keyword
MENU ▼
Read by QxMD icon Read
search

pain, neurosciences

keyword
https://www.readbyqxmd.com/read/29894151/dark-classics-in-chemical-neuroscience-fentanyl
#1
S Mallory Burns, Christopher W Cunningham, Susan L Mercer
Fentanyl rose to prominence as an alternative analgesic to morphine nearly 50 years ago; today, fentanyl has re-emerged as a dangerous recreational substance. The increased potency and analgesic effect of fentanyl are advantageous in the treatment of pain but are also responsible for the rise in unintentional opioid overdose deaths. In response to this crisis, fentanyl, its analogues, and even precursors are under heightened regulatory scrutiny. Despite this controversial history, derivatization of fentanyl has resulted in numerous synthetic analogues that provide valuable insights into opioid receptor binding and signaling events...
June 12, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29875641/an-integrative-neuroscience-framework-for-the-treatment-of-chronic-pain-from-cellular-alterations-to-behavior
#2
Jess D Greenwald, Keith M Shafritz
Chronic pain can result from many pain syndromes including complex regional pain syndrome (CRPS), phantom limb pain and chronic low back pain, among others. On a molecular level, chronic pain syndromes arise from hypersensitization within the dorsal horn of the spinal cord, a process known as central sensitization. Central sensitization involves an upregulation of ionotropic and metabotropic glutamate receptors (mGluRs) similar to that of long-term potentiation (LTP). Regions of the brain in which LTP occurs, such as the amygdala and hippocampus, are implicated in fear- and memory-related brain circuity...
2018: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/29861242/a-critical-overview-of-the-current-myofascial-pain-literature-april-2018
#3
Jan Dommerholt, Li-Wei Chou, Michelle Finnegan, Todd Hooks
Twenty-four basic and clinical studies and case reports are included in this quarterly review of the myofascial pain literature. The majority of publications focus on invasive techniques, especially dry needling. We hope, that this not suggest that clinicians and researchers are slowly moving away from manual trigger point (TrP) approaches. While some physiotherapists have bought into the notion that hands-on approaches are a thing of the past, since "pain is in the brain" and "the issues are not in the tissues," there is also a body of research that aims to combine so-called top-down and bottom-up therapies...
April 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29852083/endogenous-and-exogenous-opioids-in-pain
#4
Gregory Corder, Daniel C Castro, Michael R Bruchas, Grégory Scherrer
Opioids are the most commonly used and effective analgesic treatments for severe pain, but they have recently come under scrutiny owing to epidemic levels of abuse and overdose. These compounds act on the endogenous opioid system, which comprises four G protein-coupled receptors (mu, delta, kappa, and nociceptin) and four major peptide families (β-endorphin, enkephalins, dynorphins, and nociceptin/orphanin FQ). In this review, we first describe the functional organization and pharmacology of the endogenous opioid system...
May 31, 2018: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/29753112/patients-with-chronic-spinal-pain-benefit-from-pain-neuroscience-education-regardless-the-self-reported-signs-of-central-sensitization-secondary-analysis-of-a-randomized-controlled-multicentre-trial
#5
Anneleen Malfliet, Jeroen Kregel, Mira Meeus, Lieven Danneels, Barbara Cagnie, Nathalie Roussel, Jo Nijs
BACKGROUND: Pain neuroscience education is effective in chronic pain management. Central sensitization (i.e. generalized hypersensitivity) is often explained as underlying mechanism for chronic pain, because of its clinical relevance and influence on pain severity, prognosis, and treatment outcome. OBJECTIVES: To examine whether patients with more or fewer symptoms of central sensitization respond differently to pain neuroscience education. DESIGN: A secondary analysis of a multicentre, triple-blind randomized controlled trial SETTING: University hospital Ghent and University Hospital Brussels, Belgium...
