur...
2023: Translational Medicine @ UniSa
#16
JOURNAL ARTICLE
Nicholas Dcunha, Dhananjayan Sakhti, Elanthendral Sigamani, Jagan Chandramohan, Anu Korula, Biju George, Marie Therese Manipadam, Rekha Pai
UNLABELLED: Classifying diffuse large B cell lymphomas, not otherwise specified (DLBCL, NOS), is based on their cell-of-origin (COO) which is included in the WHO classification (2016), is essential to characterize them better in context of prognostication. While gene expression profiling (GEP) considered the gold standard and more recently, the Nanostring-based approach, classify these tumors accurately, many laboratories with limited resources and instrumentation need an alternate approach that is reliable, inexpensive, and with a reasonable turnaround...
2023: Indian Journal of Pathology & Microbiology
#17
JOURNAL ARTICLE
Jagan P, Sasirekha Gvk, Madhav Rao, Jyotsna Bapat, Debabrata Das
IoT in healthcare brought a technological revolution in rehabilitation, enabling the patients to get rehabilitation in the comfort of their home, while being supervised remotely by the professionals. IoT enabled rehabilitation ensures a best possible way towards recovery, without inflicting further injuries. It also allows customization of rehabilitation plan based on the patient profile and progress, while helping in defining their personalised milestones. The main contribution of this paper is a novel wheelchair based IoT enabled 'XoRehab", exoskeleton for rehabilitation; a device for lower limb, with a backrest mechanism...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
#18
JOURNAL ARTICLE
Robert S Hurley, Jagan A Pillai, James B Leverenz
In 2022, Bruce Willis' family released a statement saying that he had been diagnosed with aphasia (an acquired language impairment) and would no longer be acting. Ten months later, the Willis family released another statement indicating that he received a more specific diagnosis of frontotemporal degeneration (FTD). This resulted in an explosion of media coverage, as prominent news outlets scrambled to produce stories describing FTD to a public largely unfamiliar with the disease. The quality of these stories varied widely, and in many cases the relationship between aphasia and FTD was misrepresented, as were basic descriptions and facts about FTD...
2023: Innovation in Aging
#19
REVIEW
Gokul Sudhakaran, P Snega Priya, Kannan Jagan, B Haridevamuthu, Ramu Meenatchi, Jesu Arockiaraj
Polycystic Ovary Syndrome (PCOS) and osteoporosis, though seemingly unrelated, exhibit intricate connections influenced by genetic and epigenetic factors. PCOS, characterized by elevated androgen levels, insulin resistance, and increased body weight, has historically been considered protective against bone fragility disorders. However, emerging research suggests that chronic inflammation, prevalent in PCOS, can adversely affect bone health. Studies have demonstrated variable bone mineral density loss in PCOS, often associated with leptin resistance and hyperinsulinemia...
December 15, 2023: Life Sciences
#20
JOURNAL ARTICLE
Ashish Singh, Josh Thomas Georgy, Sakthi Dhananjayan, Elanthenral Sigamani, Ajoy Oommen John, Anjana Joel, Jagan Chandramohan, Rajadurai Abarna, Grace Rebekah, Selvamani Backianathan, Deepak Thomas Abraham, Mazhuvanchary Jacob Paul, Raju Titus Chacko, Marie Therese Manipadam, Rekha Pai
Triple-negative breast cancer (TNBC) is a heterogeneous disease with poor survival compared to other subtypes. Patients with residual disease after neoadjuvant chemotherapy (NAC) face an increased risk of relapse and death. We aimed to characterize the mutational landscape of this subset to offer insights into relapse pathogenesis and potential therapeutic targets. We retrospectively analyzed archived paired (pre- and post-NAC) tumor samples from 25 patients with TNBC with residual disease using a targeted 72-gene next-generation sequencing panel...
November 9, 2023: Gene
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