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https://www.readbyqxmd.com/read/27713124/neutrophilia-in-locally-advanced-cervical-cancer-a-novel-biomarker-for-image-guided-adaptive-brachytherapy
#1
Alexandre Escande, Christine Haie-Meder, Pierre Maroun, Sébastien Gouy, Renaud Mazeron, Thomas Leroy, Enrica Bentivegna, Philippe Morice, Eric Deutsch, Cyrus Chargari
OBJECTIVE: To study the prognostic value of leucocyte disorders in a prospective cohort of cervical cancer patients receiving definitive chemoradiation plus image-guided adaptive brachytherapy (IGABT). RESULTS: 113 patients were identified. All patients received a pelvic irradiation concomitant with chemotherapy, extended to the para-aortic area in 13 patients with IVB disease. Neutrophilia and leukocytosis were significant univariate prognostic factors for poorer local failure-free survival (p = 0...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27623508/immunotherapy-in-head-and-neck-cancer-harnessing-profit-on-a-system-disruption
#2
REVIEW
Chloé Rancoule, Alexis Vallard, Sophie Espenel, Jean-Baptiste Guy, Yaoxiong Xia, Anis El Meddeb Hamrouni, Claire Rodriguez-Lafrasse, Cyrus Chargari, Eric Deutsch, Nicolas Magné
Immune system deregulation and evasion play a key role in cancers' evolution and progression, including squamous cell carcinoma of the head and neck (SCCHN). Development of basic research proposed a whole new vision of cancer treatment, based on a strong biological rational, and targeting intrinsic deregulations. Immunotherapies provide an encouraging strategy for patients' improved outcomes. Immune-based therapies could act on cancer growth and/or development throughout many pathways. If cetuximab is for now the only monoclonal antibody approved for SCCHN management, other strategies, e...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27614680/preoperative-image-guided-brachytherapy-in-early-stage-cervical-cancers
#3
Alexandre Escande, Renaud Mazeron, Sebastien Gouy, Enrica Bentivegna, Pierre Maroun, Georges Fahra, Anne-Sophie Oberlander, Isabelle Dumas, Pauline Castelnau-Marchand, Eric Deutsch, Philippe Morice, Christine Haie-Meder, Cyrus Chargari
OBJECTIVE: To examine the clinical results of a preoperative image-guided pulse-dose-rate brachytherapy (PDR-BT) in early stage cervical cancer. MATERIALS/METHODS: We examined the outcome of consecutive patients with early stage cervical cancer undergoing preoperative image-guided PDR-BT between 2004 and 2013 because of risk factors (lymphovascular embols and/or tumour>2cm). The objective was to deliver 60Gy to 100% of the intermediate risk clinical target volume...
September 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27530648/impact-of-primary-para-aortic-lymphadenectomy-on-distant-failure-in-locally-advanced-cervical-cancer-patients-treated-in-the-era-of-image-guided-adaptive-brachytherapy
#4
Cyrus Chargari, Renaud Mazeron, Ariane Dunant, Sébastien Gouy, Claire Petit, Pierre Maroun, Catherine Uzan, Pierre Annede, Enrica Bentivegna, Corinne Balleyguier, Catherine Genestie, Patricia Pautier, Alexandra Leary, Catherine Lhomme, Eric Deutsch, Philippe Morice, Christine Haie-Meder
To investigate the impact of a primary para-aortic lymphadenectomy (PAL) in locally advanced cervical cancer patients receiving definitive chemoradiation, we reviewed the clinical records of consecutive patients treated in our Institution and receiving an external beam irradiation followed with an image-guided adaptive brachytherapy for a locally advanced cervical cancer. We examined the impact of performing a primary PAL as part of primary staging for guiding irradiation fields in patients without extra-pelvic PET uptake...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27492204/post-radiation-hysterectomy-in-locally-advanced-cervical-cancer-outcomes-and-dosimetric-impact
#5
Renaud Mazeron, Sébastien Gouy, Cyrus Chargari, Eleonor Rivin Del Campo, Isabelle Dumas, Augustin Mervoyer, Catherine Genestie, Enrica Bentivegna, Corinne Balleyguier, Patricia Pautier, Philippe Morice, Christine Haie-Meder
PURPOSES: Firstly, to evaluate the impact of completion hysterectomy after chemoradiation and image-guided adaptive brachytherapy (IGABT) in locally advanced cervical cancer. Secondly, to assess a potential differential dose-effect relationship for the rectum and bladder according to the realization of hysterectomy. MATERIAL AND METHODS: Two cohorts of patients were identified, differing by the realization of completion hysterectomy. Inclusions were limited to FIGO stage I-II, with no para-aortic involvement...
