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https://www.readbyqxmd.com/read/28797134/looking-beyond-the-intervertebral-disc-the-need-for-behavioral-assays-in-models-of-discogenic-pain
#1
REVIEW
Grace E Mosley, Thomas W Evashwick-Rogler, Alon Lai, James C Iatridis
Orthopedic research into chronic discogenic back pain has commonly focused on aging- and degeneration-related changes in intervertebral disc structure, biomechanics, and biology. However, the primary spine-related reason for physician office visits is pain. The ambiguous nature of the human condition of discogenic low back pain motivates the use of animal models to better understand the pathophysiology. Discogenic back pain models must consider both emergent behavioral changes following pain induction and changes in the nervous system that mediate such behavior...
August 10, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28780368/atlanto-occipital-catheterization-of-young-rats-for-long-term-drug-delivery-into-the-lumbar-subarachnoid-space-combined-with-in-vivo-testing-and-electrophysiology-in-situ
#2
Olga Kopach, Volodymyr Krotov, Nana Voitenko
BACKGROUND: Catheterization has been widely used in neuroscience and pain research for local drug delivery. Though different modifications were developed, the use of young animals for spinal catheterization remains limited because of a little success rate. A reliable technique is needed to catheterize young animals aimed for in vivo testing combined with spinal cord electrophysiology, often limited by animal age, to facilitate pain research. NEW METHODS: We describe intrathecal catheterization of young rats (3-week-old) through atlanto-occipical approach for long-lasting drug delivery into the lumbar subarachnoid space...
August 2, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28759805/common-and-distinct-neural-mechanisms-associated-with-the-conscious-experience-of-vicarious-pain
#3
Thomas Grice-Jackson, Hugo D Critchley, Michael J Banissy, Jamie Ward
Vicarious pain perception has been an influential paradigm for investigating the social neuroscience of empathy. This research has highlighted the importance of both shared representations (i.e., involved in both experiencing first-hand physical pain and observing pain) and mechanisms that discriminate between self and other. The majority of this research has been conducted in healthy younger adults using a group-average approach. There are, however, known inter-individual differences that can contribute to vicarious experience...
July 3, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28736211/applying-contemporary-neuroscience-in-exercise-interventions-for-chronic-spinal-pain-treatment-protocol
#4
Malfliet Anneleen, Kregel Jeroen, Meeus Mira, Cagnie Barbara, Roussel Nathalie, Dolphens Mieke, Danneels Lieven, Nijs Jo
BACKGROUND: Nonspecific chronic spinal pain is a common problem within the chronic pain population and is characterized by high social, economic and personal impact. To date, therapists are still struggling in adequately treating these types of patients, as seen in the small and short-term benefits of frequently applied primary care treatments. It is remarkable that despite the well-documented presence of abnormalities in central nociceptive processing in nonspecific chronic spinal pain patients, the implementation of this knowledge in clinical practice is still nearly non-existent...
July 8, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28694679/a-clinical-perspective-on-a-pain-neuroscience-education-approach-to-manual-therapy
#5
Adriaan Louw, Jo Nijs, Emilio J Puentedura
In recent years, there has been an increased interest in pain neuroscience education (PNE) in physical therapy. There is growing evidence for the efficacy of PNE to decrease pain, disability, fear-avoidance, pain catastrophization, limited movement, and health care utilization in people struggling with pain. PNE teaches people in pain more about the biology and physiology of their pain experience including processes such as central sensitization, peripheral sensitization, allodynia, inhibition, facilitation, neuroplasticity and more...
July 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28650070/the-human-ventilatory-response-to-stress-rate-or-depth
#6
Michael J Tipton, Abbi Harper, Julian F R Paton, Joseph T Costello
Many stressors cause an increase in ventilation in humans. This is predominantly reported as an increase in minute ventilation (V̇E). But, the same V̇E can be achieved by a wide variety of changes in the depth (tidal volume, VT ) and number of breaths (respiratory frequency, ƒR ). This review investigates the impact of stressors including: cold, heat, hypoxia, pain and panic on the contributions of ƒR and VT to V̇E to see if they differ with different stressors. Where possible we also consider the potential mechanisms that underpin the responses identified, and propose mechanisms by which differences in ƒR and VT are mediated...
June 26, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28650061/-effectiveness-of-education-based-on-neuroscience-in-the-treatment-of-musculoskeletal-chronic-pain
#7
J D Cuenda-Gago, L Espejo-Antunez
INTRODUCTION: Chronic pain is one of the most frequent health, economic and social problems. Given this, numerous approaches have been described, one of which is pain neuroscience education. AIM: To examine the effectiveness of pain neuroscience education in the treatment of musculoskeletal disorders with chronic pain and to explore the impact of specific aspects of the technique on its effectiveness. MATERIAL AND METHODS: Relevant studies published between 2000 and 2015 were identified by searching PubMed, Scopus and Web of Science...
