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pain, neurosciences

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https://www.readbyqxmd.com/read/28605207/kinesiophobia-and-maladaptive-coping-strategies-prevent-improvements-in-pain-catastrophizing-following-pain-neuroscience-education-in-fibromyalgia-chronic-fatigue-syndrome-an-explorative-study
#1
Anneleen Malfliet, Jessica Van Oosterwijck, Mira Meeus, Barbara Cagnie, Lieven Danneels, Mieke Dolphens, Ronald Buyl, Jo Nijs
Many patients with chronic fatigue syndrome(CFS) and/or fibromyalgia(FM) have little understanding of their condition, leading to maladaptive pain cognitions and coping strategies. These should be tackled during therapy, for instance by pain neurophysiology education (PNE). Although positive effects of PNE are well-established, it remains unclear why some patients benefit more than others. This paper aims at exploring characteristics of patients responding poor to PNE to further improve its effectiveness. Data from two RCT's were pooled to search for baseline predictors...
June 12, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28579013/modern-pain-neuroscience-in-clinical-practice-applied-to-post-cancer-paediatric-and-sports-related-pain
#2
REVIEW
Anneleen Malfliet, Laurence Leysen, Roselien Pas, Kevin Kuppens, Jo Nijs, Paul Van Wilgen, Eva Huysmans, Lisa Goudman, Kelly Ickmans
In the last decade, evidence regarding chronic pain has developed exponentially. Numerous studies show that many chronic pain populations show specific neuroplastic changes in the peripheral and central nervous system. These changes are reflected in clinical manifestations, like a generalized hypersensitivity of the somatosensory system. Besides a hypersensitivity of bottom-up nociceptive transmission, there is also evidence for top-down facilitation of pain due to malfunctioning of the endogenous descending nociceptive modulatory systems...
May 19, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28572737/observational-study-to-calculate-addictive-risk-to-opioids-a-validation-study-of-a-predictive-algorithm-to-evaluate-opioid-use-disorder
#3
Ashley Brenton, Steven Richeimer, Maneesh Sharma, Chee Lee, Svetlana Kantorovich, John Blanchard, Brian Meshkin
BACKGROUND: Opioid abuse in chronic pain patients is a major public health issue, with rapidly increasing addiction rates and deaths from unintentional overdose more than quadrupling since 1999. PURPOSE: This study seeks to determine the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated single-nucleotide polymorphisms (SNPs). PATIENTS AND METHODS: The Proove Opioid Risk (POR) algorithm determines the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated SNPs...
2017: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/28569221/a-four-part-working-bibliography-of-neuroethics-part-4-ethical-issues-in-clinical-and-social-applications-of-neuroscience
#4
EDITORIAL
Kira Becker, John R Shook, Martina Darragh, James Giordano
BACKGROUND: As a discipline, neuroethics addresses a range of questions and issues generated by basic neuroscientific research (inclusive of studies of putative neurobiological processes involved in moral and ethical cognition and behavior), and its use and meanings in the clinical and social spheres. Here, we present Part 4 of a four-part bibliography of the neuroethics literature focusing on clinical and social applications of neuroscience, to include: the treatment-enhancement discourse; issues arising in neurology, psychiatry, and pain care; neuroethics education and training; neuroethics and the law; neuroethics and policy and political issues; international neuroethics; and discourses addressing "trans-" and "post-" humanity...
May 31, 2017: Philosophy, Ethics, and Humanities in Medicine: PEHM
https://www.readbyqxmd.com/read/28524700/what-is-important-in-transdisciplinary-pain-neuroscience-education-a-qualitative-study
#5
Amarins J Wijma, Caroline M Speksnijder, Astrid F Crom-Ottens, J M Corine Knulst-Verlaan, Doeke Keizer, Jo Nijs, C Paul van Wilgen
PURPOSE: The main focus of Pain Neuroscience Education is around changing patients' pain perceptions and minimizing further medical care. Even though Pain Neuroscience Education has been studied extensively, the experiences of patients regarding the Pain Neuroscience Education process remain to be explored. Therefore, the aim of this study was to explore the experiences in patients with non-specific chronic pain. MATERIALS AND METHODS: Fifteen patients with non-specific chronic pain from a transdisciplinary treatment centre were in-depth interviewed...
May 19, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28523733/the-development-of-cognitive-empathy-and-concern-in-preschool-children-a-behavioral-neuroscience-investigation
#6
Jean Decety, Kimberly L Meidenbauer, Jason M Cowell
This developmental neuroscience study examined the electrophysiological responses (EEG and ERPs) associated with perspective taking and empathic concern in preschool children, as well as their relation to parental empathy dispositions and children's own prosocial behavior. Consistent with a body of previous studies using stimuli depicting somatic pain in both children and adults, larger early (~200 ms) ERPs were identified when perceiving painful versus neutral stimuli. In the slow wave window (~800 ms), a significant interaction of empathy condition and stimulus type was driven by a greater difference between painful and neutral images in the empathic concern condition...
