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JOURNAL ARTICLE
Zeyang Chen, Xiaojiao Zhou, Hongmei Qu, Xiaolu Zhang, Joanne Kwak-Kim, Wenjuan Wang
Regulatory T cells (Tregs) are activated and expanded after exposure to fetal-specific (paternal) antigens. A proportion of Tregs differentiate into memory Tregs (mTregs), exhibiting immune memory function and exerting more potent immunosuppression than naive Tregs (nTregs). However, it is unclear how mTregs are regulated during normal and pathological pregnancies (e.g., gestational diabetes mellitus (GDM) and preeclampsia (PE)). In this study, PD-1, HLA-G, and HLA-DR expressions on memory CD4+ T cells, naive CD4+ T cells, Tregs, mTregs, and nTregs in healthy non-pregnant women (n=20), healthy first (n=20), second (n=20), and third-trimester women (n=20), postpartum women (n=20), GDM (n=20), and PE patients (n=20) were analyzed...
March 19, 2024: Journal of Reproductive Immunology
#2
REVIEW
Sarah J Norman, Gena Fontus, Chancée Forestier, Tasneem Hiba, Stephanie Colon Pagan, Michael Osondu, Volha Shylovich
A review of the current literature on preeclampsia (PE) confirms that this pregnancy complication remains a common cause of maternal mortality. Within the last several decades, obstetric and gynecological researchers worldwide have indicated an association between prior abortions and the development of PE. Different studies have debated whether abortion is a protective or risk factor for PE. However, the most current literature demonstrates a stronger likelihood that a positive history of abortions will offer a protective effect against PE...
February 2024: Curēus
#3
REVIEW
Akitoshi Nakashima, Atsushi Furuta, Mihoko Yoshida-Kawaguchi, Kiyotaka Yamada, Haruka Nunomura, Keiko Morita, Ippei Yasuda, Satoshi Yoneda, Akemi Yamaki-Ushijima, Tomoko Shima, Sayaka Tsuda
Autophagy is a bulk degradation system that maintains cellular homeostasis by producing energy and/or recycling excess proteins. During early placentation, extravillous trophoblasts invade the decidua and uterine myometrium, facing maternal immune cells, which participate in the immune suppression of paternal and fetal antigens. Regulatory T cells will likely increase in response to a specific antigen before and during early pregnancy. Insufficient expansion of antigen-specific Treg cells, which possess the same T cell receptor, is associated with the pathophysiology of preeclampsia, suggesting sterile systemic inflammation...
March 2024: American Journal of Reproductive Immunology: AJRI
#4
JOURNAL ARTICLE
Heidi E Fjeldstad, Daniel P Jacobsen, Guro M Johnsen, Meryam Sugulle, Angel Chae, Sami B Kanaan, Hilary S Gammill, Anne Cathrine Staff
Fetal microchimerism (FMc) arises when fetal cells enter maternal circulation, potentially persisting for decades. Increased FMc is associated with fetal growth restriction, preeclampsia, and anti-angiogenic shift in placenta-associated proteins in diabetic and normotensive term pregnancies. The two-stage model of preeclampsia postulates that placental dysfunction causes such shift in placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFLt-1), triggering maternal vascular inflammation and endothelial dysfunction...
March 2024: Journal of Reproductive Immunology
#5
JOURNAL ARTICLE
Maria Carolina Borges, Gemma L Clayton, Rachel M Freathy, Janine F Felix, Alba Fernández-Sanlés, Ana Gonçalves Soares, Fanny Kilpi, Qian Yang, Rosemary R C McEachan, Rebecca C Richmond, Xueping Liu, Line Skotte, Amaia Irizar, Andrew T Hattersley, Barbara Bodinier, Denise M Scholtens, Ellen A Nohr, Tom A Bond, M Geoffrey Hayes, Jane West, Jessica Tyrrell, John Wright, Luigi Bouchard, Mario Murcia, Mariona Bustamante, Marc Chadeau-Hyam, Marjo-Riitta Jarvelin, Martine Vrijheid, Patrice Perron, Per Magnus, Romy Gaillard, Vincent W V Jaddoe, William L Lowe, Bjarke Feenstra, Marie-France Hivert, Thorkild I A Sørensen, Siri E Håberg, Sylvain Serbert, Maria Magnus, Deborah A Lawlor
BACKGROUND: Higher maternal pre-pregnancy body mass index (BMI) is associated with adverse pregnancy and perinatal outcomes. However, whether these associations are causal remains unclear. METHODS: We explored the relation of maternal pre-/early-pregnancy BMI with 20 pregnancy and perinatal outcomes by integrating evidence from three different approaches (i.e. multivariable regression, Mendelian randomisation, and paternal negative control analyses), including data from over 400,000 women...