May 9, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29725317/psychopathy-to-altruism-neurobiology-of-the-selfish-selfless-spectrum
#6
REVIEW
James W H Sonne, Don M Gash
The age-old philosophical, biological, and social debate over the basic nature of humans as being "universally selfish" or "universally good" continues today highlighting sharply divergent views of natural social order. Here we analyze advances in biology, genetics and neuroscience increasing our understanding of the evolution, features and neurocircuitry of the human brain underlying behavior in the selfish-selfless spectrum. First, we examine evolutionary pressures for selection of altruistic traits in species with protracted periods of dependence on parents and communities for subsistence and acquisition of learned behaviors...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29710099/effect-of-pain-neuroscience-education-combined-with-cognition-targeted-motor-control-training-on-chronic-spinal-pain-a-randomized-clinical-trial
#7
Anneleen Malfliet, Jeroen Kregel, Iris Coppieters, Robby De Pauw, Mira Meeus, Nathalie Roussel, Barbara Cagnie, Lieven Danneels, Jo Nijs
Importance: Effective treatments for chronic spinal pain are essential to reduce the related high personal and socioeconomic costs. Objective: To compare pain neuroscience education combined with cognition-targeted motor control training with current best-evidence physiotherapy for reducing pain and improving functionality, gray matter morphologic features, and pain cognitions in individuals with chronic spinal pain. Design, Setting, and Participants: Multicenter randomized clinical trial conducted from January 1, 2014, to January 30, 2017, among 120 patients with chronic nonspecific spinal pain in 2 outpatient hospitals with follow-up at 3, 6, and 12 months...
April 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29690896/marine-derived-protein-kinase-inhibitors-for-neuroinflammatory-diseases
#8
REVIEW
Chong Ning, Hui-Min David Wang, Rong Gao, Yu-Chia Chang, Fengqing Hu, Xianjun Meng, Shi-Ying Huang
Neuroinflammation is primarily characterized by overexpression of proinflammatory mediators produced by glial activation or immune cell infiltration. Several kinases have been shown to be critical mediators in neuroinflammation. One of the largest groups of kinases is protein kinases, which have been the second most studied group of drug targets after G-protein-coupled receptors. Thus far, most of the approved kinase inhibitor drugs are adenosine triphosphate-competitive inhibitors with various off-target liabilities because of cross-reactivities; however, marine-derived compounds provide opportunities for discovering allosteric kinase inhibitors...
April 24, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29673529/neurochemistry-of-anesthetic-states
#9
Ralph Lydic, Helen A Baghdoyan, Amanda L May
Anesthetic mechanisms that eliminate consciousness and perception of pain are products of the nervous system. Chemical approaches to the study of anesthetic mechanisms have the potential to serve as an ideal interface between basic and clinical neuroscience. There are disproportionately more basic neurochemical studies than clinical studies of anesthetic mechanisms. Even within neuroscience, the study of anesthetic mechanisms is sparse. The Society for Neuroscience hosts one of the world's largest and most vibrant scientific meetings, yet the content themes of that meeting do not include anesthesia...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29669562/comfort-in-palliative-sedation-compas-a-transdisciplinary-mixed-method-study-protocol-for-linking-objective-assessments-to-subjective-experiences
#10
Stefaan Six, Steven Laureys, Jan Poelaert, Johan Bilsen, Peter Theuns, Reginald Deschepper
BACKGROUND: In case of untreatable suffering at the end of life, palliative sedation may be chosen to assure comfort by reducing the patient's level of consciousness. An important question here is whether such sedated patients are completely free of pain. Because these patients cannot communicate anymore, caregivers have to rely on observation to assess the patient's comfort. Recently however, more sophisticated techniques from the neurosciences have shown that sometimes consciousness and pain are undetectable with these traditional behavioral methods...
