keyword
https://read.qxmd.com/read/36131920/increased-risk-of-early-onset-childhood-systemic-lupus-erythematosus-for-children-born-to-affected-parents-a-nationwide-child-parent-cohort-study
#21
JOURNAL ARTICLE
Chun-Hsin Wu, Chih-An Chen, Sheng-Hsiang Lin, Chia-Tse Weng, Pao-Lin Kuo, Chi-Chang Shieh
Objective: Children of women with systemic lupus erythematosus (SLE) are at risk for childhood-onset SLE (cSLE). This study evaluated the incidence of early-onset cSLE and associated risk factors, including concomitant maternal and paternal autoimmune diseases, for these children. Methods: A population-based cohort study was conducted using national databases including the linked information of children and parents. Children of women with SLE and those of women without SLE were identified between 2004 and 2015...
2022: Frontiers in Immunology
https://read.qxmd.com/read/35485252/is-the-lack-of-prior-exposure-to-sperm-antigens-associated-with-worse-neonatal-and-maternal-outcomes-a-10-years-single-center-experience-comparing-icsi-tese-pregnancies-to-icsi-pregnancies
#22
JOURNAL ARTICLE
Federico Cirillo, Paola Costa, Massimo Romano, Luciano Negri, Emanuela Morenghi, Elena Albani, Paolo Emanuele Levi Setti
BACKGROUND: Nowadays pathogenesis of preeclampsia is still unknown. Among the different etiological hypotheses, some authors proposed that it might be due to an abnormal immunologic response to foreign fetal antigen derived from the father's sperm. Indeed, the fetus is considered a semi allograft, being one half paternally derived in its antigenicity, and the first pathogenic insult of preeclampsia may be an abnormal maternal immune response towards this semi-allogenic implant. In the context of Artificial Reproductive Techniques, it has been shown that the use of donor and surgically retrieved spermatozoa (e...
April 29, 2022: Andrology
https://read.qxmd.com/read/35468528/cutting-edge-the-regulatory-mechanisms-of-macrophage-polarization-and-function-during-pregnancy
#23
JOURNAL ARTICLE
Li-Ling Wang, Zhi-Hui Li, Huan Wang, Joanne Kwak-Kim, Ai-Hua Liao
Macrophages are highly diverse cells and represent the major antigen-presenting cell at the maternal-fetal interface. Except for protecting the embryo with half of the paternal antigens from attack by the maternal immune system, decidua macrophages also have a critical role in implantation, trophoblast invasion, spiral artery remodeling, angiogenesis, and pathogen clearance. The classically activated (M1) and alternatively activated (M2) macrophages are the simplified classifications of macrophages, often applied to differentiate decidual macrophages...
April 18, 2022: Journal of Reproductive Immunology
https://read.qxmd.com/read/35414772/immunologic-memory-in-pregnancy-focusing-on-memory-regulatory-t-cells
#24
REVIEW
Yu-Jing Zhang, Li Shen, Tao Zhang, Kahindo P Muyayalo, Jing Luo, Gil Mor, Ai-Hua Liao
A successful pregnancy requires the maternal immune system to tolerate an allogeneic fetus. The incidence of preeclampsia and other complications related to impaired fetal tolerance is lower during the second pregnancy than during the first pregnancy. At the same time, compared with normal pregnant women in the previous pregnancy, patients with pregnancy complications in the previous pregnancy also have an increased risk of the disease when they become pregnant again. This difference may be related to the immunological memory of pregnancy...
2022: International Journal of Biological Sciences
https://read.qxmd.com/read/35360083/effects-of-paternal-obesity-on-fetal-development-and-pregnancy-complications-a-prospective-clinical-cohort-study
#25
JOURNAL ARTICLE
Jing Lin, Wei Gu, Hefeng Huang
Objectives: To evaluate the association between paternal obesity and fetal development and pregnancy complications. Study Design: This prospective cohort clinical trial analyzed data from 7683 women with singleton pregnancies. All study subjects were sequentially divided into four groups based on paternal BMI. We compared the differences in fetal growth and pregnancy complications between different paternal BMI groups by univariate logistic regression and independent t-test...
