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https://www.readbyqxmd.com/read/28702057/role-of-fluoride-varnish-in-preventing-early-childhood-caries-a-systematic-review
#1
REVIEW
Poulami Mishra, Nusrath Fareed, Hemant Battur, Sanjeev Khanagar, Manohar A Bhat, Jagan Palaniswamy
BACKGROUND: Early childhood caries is a public health problem that continues to affect babies and preschool children worldwide. This untreated caries process results in progressive destruction of the crowns of the teeth, often accompanied by severe pain and suffering, affecting the quality of life. Fluoride varnish which is one of the most important materials to prevent ECC is easy to apply and well tolerated by children. This study aimed to evaluate the scientific evidence regardingthe role of fluoride varnish in preventing early childhood caries...
May 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28694639/primary-paraspinal-hydatidosis-causing-acute-paraplegia
#2
Srihari Sridharan, G S Jagan Narayana, Kalyanasundarabharathi Chidambaram, Anand Prasath Jayachandiran
The zoonotic infection hydatidosis is caused by the tapeworm cestode, Echinococcus granulosus. Though considered endemic in India where association of humans with sheep and dogs form part of the livelihood, primary skeletal muscle involvement of the disease is an extremely rare event. We report a case of primary paraspinal hydatidosis with extradural extension causing acute paraplegia. Excision of the cyst and decompression of the cord was done along with albendazole therapy. Paraspinal hydatid disease is a rare entity, and in regions where hydatid disease is endemic, it can be involved in the differential diagnosis of acute compressive myelopathy...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28593730/dynamics-of-cytokine-gene-expression-in-peripheral-blood-mononuclear-cells-of-indigenous-and-exotic-breeds-of-pigs-in-india
#3
Perumalraja Kirthika, Mohammad Ayub Ali, Parthasarathi Behera, Prasant Kumar Subudhi, Thingujam Chaa Tolenkhomba, Jagan Mohanarao Gali
To incorporate immune competence traits in swine breeding programs, association between immune responsiveness and susceptibility to specific infectious diseases must be established. In order to understand the differences in immune competence between indigenous (Zovawk) and exotic (Large White Yorkshire: LWY) pigs reared in India, we carried out a time course expression analysis of immune-regulating key cytokine genes (interleukin (IL)-2, interferon (IFN)-γ, IL-4 and IL-10) in the phytohemagglutinin-P stimulated peripheral blood mononuclear cells (PBMCs)...
June 8, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28546722/malignant-peripheral-nerve-sheath-tumour-of-the-small-bowel-presenting-with-intussusception-and-perforation-a-double-jeopardy
#4
Ananth P Abraham, Joshua Franklyn, Jagan Chandramohan, Pranay Gaikwad, John C Muthusami
Malignant peripheral nerve sheath tumours (MPNST) are rare soft tissue sarcomas which largely occur in the extremities and the head and neck region. The tumours are aggressive with a high rate of recurrence. Radical surgical resection remains the treatment of choice with adjuvant radiation therapy and chemotherapy still failing to demonstrate a clear benefit. The gastrointestinal tract is an exceedingly rare site for these tumours. We report an unusual case of a young male with an MPNST of the small bowel who presented with an ileocolic intussusception and sigmoid perforation...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28513161/improved-synthesis-for-modular-ascarosides-uncovers-biological-activity
#5
Ying K Zhang, Marco A Sanchez-Ayala, Paul W Sternberg, Jagan Srinivasan, Frank C Schroeder
A versatile synthesis of modular ascarosides, a family of signaling molecules from Caenorhabditis elegans and other nematodes, via hydrogenolysis of a cyclic sulfate derived from methyl-α-l-rhamnopyranoside is reported. The route enables selective introduction of different side chains at the 1, 2, and 4 positions of the sugar, as demonstrated for ascarosides from C. elegans and Pristionchus pacificus. Bioassays with synthetic samples of 4'-tigloyl ascaroside mbas#3 revealed its role as an avoidance or dispersal signal...