January 29, 2024: BMC Medicine
#6
JOURNAL ARTICLE
Xin Li, Ting Luan, Chun Zhao, Xiufeng Ling
The objective was to analyze the effect of paternal body mass index (BMI) on maternal and child-health outcomes of singletons after frozen-thawed embryo transfer (FET) cycles. A retrospective cohort study was conducted between January 2019 and December 2021. Pregnancy, perinatal complications and neonatal outcomes were compared among different paternal BMI. Multivariate logistic regression was performed to evaluate the relationship between different paternal BMI and pregnancy, obstetric and neonatal outcomes...
December 2024: Human Fertility: Journal of the British Fertility Society
#7
JOURNAL ARTICLE
Sadia Farrukh, Saeeda Baig, Rubina Hussain, Rehan Imad, Ome Kulsoom, Mehreen Yousaf Rana
Telomere and telomerase genes (TERC and TERT) highlighted many novel genetic polymorphisms related to common diseases. This study explored the polymorphic alleles of TERC and TERT gene in parents-newborn (triad) and its association with telomere length (TL) and parental diseases (mother: Gestational Diabetes Mellitus (GDM), Preeclampsia, fathers: Diabetes, Hypertension). In this cross-sectional study, the blood samples (n = 612) were collected from parents-newborn triad (204 each) for TL (T/S ratio) quantification by using qPCR, and gene (TERC and TERT) polymorphism was detected by Sanger sequencing...
February 2024: Saudi Journal of Biological Sciences
#8
JOURNAL ARTICLE
Shaohua Yin, Yubo Zhou, Cheng Zhao, Jing Yang, Pengbo Yuan, Yangyu Zhao, Hongbo Qi, Yuan Wei
Maternal and paternal age at birth is increasing globally. Maternal age may affect perinatal outcomes, but the effect of paternal age and its joint effect with maternal age are not well established. This prospective, multicenter, cohort analysis used data from the University Hospital Advanced Age Pregnant Cohort Study in China from 2016 to 2021, to investigate the separate association of paternal age and joint association of paternal and maternal age with adverse perinatal outcomes. Of 16,114 singleton deliveries, mean paternal and maternal age (± SD) was 38...
January 8, 2024: Journal of Epidemiology and Global Health
#9
JOURNAL ARTICLE
Robin N Beaumont, Christopher Flatley, Marc Vaudel, Xiaoping Wu, Jing Chen, Gunn-Helen Moen, Line Skotte, Øyvind Helgeland, Pol Solé-Navais, Karina Banasik, Clara Albiñana, Justiina Ronkainen, João Fadista, Sara Elizabeth Stinson, Katerina Trajanoska, Carol A Wang, David Westergaard, Sundararajan Srinivasan, Carlos Sánchez-Soriano, Jose Ramon Bilbao, Catherine Allard, Marika Groleau, Teemu Kuulasmaa, Daniel J Leirer, Frédérique White, Pierre-Étienne Jacques, Haoxiang Cheng, Ke Hao, Ole A Andreassen, Bjørn Olav Åsvold, Mustafa Atalay, Laxmi Bhatta, Luigi Bouchard, Ben Michael Brumpton, Søren Brunak, Jonas Bybjerg-Grauholm, Cathrine Ebbing, Paul Elliott, Line Engelbrechtsen, Christian Erikstrup, Marisa Estarlich, Stephen Franks, Romy Gaillard, Frank Geller, Jakob Grove, David M Hougaard, Eero Kajantie, Camilla S Morgen, Ellen A Nohr, Mette Nyegaard, Colin N A Palmer, Ole Birger Pedersen, Fernando Rivadeneira, Sylvain Sebert, Beverley M Shields, Camilla Stoltenberg, Ida Surakka, Lise Wegner Thørner, Henrik Ullum, Marja Vaarasmaki, Bjarni J Vilhjalmsson, Cristen J Willer, Timo A Lakka, Dorte Gybel-Brask, Mariona Bustamante, Torben Hansen, Ewan R Pearson, Rebecca M Reynolds, Sisse R Ostrowski, Craig E Pennell, Vincent W V Jaddoe, Janine F Felix, Andrew T Hattersley, Mads Melbye, Deborah A Lawlor, Kristian Hveem, Thomas Werge, Henriette Svarre Nielsen, Per Magnus, David M Evans, Bo Jacobsson, Marjo-Riitta Järvelin, Ge Zhang, Marie-France Hivert, Stefan Johansson, Rachel M Freathy, Bjarke Feenstra, Pål R Njølstad
A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids...