September 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27430207/fertility-results-and-pregnancy-outcomes-after-conservative-treatment-of-cervical-cancer-a-systematic-review-of-the-literature
#6
Enrica Bentivegna, Amandine Maulard, Patricia Pautier, Cyrus Chargari, Sebastien Gouy, Philippe Morice
OBJECTIVES: To evaluate the fertility results, obstetric outcomes, and the management of infertility in patients submitted to fertility-sparing surgery (FSS) for invasive cervical cancer. DESIGN: Systematic review. SETTING: Not applicable. PATIENT(S): Patients submitted to FSS for invasive cervical cancer (stage IB). INTERVENTION(S): Five different FSS procedures were studied. MAIN OUTCOMES MEASURE(S): Fertility, pregnancy outcomes, and management of infertility...
July 15, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27379688/image-guided-adaptive-brachytherapy-in-locally-advanced-cervical-cancer-recent-advances-and-perspectives
#7
Pauline Castelnau-Marchand, Cyrus Chargari, Christine Haie-Meder, Renaud Mazeron
PURPOSE OF REVIEW: Image-guided adaptive brachytherapy (IGABT) is a high-precision radiation that allows defining accurately treatment targets and optimizing their coverage whereas sparing efficiently the surrounding organs at risk. Ten years ago, in a will of harmonizing the reporting of brachytherapy, the Groupe Européen de Curiethérapie - European Society for Radiation Oncology (GEC-ESTRO) published recommendations on target definitions and dosimetric parameters. During the last years, clinical and dosimetric studies supporting their relevance led the International Commission on Radiation Units and Measurements to propose a report on prescribing and reporting...
September 2016: Current Opinion in Oncology
https://www.readbyqxmd.com/read/27371991/tumor-dose-volume-response-in-image-guided-adaptive-brachytherapy-for-cervical-cancer-a-meta-regression-analysis
#8
Renaud Mazeron, Pauline Castelnau-Marchand, Alexandre Escande, Eleonor Rivin Del Campo, Pierre Maroun, Dimitri Lefkopoulos, Cyrus Chargari, Christine Haie-Meder
PURPOSE: Image-guided adaptive brachytherapy is a high precision technique that allows dose escalation and adaptation to tumor response. Two monocentric studies reported continuous dose-volume response relationships, however, burdened by large confidence intervals. The aim was to refine these estimations by performing a meta-regression analysis based on published series. METHODS AND MATERIALS: Eligibility was limited to series reporting dosimetric parameters according to the Groupe Européen de Curiethérapie-European SocieTy for Radiation Oncology recommendations...
September 2016: Brachytherapy
https://www.readbyqxmd.com/read/27308857/brachytherapy-and-fertility
#9
Alexander Tuan Falk, Cyrus Chargari, Jean-Michel Hannoun-Lévi, Caroline Adrados, Julie Antomarchi, Jean-Baptiste Guy, Renaud Mazeron, Christine Haie-Meder, Nicolas Magné
Fertility is a major part of the global care of patients treated for cancer. A new discipline known as oncofertility has emerged in some countries. Although the relationship between chemotherapy and external radiotherapy and fertility has been studied and reported, there is only scarce data available on brachytherapy. This systematic review aims to report available knowledge on the impact of brachytherapy on fertility. Specific consultations should be considered before brachytherapy to inform patients about their fertility preservation options...
June 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27299280/oncological-outcomes-after-fertility-sparing-surgery-for-cervical-cancer-a-systematic-review
#10
REVIEW
Enrica Bentivegna, Sebastien Gouy, Amandine Maulard, Cyrus Chargari, Alexandra Leary, Philippe Morice
Fertility preservation in young patients with cervical cancer is suitable only for patients with good prognostic factors and disease amenable to surgery without adjuvant therapy. Consequently, it is only offered to patients with early-stage disease (stage IB tumours <4 cm), negative nodes, and non-aggressive histological subtypes. To determine whether fertility preservation is suitable, the first step is pelvic-node dissection to establish nodal spread. Tumour size (≤2 cm vs >2 cm) and lymphovascular space invasion status are two main factors to determine the best fertility-sparing surgical technique...
June 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27200491/can-immunostimulatory-agents-enhance-the-abscopal-effect-of-radiotherapy
#11
REVIEW
Antonin Levy, Cyrus Chargari, Aurelien Marabelle, Jean-Luc Perfettini, Nicolas Magné, Eric Deutsch
Ionising radiation (IR) may harm cancer cells through a rare indirect out-of-field phenomenon described as the abscopal effect. Increasing evidence demonstrates that radiotherapy could be capable of generating tumour-specific immune responses. On the other hand, effects of IR also include inhibitory immune signals on the tumour microenvironment. Following these observations, and in the context of newly available immunostimulatory agents in metastatic cancers (anti-cytotoxic T lymphocyte-associated antigen 4 and programmed cell death protein-1 or -ligand 1 [PD1 or PDL-1]), there is a remarkable potential for synergistic combinations of IR with such agents that act through the reactivation of immune surveillance...