2022: Frontiers in Endocrinology
https://read.qxmd.com/read/35043656/childhood-blood-pressure-carotid-intima-media-thickness-and-distensibility-after-in-utero-exposure-to-gestational-hypertensive-disorders
#26
JOURNAL ARTICLE
Clarissa J Wiertsema, Vincent W V Jaddoe, Annemarie G M G J Mulders, Romy Gaillard
Background Offspring exposed to gestational hypertensive disorders have higher blood pressure and increased risk of stroke in later life. Gestational hypertensive disorders might influence vascular development in the offspring, predisposing them to a higher blood pressure and stroke in later life. Methods and Results In a population-based cohort among 4777 mother-offspring pairs, we examined whether gestational hypertension, preeclampsia, and higher gestational blood pressure across the full blood pressure spectrum were associated with offspring blood pressure, carotid intima media thickness, and distensibility at the age of 10 years...
January 19, 2022: Journal of the American Heart Association
https://read.qxmd.com/read/34521807/paternal-weight-prior-to-conception-and-infant-birthweight-a-prospective-cohort-study
#27
JOURNAL ARTICLE
Ravi Retnakaran, Shi Wu Wen, Hongzhuan Tan, Shujin Zhou, Chang Ye, Minxue Shen, Graeme N Smith, Mark C Walker
BACKGROUND/OBJECTIVE: Previous studies have consistently demonstrated that maternal weight status both before and during pregnancy is associated with infant birthweight. However, a fundamental limitation across this literature remains that previous studies have not evaluated the concomitant impact of paternal weight at conception, owing to the paucity of studies in which fathers were assessed prior to pregnancy. Thus, we established a cohort of preconception couples to prospectively evaluate the associations of maternal and paternal weight prior to pregnancy with infant birthweight at delivery...
September 14, 2021: Nutrition & Diabetes
https://read.qxmd.com/read/34464904/primipaternities-and-human-birthweights
#28
JOURNAL ARTICLE
Pierre-Yves Robillard, Gustaaf Dekker, Gérard Chaouat, Marco Scioscia, Malik Boukerrou
OBJECTIVES: To investigate in singleton multiparous pregnancies the effect of having a new father for an index pregnancy on new-borns' birthweights and intrauterine growth restriction. DESIGN: 20 year-observational cohort study (2001-2020). SETTINGS: Centre Hospitalier Universitaire Hospitalier Sud Reunion's maternity (French overseas department, Indian Ocean). MAIN OUTCOMES AND MEASURES: Comparing the 811 multiparas (cases) who had a new partner with the 49,712 who did not (controls), there were no differences concerning maternal age, education, ovulation induction/IVF, previous miscarriages, exams during pregnancies, pre-pregnancy BMI, gestational diabetes, and chronic hypertension...
August 20, 2021: Journal of Reproductive Immunology
https://read.qxmd.com/read/34394125/cytokines-hormones-and-cellular-regulatory-mechanisms-favoring-successful-reproduction
#29
REVIEW
Marie-Pierre Piccinni, Raj Raghupathy, Shigeru Saito, Julia Szekeres-Bartho
Its semi-allogeneic nature renders the conceptus vulnerable to attack by the maternal immune system. Several protective mechanisms operate during gestation to correct the harmful effects of anti-fetal immunity and to support a healthy pregnancy outcome. Pregnancy is characterized by gross alterations in endocrine functions. Progesterone is indispensable for pregnancy and humans, and it affects immune functions both directly and via mediators. The progesterone-induced mediator - PIBF - acts in favor of Th2-type immunity, by increasing Th2 type cytokines production...
2021: Frontiers in Immunology
https://read.qxmd.com/read/34368147/coordinated-expressional-landscape-of-the-human-placental-mirnome-and-transcriptome
#30
JOURNAL ARTICLE
Rain Inno, Triin Kikas, Kristiina Lillepea, Maris Laan
Placenta is a unique organ that serves its own function, and contributes to maternal gestational adaptation and fetal development. Coordination of its transcriptome to satisfy all the maternal-fetal needs across gestation is not fully understood. MicroRNAs are powerful transcriptome modulators capable to adjust rapidly the expression level and dynamics of large gene sets. This MiR-Seq based study presents a multi-omics investigation of the human placental miRNome and its synergy with the transcriptome. The analysis included 52 placentas representing three trimesters of normal pregnancy, and term cases of late-onset preeclampsia (LO-PE), gestational diabetes and affected fetal growth...
