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Régis Fuzier, Floriane Puel, Philippe Izard, Agnès Sommet, Sébastien Pierre
PURPOSE: Pain after tumorectomy and sentinel lymph node dissection is poorly reported in the literature. We carried out a prospective survey aimed at assessing pain three months after such minor surgery for breast cancer. METHODS: The study was approved by the local ethics committee. Most surgeries followed a standard protocol involving general anesthesia with no regional analgesia technique, laryngeal mask, sufentanil and propofol for induction, and multimodal analgesia during the postoperative period...
November 24, 2016: Journal of Anesthesia
Renaud Evrard, Erika Annabelle Pratte
The physician and botanist Timothée Puel (1812-1890) lived through a pivotal period of psychology (1848-1878), between the academic prohibition of the study of animal magnetism to its disjointed recovery in hypnotism and psychical research. One of his cases of "catalepsy complicated with somnambulism" triggered a lively debate on "extraordinary neuroses" within the young Société médico-psychologique [Medico-psychological Society]. In 1874, Puel founded the Revue de psychologie expérimentale [Journal of Experimental Psychology], the first of its kind in French, which he intended as the vehicle of international interest in psychical research, the scholarly and institutionalized study of "psychism" that prepared the way for the recognition of academic psychology...
October 31, 2016: History of Psychology
Nesrine Benkafadar, Julien Menardo, Jérôme Bourien, Régis Nouvian, Florence François, Didier Decaudin, Domenico Maiorano, Jean-Luc Puel, Jing Wang
Cisplatin is a widely used chemotherapy drug, despite its significant ototoxic side effects. To date, the mechanism of cisplatin-induced ototoxicity remains unclear, and hearing preservation during cisplatin-based chemotherapy in patients is lacking. We found activation of the ATM-Chk2-p53 pathway to be a major determinant of cisplatin ototoxicity. However, prevention of cisplatin-induced ototoxicity is hampered by opposite effects of ATM activation upon sensory hair cells: promoting both outer hair cell death and inner hair cell survival...
October 28, 2016: EMBO Molecular Medicine
Leila Maidana, Juliana R Gerez, Rhoda El Khoury, Felipe Pinho, Olivier Puel, Isabelle P Oswald, Ana Paula F R L Bracarense
Patulin (PAT) is a secondary metabolite mainly produced by Aspergillus and Penicillium that is frequently found contaminating apples and rotten fruits. Patulin can be transformed in potencially less toxic compounds such as ascladiol (ASC). Toxic effects of patulin were described in rats and in in vitro models, however concerning ascladiol, data are restricted to metabolic pathways. The aim of the present study was to evaluate the effects of different concentrations of PAT (10 μM, 30 μM, 100 μM) and ASC (30 μM, 100 μM) on intestinal tissue using the jejunal explant model...
October 4, 2016: Food and Chemical Toxicology
Sabine Ladrech, Jing Wang, Marc Mathieu, Jean-Luc Puel, Marc Lenoir
High mobility group box 1 (HMGB1) is a DNA-binding protein that facilitates gene transcription and may act extracellularly as a late mediator of inflammation. The roles of HMGB1 in the pathogenesis of the spiral ganglion neurons (SGNs) of the cochlea are currently unknown. In the present study, we tested the hypothesis that early phenotypical changes in the SGNs of the amikacin-poisoned rat cochlea are mediated by HMGB1. Our results showed that a marked downregulation of HMGB1 had occurred by completion of amikacin treatment, coinciding with acute damage at the dendrite extremities of the SGNs...