October 5, 2023: Nature Genetics
#10
JOURNAL ARTICLE
Karin Fast, Elisabet Wentz, Josefine Roswall, Maxwell Strandberg, Stefan Bergman, Jovanna Dahlgren
AIM: To investigate the prevalence of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in a population-based birth cohort and correlate the findings with prenatal and perinatal factors. We hypothesized that children born preterm, having experienced preeclampsia or maternal overweight, would have an increased risk of ADHD or ASD. METHOD: A Swedish cohort of 2666 children (1350 males, 1316 females) has been followed from birth with parental and perinatal data...
September 22, 2023: Developmental Medicine and Child Neurology
#11
JOURNAL ARTICLE
Abiyot Wolie Asres, Abigiya Wondimagegnehu Tilahun, Adamu Addissie
PURPOSE: Little is known about the factors contributing to preeclampsia in Ethiopia. Therefore, this study was conducted to determine factors associated with preeclampsia among pregnant women in public hospitals. METHODS AND MATERIALS: An institution based unmatched case-control study was conducted. Women with preeclampsia were cases, and those without preeclampsia were controls. The study participants were selected using the consecutive sampling method with a case-to-control ratio of 1:2...
December 2023: Blood Pressure
#12
REVIEW
Habiba Ishmail, Olive Pearl Khaliq, Nnabuike Chibuoke Ngene
Racial disparities exist in the prevalence of preeclampsia (PE), with women of African ancestry suffering the highest rates of morbidity and mortality. Genetic changes may play a role in the preponderance of PE among women of African ancestry. This review discusses 30 genes with variants that have been studied in PE in women of African ancestry. These studies found that a single gene is not responsible for PE susceptibility as 13 genes have been implicated. These genes subserve endothelial, immune, hemodynamic, homeostatic, thrombophilic, oxidative stress, and lipid metabolic pathways...
August 25, 2023: Journal of Reproductive Immunology
#13
REVIEW
Ye Meng, Jinghua Liu, Chenxi Ji, Ruting Zhang, Zixiao Hua, Jing Chen, Haoqi Wang, Shan Wan, Shangshang Gao, Xiaoqin Yang
Preeclampsia remains enigmatic and responsible for vast maternal and fetal morbidity and mortality worldwide. Our objective was to assess the strength of the effect of the 14 bp deletion/insertion polymorphism in exon 8 of the 3'UTR region of the human leukocyte antigen-G (HLA-G) gene on preeclampsia risk across different populations. A systematic review by a meta-analysis was performed to summarize the scattered epidemiologic evidence, which remains inconclusive and controversial. A systematic literature search according to the PRISMA guidelines was conducted to screen relevant publications...
August 16, 2023: Journal of Reproductive Immunology
#14
JOURNAL ARTICLE
Yuhya Hirahara, Midori Yamaguchi, Kaoru Takase-Minegishi, Yohei Kirino, Shigeru Aoki, Lisa Hirahara, Soichiro Obata, Michi Kasai, Ayaka Maeda, Naomi Tsuchida, Ryusuke Yoshimi, Nobuyuki Horita, Hideaki Nakajima, Etsuko Miyagi
OBJECTIVE: The relationship between familial Mediterranean fever (FMF) and pregnancy outcomes remains unclear. This systematic review and meta-analysis aimed to clarify this association. METHODS: Electronic databases-the PubMed, Web of Science, Cochrane, and Embase-were searched on 20 December 2022, using specific search terms. Case-control, cohort, and randomised clinical trial studies comparing patients with FMF and healthy controls were considered eligible. We excluded systematic reviews, meta-analyses, case series with fewer than five cases, republished articles without new findings on pregnancy outcomes, studies targeting paternal FMF, and those not published in English...
