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Sperm and preeclampsia

Sarah A Robertson, David J Sharkey
Seminal fluid is often viewed as simply a vehicle to carry sperm to fertilize the oocyte, but a more complex function in influencing female reproductive physiology is now evident. Remarkably, seminal fluid contains soluble and exosome-born signaling agents that interact with the female reproductive tract to prime the immune response, with consequences for fertility and pregnancy outcome. Experiments in rodent models demonstrate a key role for seminal fluid in enabling robust embryo implantation and optimal placental development...
September 1, 2016: Fertility and Sterility
Greene Donald Royster, Kavitha Krishnamoorthy, John M Csokmay, Belinda J Yauger, Rebecca J Chason, Alan H DeCherney, Erin F Wolff, Micah J Hill
OBJECTIVE: To evaluate whether intracytoplasmic sperm injection (ICSI) use and E2 on the final day of assisted reproductive technology (ART) stimulation are associated with adverse obstetric complications related to placentation. DESIGN: Retrospective cohort study. SETTING: Large private ART practice. PATIENT(S): A total of 383 women who underwent ART resulting in a singleton live birth. INTERVENTION(S): None...
August 2016: Fertility and Sterility
Alexandra J Bensdorp, Chantal W Hukkelhoven, Fulco van der Veen, Ben W J Mol, Cornelis B Lambalk, Madelon van Wely
OBJECTIVE: To compare maternal and perinatal outcomes in dizygotic twin pregnancies conceived after medically assisted reproduction (MAR) with outcomes after natural conception (NC). DESIGN: Nationwide registry based study. SETTING: Academic medical center. PATIENT(S): Primiparous women who delivered opposite sex twins between January 2000 and December 2012 in the Netherlands, comprising dizygotic twin pregnancies: 6,694 women, 470 after ovulation induction (OI), 511 after intrauterine insemination with controlled ovarian hyperstimulation (IUI-COH), 2,437 after in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI), and 3,276 after NC...
August 2016: Fertility and Sterility
Brenda Valenzuela-Alcaraz, Fátima Crispi, Dolors Manau, Mónica Cruz-Lemini, Aina Borras, Juan Balasch, Eduard Gratacós
Objectives To examine perinatal outcomes in pregnancies conceived by different methods: fertile women with spontaneous pregnancies, infertile women who achieved pregnancy without treatment, pregnancies achieved by ovulation induction (OI) and in vitro fertilization or intra-cytoplasmic sperm injection (IVF/ICSI). Methods Retrospective single-center cohort study including 200 fertile and 748 infertile women stratified according to infertility treatment. The outcome measurements were preterm delivery (PTD), small-for-gestational-age (SGA), gestational diabetes, placenta previa or preeclampsia...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
Natalie Dayan, Andrea Lanes, Mark C Walker, Karen A Spitzer, Carl A Laskin
OBJECTIVE: To evaluate maternal and neonatal outcomes in women with chronic hypertension who conceive using assisted reproductive technologies (ART). DESIGN: Population-based retrospective cohort study. SETTING: Obstetric hospitals. PATIENT(S): Singleton pregnancies of at least 20 weeks' gestational age to women 18 years and older who delivered a live or stillborn infant between April 1, 2006, and March 31, 2012, categorized as exposed based on a diagnosis of chronic hypertension in the mother predating the index pregnancy...
April 2016: Fertility and Sterility
Asha R Rao, Karishma Dafle, G Padmashri, Damodar R Rao, N C Sivakumar
Partial/complete hydatidiform mole with coexisting fetus is a rare condition. Optimal management is a challenge that remains a dilemma since these pregnancies are associated with maternal as well as fetal complications including hemorrhage, preeclampsia, thromboembolic disease, intra uterine demise and increased risk of persistent trophoblastic disease. Here we report 2 cases of partial mole with live fetus after ICSI and a case of complete mole with coexisting fetus after ICSI in a turner mosaic that resulted in a live birth...
July 2015: Journal of Human Reproductive Sciences
Pierre-Yves Robillard, Gustaaf Dekker, Silvia Iacobelli, Gérard Chaouat
This workshop had four main objectives: (A) Trying to look at the preeclampsia (PE) problem "from the Space Shuttle": why preeclampsia has emerged in humans (a specific human reproductive feature among 4300 mammal species)? (B) Epidemiology: there are major geographical differences concerning early onset PE and late onset PE throughout the world. (C) Vascular: The very promising use of pravastatin in the treatment of the vascular maternal syndrome (based on the metabolism of carbon monoxide (CO), the role of inositol phosphate glycans P-type (IPG-P), a major role in comprehending the insulin resistance phenotype in preeclampsia...