October 4, 2016: Histochemistry and Cell Biology
Yi Wang, Cindy S Ma, Yun Ling, Aziz Bousfiha, Yildiz Camcioglu, Serge Jacquot, Kathryn Payne, Elena Crestani, Romain Roncagalli, Aziz Belkadi, Gaspard Kerner, Lazaro Lorenzo, Caroline Deswarte, Maya Chrabieh, Etienne Patin, Quentin B Vincent, Ingrid Müller-Fleckenstein, Bernhard Fleckenstein, Fatima Ailal, Lluis Quintana-Murci, Sylvie Fraitag, Marie-Alexandra Alyanakian, Marianne Leruez-Ville, Capucine Picard, Anne Puel, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Marie Malissen, Bernard Malissen, Laurent Abel, Alain Hovnanian, Luigi D Notarangelo, Emmanuelle Jouanguy, Stuart G Tangye, Vivien Béziat, Jean-Laurent Casanova
Combined immunodeficiency (CID) refers to inborn errors of human T cells that also affect B cells because of the T cell deficit or an additional B cell-intrinsic deficit. In this study, we report six patients from three unrelated families with biallelic loss-of-function mutations in RLTPR, the mouse orthologue of which is essential for CD28 signaling. The patients have cutaneous and pulmonary allergy, as well as a variety of bacterial and fungal infectious diseases, including invasive tuberculosis and mucocutaneous candidiasis...
October 17, 2016: Journal of Experimental Medicine
J Toubiana, J L Casanova, A Puel
No abstract text is available yet for this article.
June 2016: Médecine et Maladies Infectieuses
Laure Saint-Aubert, Jérémie Pariente, Herve Dumas, Pierre Payoux, Jean-Philippe Brandel, Michèle Puel, Anne Vital, Eric Guedj, Suzanne Lesage, Katell Peoc'h, Christine Brefel Courbon, Fabienne Ory Magne
BACKGROUND: Few patients are reported with dementia with Lewy bodies before fifty years-old, which may partly reflect the difficulty of accurate diagnosis in young population. We report the case of a 44-year-old male with pathologically confirmed sporadic dementia with Lewy bodies, who did not fulfil the revised clinical criteria for this disease. CASE PRESENTATION: We document this atypical case with clinical and cognitive evaluation, imaging, biochemistry, genetics and pathology investigations...
2016: BMC Neurology
Cindy S Ma, Natalie Wong, Geetha Rao, Akira Nguyen, Danielle T Avery, Kathryn Payne, James Torpy, Patrick O'Young, Elissa Deenick, Jacinta Bustamante, Anne Puel, Satoshi Okada, Masao Kobayashi, Ruben Martinez-Barricarte, Michael Elliott, Sara Sebnem Kilic, Jamila El Baghdadi, Yoshiyuki Minegishi, Aziz Bousfiha, Nic Robertson, Sophie Hambleton, Peter D Arkwright, Martyn French, Annaliesse K Blincoe, Peter Hsu, Dianne E Campbell, Michael O Stormon, Melanie Wong, Stephen Adelstein, David A Fulcher, Matthew C Cook, Polina Stepensky, Kaan Boztug, Rita Beier, Aydan Ikincioğullari, John B Ziegler, Paul Gray, Capucine Picard, Stéphanie Boisson-Dupuis, Tri Giang Phan, Bodo Grimbacher, Klaus Warnatz, Steven M Holland, Gulbu Uzel, Jean-Laurent Casanova, Stuart G Tangye
Naive CD4(+) T cells differentiate into specific effector subsets-Th1, Th2, Th17, and T follicular helper (Tfh)-that provide immunity against pathogen infection. The signaling pathways involved in generating these effector cells are partially known. However, the effects of mutations underlying human primary immunodeficiencies on these processes, and how they compromise specific immune responses, remain unresolved. By studying individuals with mutations in key signaling pathways, we identified nonredundant pathways regulating human CD4(+) T cell differentiation in vitro...
July 25, 2016: Journal of Experimental Medicine
Joanna Tannous, Ali Atoui, André El Khoury, Ziad Francis, Isabelle P Oswald, Olivier Puel, Roger Lteif
Penicillium expansum is among the most ubiquitous fungi disseminated worldwide, that could threaten the fruit sector by secreting patulin, a toxic secondary metabolite. Nevertheless, we lack sufficient data regarding the growth and the toxigenesis conditions of this species. This work enables a clear differentiation between the favorable conditions to the P. expansum growth and those promising for patulin production. A mathematical model allowing the estimation of the P. expansum growth rate according to temperature, a W, and pH, was also developed...