April 18, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29669082/cognitive-functional-therapy-an-integrated-behavioral-approach-for-the-targeted-management-of-disabling-low-back-pain
#11
Peter B O'Sullivan, J P Caneiro, Mary O'Keeffe, Anne Smith, Wim Dankaerts, Kjartan Fersum, Kieran O'Sullivan
Biomedical approaches for diagnosing and managing disabling low back pain (LBP) have failed to arrest the exponential increase in health care costs, with a concurrent increase in disability and chronicity. Health messages regarding the vulnerability of the spine and a failure to target the interplay among multiple factors that contribute to pain and disability may partly explain this situation. Although many approaches and subgrouping systems for disabling LBP have been proposed in an attempt to deal with this complexity, they have been criticized for being unidimensional and reductionist and for not improving outcomes...
May 1, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29669079/blended-learning-pain-neuroscience-education-for-people-with-chronic-spinal-pain-randomized-controlled-multicenter-trial
#12
Anneleen Malfliet, Jeroen Kregel, Mira Meeus, Nathalie Roussel, Lieven Danneels, Barbara Cagnie, Mieke Dolphens, Jo Nijs
Background: Available evidence favors the use of pain neuroscience education (PNE) in patients with chronic pain. However, PNE trials are often limited to small sample sizes and, despite the current digital era, the effects of blended-learning PNE (ie, the combination of online digital media with traditional educational methods) have not yet been investigated. Objective: The study objective was to examine whether blended-learning PNE is able to improve disability, catastrophizing, kinesiophobia, and illness perceptions...
May 1, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29604314/zebrafish-models-relevant-to-studying-central-opioid-and-endocannabinoid-systems
#13
REVIEW
Konstantin A Demin, Darya A Meshalkina, Elana V Kysil, Kristina A Antonova, Andrey D Volgin, Oleg A Yakovlev, Polina A Alekseeva, Maria M Firuleva, Anton M Lakstygal, Murilo S de Abreu, Leonardo J G Barcellos, Wandong Bao, Ashton J Friend, Tamara G Amstislavskaya, Denis B Rosemberg, Pavel E Musienko, Cai Song, Allan V Kalueff
The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that modulate drug abuse, anxiety, pain, cognition, neurogenesis and immune activity. Although they are involved in such critical functions, our understanding of endocannabinoid and opioid physiology remains limited, necessitating further studies, novel models and new model organisms in this field. Zebrafish (Danio rerio) is rapidly emerging as one of the most effective translational models in neuroscience and biological psychiatry...
March 28, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29601227/the-use-of-pain-neuroscience-education-in-older-adults-with-chronic-back-and-or-lower-extremity-pain
#14
Adam Rufa, Katherine Beissner, Michelle Dolphin
INTRODUCTION: Chronic pain due to musculoskeletal disorders is the leading cause of disability among older adults and is associated with a lower quality of life, reduced function, and increased risk of institutionalization. Pain Neuroscience Education (PNE) has demonstrated effectiveness in reducing pain and improving pain self-efficacy in individuals under 60 years of age, but there is a paucity of research examining its use with older adults. If PNE has similar effects in older adults, it has the potential to be a useful non-pharmacological intervention for this population...
March 30, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29589782/immediate-preoperative-outcomes-of-pain-neuroscience-education-for-patients-undergoing-total-knee-arthroplasty-a-case-series
#15
Adriaan Louw, Kory Zimney, Jordan Reed, Merrill Landers, Emilio J Puentedura
BACKGROUND: Standard preoperative education for total knee arthroplasty (TKA) has been shown to have no effect on postoperative outcomes. This may be because such education programs fail to educate patients about pain. Pain neuroscience education (PNE) focuses on teaching people more about pain from a neurobiological and neurophysiological perspective. DESIGN AND SETTING: Case Series. AIM: To determine the immediate effects, if any, of providing PNE before TKA surgery on patient self-report measures...