April 2016: Journal of Reproductive Immunology
Erkan Kalafat, Mehmet Murat Seval, Batuhan Turgay, Acar Koç
Cell-free fetal DNA has received significant attention for the purposes of prenatal genetic testing in the past decade. Fetal DNA testing is a new method and promising for many applications such as aneuploidy screening, prenatal diagnosis, prediction of preeclampsia and more. A 37-year-old primigravida, with a pregnancy conceived by intracytoplasmic sperm injection (ICSI), was offered non-invasive prenatal testing (NIPT) due to advanced maternal age. NIPT performed at 23 weeks' gestation reported a diagnosis of monosomy X...
2015: BMJ Case Reports
Mireia González-Comadran, Julio Urresta Avila, Alejandro Saavedra Tascón, Radhanari Jimenéz, Ivan Solà, Mario Brassesco, Ramón Carreras, Miguel Ángel Checa
A systematic review and meta-analysis were performed to evaluate whether women who conceive with donor sperm have an increased risk of preeclampsia compared with those who use their partner's sperm. Studies that compared women who were impregnated by donor and partner sperm were included. The main outcomes assessed were preeclampsia and gestational hypertension rates. Altogether, 10,898 women (2342 pregnancies by donor sperm versus 8556 by the partner's sperm) were included from seven observational studies...
November 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Elena Moretti, Natale Figura, Giulia Collodel, Antonio Ponzetto
Helicobacter pylori (H. pylori) infection could be associated with extra-digestive diseases. Here, we report the evidences concerning the decrease in reproductive potential occurring in individuals infected by H. pylori, especially by strains expressing CagA. This infection is more prevalent in individuals with fertility disorders. Infected women have anti-H. pylori antibodies in cervical mucus and follicular fluid that may decrease sperm motility and cross react immunologically with spermatozoa, conceivably hampering the oocyte/sperm fusion...
May 21, 2014: World Journal of Gastroenterology: WJG
Burcuartunc Ulkumen, Dilekbenk Silfeler, Kenan Sofuoglu, Ibrahim Silfeler, Vedat Dayicioglu
OBJECTIVE: We aimed to evaluate the association between infertility etiology in ICSI pregnancies and preeclampsia; besides, we aimed to discuss the effect of the paternal factor in the pathogenesis of preeclampsia. HYPOTHESIS: We hypothesized that preeclampsia is more common in ICSI pregnancies with male factor. It is known that maternal exposure to paternal sperm cells over a time period has a protective effect against preeclampsia. Male partners with azospermia have no sperm cells in their seminal fluid, whose female partners will not be able to develop some protective immunity against preeclampsia...
January 2014: Pakistan Journal of Medical Sciences Quarterly
Elham Amirchaghmaghi, Seyed Abdolvahab Taghavi, Farnaz Shapouri, Shaghayegh Saeidi, Abbas Rezaei, Reza Aflatoonian
For many years, the innate immunity was of less interest than the adaptive immunity because it was perceived to have secondary importance in the functionality of the immune system. During the past decades, with the advancement of knowledge about innate immune system, interest in innate immunity has grown dramatically and thus its function has been extensively studied. Innate immunity plays fundamental roles in the initiation and induction of adaptive immune responses. It consists of several cells and receptors including natural killer (NK) cells, macrophages (MQs), dendritic cells (DCs) and pattern recognition receptors (PRRs)...
October 2013: International Journal of Fertility & Sterility
Nanette Okun, Sony Sierra
OBJECTIVE: To review the effect of assisted human reproduction (AHR) on perinatal outcomes, to identify areas requiring further research with regard to birth outcomes and AHR, and to provide guidelines to optimize obstetrical management and counselling of prospective Canadian parents. OUTCOMES: This document compares perinatal outcomes of different types of AHR pregnancies with each other and with those of spontaneously conceived pregnancies. Clinicians will be better informed about the adverse outcomes that have been documented in association with AHR, including obstetrical complications, adverse perinatal outcomes, multiple gestations, structural congenital abnormalities, chromosomal abnormalities, and imprinting disorders...
January 2014: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
H Kentenich, C Sibold, A Tandler-Schneider
Since the delivery of the first baby conceived via in vitro fertilization (IVF) in 1978, IVF has become a standard procedure in sterility treatment. In Germany, 78,000 IVF/intracytoplasmic sperm injection (ICSI) cycles are performed annually with a delivery rate per embryo transfer of about 20 %. The cumulative delivery rate after three trials is more than 50 %. The main medical problems are the high rates of multiple pregnancies of more than 20 %, which carry an increased risk for mothers (preeclampsia) and children (preterm delivery, lung immaturity, brain problems)...
