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Atsuro Uchida, Jagan A Pillai, Robert Bermel, Aaron Bonner-Jackson, Alexander Rae-Grant, Hubert Fernandez, James Bena, Stephen E Jones, James B Leverenz, Sunil K Srivastava, Justis P Ehlers
Purpose: To investigate outer retinal parameters among patients with various chronic neurodegenerative disorders by using spectral-domain coherence tomography (OCT) in a prospective cross-sectional cohort study. Methods: A total of 132 participants were enrolled following a comprehensive diagnostic evaluation with neurologic, neuropsychology, and magnetic resonance imaging volumetric evaluations. Participants were 50 years or older, either diagnosed with Alzheimer's disease (AD) dementia, amnestic mild cognitive impairment (MCI), non-AD dementia, Parkinson's disease (PD), or age- and sex-matched controls...
June 1, 2018: Investigative Ophthalmology & Visual Science
Elanthenral Sigamani, Jagan Chandramohan, Sheila Nair, Geeta Chacko, Meera Thomas, Leni Grace Mathew, Susanne Pulimood, Marie Therese Manipadam
Context: Lymphomatoid granulomatosis (LYG) is a rare B-lymphoproliferative disorder characterised by an angiocentric and angiodestructive pattern along with Epstein - Barr virus (EBV) association. It is one of the diagnostic challenges in lymphoma pathology. Deregulation of EBV immune surveillance is one of the narrated hypotheses in the literature. Extrapulmonary manifestations are rare with LYG. Morphological grading is done based on the number of EBV-positive B cells, which is useful to strategize treatment protocol...
April 2018: Indian Journal of Pathology & Microbiology
P Jagan, Nusrath Fareed, Hemanth Battur, Sanjeev Khanagar, Manohar Bhat
Objective: To measure conceptual oral health knowledge among school teachers using comprehensive measure of oral health knowledge (CMOHK) instrument. Materials and Methods: A total of 240 school teachers drawn through cluster random sampling from across Sullia taluk. Conceptual knowledge was assessed using Comprehensive measure of oral health knowledge questionnaire. Oral health status was recorded on a World Health Organization oral health assessment Proforma. Results: Overall distribution of CMOHK scores revealed that 106(44%) subjects had good conceptual oral health knowledge, 81(33...
January 2018: European Journal of Dentistry
Vijaykumar Sayeli, Jagan Nadipelly, Parimala Kadhirvelu, Binoy Varghese Cheriyan, Jaikumar Shanmugasundaram, Viswanathan Subramanian
BACKGROUND: Peripheral neuropathy is the dose limiting side effect of many anticancer drugs. Flavonoids exhibit good antinociceptive effect in animal models. Their efficacy against different types of nociception has been documented. The present study investigated the effect of flavonol (3-hydroxy flavone), 3',4'-dimethoxy flavonol, 6,3'-dimethoxy flavonol, 7,2'-dimethoxy flavonol and 7,3'-dimethoxy flavonol against paclitaxel-induced peripheral neuropathy in mice. METHODS: A single dose of paclitaxel (10 mg/kg, i...
April 13, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Sulthan Ibrahim Raja Khan, Anupama Ramachandran, Abdulmohsen Alfadley, Jagan Kumar Baskaradoss
OBJECTIVES: This study aims to compare the ex vivo fracture resistance of root canal treated (RCT) teeth restored with four different types of fibers under composite resin. SUBJECTS AND METHODS: One hundred and forty extracted mandibular first molar teeth were assigned to seven groups (n = 20/group). Group 1 was the control group. In groups 2-7, endodontic access and standard Mesio-occluso-distal (MOD) cavities were prepared. Following RCT, group 2 was left unrestored...
June 2018: Journal of the Mechanical Behavior of Biomedical Materials
Jagan K Baskaradoss, Abdulaziz Alrumaih, Abdulrahman Alshebel, Ahmed Alfaqih, Mohammed Aleesa, Saleh Alkhashan, Mohamad Altuwaijri
AIM: The aim of the present study was to investigate the pattern of antibiotic prescription and dentists' awareness about the recent guidelines for antibiotic prescription. METHODS: This cross-sectional study was conducted among 282 dentists practicing in Riyadh, Saudi Arabia. The data were collected from 20 randomly-selected dental clinics from each of the five administrative blocks in Riyadh. In addition, data were also collected from four tertiary care centers and three academic universities...
April 1, 2018: Journal of Investigative and Clinical Dentistry
Kalaivanan Kalpana, Emayavaramban Priyadarshini, S Sreeja, Kalivarathan Jagan, Carani Venkatraman Anuradha
Endoplasmic reticulum (ER), a dynamic organelle, plays an essential role in organizing the signaling pathways involved in cellular adaptation, resilience, and survival. Impairment in the functions of ER occurs in a variety of nutritive disorders including obesity and type 2 diabetes. Here, we hypothesize that (scopoletin) SPL, a coumarin, has the potential to alleviate ER stress induced in vitro and in vivo models by lipotoxicity. To test this hypothesis, the ability of SPL to restore the levels of proteins of ER stress was analyzed...