July 2016: Food Science & Nutrition
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
L Buret, G Rebillard, E Brun, C Angebault, M Pequignot, M Lenoir, M Do-Cruzeiro, E Tournier, K Cornille, A Saleur, N Gueguen, P Reynier, P Amati-Bonneau, A Barakat, C Blanchet, P Chinnery, P Yu-Wai-Man, J Kaplan, A-F Roux, G Van Camp, B Wissinger, O Boespflug-Tanguy, F Giraudet, J-L Puel, G Lenaers, C Hamel, B Delprat, C Delettre
In vertebrates, 14-3-3 proteins form a family of seven highly conserved isoforms with chaperone activity, which bind phosphorylated substrates mostly involved in regulatory and checkpoint pathways. 14-3-3 proteins are the most abundant protein in the brain and are abundantly found in the cerebrospinal fluid in neurodegenerative diseases, suggesting a critical role in neuron physiology and death. Here we show that 14-3-3eta-deficient mice displayed auditory impairment accompanied by cochlear hair cells' degeneration...
March 7, 2016: Cell Death Discovery
Céline Pomié, Vincent Blasco-Baque, Pascale Klopp, Simon Nicolas, Aurélie Waget, Pascale Loubières, Vincent Azalbert, Anthony Puel, Frédéric Lopez, Cédric Dray, Philippe Valet, Benjamin Lelouvier, Florence Servant, Michael Courtney, Jacques Amar, Rémy Burcelin, Lucile Garidou
OBJECTIVE: To demonstrate that glycemia and insulin resistance are controlled by a mechanism involving the adaptive immune system and gut microbiota crosstalk. METHODS: We triggered the immune system with microbial extracts specifically from the intestinal ileum contents of HFD-diabetic mice by the process of immunization. 35 days later, immunized mice were fed a HFD for up to two months in order to challenge the development of metabolic features. The immune responses were quantified...
June 2016: Molecular Metabolism
Noura Gannouni, Abada Mhamdi, Marc Lenoir, Jean Luc Puel, Olfa Tebourbi, Michèle El May, Rafik Gharbi, Mohsen Sakly, Khémais Ben Rhouma
BACKGROUND: The noise is considered as a factor of environmental stress, causing a wide range of health effects such as acoustic, cardiovascular, nervous and endocrine systems. PURPOSE: The present study was conducted to examine the affects of repeated exposure to noise on the peripheral auditory system, adrenal gland and heart tissue. METHOD: The White strain rats "Wistar" were exposed to chronic and repetitive exposure noise at two different intensity levels of 70 and 85dB (A)...
December 2015: La Tunisie Médicale
B Pilmis, A Puel, O Lortholary, F Lanternier
Incidence of invasive fungal infections increases over time with the rise in at-risk populations; in particular, patients with acquired immunodeficiencies due to immunosuppressive therapies such as anti-tumour necrosis factor-α (TNF-α) treatment, cirrhosis or burns. Some primary immunodeficiencies (PID) can also predispose selectively to invasive fungal diseases. Conversely, some atypical fungal diseases can reveal new PID. Deep dermatophytosis, Candida central nervous system infections or gastrointestinal disease, or disseminated phaeohyphomycosis-revealed CARD9 deficiency...
August 2016: Clinical Microbiology and Infection
Antoine Huet, Charlène Batrel, Yong Tang, Gilles Desmadryl, Jing Wang, Jean-Luc Puel, Jérôme Bourien
Gerbils possess a very specialized cochlea in which the low-frequency inner hair cells (IHCs) are contacted by auditory nerve fibers (ANFs) having a high spontaneous rate (SR), whereas high frequency IHCs are innervated by ANFs with a greater SR-based diversity. This specificity makes this animal a unique model to investigate, in the same cochlea, the functional role of different pools of ANFs. The distribution of the characteristic frequencies of fibers shows a clear bimodal shape (with a first mode around 1...