July 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27181759/-prognosis-prediction-of-febrile-neutropenia-by-mascc-score-a-retrospective-study
#12
Louise Cervetti, Alexis Vallard, Sylvestre Le Moulec, Sophie Espenel, Alexander Tuan Falk, Majed Ben Mrad, Jean-Baptiste Guy, Peng Diao, Benoîte Méry, Julien Langrand-Escure, François-Régis Ferrand, Romain Rivoirard, Bernard Ceccaldi, Lionel Védrine, Nicolas Magné, Cyrus Chargari
INTRODUCTION: The score of the MASCC, by means of clinical criteria, estimates the risk of serious complications in patients with neutropenic fever induced by chemotherapy. METHODS: We retrospectively studied a cohort of patients hospitalized for a neutropenic fever and analyzed complications according to the criteria defined by the MASCC. RESULTS: Eighty-one neutropenic fevers in 71 patients were identified. Microbiological documentation was obtained in 33% of cases only...
June 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27180130/mri-guided-brachytherapy-in-locally-advanced-cervical-cancer-small-bowel-formula-see-text-and-formula-see-text-are-not-predictive-of-late-morbidity
#13
Claire Petit, Isabelle Dumas, Cyrus Chargari, Florent Martinetti, Pierre Maroun, Kaya Doyeux, Anne Tailleur, Christine Haie-Meder, Renaud Mazeron
PURPOSE: To establish dose-volume effect correlations for late small bowel (SB) toxicities in patients treated for locally advanced cervical cancer with concomitant chemoradiation followed by pulsed-dose rate MRI-guided adaptive brachytherapy. METHODS AND MATERIALS: Patients treated with curative intent and followed prospectively were included. The SB loops closed to CTV were delineated, but no specific dose constraint was applied. The dosimetric data, converted in 2-Gy equivalent, were confronted with the occurrence of late morbidity assessed using the CTC-AE 3...
July 2016: Brachytherapy
https://www.readbyqxmd.com/read/27180129/image-guided-adaptive-brachytherapy-in-cervical-cancer-patterns-of-relapse-by-brachytherapy-planning-parameters
#14
Cyrus Chargari, Renaud Mazeron, Alexandre Escande, Pierre Maroun, Isabelle Dumas, Florent Martinetti, Alain Tafo-Guemnie, Eric Deutsch, Philippe Morice, Christine Haie-Meder
PURPOSE: Cervical cancer patients with a bulky high-risk clinical target volume (HR-CTV) get the largest benefit of dose escalation in terms of local control. However, the expected survival benefit could be lessened by a higher metastatic risk. We examined the patterns of relapse according to major prognostic factors: the HR-CTV volume and to the D90 HR-CTV. METHODS AND MATERIALS: The clinical records of patients treated with pulsed-dose-rate image-guided adaptive brachytherapy after concurrent pelvic chemoradiation were reviewed...
July 2016: Brachytherapy
https://www.readbyqxmd.com/read/27057742/clinical-impact-of-bevacizumab-in-patients-with-relapsed-glioblastoma-focus-on-a-real-life-monocentric-survey-sv1-study
#15
Romain Rivoirard, Cyrus Chargari, Jean-Baptiste Guy, Christophe Nuti, Michel Peoc'h, Fabien Forest, Alexander Tuan Falk, Clemence Garin, Anissa Adjabi, Delphine Hoarau, Marie-Jeannette Fotso, Julien Langrand Escure, Guillaume Moriceau, Pierre Fournel, Claire Boutet, Nicolas Magné
OBJECTIVES: Glioblastoma is one of the most frequent primitive brain tumors. Patients who experience tumor relapse after surgery and concomitant radiochemotherapy have a dismal prognosis. The objective of this study is to analyze efficacy data in terms of overall survival (OS) and progression- free survival (PFS) following combination therapy with bevacizumab (BVZ) and irinotecan among patients with relapsed glioblastoma. Safety data will also be reviewed and all results will be compared with data of the literature...
