keyword
MENU ▼
Read by QxMD icon Read
search

Hiv exposed non infected children

keyword
https://www.readbyqxmd.com/read/27856673/associations-of-memory-and-executive-functioning-with-academic-and-adaptive-functioning-among-youth-with-perinatal-hiv-exposure-and-or-infection
#1
Patricia A Sirois, Miriam C Chernoff, Kathleen M Malee, Patricia A Garvie, Lynnette L Harris, Paige L Williams, Steven P Woods, Molly L Nozyce, Betsy L Kammerer, Cenk Yildirim, Sharon L Nichols
BACKGROUND: Perinatally acquired HIV (PHIV) confers risk for neurocognitive impairment, which potentially affects school performance and functional independence of infected children. In this study, we examined the associations of 2 key neurocognitive domains, memory and executive function (EF), with academic and adaptive skills among youth with PHIV and perinatally HIV-exposed but uninfected (PHEU) youth. METHODS: Participants ages 9 to <19 years enrolled in the Pediatric HIV/AIDS Cohort Study's Memory and Executive Functioning Study completed standardized measures of reading and math...
December 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27856672/executive-functioning-in-children-and-adolescents-with-perinatal-hiv-infection-and-perinatal-hiv-exposure
#2
Sharon L Nichols, Miriam C Chernoff, Kathleen M Malee, Patricia A Sirois, Steven P Woods, Paige L Williams, Cenk Yildirim, Dean Delis, Betsy Kammerer
BACKGROUND: Executive functions (EFs) are critical for management of life activities, but few studies have evaluated EFs in children and adolescents with perinatally acquired HIV (PHIV), who are at risk for problems in academics, behavior, and medication adherence. We compared EFs in youth with PHIV and in perinatally HIV-exposed but uninfected (PHEU) youth. METHODS: Four Delis-Kaplan Executive Function System (D-KEFS) subtests were administered to 173 youth with PHIV and 85 PHEU youth, aged 9 to <19 years, who were enrolled in the Pediatric HIV/AIDS Cohort Study (PHACS) Memory and Executive Functioning Study...
December 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27836020/high-levels-of-pre-treatment-hiv-drug-resistance-and-treatment-failure-in-nigerian-children
#3
Ragna S Boerma, T Sonia Boender, Kim C E Sigaloff, Tobias F Rinke de Wit, Michael Boele van Hensbroek, Nicaise Ndembi, Titilope Adeyemo, Edamisan O Temiye, Akin Osibogun, Pascale Ondoa, Job C Calis, Alani Sulaimon Akanmu
INTRODUCTION: Pre-treatment HIV drug resistance (PDR) is an increasing problem in sub-Saharan Africa. Children are an especially vulnerable population to develop PDR given that paediatric second-line treatment options are limited. Although monitoring of PDR is important, data on the paediatric prevalence in sub-Saharan Africa and its consequences for treatment outcomes are scarce. We designed a prospective paediatric cohort study to document the prevalence of PDR and its effect on subsequent treatment failure in Nigeria, the country with the second highest number of HIV-infected children in the world...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27798548/growth-at-two-years-of-age-in-hiv-exposed-uninfected-children-in-the-us-by-trimester-of-maternal-antiretroviral-initiation
#4
Denise L Jacobson, Kunjal Patel, Paige L Williams, Mitchell E Geffner, George K Siberry, Linda A Dimeglio, Marilyn J Crain, Ayesha Mirza, Janet S Chen, Elizabeth McFarland, Deborah Kacanek, Margarita Silio, Kenneth Rich, William Borkowsky, Russell B Van Dyke, Tracie L Miller
BACKGROUND: Abnormal childhood growth may affect future health. Maternal tenofovir (TFV) use was associated with lower body length and head circumference at one year of age in HIV-exposed uninfected (HEU) US children. METHODS: We studied 509 HEU children in the US-based Surveillance Monitoring of ART Toxicities cohort whose HIV-infected mothers were not using antiretrovirals at the last menstrual period and began combination antiretroviral therapy (cART) in pregnancy (cART-initiators)...
