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Quality of life measures

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https://www.readbyqxmd.com/read/27933615/immediate-release-versus-controlled-release-carbamazepine-in-the-treatment-of-epilepsy
#1
REVIEW
Graham Powell, Matthew Saunders, Alexandra Rigby, Anthony G Marson
BACKGROUND: Carbamazepine (CBZ) is a commonly used drug for epilepsy that is associated with troublesome adverse events including dizziness, double vision, drowsiness, poor co-ordination and unsteadiness. These adverse events often occur during peaks in drug plasma concentration. These adverse events may limit the daily dose of CBZ that can be tolerated and reduce the chances of seizure control in patients who require high doses. A controlled-release formulation of CBZ delivers the same dose over a longer period of time when compared to a standard immediate-release formulation, thereby reducing post-dose peaks in CBZ plasma concentration and potentially reducing adverse events...
December 8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27933450/effects-of-exercise-intervention-in-breast-cancer-patients-is-mobile-health-mhealth-with-pedometer-more-effective-than-conventional-program-using-brochure
#2
Kyeong Eun Uhm, Ji Sung Yoo, Seung Hyun Chung, Jong Doo Lee, Ilkyun Lee, Joong Il Kim, Se Kyung Lee, Seok Jin Nam, Yong Hyun Park, Ji Youl Lee, Ji Hye Hwang
PURPOSE: To investigate and compare the effects of mobile health (mHealth) and pedometer with conventional exercise program using a brochure on physical function and quality of life (QOL). METHODS: The study was a prospective, quasi-randomized multicenter trial where 356 patients whose cancer treatment had been terminated were enrolled. All patients were instructed to perform a 12-week regimen of aerobic and resistance exercise. The mHealth group received a pedometer and a newly developed smartphone application to provide information and monitor the prescribed exercises...
December 8, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27933428/in-6-to-8-year-old-children-cardiorespiratory-fitness-moderates-the-relationship-between-severity-of-life-events-and-health-related-quality-of-life
#3
Markus Gerber, Katharina Endes, Serge Brand, Christian Herrmann, Flora Colledge, Lars Donath, Oliver Faude, Henner Hanssen, Uwe Pühse, Lukas Zahner
PURPOSE: In children, the pathways by which physical activity and fitness are associated with physical and psychological wellbeing are still not fully understood. The present study examines for the first time in young children whether high levels of cardiorespiratory fitness and physical activity moderate the relationship between severity of life events and health-related quality of life. METHODS: Three hundred and seventy-eight children (188 girls, 190 boys, M age = 7...
December 8, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27933382/the-impact-of-hereditary-multiple-exostoses-on-quality-of-life-satisfaction-global-health-status-and-pain
#4
Riccardo D'Ambrosi, Vincenza Ragone, Camilla Caldarini, Nicola Serra, Federico Giuseppe Usuelli, Renato Mario Facchini
PURPOSE: The aim of the study was to evaluate quality of life (QOL), global health status, pain, and level of satisfaction in patients with hereditary multiple exostoses (HME), and to correlate the association between the severity of diseases and age, sex, number of surgical procedures, and number of exostoses. METHODS: The data of 50 patients with HME were retrospectively evaluated and recorded. QOL was evaluated with the Short-Form Health Survey (SF-12) questionnaire, the 12-Item General Health Questionnaire (GHQ-12), and Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q-SF); intensity of pain was measured using the visual analogue scale (VAS)...
December 8, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27933259/deformity-correction-and-extremity-lengthening-in-the-lower-leg-comparison-of-clinical-outcomes-with-two-external-surgical-procedures
#5
Eugen Reitenbach, Robert Rödl, Georg Gosheger, Björn Vogt, Frank Schiedel
OBJECTIVE: Distraction osteogenesis is a method of stimulating the growth of new bone tissue in order to lengthen the extremities or bridge resected bone defects. In addition to the now-established intramedullary procedures, two different fixator systems are in use. The present study investigated the classical Ilizarov ring fixator (IRF) and a hexapod to assess the precision of lower-leg lengthening and complications classified using the Paley criteria for problems, obstacles, and complications...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933161/parallel-reductions-of-ige-and-exhaled-nitric-oxide-after-optimized-anti-inflammatory-asthma-treatment
#6
Jörgen Syk, Andrei Malinovschi, Magnus P Borres, Anna-Lena Undén, Anna Andreasson, Mats Lekander, Kjell Alving
Immunoglobulin E (IgE) is crucial for the development of airway inflammation in atopic asthma, and inhibition of IgE using monoclonal antibodies is now part of asthma therapy. However, the impact of ordinary anti-inflammatory treatment on IgE is unclear. The aim of this study was to investigate if optimization of treatment with inhaled corticosteroid (ICS) and leukotriene-receptor antagonist (LTRA) according to symptoms or exhaled nitric oxide (FENO) levels over a one-year period affects IgE concentrations...