May 18, 2017: Developmental Science
https://www.readbyqxmd.com/read/28514231/preoperative-pain-neuroscience-education-combined-with-knee-joint-mobilization-for-knee-osteoarthritis-a-randomized-controlled-trial
#7
Enrique Lluch, Lirios Dueñas, Deborah Falla, Isabel Baert, Mira Meeus, Jose Sánchez-Frutos, Jo Nijs
OBJECTIVES: This study aimed to first compare the effects of a preoperative treatment combining pain neuroscience education (PNE) with knee joint mobilization versus biomedical education with knee joint mobilization on central sensitization (CS) in patients with knee osteoarthritis, both before and after surgery. Second, we wanted to compare the effects of both interventions on knee pain, disability, and psychosocial variables. MATERIALS AND METHODS: Forty-four patients with knee osteoarthritis were allocated to receive 4 sessions of either PNE combined with knee joint mobilization or biomedical education with knee joint mobilization before surgery...
May 16, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28441116/nerve-growth-factor-and-pain-mechanisms
#8
Franziska Denk, David L Bennett, Stephen B McMahon
Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led to our current understanding of NGF biology. We also discuss the surprising number of questions that remain about NGF expression patterns and NGF's various functions and interaction partners in relation to persistent pain and the potential side effects of anti-NGF therapy...
April 24, 2017: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/28420985/mapping-dorsal-and-ventral-caudate-in-older-adults-method-and-validation
#9
Haiqing Huang, Peter T Nguyen, Nadine A Schwab, Jared J Tanner, Catherine C Price, Mingzhou Ding
The caudate nucleus plays important roles in cognition and affect. Depending on associated connectivity and function, the caudate can be further divided into dorsal and ventral aspects. Dorsal caudate, highly connected to dorsolateral prefrontal cortex (DLPFC), is implicated in executive function and working memory; ventral caudate, more interconnected with the limbic system, is implicated in affective functions such as pain processing. Clinically, certain brain disorders are known to differentially impact dorsal and ventral caudate...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28420449/interpersonal-harm-aversion-as-a-necessary-foundation-for-morality-a-developmental-neuroscience-perspective
#10
Jean Decety, Jason M Cowell
Growing evidence from developmental psychology and social neuroscience emphasizes the importance of third-party harm aversion for constructing morality. A sensitivity to interpersonal harm emerges very early in ontogeny, as reflected in both the capacity for implicit social evaluation and an aversion for antisocial agents. Yet it does not necessarily entail avoidance toward inflicting pain to others. Later, an understanding that harmful actions cause suffering emerges, followed by an integration of rules that can depend on social contexts and cultures...
April 19, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28418641/classics-in-chemical-neuroscience-ketamine
#11
Marshall W Tyler, Harmony B Yourish, Dawn F Ionescu, Stephen J Haggarty
Ketamine, a molecule of many faces, has contributed immeasurably to numerous realms of clinical practice and scientific inquiry. From anesthesia and analgesia to depression and schizophrenia, it continues to shed light on the molecular underpinnings of pain, consciousness, and the pathophysiology of neuropsychiatric disorders. In particular, research on ketamine's mechanism of action is providing new hope in the search for therapies for treatment-resistant depression and affords insights into disorders of glutamatergic dysfunction...
June 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28407728/long-lasting-improvements-in-health-related-quality-of-life-among-women-with-chronic-pain-following-multidisciplinary-rehabilitation
#12
Sigrún Vala Björnsdóttir, Jan Triebel, Margrét Arnljótsdóttir, Gunnar Tómasson, Unnur Anna Valdimarsdóttir
PURPOSE: To determine whether observed health-related quality-of-life improvements after four-week traditional multidisciplinary pain management program and additional neuroscience education and mindfulness-based cognitive therapy for chronic pain are sustained at six-month follow-up. METHOD: This observational longitudinal follow-up study, with complete follow-up of 75 women, 61.5% of initial traditional approach group (treated 2001-2005) and 56 (62.2%) receiving the new approach (treated 2006-2009)...
April 14, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28399689/the-cognitive-neuroscience-of-placebo-effects-concepts-predictions-and-physiology
#13
Stephan Geuter, Leonie Koban, Tor D Wager
Placebos have been used ubiquitously throughout the history of medicine. Expectations and associative learning processes are important psychological determinants of placebo effects, but their underlying brain mechanisms are only beginning to be understood. We examine the brain systems underlying placebo effects on pain, autonomic, and immune responses. The ventromedial prefrontal cortex (vmPFC), insula, amygdala, hypothalamus, and periaqueductal gray emerge as central brain structures underlying placebo effects...