2021: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/34308244/pregnancy-induced-hypertension-and-uric-acid-levels-among-pregnant-women-attending-ruhengeri-referral-hospital-in-rwanda
#31
JOURNAL ARTICLE
Francois Niyongabo Niyonzima, Ally Dusabimana, Jean Berchmas Mutijima
Background: Pregnancy Induced Hypertension (PIH) is a common burden during pregnancy usually associoted with adverse maternal and paternal outcomes. The uric acid serum level was identified as an important biochemical marker which can predict preeclampsia, a type of PIH. This study was conducted to evaluate the effects of serum uric acid levels in association with blood pressure among pregnant women attending Ruhengeri Referral Hospital. Methodology: A cross-sectional study was designed and 80 pregnant women in different gestation trimesters participated in the study...
2021: East African Health Research Journal
https://read.qxmd.com/read/34280982/the-association-of-familial-hypertension-and-risk-of-gestational-hypertension-and-preeclampsia
#32
JOURNAL ARTICLE
Małgorzata Lewandowska
It has not been established how history of hypertension in the father or mother of pregnant women, combined with obesity or smoking, affects the risk of main forms of pregnancy-induced hypertension. A cohort of 912 pregnant women, recruited in the first trimester, was assessed; 113 (12.4%) women developed gestational hypertension (GH), 24 (2.6%) developed preeclampsia (PE) and 775 women remained normotensive (a control group). Multiple logistic regression was used to calculate adjusted odds ratios (AOR) (and 95% confidence intervals) of GH and PE for chronic hypertension in the father or mother of pregnant women...
July 1, 2021: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/34031868/triploid-pregnancy-clinical-implications
#33
REVIEW
Diana Massalska, Julia Bijok, Anna Kucińska-Chahwan, Janusz Grzegorz Zimowski, Katarzyna Ozdarska, Grzegorz Panek, Tomasz Roszkowski
Triploidy is a life-limiting genetic aberration resulting from an extra haploid set of chromosomes of paternal (diandric triploidy) or maternal origin (digynic triploidy). Triploidy affects around 1%-2% of all conceptions. The majority of cases is miscarried at early developmental stages. In consequence of genomic imprinting, parental origin affects the phenotype of triploid pregnancies as well as the prevalence and spectrum of related maternal complications. Distinctive ultrasound features of both triploid phenotypes as well as characteristic patterns of biochemical markers may be useful in diagnosis...
October 2021: Clinical Genetics
https://read.qxmd.com/read/33866064/prenatal-and-perinatal-factors-associated-with-developing-multiple-sclerosis-later-in-life-a-systematic-review-and-meta-analysis
#34
REVIEW
Negin Badihian, Roya Riahi, Parvin Goli, Shervin Badihian, Parnian Poursafa, Roya Kelishadi
OBJECTIVE: Both genetic and environmental factors play roles in Multiple sclerosis (MS) etiopathogenesis. The relationship between prenatal/perinatal factors/exposures and future MS occurrence in the offspring remains controversial. Here, we aimed to review the available evidence on prenatal/perinatal factors associated with later MS occurrence. METHOD: We performed systematic search of PubMed, Web of Science, and Scopus from inception to October 2020. We included original observational studies conducted on human participants addressing the association between prenatal/perinatal factors and MS occurrence...
April 15, 2021: Autoimmunity Reviews
https://read.qxmd.com/read/33544695/impacts-of-paternal-environment-and-lifestyle-on-maternal-heath-during-pregnancy
#35
REVIEW
Afsaneh Khoshkerdar, Ece Eryasar, Hannah L Morgan, Adam J Watkins
Pregnancy represents a time of dramatic physiological adaptation by the mother in which dramatic changes in maternal cardiovascular, metabolic and immune systems occur. These adaptations, initiated from the earliest stages of gestation, are crucial for the implantation and continued development of the embryo, the establishment of the placenta and the growth of the fetus. Impairments in the normal adaptation of the maternal cardiovascular, metabolic and immune systems underlie the aetiology of gestational disorders such as preeclampsia and gestational diabetes...
February 1, 2021: Reproduction
https://read.qxmd.com/read/33231792/maternal-and-paternal-carriage-of-the-annexin-a5-m2-haplotype-a-possible-risk-factor-for-recurrent-implantation-failure-rif
#36
JOURNAL ARTICLE
Nina Rogenhofer, Arseni Markoff, Xenia Ennerst, Nadja Bogdanova, Christian Thaler
OBJECTIVE: This study was carried out to determine the potential role of the M2/ANXA5 haplotype as a risk factor for recurrent implantation failure (RIF). Carriage of the M2/ANXA5 haplotype that induces prothrombotic changes has been implicated in failure of early pregnancies and placenta-mediated complications (preeclampsia, IUGR, preterm birth). MATERIAL AND METHODS: In the present case control study, 63 couples (females and males) with RIF presenting for IVF/ICSI to the Fertility Center of [masked] were analyzed...