June 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27933020/feasibility-of-group-schema-therapy-for-outpatients-with-severe-borderline-personality-disorder-in-germany-a-pilot-study-with-three-year-follow-up
#7
Eva Fassbinder, Maren Schuetze, Annika Kranich, Valerija Sipos, Fritz Hohagen, Ida Shaw, Joan Farrell, Arnoud Arntz, Ulrich Schweiger
Borderline Personality Disorder (BPD) is a severe, challenging to treat mental disorder. Schema therapy (ST) as an individual therapy has been proven to be an effective psychological treatment for BPD. A group format of ST (GST) has been developed and evaluated in a randomized controlled trial in the United States and piloted in The Netherlands. These results suggest that GST speeds up and amplifies treatment effects of ST and might reduce delivery costs. However, feasibility in the German health care system and with BPD patients with high BPD severity and comorbidity, and frequent hospitalization, has not been tested to date...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27932885/health-behaviors-of-patients-diagnosed-with-type-2-diabetes-mellitus-and-their-influence-on-the-patients-satisfaction-with-life
#8
Anna Rosiek, Tomasz Kornatowski, Natalia Frąckowiak-Maciejewska, Aleksandra Rosiek-Kryszewska, Przemysław Wyżgowski, Krzysztof Leksowski
BACKGROUND: The diagnosis of type 2 diabetes mellitus (T2DM) carries with it a number of changes to the patient's lifestyle. A healthy lifestyle, health and preventive behaviors, as well as healthy nutrition habits play a key role in treating T2DM as well as limiting its complications. MATERIALS AND METHODS: The aim of this study was the analysis of the correlation of T2DM patients' health behaviors and their influence on the patients' quality of life. The study was performed on a group of 50 patients from the Kuyavian-Pomeranian Voivodeship...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27932530/affective-alterations-in-patients-with-cushing-s-syndrome-in-remission-are-associated-with-decreased-bdnf-and-cortisone-levels
#9
E Valassi, I Crespo, B G Keevil, A Aulinas, E Urgell, A Santos, P J Trainer, S M Webb
OBJECTIVE: Affective alterations and poorer quality of life often persist in patients with Cushing's syndrome (CS) in remission. Brain-derived neurotrophic factor (BDNF) regulates the hypothalamic-pituitary-adrenal axis (HPA) and is highly expressed in brain areas controlling mood and response to stress. Our aims were to assess affective alterations after long-term remission of CS and evaluate whether they are associated with serum BDNF, salivary cortisol (SalF) and/or cortisone (SalE) concentrations...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27932335/multicentre-randomised-placebo-controlled-trial-of-oral-anticoagulation-with-apixaban-in-systemic-sclerosis-related-pulmonary-arterial-hypertension-the-sphinx-study-protocol
#10
Alicia Calderone, Wendy Stevens, David Prior, Harshal Nandurkar, Eli Gabbay, Susanna M Proudman, Trevor Williams, David Celermajer, Joanne Sahhar, Peter K K Wong, Vivek Thakkar, Nathan Dwyer, Jeremy Wrobel, Weng Chin, Danny Liew, Margaret Staples, Rachelle Buchbinder, Mandana Nikpour
INTRODUCTION: Systemic sclerosis (SSc) is a severe and costly multiorgan autoimmune connective tissue disease characterised by vasculopathy and fibrosis. One of the major causes of SSc-related death is pulmonary arterial hypertension (PAH), which develops in 12-15% of patients with SSc and accounts for 30-40% of deaths. In situ thrombosis in the small calibre peripheral pulmonary vessels resulting from endothelial dysfunction and an imbalance of anticoagulant and prothrombotic mediators has been implicated in the complex pathophysiology of SSc-related PAH (SSc-PAH), with international clinical guidelines recommending the use of anticoagulants for some types of PAH, such as idiopathic PAH...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27932278/patient-perceived-flares-in-rheumatoid-arthritis-a-sub-analysis-of-the-strass-treatment-tapering-strategy-trial
#11
Agnès Portier, Laure Gossec, Florence Tubach, Toni Alfaiate, Thao Pham, Alain Saraux, Martin Soubrier, Thierry Schaeverbeke, Jean-Francis Maillefert, Xavier Mariette, David Hajage, Bruno Fautrel
OBJECTIVES: Patient's and physician's perspective can differ in rheumatoid arthritis (RA). The aim was to define the concept of patient-reported flares. METHODS: Post-hoc analysis of a randomized controlled trial of a step-down strategy in RA patients treated with anti-TNF, in DAS28-remission for ≥6 months, randomized to either "spacing" or "maintaining" anti-TNF. The occurrence of patient-reported flares (PRF) was evaluated every 3 months for 18 months by: "Over the last 3 months, did you experience symptoms suggestive of disease exacerbation?"...