March 28, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29588615/management-of-pain-in-patients-with-temporomandibular-disorder-tmd-challenges-and-solutions
#16
REVIEW
Alfonso Gil-Martínez, Alba Paris-Alemany, Ibai López-de-Uralde-Villanueva, Roy La Touche
Thanks to advances in neuroscience, biopsychosocial models for diagnostics and treatment (including physical, psychological, and pharmacological therapies) currently have more clinical support and scientific growth. At present, a conservative treatment approach prevails over surgery, given it is less aggressive and usually results in satisfactory clinical outcomes in mild-moderate temporomandibular disorder (TMD). The aim of this review is to evaluate the recent evidence, identify challenges, and propose solutions from a clinical point of view for patients with craniofacial pain and TMD...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29561359/title-comparative-transcriptome-profiling-of-the-human-and-mouse-dorsal-root-ganglia-an-rna-seq-based-resource-for-pain-and-sensory-neuroscience-research
#17
Pradipta Ray, Andrew Torck, Lilyana Quigley, Andi Wangzhou, Matthew Neiman, Chandranshu Rao, Tiffany Lam, Ji-Young Kim, Tae Hoon Kim, Michael Q Zhang, Gregory Dussor, Theodore J Price
Molecular neurobiological insight into human nervous tissues is needed to generate next generation therapeutics for neurological disorders like chronic pain. We obtained human Dorsal Root Ganglia (DRG) samples from organ donors and performed RNA-sequencing (RNA-seq) to study the human DRG (hDRG) transcriptional landscape, systematically comparing it with publicly available data from a variety of human and orthologous mouse tissues, including mouse DRG (mDRG). We characterized the hDRG transcriptional profile in terms of tissue-restricted gene co-expression patterns and putative transcriptional regulators, and formulated an information-theoretic framework to quantify DRG enrichment...
March 20, 2018: Pain
https://www.readbyqxmd.com/read/29550259/development-and-feasibility-testing-of-a-pain-neuroscience-education-program-for-children-with-chronic-pain-treatment-protocol
#18
Roselien Pas, Mira Meeus, Anneleen Malfliet, Isabel Baert, Sophie Van Oosterwijck, Laurence Leysen, Jo Nijs, Kelly Ickmans
BACKGROUND: Current treatment for adults with chronic pain often includes Pain Neuroscience Education (PNE) to make people understand the nature underlying their pain and thus provides a clear rational for a biopsychosocial approach. Despite recommendations to use Pain Neuroscience Education as well in children with chronic pain, a specific program, tailored to children aged 6-12 years is lacking. OBJECTIVES: The aim of this study was to develop a Pain Neuroscience Education program for children with chronic pain and test its feasibility...
May 2018: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/29535617/yoga-therapy-and-polyvagal-theory-the-convergence-of-traditional-wisdom-and-contemporary-neuroscience-for-self-regulation-and-resilience
#19
Marlysa B Sullivan, Matt Erb, Laura Schmalzl, Steffany Moonaz, Jessica Noggle Taylor, Stephen W Porges
Yoga therapy is a newly emerging, self-regulating complementary and integrative healthcare (CIH) practice. It is growing in its professionalization, recognition and utilization with a demonstrated commitment to setting practice standards, educational and accreditation standards, and promoting research to support its efficacy for various populations and conditions. However, heterogeneity of practice, poor reporting standards, and lack of a broadly accepted understanding of the neurophysiological mechanisms involved in yoga therapy limits the structuring of testable hypotheses and clinical applications...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29430052/-i-didn-t-pay-her-to-teach-me-how-to-fix-my-back-a-focused-ethnographic-study-exploring-chiropractors-and-chiropractic-patients-experiences-and-beliefs-regarding-exercise-adherence
#20
Peter Stilwell, Katherine Harman
Aim: To inform future research and exercise prescription for patients with chronic low back pain (CLBP), this study explored chiropractors' and chiropractic patients' experiences and beliefs regarding the barriers and facilitators to prescribed exercise adherence. Methods: A focused ethnographic approach was used involving 16 semi-structured interviews, including pilot interviews (n = 4) followed by interviews with chiropractors (n = 6) and chiropractic patients with CLBP (n = 6)...
December 2017: Journal of the Canadian Chiropractic Association
keyword
keyword
81928
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"