May 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/28477145/efficient-production-of-prebiotic-gluco-oligosaccharides-in-orange-juice-using-immobilized-and-co-immobilized-dextransucrase
#6
Jagan Mohan Rao Tingirikari, Wesley Faria Gomes, Sueli Rodrigues
Dextransucrase from Leuconostoc mesenteroides NRRL B-512F was subjected to immobilization and co-immobilization with dextranase from Chaetomium erraticum. Immobilization has enhanced the operational and storage stability of dextransucrase. Two hundred milligrammes (2.4 IU/mg) of alginate beads (immobilized and co-immobilized) were found to be optimum for the production of gluco-oligosaccharides (GOS) in orange juice with a high degree of polymerization. The pulp of the orange juice did not interfere in the reaction...
May 6, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28466041/indian-porcine-reproductive-and-respiratory-syndrome-virus-bears-discontinuous-deletion-of-30-amino-acids-in-nonstructural-protein-2
#7
T K Rajkhowa, G Jagan Mohanarao, A Gogoi, L Hauhnar
Since its first outbreak in 2013, porcine reproductive and respiratory syndrome (PRRS) has established as an enzootic disease in pig population of Mizoram state, India. Our previous studies based on phylogenetic analysis of ORF5 and ORF7 gene sequences revealed close relationship of Indian PRRSV with the highly pathogenic variant of PRRSV (HP-PRRSV) of Chinese origin. Despite the control measures, second major outbreak of the disease was recorded in Aizawl district of Mizoram in 2015. The objective of the present study was to examine the origin of PRRSV isolates of 2015 outbreak, identification of deleted region in Nsp2 gene and determination of any genetic variation between 2013 and 2015 isolates of PRRSV...
September 2016: Virusdisease
https://www.readbyqxmd.com/read/28441579/geldanamycin-inspired-compounds-induce-direct-trans-differentiation-of-human-mesenchymal-stem-cells-to-neurons
#8
Srinivas Jogula, Anand Ram Soorneedi, Jagan Gaddam, Srinivas Chamakuri, Girdhar Singh Deora, Ranjith Kumar Indarapu, Murali Krishna Ramgopal, Subhadra Dravida, Prabhat Arya
Inspired from geldanamycin, the synthesis of a new series of 20-membered macrocyclic compounds is developed. The key features in our design are (i) retention of the fragment having the precise chiral functional groups of geldanamycin at C10, C11, C12 and C14, and (ii) replacement of an olefin moiety with the ester group, and the quinoid sub-structure with the triazole ring. The southern fragment needed for the macrocyclic ring formation was obtained from Evans' syn aldol as the key reaction and with the use of D-mannitol as the cheap source of a chiral starting material...
April 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28258270/oral-health-status-and-oral-health-related-quality-of-life-among-hospitalized-and-nonhospitalized-geriatric-patients
#9
Abdulaziz M AlBaker, Fahad F AlBaqami, Tariq M AlHarbi, Mohammad D AlAmri, Jagan K Baskaradoss
INTRODUCTION: The purpose of this study was to compare the oral health status and its effect on the oral health-related quality of life (OHRQoL) of hospitalized and nonhospitalized elderly patients in a single community. The null hypothesis for the study states that there is no difference in the oral health status and OHRQoL between hospitalized and nonhospitalized elderly patients. MATERIALS AND METHODS: This study was conducted at the King Khalid Hospital and College of Dentistry, King Saud University, Riyadh, Kingdom of Saudi Arabia...
