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"circadian rhythm", "sleep", "hyperglycemia"

Katsutaka Oishi, Sumika Ohyama, Sayaka Higo-Yamamoto
Sleep disturbances are associated with various metabolic diseases such as hypertension and diabetes. We had previously established a mouse model of a psychophysiological stress-induced chronic sleep disorder (CSD) characterized by disrupted circadian rhythms of wheel-running activity, core body temperature, and sleep-wake cycles. To evaluate the underlying mechanisms of metabolic disorders induced by CSD, we created mice with CSD for six weeks and fed them with a high-fat diet. Glucose intolerance with hyperglycemia resulted, although plasma insulin levels and body weight increases were identical between control and CSD mice...
January 22, 2018: Biochemical and Biophysical Research Communications
Priyathama Vellanki, Rachel Bean, Festus A Oyedokun, Francisco J Pasquel, Dawn Smiley, Farnoosh Farrokhi, Christopher Newton, Limin Peng, Guillermo E Umpierrez
OBJECTIVE: Clinical guidelines recommend point-of-care glucose testing and the use of supplemental doses of rapid-acting insulin before meals and at bedtime for correction of hyperglycemia. The efficacy and safety of this recommendation, however, have not been tested in the hospital setting. RESEARCH DESIGN AND METHODS: In this open-label, randomized controlled trial, 206 general medicine and surgery patients with type 2 diabetes treated with a basal-bolus regimen were randomized to receive either supplemental insulin (n = 106) at bedtime for blood glucose (BG) >7...
April 2015: Diabetes Care
Wen Bun Leong, Dev Banerjee, Melissa Nolen, Peymané Adab, G Neil Thomas, Shahrad Taheri
CONTEXT: Obstructive sleep apnea (OSA) has been shown to be associated with type 2 diabetes mellitus (DM). Studies on healthy individuals found that OSA is associated with lower insulin sensitivity. We hypothesized that nocturnal hypoxemia from OSA is associated with poorer glycemia in severely obese DM individuals. DESIGN AND SETTING: This was a retrospective observational study of 122 non-DM, 126 non-insulin-treated DM, and 35 insulin-treated DM patients. Data were collected on demographic characteristics, body mass index, and comorbidities...
September 2014: Journal of Clinical Endocrinology and Metabolism
Daisuke Tsujino, Kazunori Utsunomiya
Self-monitoring of blood glucose (SMBG) is now commonly used as a tool to measure blood glucose levels of diabetic patients, as health insurance started to cover its cost for patients receiving insulin. However, SMBG is used to evaluate blood glucose levels at different time points, making it impossible to speculate on changes in blood glucose levels occurring before and after measurement. Currently, continuous glucose monitoring (CGM), which determines diurnal blood glucose patterns on a continuous basis, is being introduced into routine clinical diabetic care...
January 2014: Rinsho Byori. the Japanese Journal of Clinical Pathology
Sirimon Reutrakul, Eve Van Cauter
Sleep disturbances, including sleep insufficiency and sleep fragmentation, have been linked to abnormal glucose metabolism and increased diabetes risk. Well-controlled laboratory studies have provided insights regarding the underlying mechanisms. Several large prospective studies suggest that these sleep disturbances are associated with an increased risk of incident diabetes. Obstructive sleep apnea, which combines sleep fragmentation and hypoxemia, is a major risk factor for insulin resistance and possibly diabetes...
April 2014: Annals of the New York Academy of Sciences
Theresa Mayes, Michele M Gottschlich, Jane Khoury, Narong Simakajornboon, Richard J Kagan
Hyperglycemia after severe burn injury has long been recognized, whereas sleep deprivation after burns is a more recent finding. The postburn metabolic effects of poor sleep are not clear despite reports in other populations demonstrating the association between sleep insufficiency and deleterious endocrine consequences. The aim of this study was to determine whether a relationship between sleep and glucose dynamics exists in acutely burned children. Two overnight polysomnography runs (2200 to 0600) per subject were conducted in 40 patients with a mean (± SEM) age of 9...