December 5, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27932051/functional-and-exercise-limitations-after-a-first-episode-of-pulmonary-embolism-results-of-the-elope-prospective-cohort-study
#12
Susan R Kahn, Andrew M Hirsch, Arash Akaberi, Paul Hernandez, David R Anderson, Philip S Wells, Marc Rodger, Susan Solymoss, Michael J Kovacs, Lawrence Rudski, Avi Shimony, Carole Dennie, Christopher Rush, William H Geerts, Shawn D Aaron, John T Granton
BACKGROUND: We aimed to determine the frequency and predictors of exercise limitation after pulmonary embolism (PE), and to assess its association with health-related quality of life (HRQOL) and dyspnea. METHODS: 100 patients with acute PE were recruited at five Canadian hospitals from 2010-2013. Cardiopulmonary exercise testing (CPET) was performed at 1 and 12 months. Quality of life, dyspnea, six-minute walk distance (6MWD), residual clot burden (perfusion (Q) scan; CT pulmonary angiography (CTPA)), cardiac function (echocardiogram) and pulmonary function tests (PFT) were measured during follow-up...
December 5, 2016: Chest
https://www.readbyqxmd.com/read/27932016/to-dance-or-not-to-dance-a-comparison-of-balance-physical-fitness-and-quality-of-life-in-older-irish-set-dancers-and-age-matched-controls
#13
J Shanahan, L Coman, F Ryan, J Saunders, K O'Sullivan, O Ni Bhriain, A M Clifford
OBJECTIVE: The objective of this study is to determine if older adults regularly participating in Irish set dancing have superior balance, physical fitness and quality of life compared to age-matched controls. STUDY DESIGN: This study used a community-based, observational cross-sectional design. METHODS: Regular set dancers (n = 39) and age-matched controls (n = 33) were recruited. Participants were assessed using the physical activity scale for the elderly (physical activity levels), mini-BESTest (balance) and senior fitness test (battery of functional fitness tests)...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931905/ethnic-differences-in-the-effectiveness-of-cognitive-behavioral-therapy-combined-with-medication-comparing-asian-american-and-white-psychiatric-patients
#14
Jennifer Y Tang, Chieh Li, Rachel F Rodgers, Mary Ballou
Several meta-analyses have demonstrated the effectiveness of treatment utilizing cognitive behavioral therapy (CBT) combined with medication. There is, however, a paucity of research comparing the effectiveness of this combined treatment with psychiatric patients from different ethnic backgrounds. This study is the first of its kind to compare the effectiveness of CBT combined with medication for Asian American and White patients' psychiatric symptom severity levels of depression, anxiety, psychological well-being, and quality of life...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931699/recovery-after-same-day-surgery-in-patients-receiving-general-anesthesia-a-cohort-study-using-the-quality-of-recovery-40-questionnaire
#15
Herdis Sveinsdottir, Thordis Borgthorsdottir, Maria Titia Asgeirsdottir, Kolbrun Albertsdottir, Lara Borg Asmundsdottir
BACKGROUND: The contemporary rise in the number of elective procedures performed in same-day surgery (SDS) requires that health care professionals increase their knowledge of patient satisfaction and recovery, including patient-assessed quality of life. This study investigates the quality of recovery (QoR) of anesthetized SDS patients. METHODS: Data from SDS patients were collected from hospital records at T1 (the morning before operation), T2 (day 1 postsurgery), and T3 (day 4 postsurgery)...