October 27, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27676257/pre-exposure-prophylaxis-use-by-breastfeeding-hiv-uninfected-women-a-prospective-short-term-study-of-antiretroviral-excretion-in-breast-milk-and-infant-absorption
#5
Kenneth K Mugwanya, Craig W Hendrix, Nelly R Mugo, Mark Marzinke, Elly T Katabira, Kenneth Ngure, Nulu B Semiyaga, Grace John-Stewart, Timothy R Muwonge, Gabriel Muthuri, Andy Stergachis, Connie L Celum, Jared M Baeten
BACKGROUND: As pre-exposure prophylaxis (PrEP) becomes more widely used in heterosexual populations, an important consideration is its safety in infants who are breastfed by women taking PrEP. We investigated whether tenofovir and emtricitabine are excreted into breast milk and then absorbed by the breastfeeding infant in clinically significant concentrations when used as PrEP by lactating women. METHODS AND FINDINGS: We conducted a prospective short-term, open-label study of daily oral emtricitabine-tenofovir disoproxil fumarate PrEP among 50 HIV-uninfected breastfeeding African mother-infant pairs between 1-24 wk postpartum (ClinicalTrials...
September 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27599655/rethinking-the-risk-benefit-ratio-of-efavirenz-in-hiv-infected-children
#6
REVIEW
Lisa Van de Wijer, Arnt F A Schellekens, David M Burger, Judith R Homberg, Quirijn de Mast, Andre J A M van der Ven
The non-nucleoside reverse transcriptase inhibitor efavirenz is part of the WHO guidelines for preferred first-line treatment of HIV-1-infected adults, pregnant and lactating women, and children. Efavirenz is well known to cause CNS toxicity. Although good data for CNS toxicity are available for adults, the opposite is true for children. Paediatric studies on this topic frequently suffer from small sample sizes or absence of thorough neuropsychiatric assessments. In this Personal View, we focus on two knowledge gaps of CNS toxicity of efavirenz in children...
May 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27595698/the-aetiology-of-diarrhoea-pneumonia-and-respiratory-colonization-of-hiv-exposed-infants-randomized-to-breast-or-formula-feeding
#7
Rebecca M Zash, Roger L Shapiro, Jean Leidner, Carolyn Wester, Alexander J McAdam, Richard L Hodinka, Ibou Thior, Claire Moffat, Joseph Makhema, Kenneth McIntosh, Max Essex, Shahin Lockman
BACKGROUND: Diarrhoea and pneumonia are common causes of childhood death in sub-Saharan Africa but there are few studies describing specific pathogens. OBJECTIVES: The study aimed to describe the pathogens associated with diarrhoea, pneumonia and oropharyngeal colonization in children born to HIV-infected women (HIV-exposed infants). METHODS: The Mashi Study randomized 1200 HIV-infected women and their infants to breastfeed for 6 months with ZDV prophylaxis or formula-feed with 4 weeks of ZDV...
August 2016: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/27406638/randomised-controlled-trial-testing-the-effect-of-cotrimoxazole-prophylaxis-on-morbidity-and-mortality-outcomes-in-breastfed-hiv-exposed-uninfected-infants-study-protocol
#8
Anna Coutsoudis, Brodie Daniels, Eshia Moodley-Govender, Noluthando Ngomane, Linda Zako, Elizabeth Spooner, Photini Kiepiela, Shabashini Reddy, Louise Kuhn, Gita Ramjee
INTRODUCTION: No randomised controlled trial (RCT) has examined the efficacy of cotrimoxazole (CTX) prophylaxis in HIV-exposed uninfected (HEU) infants during the breastfeeding period, in this new era of effective prevention of mother-to-child transmission (PMTCT) prophylaxis. The efficacy of CTX prophylaxis has presently been demonstrated only in HIV-infected children. The absence of proven benefits in HEU breastfed infants associated with infectious diseases justifies an RCT as proposed...