January 2021: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/32950844/maternal-antenatal-stress-and-mental-and-behavioral-disorders-in-their-children
#37
JOURNAL ARTICLE
Soile Tuovinen, Marius Lahti-Pulkkinen, Polina Girchenko, Kati Heinonen, Jari Lahti, Rebecca M Reynolds, Esa Hämäläinen, Pia M Villa, Eero Kajantie, Hannele Laivuori, Katri Raikkonen
BACKGROUND: Maternal antenatal stress, including symptoms of depression, anxiety and perceived stress, is associated with mental and behavioral problems in children. Whether it is associated with child mental and behavioral disorders remains uncertain. We examined if maternal antenatal symptoms of depression, anxiety and perceived stress were associated with mental and behavioral disorders in their children, if the associations varied according to gestational week, stress type, fluctuating or consistently high symptoms, and if they were driven by maternal or paternal lifetime mood or anxiety disorders...
September 15, 2020: Journal of Affective Disorders
https://read.qxmd.com/read/32755415/c-allele-of-rs4769613-near-flt1-represents-a-high-confidence-placental-risk-factor-for-preeclampsia
#38
JOURNAL ARTICLE
Triin Kikas, Rain Inno, Kaspar Ratnik, Kristiina Rull, Maris Laan
The variant rs4769613 T/C within the enhancer element near FLT1, an acknowledged gene in preeclampsia, was previously identified as a risk factor for preeclampsia in the genome-wide association study (GWAS) targeting placental genotypes. We aimed to test the robustness of this association in 2 Estonian cohorts. Both placental sample sets HAPPY PREGNANCY (Development of novel non-invasive biomarkers for fertility and healthy pregnancy; preeclampsia, n=44 versus nonpreeclampsia, n=1724) and REPROMETA (REPROgrammed fetal and/or maternal METAbolism; 52/277) exhibited suggestive association between rs4769613[C] variant and preeclampsia (logistic regression adjusted for gestational age and fetal sex, nominal P <0...
August 3, 2020: Hypertension
https://read.qxmd.com/read/32720760/maternal-folate-one-carbon-metabolism-and-pregnancy-outcomes
#39
JOURNAL ARTICLE
Tanja Jankovic-Karasoulos, Denise L Furness, Shalem Y Leemaqz, Gustaaf A Dekker, Luke E Grzeskowiak, Jessica A Grieger, Prabha H Andraweera, Dylan McCullough, Dale McAninch, Lesley M McCowan, Tina Bianco-Miotto, Claire T Roberts
Single nucleotide polymorphisms and pre- and peri-conception folic acid (FA) supplementation and dietary data were used to identify one-carbon metabolic factors associated with pregnancy outcomes in 3196 nulliparous women. In 325 participants, we also measured circulating folate, vitamin B12 and homocysteine. Pregnancy outcomes included preeclampsia (PE), gestational hypertension (GHT), small for gestational age (SGA), spontaneous preterm birth (sPTB) and gestational diabetes mellitus (GDM). Study findings show that maternal genotype MTHFR A1298C(CC) was associated with increased risk for PE, whereas TCN2 C766G(GG) had a reduced risk for sPTB...
January 2021: Maternal & Child Nutrition
https://read.qxmd.com/read/32691841/on-use-of-animal-models
#40
REVIEW
David A Clark
Human pregnancy, critical for our species survival, is inefficient and prone to complications such as infertility, spontaneous miscarriages and preeclampsia (PE). Immunological factors may be important as the embryo is 50% paternal and foreign to the mother. Mouse pregnancy models, and in particular the murine CBA/J x DBA/2 mating combination, has been widely used to investigate mechanisms causing and preventing partner-specific recurrent miscarriages (RM) and PE. Occult losses can represent T cell-mediated rejection, and antigen-specific regulatory T cells (Tregs) with classical αβ T cell receptors (TcR) activated by semen antigens at the time of mating are protective...
September 8, 2020: Emerging Topics in Life Sciences
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