July 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28605207/kinesiophobia-and-maladaptive-coping-strategies-prevent-improvements-in-pain-catastrophizing-following-pain-neuroscience-education-in-fibromyalgia-chronic-fatigue-syndrome-an-explorative-study
#8
Anneleen Malfliet, Jessica Van Oosterwijck, Mira Meeus, Barbara Cagnie, Lieven Danneels, Mieke Dolphens, Ronald Buyl, Jo Nijs
Many patients with chronic fatigue syndrome(CFS) and/or fibromyalgia(FM) have little understanding of their condition, leading to maladaptive pain cognitions and coping strategies. These should be tackled during therapy, for instance by pain neurophysiology education (PNE). Although positive effects of PNE are well-established, it remains unclear why some patients benefit more than others. This paper aims at exploring characteristics of patients responding poor to PNE to further improve its effectiveness. Data from two RCT's were pooled to search for baseline predictors...
June 12, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28579013/modern-pain-neuroscience-in-clinical-practice-applied-to-post-cancer-paediatric-and-sports-related-pain
#9
REVIEW
Anneleen Malfliet, Laurence Leysen, Roselien Pas, Kevin Kuppens, Jo Nijs, Paul Van Wilgen, Eva Huysmans, Lisa Goudman, Kelly Ickmans
In the last decade, evidence regarding chronic pain has developed exponentially. Numerous studies show that many chronic pain populations show specific neuroplastic changes in the peripheral and central nervous system. These changes are reflected in clinical manifestations, like a generalized hypersensitivity of the somatosensory system. Besides a hypersensitivity of bottom-up nociceptive transmission, there is also evidence for top-down facilitation of pain due to malfunctioning of the endogenous descending nociceptive modulatory systems...
July 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28572737/observational-study-to-calculate-addictive-risk-to-opioids-a-validation-study-of-a-predictive-algorithm-to-evaluate-opioid-use-disorder
#10
Ashley Brenton, Steven Richeimer, Maneesh Sharma, Chee Lee, Svetlana Kantorovich, John Blanchard, Brian Meshkin
BACKGROUND: Opioid abuse in chronic pain patients is a major public health issue, with rapidly increasing addiction rates and deaths from unintentional overdose more than quadrupling since 1999. PURPOSE: This study seeks to determine the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated single-nucleotide polymorphisms (SNPs). PATIENTS AND METHODS: The Proove Opioid Risk (POR) algorithm determines the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated SNPs...
2017: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/28569221/a-four-part-working-bibliography-of-neuroethics-part-4-ethical-issues-in-clinical-and-social-applications-of-neuroscience
#11
EDITORIAL
Kira Becker, John R Shook, Martina Darragh, James Giordano
BACKGROUND: As a discipline, neuroethics addresses a range of questions and issues generated by basic neuroscientific research (inclusive of studies of putative neurobiological processes involved in moral and ethical cognition and behavior), and its use and meanings in the clinical and social spheres. Here, we present Part 4 of a four-part bibliography of the neuroethics literature focusing on clinical and social applications of neuroscience, to include: the treatment-enhancement discourse; issues arising in neurology, psychiatry, and pain care; neuroethics education and training; neuroethics and the law; neuroethics and policy and political issues; international neuroethics; and discourses addressing "trans-" and "post-" humanity...
May 31, 2017: Philosophy, Ethics, and Humanities in Medicine: PEHM
https://www.readbyqxmd.com/read/28524700/what-is-important-in-transdisciplinary-pain-neuroscience-education-a-qualitative-study
#12
Amarins J Wijma, Caroline M Speksnijder, Astrid F Crom-Ottens, J M Corine Knulst-Verlaan, Doeke Keizer, Jo Nijs, C Paul van Wilgen
PURPOSE: The main focus of Pain Neuroscience Education is around changing patients' pain perceptions and minimizing further medical care. Even though Pain Neuroscience Education has been studied extensively, the experiences of patients regarding the Pain Neuroscience Education process remain to be explored. Therefore, the aim of this study was to explore the experiences in patients with non-specific chronic pain. MATERIALS AND METHODS: Fifteen patients with non-specific chronic pain from a transdisciplinary treatment centre were in-depth interviewed...
May 19, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28523733/the-development-of-cognitive-empathy-and-concern-in-preschool-children-a-behavioral-neuroscience-investigation
#13
Jean Decety, Kimberly L Meidenbauer, Jason M Cowell
This developmental neuroscience study examined the electrophysiological responses (EEG and ERPs) associated with perspective taking and empathic concern in preschool children, as well as their relation to parental empathy dispositions and children's own prosocial behavior. Consistent with a body of previous studies using stimuli depicting somatic pain in both children and adults, larger early (~200 ms) ERPs were identified when perceiving painful versus neutral stimuli. In the slow wave window (~800 ms), a significant interaction of empathy condition and stimulus type was driven by a greater difference between painful and neutral images in the empathic concern condition...