2016: BMJ Open
https://www.readbyqxmd.com/read/27077612/the-aetiology-of-diarrhoea-pneumonia-and-respiratory-colonization-of-hiv-exposed-infants-randomized-to-breast-or-formula-feeding
#9
Rebecca M Zash, Roger L Shapiro, Jean Leidner, Carolyn Wester, Alexander J McAdam, Richard L Hodinka, Ibou Thior, Claire Moffat, Joseph Makhema, Kenneth McIntosh, Max Essex, Shahin Lockman
BACKGROUND: Diarrhoea and pneumonia are common causes of childhood death in sub-Saharan Africa but there are few studies describing specific pathogens. OBJECTIVES: The study aimed to describe the pathogens associated with diarrhoea, pneumonia and oropharyngeal colonization in children born to HIV-infected women (HIV-exposed infants). METHODS: The Mashi Study randomized 1200 HIV-infected women and their infants to breastfeed for 6 months with ZDV prophylaxis or formula-feed with 4 weeks of ZDV...
January 29, 2016: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/27015798/missed-opportunities-of-inclusion-in-a-cohort-of-hiv-infected-children-to-initiate-antiretroviral-treatment-before-the-age-of-two-in-west-africa-2011-to-2013
#10
Désiré L Dahourou, Madeleine Amorissani-Folquet, Malik Coulibaly, Divine Avit-Edi, Nicolas Meda, Marguerite Timite-Konan, Vic Arendt, Diarra Ye, Clarisse Amani-Bosse, Roger Salamon, Philippe Lepage, Valériane Leroy
INTRODUCTION: The World Health Organization (WHO) 2010 guidelines recommended to treat all HIV-infected children less than two years of age. We described the inclusion process and its correlates of HIV-infected children initiated on early antiretroviral therapy (EART) at less than two years of age in Abidjan, Côte d'Ivoire, and Ouagadougou, Burkina Faso. METHODS: All children with HIV-1 infection confirmed with a DNA PCR test of a blood sample, aged less than two years, living at a distance less than two hours from the centres and whose parents (or mother if she was the only legal guardian or the legal caregiver if parents were not alive) agreed to participate in the MONOD ANRS 12206 project were included in a cohort to receive EART based on lopinavir/r...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/26979496/the-enduring-impact-of-violence-against-children
#11
Susan D Hillis, James A Mercy, Janet R Saul
More than one billion children - half of all children in the world - are exposed to violence every year. The violence children are exposed to includes both direct experiences of physical, sexual, and emotional abuse, as well as indirectly witnessing violence in their homes, schools, and communities. What these various forms of violence share, based on a review of the literature, is their enduring potential for life-long consequences. These consequences include increases in the risks of injury, HIV, sexually transmitted infections, mental health problems, reproductive health problems, and non-communicable diseases, including cardiovascular disease, cancer, chronic lung disease, and diabetes...
March 16, 2016: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/26967812/learning-and-memory-in-children-and-adolescents-with-perinatal-hiv-infection-and-perinatal-hiv-exposure
#12
Sharon L Nichols, Miriam C Chernoff, Kathleen Malee, Patricia A Sirois, Paige L Williams, Veronica Figueroa, Steven P Woods
BACKGROUND: Learning and memory in youth with perinatally acquired HIV (PHIV) are poorly understood, despite their importance for academic, healthcare and daily functioning. METHODS: PHIV (n = 173) and perinatally HIV-exposed but uninfected (PHEU, n = 85) participants (aged 9-19 years) in a substudy of the Pediatric HIV/AIDS Cohort Study completed age-standardized tests of verbal and visual learning and delayed memory. Linear regression models implemented via generalized estimating equations were used to compare memory measures in PHEU participants versus PHIV youth with and without Centers for Disease Control and Prevention class C diagnosis (PHIV-C, n = 45 and PHIV-non-C, n = 128, respectively), adjusting for sociodemographic covariates...