August 2016: Hearing Research
Isaura Caceres, Rhoda El Khoury, Ángel Medina, Yannick Lippi, Claire Naylies, Ali Atoui, André El Khoury, Isabelle P Oswald, Jean-Denis Bailly, Olivier Puel
Produced by several species of Aspergillus, Aflatoxin B₁ (AFB₁) is a carcinogenic mycotoxin contaminating many crops worldwide. The utilization of fungicides is currently one of the most common methods; nevertheless, their use is not environmentally or economically sound. Thus, the use of natural compounds able to block aflatoxinogenesis could represent an alternative strategy to limit food and feed contamination. For instance, eugenol, a 4-allyl-2-methoxyphenol present in many essential oils, has been identified as an anti-aflatoxin molecule...
2016: Toxins
Tracy A Briggs, Gillian I Rice, Navid Adib, Lesley Ades, Stephane Barete, Kannan Baskar, Veronique Baudouin, Ayse N Cebeci, Philippe Clapuyt, David Coman, Lien De Somer, Yael Finezilber, Moshe Frydman, Ayla Guven, Sébastien Heritier, Daniela Karall, Muralidhar L Kulkarni, Pierre Lebon, David Levitt, Martine Le Merrer, Agnes Linglart, John H Livingston, Vincent Navarro, Ericka Okenfuss, Anne Puel, Nicole Revencu, Sabine Scholl-Bürgi, Marina Vivarelli, Carine Wouters, Brigitte Bader-Meunier, Yanick J Crow
No abstract text is available yet for this article.
April 29, 2016: Journal of Clinical Immunology
Ana Karina Alves de Medeiros, Evelyn Lodewick, Delfien J A Bogaert, Filomeen Haerynck, Sabine Van Daele, Bart Lambrecht, Sara Bosma, Laure Vanderdonckt, Olivier Lortholary, Mélanie Migaud, Jean-Laurent Casanova, Anne Puel, Fanny Lanternier, Jo Lambert, Lieve Brochez, Melissa Dullaers
No abstract text is available yet for this article.
April 26, 2016: Journal of Clinical Immunology
Julie Toubiana, Satoshi Okada, Julia Hiller, Matias Oleastro, Macarena Lagos Gomez, Juan Carlos Aldave Becerra, Marie Ouachée-Chardin, Fanny Fouyssac, Katta Mohan Girisha, Amos Etzioni, Joris Van Montfrans, Yildiz Camcioglu, Leigh Ann Kerns, Bernd Belohradsky, Stéphane Blanche, Aziz Bousfiha, Carlos Rodriguez-Gallego, Isabelle Meyts, Kai Kisand, Janine Reichenbach, Ellen D Renner, Sergio Rosenzweig, Bodo Grimbacher, Frank L van de Veerdonk, Claudia Traidl-Hoffmann, Capucine Picard, Laszlo Marodi, Tomohiro Morio, Masao Kobayashi, Desa Lilic, Joshua D Milner, Steven Holland, Jean-Laurent Casanova, Anne Puel
Since their discovery in patients with autosomal dominant (AD) chronic mucocutaneous candidiasis (CMC) in 2011, heterozygous STAT1 gain-of-function (GOF) mutations have increasingly been identified worldwide. The clinical spectrum associated with them needed to be delineated. We enrolled 274 patients from 167 kindreds originating from 40 countries from 5 continents. Demographic data, clinical features, immunological parameters, treatment, and outcome were recorded. The median age of the 274 patients was 22 years (range, 1-71 years); 98% of them had CMC, with a median age at onset of 1 year (range, 0-24 years)...
June 23, 2016: Blood
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