March 25, 2018: Cell Stress & Chaperones
Zheng Liu, Maro J Kariya, Christopher D Chute, Amy K Pribadi, Sarah G Leinwand, Ada Tong, Kevin P Curran, Neelanjan Bose, Frank C Schroeder, Jagan Srinivasan, Sreekanth H Chalasani
Animals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using the interactions between Caenorhabditis elegans and its predator, Pristionchus pacificus, we show that neuronal perception by C. elegans of a predator-specific molecular signature induces instantaneous escape behavior and a prolonged reduction in oviposition. Chemical analysis revealed this predator-specific signature to consist of a class of sulfolipids, produced by a biochemical pathway required for developing predacious behavior and specifically induced by starvation...
March 19, 2018: Nature Communications
Roopa Jewel, Jubbin Jagan Jacob
Management of hyperglycaemia is crucial during labour to improve outcomes both in the newborn and in the mother. This is particularly crucial in mothers with pregestational type 1 diabetes and in all mothers requiring insulin treatment during pregnancy. The use of antenatal steroids in mothers at risk of preterm delivery complicates management of hyperglycaemia in the immediate antepartum period and requires appropriate dosing adjustments of insulin therapy. Mothers are generally asked to be nil per orum during active labour...
March 2018: JPMA. the Journal of the Pakistan Medical Association
Jasna Jagan Mohan, Prashanth Narayan, Renjini Ambika Padmanabhan, Selin Joseph, Pradeep G Kumar, Malini Laloraya
PROBLEM: Dedicator of cytokinesis (DOCK 180) involved in cytoskeletal reorganization is primarily a cytosolic molecule. It is recently shown to be nuclear in HeLa cells but its nuclear function is not known. METHOD OF STUDY: The spatiotemporal distribution of DOCK180 in uterus was studied in uterine cytoplasmic and nuclear compartments during the "window of implantation." The functional significance of nuclear DOCK180 was explored by homology modeling, co-immunoprecipitation assays, and mass spectrometric analysis...
March 8, 2018: American Journal of Reproductive Immunology: AJRI
Chuanfu Dong, Douglas K Reilly, Célia Bergame, Franziska Dolke, Jagan Srinivasan, Stephan H von Reuss
Chemical communication in nematodes such as the model organism Caenorhabditis elegans is modulated by a variety of glycosides based on the dideoxysugar l-ascarylose. Comparative ascaroside profiling of nematode exometabolome extracts using a GC-EIMS screen reveals that several basic components including ascr#1 (asc-C7), ascr#2 (asc-C6-MK), ascr#3 (asc-ΔC9), ascr#5 (asc-ωC3), and ascr#10 (asc-C9) are highly conserved among the Caenorhabditis. Three novel side chain hydroxylated ascaroside derivatives were exclusively detected in the distantly related C...
March 5, 2018: Journal of Organic Chemistry
Yvonne Shao, McKenzie Shaw, Kaitlin Todd, Maria Khrestian, Giana D'Aleo, P John Barnard, Jeff Zahratka, Jagan Pillai, Chang-En Yu, C Dirk Keene, James B Leverenz, Lynn M Bekris
The apolipoprotein E (APOE) ε4 allele is the major genetic risk factor for Alzheimer's disease (AD). Multiple regulatory elements, spanning the extended TOMM40-APOE-APOC2 region, regulate gene expression at this locus. Regulatory element DNA methylation changes occur under different environmental conditions, such as disease. Our group and others have described an APOE CpG island as hypomethylated in AD, compared to cognitively normal controls. However, little is known about methylation of the larger TOMM40-APOE-APOC2 region...
April 2018: Journal of Human Genetics
Ravi Boya, Anurupa Devi Yadavalli, Sameena Nikhat, Sreenivasulu Kurukuti, Dasaradhi Palakodeti, Jagan M R Pongubala
Genome organization in 3D nuclear-space is important for regulation of gene expression. However, the alterations of chromatin architecture that impinge on the B cell-fate choice of multi-potent progenitors are still unclear. By integrating in situ Hi-C analyses with epigenetic landscapes and genome-wide expression profiles, we tracked the changes in genome architecture as the cells transit from a progenitor to a committed state. We identified the genomic loci that undergo developmental switch between A and B compartments during B-cell fate determination...
November 2, 2017: Nucleic Acids Research
Shiva Keshava, Jagan Sundaram, Anuradha Rajulapati, Charles Esmon, Usha Pendurthi, L Vijaya Mohan Rao
Recent studies established that clotting factor VIIa (FVIIa) binds endothelial cell protein C receptor (EPCR). It has been speculated that FVIIa interaction with EPCR might augment the hemostatic effect of rFVIIa in therapeutic conditions. The present study is carried out to investigate the mechanism by which FVIIa interaction with EPCR contributes to the hemostatic effect of rFVIIa in hemophilia therapy. Active-site inhibited FVIIa, which is capable of binding to EPCR but has no ability to activate factor X, reduced the concentration of rFVIIa required to correct the bleeding following the saphenous vein injury in mouse hemophilia model systems...