May 18, 2017: Developmental Science
https://www.readbyqxmd.com/read/28514231/preoperative-pain-neuroscience-education-combined-with-knee-joint-mobilization-for-knee-osteoarthritis-a-randomized-controlled-trial
#14
Enrique Lluch, Lirios Dueñas, Deborah Falla, Isabel Baert, Mira Meeus, Jose Sánchez-Frutos, Jo Nijs
OBJECTIVES: This study aimed to first compare the effects of a preoperative treatment combining pain neuroscience education (PNE) with knee joint mobilization versus biomedical education with knee joint mobilization on central sensitization (CS) in patients with knee osteoarthritis, both before and after surgery. Second, we wanted to compare the effects of both interventions on knee pain, disability, and psychosocial variables. MATERIALS AND METHODS: Forty-four patients with knee osteoarthritis were allocated to receive 4 sessions of either PNE combined with knee joint mobilization or biomedical education with knee joint mobilization before surgery...
May 16, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28441116/nerve-growth-factor-and-pain-mechanisms
#15
Franziska Denk, David L Bennett, Stephen B McMahon
Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led to our current understanding of NGF biology. We also discuss the surprising number of questions that remain about NGF expression patterns and NGF's various functions and interaction partners in relation to persistent pain and the potential side effects of anti-NGF therapy...
July 25, 2017: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/28420985/mapping-dorsal-and-ventral-caudate-in-older-adults-method-and-validation
#16
Haiqing Huang, Peter T Nguyen, Nadine A Schwab, Jared J Tanner, Catherine C Price, Mingzhou Ding
The caudate nucleus plays important roles in cognition and affect. Depending on associated connectivity and function, the caudate can be further divided into dorsal and ventral aspects. Dorsal caudate, highly connected to dorsolateral prefrontal cortex (DLPFC), is implicated in executive function and working memory; ventral caudate, more interconnected with the limbic system, is implicated in affective functions such as pain processing. Clinically, certain brain disorders are known to differentially impact dorsal and ventral caudate...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28420449/interpersonal-harm-aversion-as-a-necessary-foundation-for-morality-a-developmental-neuroscience-perspective
#17
Jean Decety, Jason M Cowell
Growing evidence from developmental psychology and social neuroscience emphasizes the importance of third-party harm aversion for constructing morality. A sensitivity to interpersonal harm emerges very early in ontogeny, as reflected in both the capacity for implicit social evaluation and an aversion for antisocial agents. Yet it does not necessarily entail avoidance toward inflicting pain to others. Later, an understanding that harmful actions cause suffering emerges, followed by an integration of rules that can depend on social contexts and cultures...
April 19, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28418641/classics-in-chemical-neuroscience-ketamine
#18
Marshall W Tyler, Harmony B Yourish, Dawn F Ionescu, Stephen J Haggarty
Ketamine, a molecule of many faces, has contributed immeasurably to numerous realms of clinical practice and scientific inquiry. From anesthesia and analgesia to depression and schizophrenia, it continues to shed light on the molecular underpinnings of pain, consciousness, and the pathophysiology of neuropsychiatric disorders. In particular, research on ketamine's mechanism of action is providing new hope in the search for therapies for treatment-resistant depression and affords insights into disorders of glutamatergic dysfunction...
June 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28407728/long-lasting-improvements-in-health-related-quality-of-life-among-women-with-chronic-pain-following-multidisciplinary-rehabilitation
#19
Sigrún Vala Björnsdóttir, Jan Triebel, Margrét Arnljótsdóttir, Gunnar Tómasson, Unnur Anna Valdimarsdóttir
PURPOSE: To determine whether observed health-related quality-of-life improvements after four-week traditional multidisciplinary pain management program and additional neuroscience education and mindfulness-based cognitive therapy for chronic pain are sustained at six-month follow-up. METHOD: This observational longitudinal follow-up study, with complete follow-up of 75 women, 61.5% of initial traditional approach group (treated 2001-2005) and 56 (62.2%) receiving the new approach (treated 2006-2009)...
April 14, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28399689/the-cognitive-neuroscience-of-placebo-effects-concepts-predictions-and-physiology
#20
Stephan Geuter, Leonie Koban, Tor D Wager
Placebos have been used ubiquitously throughout the history of medicine. Expectations and associative learning processes are important psychological determinants of placebo effects, but their underlying brain mechanisms are only beginning to be understood. We examine the brain systems underlying placebo effects on pain, autonomic, and immune responses. The ventromedial prefrontal cortex (vmPFC), insula, amygdala, hypothalamus, and periaqueductal gray emerge as central brain structures underlying placebo effects...
July 25, 2017: Annual Review of Neuroscience
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