2016: Chemotherapy
https://www.readbyqxmd.com/read/27045782/safety-assessment-of-molecular-targeted-therapies-in-association-with-radiotherapy-in-metastatic-renal-cell-carcinoma-a-real-life-report
#16
Julien Langrand-Escure, Alexis Vallard, Romain Rivoirard, Benoîte Méry, Jean-Baptiste Guy, Sophie Espenel, Jane-Chloé Trone, Majed Ben Mrad, Peng Diao, Chloé Rancoule, Jean-Philippe Suchaud, Pierre Fournel, Aline Guillot, Cyrus Chargari, Bernard Escudier, Sylvie Négrier, Nicolas Magné
Molecular targeted therapies (TT) are the cornerstone of metastatic renal cell carcinoma (RCC) treatment. There is a paucity of data on the safety of the radiotherapy (RT)-TT association in a sequential or a concomitant setting. The aim of the present study is to retrospectively assess the safety of the RT-TT association. From 2006 to 2014, data from 84 consecutive patients treated with RT and TT for metastatic RCC were retrospectively collected. RT-TT sequential and concomitant associations were, respectively, defined by a time interval of more than five TT half-lives and less than or equal to five TT half-lives between the last TT administration and RT initiation...
June 2016: Anti-cancer Drugs
https://www.readbyqxmd.com/read/27016411/phase-i-trial-evaluating-the-antiviral-agent-cidofovir-in-combination-with-chemoradiation-in-cervical-cancer-patients
#17
Eric Deutsch, Christine Haie-Meder, Mohamed Amine Bayar, Michele Mondini, Mélanie Laporte, Renaud Mazeron, Julien Adam, Andrea Varga, Gilles Vassal, Nicolas Magné, Cyrus Chargari, Emilie Lanoy, Patricia Pautier, Antonin Levy, Jean-Charles Soria
PURPOSE: This phase I trial aimed to assess the safety and determine the recommended Phase II dose (RP2D) of Cidofovir combined with chemoradiotherapy in patients with stage IB2-IVA cervical cancer. EXPERIMENTAL DESIGN: Incremental doses (1, 2.5, 5 and 6.5 mg/kg) of IV Cidofovir were administered weekly for two weeks, and then every 2 weeks from the start of chemoradiotherapy to the initiation of utero-vaginal brachytherapy. Biological expression of HPV was analyzed during treatment and tumor response was assessed according to RECIST v1...
May 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/26987625/nanoparticles-in-radiation-oncology-from-bench-side-to-bedside
#18
REVIEW
Chloé Rancoule, Nicolas Magné, Alexis Vallard, Jean-Baptiste Guy, Claire Rodriguez-Lafrasse, Eric Deutsch, Cyrus Chargari
Nanoparticles (NP) are "in vogue" in medical research. Pre-clinical studies accumulate evidence of NP enhancing radiation therapy. On one hand, NP, selected for their intrinsic physicochemical characteristics, are radio-sensitizers. Thus, when NP accumulate in cancer cells, they increase the radiation absorption coefficient specifically in tumour tissue, sparing healthy surrounding tissue from toxicity. On the other hand, NP, by being drug vectors, can carry radio-sensitizer therapeutics to cancer cells. Finally, NP present theranostic effects...
June 1, 2016: Cancer Letters
https://www.readbyqxmd.com/read/26986027/optimize-and-refine-therapeutic-index-in-radiation-therapy-overview-of-a-century
#19
REVIEW
Cyrus Chargari, Nicolas Magne, Jean-Baptiste Guy, Chloé Rancoule, Antonin Levy, Karyn A Goodman, Eric Deutsch
In 1936, Holthusen theorized the probability of achieving tumor control and of developing normal tissue complications after radiotherapy as a function of radiation dose. This concept was formalized and further developed in 1975. Several concepts for improving the therapeutic gain had been anticipated, including the possibility of modulating the tumor/normal tissue differential response. Eight decades later, it is possible to review and analyze progress achieved in the knowledge of radiation-induced toxicity...
April 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/26970966/risk-of-second-cancers-in-the-era-of-modern-radiation-therapy-does-the-risk-benefit-analysis-overcome-theoretical-models
#20
Cyrus Chargari, Karyn A Goodman, Ibrahima Diallo, Jean-Baptiste Guy, Chloe Rancoule, Jean-Marc Cosset, Eric Deutsch, Nicolas Magne
In the era of modern radiation therapy, the compromise between the reductions in deterministic radiation-induced toxicities through highly conformal devices may be impacting the stochastic risk of second malignancies. We reviewed the clinical literature and evolving theoretical models evaluating the impact of intensity-modulated radiation therapy (IMRT) on the risk of second cancers, as a consequence of the increase in volumes of normal tissues receiving low doses. The risk increase (if any) is not as high as theoretical models have predicted in adults...
June 2016: Cancer Metastasis Reviews
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