September 2013: Journal of Burn Care & Research: Official Publication of the American Burn Association
Weimin Fang, Zhongliang Li, Li Wu, Zhongqiang Cao, Yuan Liang, Handong Yang, Youjie Wang, Tangchun Wu
OBJECTIVES: Afternoon napping is a common habit in China. We used data obtained from the Dongfeng-Tongji cohort to examine if duration of habitual afternoon napping was associated with risks for impaired fasting plasma glucose (IFG) and diabetes mellitus (DM) in a Chinese elderly population. METHODS: A total of 27,009 participants underwent a physical examination, laboratory tests, and face-to-face interview. They were categorized into four groups according to nap duration (no napping, <30, 30 to <60, 60 to <90, and > or =90 min)...
October 2013: Sleep Medicine
Kentaro Yamada, Hitomi Nakayama, Tomoko Kato, Yuji Tajiri, Shuichi Sato, Saori Hirao, Tamami Oshige, Kento Hara, Shinpei Iwata, Naoka Kato, Yuko Sasaki, Rika Hasuo, Satoko Yoshinobu, Kenshi Mitsuzaki, Tamotsu Kato, Toshihiko Hashinaga, Kazuhisa Muraishi, Tsuyoshi Ohki, Hiroh Kaku
Nighttime food intake is associated with weight gain and higher HbA1c levels. We experienced night eaters who have no memory of their nocturnal eating in the morning. In this study, the curious night eating behavior was designated as "unremembered nocturnal eating syndrome (UNES)". We screened 1,169 patients with diabetes for sleep quality and abnormal eating behavior at night using the Pittsburgh Sleep Quality Index questionnaire with an additional question regarding UNES. When abnormal nocturnal eating behavior was noted, detailed clinical information was extracted from interviews with the patients...
2013: Endocrine Journal
Bilgay Izci Balserak, Nicholas Jackson, Sarah A Ratcliffe, Allan I Pack, Grace W Pien
OBJECTIVES: Sleep disturbances in pregnancy may impair glucose mechanism. This study aimed to examine associations of sleep-disordered breathing, sleep, and nap duration with 1-h glucose challenge test (GCT) levels in pregnant women after controlling for known risk factors for gestational diabetes. METHODS: This is a case-control study of 104 pregnant women. All women underwent full polysomnography and a GCT and completed the multivariable apnea prediction and Pittsburgh Sleep Quality indexes...
September 2013: Sleep & Breathing, Schlaf & Atmung
Osamu Itani, Yoshitaka Kaneita, Atsushi Murata, Eise Yokoyama, Takashi Ohida
OBJECTIVE: The objective of this longitudinal epidemiological study was to investigate the association of risk factors for cardiovascular illness with sleep duration and shift work. METHODS: This study used data obtained at medical checkups conducted in 1999 and 2006 for the employees of a local government organization in Japan (covering 21,693 male employees and 2109 female employees). The medical checkup data included (1) body measurements, (2) blood test parameters, and (3) replies to a self-administered questionnaire (inquiring about sleep duration, with or without shift work, etc...
April 2011: Sleep Medicine
Salha Fendri, Dominique Rose, Sonia Myambu, Sandrine Jeanne, Jean-Daniel Lalau
We assessed glycaemic status in 26 overweight or obese people with type 2 diabetes suspected of having sleep apnoea syndrome (SAS). In people with SAS (n=13), nocturnal glycaemia was 38% higher, independent of body mass index (particularly during rapid eye movement sleep) compared with non-SAS subjects (p<0.008).
January 2011: Diabetes Research and Clinical Practice
Kate V Allen, Brian M Frier
OBJECTIVE: To review the features of nocturnal hypoglycemia and various preventive strategies. METHODS: We discuss the physiologic changes, the potential precipitating factors, the immediate and long-term effects, and the currently available options for treatment of nocturnal hypoglycemia in patients with diabetes. RESULTS: Nocturnal hypoglycemia is common in patients with type 1 diabetes and is usually asymptomatic. Nocturnal hyperinsulinemia frequently occurs with insulin therapy, and although blood glucose levels are often low during sleep, they are seldom measured routinely...