December 2013: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
N Yoneda, A Shiozaki, K Miura, R Yonezawa, K Takemura, S Yoneda, H Masuzaki, S Saito
Partial hydatidiform mole with a normal fetus is extremely rare. A 30-year-old woman presented at 19 weeks gestation with clinical manifestations of severe preeclampsia. The fetus revealed a normal 46,XX karyotype and the placenta revealed triploid 69,XXX from paternal isodisomy. Microsatellite analysis revealed that the fetus and the triploid partial mole were derived from one sperm and one oocyte, followed by duplication of paternal chromosomes in only a trophectodermal cell. The maternal serum levels of angiogenic factors were extremely high compared with those reported in preeclampsia, suggesting an angiogenic imbalance may have caused preeclampsia-like symptoms before 20 weeks of gestation...
July 2013: Placenta
Sara S Malchau, Anne Loft, Elisabeth C Larsen, Anna-Karina Aaris Henningsen, Steen Rasmussen, Anders Nyboe Andersen, Anja Pinborg
OBJECTIVE: To describe perinatal outcomes in children born after oocyte donation (OD) compared with in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and spontaneous conception (SC). DESIGN: National cohort study. SETTING: Fertility clinics. PATIENT(S): Three hundred seventy-five children born after OD during the period 1995-2010. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Mean birth weight, mean gestational age, risks of low birth weight (LBW), preterm birth (PTB), congenital malformations, cesarean delivery, preeclampsia, and admittance to neonatal intensive care unit...
May 2013: Fertility and Sterility
Andrea L Tranquilli, Valentina Biondini, Solmas Talebi Chahvar, Alessandra Corradetti, Daniela Tranquilli, Stefano Giannubilo
OBJECTIVE: To assess the obstetric outcomes of pregnancy following intracytoplasmic sperm injection (ICSI) using donor oocytes. METHODS: Twenty-six deliveries from oocyte donor ICSI (d-ICSI) were compared to the next two consecutive deliveries from homologous ICSI (h-ICSI group) (n = 52) and with the two consecutive deliveries from women older than 40 years (Advanced Maternal Age: AMA) (n = 52). We evaluated the occurrence of gestational hypertension (GH), preeclampsia (PE), fetal growth restriction (IUGR), gestational diabetes mellitus (GDM), preterm premature rupture of membranes (pPROM), preterm birth, placental anomalies, mode of delivery, hemorrhage, gestational age at birth and birth weight...
September 2013: Journal of Maternal-fetal & Neonatal Medicine
Sinuhe Hahn, Stavros Giaglis, Irene Hoesli, Paul Hasler
The intention of this review is to provide an overview of the potential role of neutrophil extracellular traps (NETs) in mammalian reproduction. Neutrophil NETs appear to be involved in various stages of the reproductive cycle, starting with fertility and possibly ending with fetal loss. The first suggestion that NETs may play a role in pregnancy-related disorders was in preeclampsia, where vast numbers were detected in the intervillous space of affected placentae. The induction of NETosis involved an auto-inflammatory component, mediated by the increased release of placental micro-debris in preeclampsia...
2012: Frontiers in Immunology
Ursula Zollner, Johannes Dietl
Pregnancies that occur after infertility treatment, particularly after assisted reproduction, constitute high-risk pregnancies. Occurrences of conditions such as high blood pressure, preeclampsia, growth retardations and bleeding are higher in comparison with the norm of spontaneously entered pregnancies. The rate of premature births and the frequency of intrauterine deaths are much higher than the average for all pregnancies. Furthermore, pregnancies resulting from in - vitro fertilisation (IVF) have significantly higher rates of requiring induced labour or caesarean section...
January 2013: Journal of Perinatal Medicine
Ashok Agarwal, Anamar Aponte-Mellado, Beena J Premkumar, Amani Shaman, Sajal Gupta
Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females. The adverse effects of OS on sperm quality and functions have been well documented. In females, on the other hand, the impact of OS on oocytes and reproductive functions remains unclear. This imbalance between pro-oxidants and antioxidants can lead to a number of reproductive diseases such as endometriosis, polycystic ovary syndrome (PCOS), and unexplained infertility...
2012: Reproductive Biology and Endocrinology: RB&E
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