December 2016: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/27931504/clinical-benefits-of-stem-cells-for-chronic-symptomatic-systolic-heart-failure-a-systematic-review-of-the-existing-data-and-ongoing-trials
#16
Marie-France Poulin, Anjan Deka, Burhan Mohamedali, Gary L Schaer
The benefits of stem cell therapy for patients with chronic symptomatic systolic heart failure due to ischemic and nonischemic cardiomyopathy (ICM and NICM, respectively) are unclear. We performed a systematic review of major published and ongoing trials of stem cell therapy for systolic heart failure and compared measured clinical outcomes for both types of cardiomyopathy. The majority of the 29 published studies demonstrated clinical benefits of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs)...
November 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27931254/feasibility-of-an-online-intervention-stak-d-to-promote-physical-activity-in-children-with-type-1-diabetes-protocol-for-a-randomised-controlled-trial
#17
Holly Blake, Helen Quirk, Paul Leighton, Tabitha Randell, James Greening, Boliang Guo, Cris Glazebrook
BACKGROUND: Regular physical activity has important health benefits for children with type 1 diabetes mellitus (T1DM), yet children and their parents face barriers to participation such as lack of self-efficacy or concerns around hypoglycaemia. Multimedia interventions are useful for educating children about their health and demonstrate potential to improve children's health-related self-efficacy, but few paediatric clinics offer web-based resources as part of routine care. The Steps to Active Kids with Diabetes (STAK-D) programme is an online intervention grounded in psychological theory (social cognitive theory) and informed by extensive preliminary research...
December 8, 2016: Trials
https://www.readbyqxmd.com/read/27931243/phase-1-2-study-of-pacritinib-a-next-generation-jak2-flt3-inhibitor-in-myelofibrosis-or-other-myeloid-malignancies
#18
Srdan Verstovsek, Olatoyosi Odenike, Jack W Singer, Tanya Granston, Suliman Al-Fayoumi, H Joachim Deeg
BACKGROUND: Pacritinib (SB1518) is a highly selective kinase inhibitor with specificity for JAK2, FLT3, IRAK1, and CFS1R. This multicenter phase 1/2 study evaluated the maximum tolerated dose (MTD), safety, and clinical activity of pacritinib in patients with myelofibrosis (MF) and other advanced myeloid malignancies. METHODS: In the phase 1 dose-escalation part of the study, 43 adults with advanced myeloid malignancies received pacritinib 100 to 600 mg once daily (QD)...
December 8, 2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27931214/how-effective-are-volunteers-at-supporting-people-in-their-last-year-of-life-a-pragmatic-randomised-wait-list-trial-in-palliative-care-elsa
#19
Catherine Walshe, Steven Dodd, Matt Hill, Nick Ockenden, Sheila Payne, Nancy Preston, Guillermo Perez Algorta
BACKGROUND: Clinical care alone at the end of life is unlikely to meet all needs. Volunteers are a key resource, acceptable to patients, but there is no evidence on care outcomes. This study aimed to determine whether support from a social action volunteer service is better than usual care at improving quality of life for adults in the last year of life. METHODS: A pragmatic, multi-centre wait-list controlled trial, with participants randomly allocated to receive the volunteer support intervention either immediately or after a 4 week wait...
December 9, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27930952/prevalence-and-psychosocial-correlates-of-food-addiction-in-persons-with-obesity-seeking-weight-reduction
#20
Ariana M Chao, Jena A Shaw, Rebecca L Pearl, Naji Alamuddin, Christina M Hopkins, Zayna M Bakizada, Robert I Berkowitz, Thomas A Wadden
INTRODUCTION: Food addiction is a controversial concept. The potential influence of food addiction on patients' psychosocial functioning and well-being has not been well established. The purpose of this study was to examine the relationships between psychosocial functioning (depressive symptoms and health-related quality of life [HRQOL]) and food addiction as measured by the Yale Food Addiction Scale (YFAS). We also explored whether food addiction contributed additional variance in explaining psychosocial functioning, beyond demographic and clinical factors (e...
November 23, 2016: Comprehensive Psychiatry
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