June 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26954689/safety-profile-of-the-10-valent-pneumococcal-non-typeable-haemophilus-influenzae-protein-d-conjugate-vaccine-phid-cv
#13
Sven Arne Silfverdal, Vanessa Coremans, Nancy François, Dorota Borys, Jan Cleerbout
Safety and reactogenicity data were reviewed following 10 years of experience with the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in clinical development and from post-licensure settings. Analyses of pooled clinical trial data and post-marketing reports provided an overview of its safety profile and allowed assessment of rare adverse events that might not have been identified previously. The safety of PHiD-CV was also evaluated in children at higher risk for pneumococcal infection (preterm and HIV-infected or HIV-exposed infants), for different vaccination schedules and co-administered pediatric vaccines, and with a focus on special categories of adverse events (febrile convulsions, apnea, Kawasaki disease and sudden deaths)...
March 8, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/26474709/executive-summary-of-the-consensus-document-on-post-exposure-prophylaxis-against-hiv-hbv-and-hcv-in-adults-and-children
#14
Rosa Polo Rodriguez, Fernando Lozano, Pedro González de Castro, Ma Alonso Jiménez, Oscar Miró, Jose Ramón Blanco, David Moreno, Carlos Dueñas, Enriqueta Muñoz Platón, Marina Fernández Escribano, Jesús Sanz Sanz, Carmina Fumaz, Ignacio Santos, Federico García, Ma Jesús Téllez, Raúl González Montero, Ma Victoria Vals Jimenez, Juan Emilio Losa, Ma Luisa Valle Robles, Jose Antonio Iribarren, Enrique Ortega
Post-exposure prophylaxis (PEP) can be a secondary measure to prevent infection by human immunodeficiency virus (HIV) when primary prevention has failed. PEP is advised for people with sporadic and exceptional risk exposure to HIV. This consensus document about occupational and non-occupational PEP recommendations aims to be a technical document for healthcare professionals. Its main objective is to facilitate the appropriate use of PEP. To this end, some recommendations have been established to assess the risk of transmission in different types of exposure, situations where PEP should be recommended, special circumstances to take into account, antiretroviral (ARV) guidelines including start and end of the treatment, early monitoring of tolerance and adherence to the treatment, subsequent monitoring of people exposed, independently of having received PEP or not, and need of psychological support...
February 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/26319052/antiretroviral-treatment-and-resistance-patterns-in-hiv-infected-children
#15
Olatunji Adetokunboh, Oluyemi Atibioke, Tolulope Balogun, Mojisola Oluwasanu
Paediatric HIV-infected patients have higher risk of developing resistance to antiretroviral drugs, and from public health perspective, drug resistance remains a limiting factor for effective management of HIV infection in children. We reviewed the current evidences available on the antiretroviral treatment and resistance patterns in HIV-infected children. Prevalence of HIV drug resistance varied among the three main classes of antiretroviral drugs, namely nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and protease inhibitors in both treatment naïve and treatment-experienced children in different countries...
October 2015: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/26259542/delayed-bcg-vaccination-results-in-minimal-alterations-in-t-cell-immunogenicity-of-acellular-pertussis-and-tetanus-immunizations-in-hiv-exposed-infants
#16
RANDOMIZED CONTROLLED TRIAL
Anna K Blakney, Christophe Toukam Tchakoute, Anneke C Hesseling, Elvis B Kidzeru, Christine E Jones, Jo-Ann S Passmore, Donald L Sodora, Clive M Gray, Heather B Jaspan
BACKGROUND: Bacille Calmette-Guerin (BCG) is effective in preventing disseminated tuberculosis (TB) in children but may also have non-specific benefits, and is thought to improve immunity to unrelated antigens through trained innate immunity. In HIV-infected infants, there is a risk of BCG-associated adverse events. We aimed to explore whether delaying BCG vaccination by 8 weeks, in utero or perinatal HIV infection is excluded, affected T-cell responses to B. pertussis (BP) and tetanus toxoid (TT), in HIV-exposed, uninfected infants...