August 18, 2023: Rheumatology
#15
JOURNAL ARTICLE
Sarah Inés Ramírez
Well-coordinated prenatal care that follows an evidence-based, informed process results in fewer hospital admissions, improved education, greater satisfaction, and lower pregnancy-associated morbidity and mortality. Care initiated at 10 weeks or earlier improves outcomes. Identification and treatment of periodontal disease decreases preterm delivery risk. A prepregnancy body mass index greater than 25 kg per m2 is associated with gestational diabetes mellitus, hypertension, miscarriage, and stillbirth. Advanced maternal and paternal age (35 years or older) is associated with gestational diabetes, hypertension, miscarriage, intrauterine growth restriction, aneuploidy, birth defects, and stillbirth...
August 2023: American Family Physician
#16
REVIEW
Shigeru Saito, Sayaka Tsuda, Akitoshi Nakashima
Preeclampsia is more common in nulliparous women, their first pregnancies with a new partner in multiparous women, pregnant women with short duration of cohabitation, and in pregnancies with donor eggs, where the fetus is completely foreign to the mother. The epidemiological study findings strongly suggest that inadequate induction of tolerance to paternal/fetal antigens is involved in the pathogenesis of preeclampsia. This review proposes that preeclampsia may be caused by a reduction in paternal/fetal antigen-specific regulatory T (Treg) cells and decreased PD-1 expression on clonally expanded CD8+ effector memory T (TEM ) cells, resulting in a breakdown of mother-to-fetus tolerance...
August 2, 2023: Journal of Reproductive Immunology
#17
JOURNAL ARTICLE
Lydia Baird, Ping Cannon, Manju Kandel, Tuong-Vi Nguyen, Anna Nguyen, Georgia Wong, Cíara Murphy, Fiona C Brownfoot, Elif Kadife, Natalie J Hannan, Stephen Tong, Lucy A Bartho, Tu'uhevaha J Kaitu'u-Lino
BACKGROUND: Preeclampsia is a severe complication of pregnancy which is attributed to placental dysfunction. The retrotransposon, Paternal Expressed Gene 10 (PEG10) harbours critical placental functions pertaining to placental trophoblast cells. Limited evidence exists on whether PEG10 is involved in preeclampsia pathogenesis. This study characterised the expression and regulation of PEG10 in placentas from patients with early-onset preeclampsia compared to gestation-matched controls...
July 18, 2023: Reproductive Biology and Endocrinology: RB&E
#18
JOURNAL ARTICLE
Natav Hendin, Raanan Meyer, Ravit Peretz-Machluf, Loren Elbaz, Ettie Maman, Micha Baum
OBJECTIVE: Evaluation of preeclampsia (PE) incidence among participants undergoing in vitro fertilization (IVF) after various cycles of sperm donation (SD) via intrauterine inseminations (IUI) or IVF. STUDY DESIGN: A retrospective case-control study was conducted at a single tertiary medical center between 2011 and 2019 which included participants who conceived via IVF using SD from a single sperm bank and had a successful singleton birth at Sheba Medical Center...
March 24, 2023: European Journal of Obstetrics, Gynecology, and Reproductive Biology
#19
REVIEW
Wilfried Gyselaers
The importance of uterine microvascular adaptations during placentation in pregnancy has been well established for decades. Inadequate dilatation of spiral arteries is associated with gestational complications, such as preeclampsia and/or intrauterine growth restriction. More recently, it has become clear that trophoblast cells invade and adapt decidual veins and lymphatic vessels 1 month before spiral arteries become patent and before intervillous space perfusion starts. Normal intervillous space hemodynamics is characterized by high volume flow at low velocity and pressure in the interseptal compartments surrounding the chorionic villi, hereby facilitating efficient maternal-fetal exchange...
June 2023: American Journal of Obstetrics and Gynecology
#20
REVIEW
Shigeru Saito
Regulatory T (Treg) cells play an important role in embryo implantation and pregnancy maintenance after allogeneic mating. Implantation failure, miscarriage, and preeclampsia are associated with decreased Treg cell numbers or dysfunctional Treg cells. Memory naturally occurring Treg (nTreg or thymus-derived Treg (tTreg)) cells were recently reported to accumulate in the uterus during the early pregnancy period and contribute to pregnancy establishment. Miscarriage cases are characterized by the downregulation of the total Treg cell numbers rather than the downregulation of paternal/fetal antigen-specific Treg cell numbers...
October 4, 2022: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
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