November 2003: Endocrine Practice
S Yokoyama, H Hirakawa, J Soeda, S Ueno, T Mitomi
OBJECTIVE: To detect the effect of the loss of alimentation rhythmicity on a circadian rhythm of human growth hormone (HGH) secretion, a 24-hour profile of HGH was studied in a growing child on cyclic nocturnal total parenteral nutrition (TPN). Twenty-four-hour profiles of substrates and metabolic hormones were also studied to evaluate the efficiency of cyclic nocturnal TPN on childhood growth. STUDY DESIGN: Periodic blood samples from a child with megacystis-microcolon-intestinal-hypoperistalsis syndrome were obtained on five occasions, at ages 6, 7, 8, 9, and 11, when she was on cyclic nocturnal TPN...
December 1997: Pediatrics
G Boden, J Ruiz, J L Urbain, X Chen
Insulin secretion was studied in healthy volunteers at three different levels of glycemia. Plasma glucose was clamped at approximately 5, approximately 8.8 and approximately 12.6 mM for 68 h. Measured were serum insulin concentration and insulin secretion rates (ISR), the latter by deconvolution of plasma C-peptide concentration. Rhythmic patterns of ISR were identified (with a refined first-order Fourier transform) at all three glucose concentrations tested but were most clearly seen at 12.6 mM. ISR and serum insulin concentration changed in a circadian (approximately 24 h) rhythm, increasing from a nadir between midnight and 6 A...
August 1996: American Journal of Physiology
G Boden, X Chen, J L Urbain
Diurnal variation in insulin sensitivity in patients with NIDDM has long been suspected but has been difficult to document mainly because of the interdependence of changes in glucose and insulin. Stable serum insulin levels during hyperglycemic clamping in patients with NIDDM in the present study provided the opportunity to examine changes in insulin sensitivity unaffected by changes in blood glucose and insulin concentrations. Six patients with NIDDM (four men and two women, BMI 33.9 +/- 2.5) underwent hyperglycemic (11...
August 1996: Diabetes
R J Winter
Twenty-four hr glucose and hormonal monitoring was conducted in 34 randomly selected children with insulin dependent diabetes. Asymptomatic nocturnal hypoglycemia was present in 18% (6/34). The nocturnal plasma glucose decline of 20-25 mg/dl/hr reached a mean nadir of 50 mg/dl. The mean rebound hyperglycemia of 300 mg/dl over the subsequent 6.4 hrs. was significantly greater than any glucose excursion in diabetic children with daytime, symptomatic hypoglycemia (n = 5) or in those with non-hypoglycemic profiles (n = 23)...
July 1981: Metabolism: Clinical and Experimental
D C Parker, L G Rossman
No abstract text is available yet for this article.
January 1971: Journal of Clinical Endocrinology and Metabolism
G D Molnar, W F Taylor, A Langworthy, V Fatourechi
No abstract text is available yet for this article.
May 1972: Journal of Clinical Endocrinology and Metabolism
J A Atiea, F Creagh, M Page, D R Owens, M F Scanlon, J R Peters
Growth hormone (GH) hypersecretion in insulin-dependent diabetes mellitus (IDDM) subjects has been shown to be causally related to early-morning hyperglycemia. We studied the effect of nocturnal GH suppression on acute glycemic control in six IDDM patients during a constant overnight insulin infusion (0.075 In control experiments (infusion of insulin alone), plasma glucose increased from 5.6 +/- 0.6 mM at 2400 to 11.1 +/- 1.3 mM at 0900 (P = .0024). When in addition the cholinergic muscarinic antagonist pirenzepine was given (100 mg at 2200 and again at 2400), plasma glucose increased from 5...
July 1989: Diabetes Care
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