September 11, 2015: Vaccine
https://www.readbyqxmd.com/read/26193705/single-dose-nevirapine-exposure-does-not-affect-response-to-antiretroviral-therapy-in-hiv-infected-african-children-aged-below-3-years
#17
Philippa Musoke, Alexander J Szubert, Victor Musiime, Kusum Nathoo, Patricia Nahirya-Ntege, Kuda Mutasa, David Eram Williams, Andrew J Prendergast, Moira Spyer, A Sarah Walker, Diana M Gibb
OBJECTIVES: To assess the impact of exposure to single-dose nevirapine (sdNVP) on virological response in young Ugandan/Zimbabwean children (<3 years) initiating antiretroviral therapy (ART), and to investigate other predictors of response. DESIGN: Observational analysis within the ARROW randomized trial. METHODS: sdNVP exposure was ascertained by the caregiver's self-report when the child initiated non-nucleoside reverse transcriptase inhibitor (NNRTI)-based ART...
August 24, 2015: AIDS
https://www.readbyqxmd.com/read/26115861/red-for-pmtct-an-adaptation-of-immunization-s-reaching-every-district-approach-increases-coverage-access-and-utilization-of-pmtct-care-in-bondo-district-kenya
#18
Lynn Kanyuuru, Mark Kabue, Tigistu A Ashengo, Chandrakant Ruparelia, Evans Mokaya, Isaac Malonza
Gaps exist in coverage, early access, and utilization of prevention of mother-to-child transmission of HIV (PMTCT) services in Kenya. The Maternal and Child Health Integrated Program, led by Jhpiego, piloted an adaptation of immunization's Reaching Every District (RED) approach in Bondo District as a way of improving PMTCT care. Routine district-level monthly summary service delivery pre- and post-implementation data were analyzed. Marked improvements resulted in the proportion of HIV-infected and non-infected pregnant women completing four focused prenatal care visits, from 25% to 41%, and the proportion of HIV-exposed infants (HEIs) tested at six weeks, from 27% to 78% (P<0...
June 2015: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26052819/the-aetiology-of-diarrhoea-pneumonia-and-respiratory-colonization-of-hiv-exposed-infants-randomized-to-breast-or-formula-feeding
#19
Rebecca M Zash, Roger L Shapiro, Jean Leidner, Carolyn Wester, Alexander J McAdam, Richard L Hodinka, Ibou Thior, Claire Moffat, Joseph Makhema, Kenneth McIntosh, Max Essex, Shahin Lockman
BACKGROUND: Diarrhoea and pneumonia are common causes of childhood death in sub-Saharan Africa but there are few studies describing specific pathogens. OBJECTIVES: The study aimed to describe the pathogens associated with diarrhoea, pneumonia and oropharyngeal colonization in children born to HIV-infected women (HIV-exposed infants). METHODS: The Mashi Study randomized 1200 HIV-infected women and their infants to breastfeed for 6 months with ZDV prophylaxis or formula-feed with 4 weeks of ZDV...
June 8, 2015: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/25918013/-persistence-of-hepatitis-a-virus-antibodies-after-primary-immunization-and-response-to-revaccination-in-children-and-adolescents-with-perinatal-hiv-exposure
#20
Aída de Fátima Thomé Barbosa Gouvêa, Maria Isabel de Moraes Pinto, Maristela Miyamoto, Daisy Maria Machado, Silvana Duarte Pessoa, Fabiana Bononi do Carmo, Suênia Cordeiro de Vasconcelos Beltrão, Regina Célia de Menezes Succi
OBJECTIVE: To assess possible factors associated with the loss of antibodies to hepatitis A 7 years after the primary immunization in children of HIV-infected mothers and the response to revaccination in patients seronegative for hepatitis A. METHODS: Quantification of HAV antibodies by electrochemiluminescence was performed in 39 adolescents followed up at the Pediatric Aids Clinic of Federal University of São Paulo (Unifesp): 29 HIV-infected (HIVgroup) (median age: 12...
April 2015: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
keyword
keyword
81908
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"