March 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28237914/apigenin-attenuates-hippocampal-oxidative-events-inflammation-and-pathological-alterations-in-rats-fed-high-fat-fructose-diet
#10
Jagan Kalivarathan, Sathiya Priya Chandrasekaran, Kalpana Kalaivanan, Vidhya Ramachandran, Anuradha Carani Venkatraman
High calorie diet promotes oxidative stress and chronic low grade inflammation that predispose to brain dysfunction and neurodegeneration. Hippocampus region of the brain has been shown to be particularly sensitive to high calorie diet. We hypothesize that apigenin (API), a flavonoid could attenuate hippocampal derangements induced by high fat-high fructose diet (HFFD). In this study, we investigated the effects of API on oxidative stress and inflammation in the hippocampus, and compared with those of sitagliptin (STG), a standard drug with neuroprotective properties...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28223496/ehd2-restrains-dynamics-of-caveolae-by-an-atp-dependent-membrane-bound-open-conformation
#11
Maria Hoernke, Jagan Mohan, Elin Larsson, Jeanette Blomberg, Dana Kahra, Sebastian Westenhoff, Christian Schwieger, Richard Lundmark
The EH-domain-containing protein 2 (EHD2) is a dynamin-related ATPase that confines caveolae to the cell surface by restricting the scission and subsequent endocytosis of these membrane pits. For this, EHD2 is thought to first bind to the membrane, then to oligomerize, and finally to detach, in a stringently regulated mechanistic cycle. It is still unclear how ATP is used in this process and whether membrane binding is coupled to conformational changes in the protein. Here, we show that the regulatory N-terminal residues and the EH domain keep the EHD2 dimer in an autoinhibited conformation in solution...
May 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28216887/anti-nociceptive-effect-of-7-methoxy-coumarin-from-eupatorium-triplinerve-vahl-asteraceae
#12
Binoy Varghese Cheriyan, Parimala Kadhirvelu, Jagan Nadipelly, Jaikumar Shanmugasundaram, Vijaykumar Sayeli, Viswanathan Subramanian
AIM: To evaluate the anti-nociceptive activity of 7-methoxy coumarin isolated from ethyl acetate fraction of the alcoholic extract of Eupatorium triplinerve Vahl. MATERIALS AND METHODS: The shade dried leaves of E. triplinerve were extracted with ethyl alcohol and the extract was condensed. This extract was fractionated with n-hexane, ethyl acetate, and n-butanol. The ethyl acetate fraction was subjected to column chromatography which yielded a crystalline compound-A, which was investigated for spectral characteristics...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28199863/analysis-of-chemopredictive-assay-for-targeting-cancer-stem-cells-in-glioblastoma-patients
#13
Candace M Howard, Jagan Valluri, Anthony Alberico, Terrence Julien, Rida Mazagri, Robert Marsh, Hoyt Alastair, Antonio Cortese, Michael Griswold, Wanmei Wang, Krista Denning, Linda Brown, Pier Paolo Claudio
INTRODUCTION: The prognosis of glioblastoma (GBM) treated with standard-of-care maximal surgical resection and concurrent adjuvant temozolomide (TMZ)/radiotherapy remains very poor (less than 15 months). GBMs have been found to contain a small population of cancer stem cells (CSCs) that contribute to tumor propagation, maintenance, and treatment resistance. The highly invasive nature of high-grade gliomas and their inherent resistance to therapy lead to very high rates of recurrence. For these reasons, not all patients with similar diagnoses respond to the same chemotherapy, schedule, or dose...
April 2017: Translational Oncology
https://www.readbyqxmd.com/read/28174364/evaluation-of-periodontal-changes-adjacent-to-extraction-sites-during-upper-canine-retraction
#14
Azzam Al-Jundi, Basem Al Sabbagh, Jagan K Baskaradoss
INTRODUCTION: There is an intimate relationship between orthodontic therapy and the periodontal changes that occur during tooth movement. MATERIALS AND METHODS: This prospective clinical trial aims at investigating the movement of both the free and attached gingiva, as well as the movement of the alveolar bone in the extraction site of the upper 1st premolars during the retraction of the upper canines. In this study, 17 patients (10 female, 7 male) requiring 1st premolar extraction before orthodontic tooth movement were selected and treated at the Department of Orthodontics in the Faculty of Dentistry in University of Hama, Hama, Syria...