April 7, 2017: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/28386682/-update-in-neuroanesthesiology-key-publications
#14
V-S Eckle, G Schneider
One of the aims of the Scientific Working Group Neuroanesthesia (WAKNA) of the German Society of Anesthesiology and Intensive Care Medicine is to disseminate new findings in the field of neuroscience and neuroanesthesia and to propagate novel therapeutic and diagnostic options into clinical practice. Once a year, the WAKNA displays and discusses recent noteworthy publications from the past 12 months at the German Anesthesia Meeting. In 2016, a new pharmacologic strategy with dexmedetomidine to prevent postoperative pain after craniotomy, the impact of the widely used anesthetic drug propofol on GABA receptor surface expression, a study highlighting the ultrasound-guided detection of increased intracranial pressure, and an article showing the interactions of neuromuscular blocking drugs on the BIS neuromonitoring were presented...
June 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28339330/-clinical-biopsychosocial-physiotherapy-assessment-of-patients-with-chronic-pain-the-first-step-in-pain-neuroscience-education-by-amarins-j-wijma-et-al-2016
#15
Rob A B Oostendorp, Hans Elvers, Emilia Mikolajewska, Marjan Laekeman, Emiel van Trijffel, Han Samwel
No abstract text is available yet for this article.
March 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28323659/stimulus-induced-rhythmic-periodic-or-ictal-discharges-in-coma-incidence-and-interrater-reliability-of-continuous-eeg-after-a-standard-stimulation-protocol-a-prospective-study
#16
Khalid A Alsherbini, Joao Mc-OʼNeil Plancher, David M Ficker, Brandon P Foreman, Opeolu M Adeoye, Jun Ying, Michael D Privitera
PURPOSE: Stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs) are often seen during continuous electroencephalographic (cEEG) monitoring in coma. Given their uncertain clinical significance, our prospective study evaluated incidence of SIRPIDs in comatose patients in the neuroscience intensive care unit (NSICU) who underwent a standard stimulation protocol and defined interreader reliability for cEEG. METHODS: Of 146 patients prospectively screened who underwent cEEG during a 6-month period, 53 patients were included and 93 patients were excluded...
March 17, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28318531/national-survey-on-postoperative-care-and-treatment-circuits-in-neurosurgery
#17
R Valero, E Carrero, N Fàbregas, F Iturri, N Saiz-Sapena, L Valencia
INTRODUCTION: The analysis of surgical processes should be a standard of health systems. We describe the circuit of care and postoperative treatment for neurosurgical interventions in the centres of our country. MATERIAL AND METHODS: From June to October 2014, a survey dealing with perioperative treatments and postoperative circuits after neurosurgical procedures was sent to the chiefs of Anaesthesiology of 73 Spanish hospitals with neurosurgery and members of the Neuroscience Section of SEDAR...
March 16, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28284238/applying-current-concepts-in-pain-related-brain-science-to-dance-rehabilitation
#18
Sarah B Wallwork, Valeria Bellan, G Lorimer Moseley
Dance involves exemplary sensory-motor control, which is subserved by sophisticated neural processing at the spinal cord and brain level. Such neural processing is altered in the presence of nociception and pain, and the adaptations within the central nervous system that are known to occur with persistent nociception or pain have clear implications for movement and, indeed, risk of further injury. Recent rapid advances in our understanding of the brain's representation of the body and the role of cortical representations, or "neurotags," in bodily protection and regulation have given rise to new strategies that are gaining traction in sports medicine...
March 1, 2017: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/28284237/interpreting-pain-symptoms-and-how-pain-affects-neuromuscular-control-in-dancersif-i-m-in-pain-how-should-i-train
#19
Andrew P Claus, David A Macdonald
This review draws from leading research on pain neuroscience and control of posture and movement to help inform rehabilitation approaches and when it may or may not be prudent to "dance through" pain. Control of posture and movement is frequently distorted by pain perception, and that may not be altered even when the pain is resolved. It is important to exclude serious systemic disease or major tissue injury with severe, unremitting, or persistent symptoms before focusing on movement-based rehabilitation. Both specific exercises (contraction of specific muscles and use of movement techniques) and general exercises (which promote strength, power, endurance, and flexibility) can help to manage individuals with persistent pain problems...
March 1, 2017: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/28279735/development-of-a-pharmacodynamic-biomarker-to-measure-target-engagement-from-inhibition-of-the-ngf-trka-pathway
#20
Eric A Price, Alicja Krasowska-Zoladek, Kausik K Nanda, Shawn J Stachel, Darrell A Henze
BACKGROUND: NGF signaling through TrkA triggers pathways involved in a wide range of biological effects. Clinical trials targeting either NGF or TrkA are ongoing to treat various diseases in the areas of oncology, neuroscience, and for pain, but there is no described measure of target engagement of TrkA in these studies. NEW METHOD: We have developed custom ELISA assays to measure NGF-induced phosphorylation of TrkA specific for rodent and human receptors. Optimized tissue processing methods allow for detection in both the brain and in skin...
March 7, 2017: Journal of Neuroscience Methods
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