June 27, 2017: Blood Advances
Douglas K Reilly, Daniel E Lawler, Dirk R Albrecht, Jagan Srinivasan
The use of calcium indicators has greatly enhanced our understanding of neural dynamics and regulation. The nematode Caenorhabditis elegans, with its completely mapped nervous system and transparent anatomy, presents an ideal model for understanding real-time neural dynamics using calcium indicators. In combination with microfluidic technologies and experimental designs, calcium-imaging studies using these indicators are performed in both free-moving and trapped animals. However, most previous studies utilizing trapping devices, such as the olfactory chip described in Chronis et al...
September 7, 2017: Journal of Visualized Experiments: JoVE
Ryosuke Yamamoto, Jagan M Obbineni, Lea M Alford, Takahiro Ide, Mikito Owa, Juyeon Hwang, Takahide Kon, Kazuo Inaba, Noliyanda James, Stephen M King, Takashi Ishikawa, Winfield S Sale, Susan K Dutcher
Cytoplasmic assembly of ciliary dyneins, a process known as preassembly, requires numerous non-dynein proteins, but the identities and functions of these proteins are not fully elucidated. Here, we show that the classical Chlamydomonas motility mutant pf23 is defective in the Chlamydomonas homolog of DYX1C1. The pf23 mutant has a 494 bp deletion in the DYX1C1 gene and expresses a shorter DYX1C1 protein in the cytoplasm. Structural analyses, using cryo-ET, reveal that pf23 axonemes lack most of the inner dynein arms...
September 2017: PLoS Genetics
Samuel V Kemp, Dirk-Jan Slebos, Alan Kirk, Malgorzata Kornaszewska, Kris Carron, Lars Ek, Gustav Broman, Gunnar Hillerdal, Herve Mal, Christophe Pison, Amandine Briault, Nicola Downer, Kaid Darwiche, Jagan Rao, Ralf-Harto Hübner, Christof Ruwwe-Glosenkamp, Valéry Trosini-Desert, Ralf Eberhardt, Felix J Herth, Eric Derom, Thomas Malfait, Pallav L Shah, Justin L Garner, Nick H Ten Hacken, Hazem Fallouh, Sylvie Leroy, Charles H Marquette
RATIONALE: Single-center randomized controlled trials of the Zephyr endobronchial valve (EBV) treatment have demonstrated benefit in severe heterogeneous emphysema. This is the first multicenter study evaluating this treatment approach. OBJECTIVES: To evaluate the efficacy and safety of Zephyr EBVs in patients with heterogeneous emphysema and absence of collateral ventilation. METHODS: This was a prospective, multicenter 2:1 randomized controlled trial of EBVs plus standard of care or standard of care alone (SoC)...
December 15, 2017: American Journal of Respiratory and Critical Care Medicine
Chaitanya Kumar, Sakshi Kohli, Srikanth Chiliveru, Poonamalle Parthasarathy Bapsy, Minish Jain, Venkata Sathya Suresh Attili, Jagan Mohan, Ashok K Vaid, Bandana Sharan
AIM: A retrospective survival benefit analysis of APCEDEN® , APAC BIOTECH Pvt Ltd 69, Jacranda Marg, DLF PHASE II, Gurugram, Haryana, India, an autologous dendritic cell-based product for management of refractory solid malignancies, was performed in comparison with a control group. METHODS: Subjects (retrospective data) whose survival data, geographical region, age, gender, ECOG performance status and stage of disease that could be matched with the treatment group were considered for analysis...
September 2017: Immunotherapy
Poulami Mishra, Nusrath Fareed, Hemant Battur, Sanjeev Khanagar, Manohar A Bhat, Jagan Palaniswamy
BACKGROUND: Early childhood caries is a public health problem that continues to affect babies and preschool children worldwide. This untreated caries process results in progressive destruction of the crowns of the teeth, often accompanied by severe pain and suffering, affecting the quality of life. Fluoride varnish which is one of the most important materials to prevent ECC is easy to apply and well tolerated by children. This study aimed to evaluate the scientific evidence regardingthe role of fluoride varnish in preventing early childhood caries...
May 2017: Dental Research Journal
Srihari Sridharan, G S Jagan Narayana, Kalyanasundarabharathi Chidambaram, Anand Prasath Jayachandiran
The zoonotic infection hydatidosis is caused by the tapeworm cestode, Echinococcus granulosus. Though considered endemic in India where association of humans with sheep and dogs form part of the livelihood, primary skeletal muscle involvement of the disease is an extremely rare event. We report a case of primary paraspinal hydatidosis with extradural extension causing acute paraplegia. Excision of the cyst and decompression of the cord was done along with albendazole therapy. Paraspinal hydatid disease is a rare entity, and in regions where hydatid disease is endemic, it can be involved in the differential diagnosis of acute compressive myelopathy...
July 2017: Journal of Neurosciences in Rural Practice
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