February 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28155025/oral-health-related-quality-of-life-and-periodontal-status-of-pregnant-women
#15
Amrita Geevarghese, Jagan Kumar Baskaradoss, P Sankara Sarma
Aim The purpose of this study was to assess the difference in the oral health related quality of life (OHRQoL) and the oral health status between pregnant and non-pregnant women. Methods This cross-sectional study included 150 pregnant women (mean age 23.8 ± 3.01) and 150 non-pregnant women (mean age 25.2 ± 3.35). Data were collected through a self-administered structured questionnaire, followed by an oral examination. Oral health impact profile-49 (OHIP-49) questionnaire was used to capture the individual's perceived OHRQoL...
August 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28087304/sleep-and-neurodegeneration-a-critical-appraisal
#16
REVIEW
Jagan A Pillai, James B Leverenz
Sleep abnormalities are clearly recognized as a distinct clinical symptom of concern in neurodegenerative disorders. Appropriate management of sleep-related symptoms has a positive impact on quality of life in patients with neurodegenerative disorders. This review provides an overview of mechanisms that are currently being considered that tie sleep with neurodegeneration. It appraises the literature regarding specific sleep changes seen in common neurodegenerative diseases, with a focus on Alzheimer disease and synucleinopathies (ie, Parkinson disease, dementia with Lewy bodies, multiple system atrophy), that have been better studied...
June 2017: Chest
https://www.readbyqxmd.com/read/28045692/radiology-case-of-the-month-acute-onset-of-dizziness-and-paresthesias-in-an-elderly-woman
#17
Mohammed J Shaikh, Jagan D Gupta
61-year-old woman with a past medical history of dementia and Meniere's disease presents with acutely worsening dizziness and headache. The patient additionally complains of left greater than right upper extremity weakness and paresthesias.
November 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27780959/polyphasic-microbial-analysis-of-traditional-korean-jeung-pyun-sourdough-fermented-with-makgeolli
#18
Sae Bom Lim, Jagan Mohan Rao Tingirikari, Ye Won Kwon, Ling Li, Grace E Kim, Nam Soo Han
Jeung-pyun, a fermented rice cake, is prepared by fermenting rice sourdough using makgeolli, a traditional Korean rice wine, in the presence of yeast and lactic acid bacteria (LAB). The goal of this study was to conduct biochemical and microbial analyses of five different rice sourdoughs, each fermented with a different commercial makgeolli, using culture-dependent and culture-independent approaches. All sourdough samples fermented with different makgeolli for 6.5 h showed different profiles in pH, total titratable acidity, organic acid concentration, and microbial growth...
February 28, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27717652/synthesis-and-evaluation-of-the-structural-elements-in-alkylated-tetrahydroisoquinolines-for-binding-to-cns-receptors
#19
Edward Ofori, Xue Y Zhu, Jagan R Etukala, Barbara A Bricker, Seth Y Ablordeppey
Diseases of the CNS are often complex and involve multiple receptor systems and thus, the treatment options for these diseases must focus on targeting the multiple receptors implicated in the various disorders. Schizophrenia and depression are examples of such diseases and their pharmacotherapy thus depends on agents which target multiple receptors including the dopamine, serotonin and even cholinergic receptors at the same time. In our previous campaign to find multi-receptor ligands, we have identified the benzothiazole 1a as an initial lead molecule...
November 15, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27696792/immobilization-of-recombinant-pectate-lyase-from-clostridium-thermocellum-atcc-27405-on-magnetic-nanoparticles-for-bioscouring-of-cotton-fabric
#20
Soumyadeep Chakraborty, Tingirikari Jagan Mohan Rao, Arun Goyal
Recombinant pectate lyase from family 1 polysaccharide lyase (PL1B) was immobilized on synthesized magnetic nanoparticles (MNPs) after 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride activation. At 70 mg/mL MNPs 100% binding of 1 mg/mL PL1B was achieved. The immobilized PL1B-MNP displayed activity of 20.3 and 18.2 U/mg against polygalacturonic acid and citrus pectin, respectively, which was higher than the activity of free PL1B, on the same substrates of 17.8 and 16.2 U/mg. The immobilized PL1B-MNP showed 32 fold and 14 fold enhanced thermal stability at 80°C and 90°C, respectively as compared with free PL1B at same temperatures...
October 3, 2016: Biotechnology Progress
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