Theodora Agalioti, Anastasios D Giannou, Anthi C Krontira, Nikolaos I Kanellakis, Danai Kati, Malamati Vreka, Mario Pepe, Magda Spella, Ioannis Lilis, Dimitra E Zazara, Eirini Nikolouli, Nikolitsa Spiropoulou, Andreas Papadakis, Konstantina Papadia, Apostolos Voulgaridis, Vaggelis Harokopos, Panagiota Stamou, Silke Meiners, Oliver Eickelberg, Linda A Snyder, Sophia G Antimisiaris, Dimitrios Kardamakis, Ioannis Psallidas, Antonia Marazioti, Georgios T Stathopoulos
Malignant pleural effusion (MPE) is the lethal consequence of various human cancers metastatic to the pleural cavity. However, the mechanisms responsible for the development of MPE are still obscure. Here we show that mutant KRAS is important for MPE induction in mice. Pleural disseminated, mutant KRAS bearing tumour cells upregulate and systemically release chemokine ligand 2 (CCL2) into the bloodstream to mobilize myeloid cells from the host bone marrow to the pleural space via the spleen. These cells promote MPE formation, as indicated by splenectomy and splenocyte restoration experiments...
May 16, 2017: Nature Communications