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https://www.readbyqxmd.com/read/29145491/the-urine-biomarker-panel-igfbp7-x-timp-2-nephrocheck%C3%A2-parameter-does-not-correlate-with-igfbp7-and-timp-2-gene-expression-in-urinary-sediment
#1
Daniela Knafl, Markus Müller, Sahra Pajenda, Zeynep Genc, Manfred Hecking, Ludwig Wagner
BACKGROUND: Acute kidney injury (AKI) is frequently observed in serious infections, following nephrotoxic medication, surgery and trauma. Here we tested whether the detection of two recently identified biomarkers for AKI, Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) and Insulin-Like Growth Factor Binding Protein 7 (IGFBP7), depends on the expression of these proteins in cells of the urinary sediment. METHOD: We collected urine samples of 33 kidney transplant recipients and 14 non-transplanted patients who all had AKI (stages 1-3 according to KDIGO), and measured [IGFBP7]x[TIMP-2] using the NephroCheck® Astute1 40 ™ meter...
2017: PloS One
https://www.readbyqxmd.com/read/29141241/mmp-9-and-its-regulators-timp-1-and-emmprin-in-patients-with-acute-st-elevation-myocardial-infarction-a-nordistemi-substudy
#2
Trine Baur Opstad, Ingebjørg Seljeflot, Ellen Bøhmer, Harald Arnesen, Sigrun Halvorsen
OBJECTIVES: The extracellular matrix is involved in wound repair after acute myocardial infarction (AMI). We investigated whether matrix metalloproteinase (MMP)-9, tissue inhibitor of metalloproteinases (TIMP)-1, and the MMP inducer (EMMPRIN) are associated with infarct size, left ventricular function, and clinical outcome in ST-elevation-MI (STEMI). METHODS: In 243 STEMI patients, circulating EMMPRIN, MMP-9, and TIMP-1 were analyzed 3 days and 3 months post-AMI...
November 16, 2017: Cardiology
https://www.readbyqxmd.com/read/29140729/gene-expression-and-gene-associations-during-the-development-of-heart-failure-with-preserved-ejection-fraction-in-the-dahl-salt-sensitive-model-of-hypertension
#3
Jeffrey Yim, Hyokeun Cho, Simon W Rabkin
Gene expression and associations were examined in a model of heart failure with preserved ejection fraction (HFpEF), a condition with minimal effective treatment. Genes with at least two studies showing significant changes in Dahl rat with heart failure were examined by meta-analysis. Significantly increased in expression were iNOS, p47phox, ADM, ANP, OPN, ACE, MCP-1, GP91PHOX, ICAM-1, TGF-β1, CTGF, ET-1, p22phox, ETB, BNP, ETA, MMP13, Col1a1, MMP2, TIMP1, Col3a1, Il-1β, β-MHC, ECE1, MMP14, AGT, and MMP9...
November 15, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29140689/tissue-inhibitor-of-metalloprotease-2-timp-2-bioprocess-development-physicochemical-biochemical-and-biological-characterization-of-highly-expressed-recombinant-protein
#4
Ananda Chowdhury, Robert G Brinson, Beiyang Wei, William G Stetler-Stevenson
Tissue Inhibitor of Metalloprotease -2 (TIMP-2) is a secreted 21 kDa multifunctional protein first described as an endogenous inhibitor of matrix metalloproteinases (MMPs) that prevents breakdown of the extracellular matrix often observed in chronic diseases. TIMP-2 diminishes growth factor-mediated cell proliferation in vitro, as well as neoangiogenesis and tumor growth in vivo independent of its MMP-inhibitory activity, . These physiological properties make TIMP-2 an excellent candidate for further pre-clinical development as a biologic therapy of cancer...
November 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/29137364/association-between-mmp3-and-timp3-polymorphisms-and-risk-of-osteoarthritis
#5
Zhichao Tong, Yang Liu, Bo Chen, Liang Yan, Dingjun Hao
Osteoarthritis (OA) is the most commonly occurring degenerative joint disease worldwide, and its incidence has increased in recent years. We evaluated whether there is the association between MMP-3 and TIMP-3 variants and susceptibility to OA in a Chinese population. Venous blood samples were collected from 431 female participants (200 cases and 231 controls) at Hong Hui Hospital, Xi'an Jiaotong University College of Medicine between 2015 and 2016. After genotyping the samples using standard protocols, the association between MMP-3 and TIMP-3 single nucleotide polymorphisms and risk of OA was assessed by calculating odds ratios (ORs) and 95% confidence intervals (95% CIs) using unconditional logistic regression analysis...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137288/elevated-timp-1-expression-is-associated-with-a-prometastatic-phenotype-disease-relapse-and-poor-survival-in-neuroblastoma
#6
Pritha Paul, Eric J Rellinger, Jingbo Qiao, Sora Lee, Natasha Volny, Chandrasekhar Padmanabhan, Carmelle V Romain, Bret Mobley, Hernan Correa, Dai H Chung
Approximately two-thirds of patients with neuroblastoma are found to have metastatic disease at time of diagnosis with frequent skeletal, lymph node, central nervous system, and liver involvement. Using a serial in vivo splenic injection model, we have isolated an aggressive subclone (BE(2)-C/LM2) from MYCN-amplified neuroblastomas that demonstrate an enhanced propensity to develop metastatic liver lesions. BE(2)-C/LM2 subclone cells demonstrate increased adherent, soft agar colony and tumorsphere growth in vitro...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29132130/effect-of-huagantongluofang-a-chinese-traditional-medicine-in-hepatic-fibrogenesis-in-a-mouse-model-of-biliary-cirrhosis
#7
Ji Xuan, Wei Wen, Yong Wang, Feng Wang, Hua-Bing Xu, Mei Shao, Ya Yang, Yao-Zhou Tian
BACKGROUND: Biliary cirrhosis (BC) is a chronic cholestatic liver disease, in which hepatic fibrosis is an early symptom. This study aimed to identify the biological function and the therapeutic effect of a Chinese traditional medicine, HuaGanTongLuoFang (HGTLF), in a mouse model of BC. METHODS: The mice (n = 72) were randomly divided into a sham group (n =12) and BC group (n = 60). The animals in the BC group were then randomly divided into five groups (n = 12 in each) and treated with three different doses of HGTLF, ureodeoxycholic acid (UDCA), or normal saline (the model group)...
November 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29130646/investigating-the-expression-of-mmps-and-timps-in-preterm-placenta-and-role-of-cpg-methylation-in-regulating-mmp-9-expression
#8
Deepali Sundrani, Ankita Narang, Savita Mehendale, Sadhana Joshi, Preeti Chavan-Gautam
Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) are crucial to the processes of normal labor and parturition. We have previously reported aberrant protein levels of MMPs in placenta of women delivering preterm as compared to term. In this study, we examine the mRNA levels of MMPs (MMP-1, MMP-2, and MMP-9) and TIMPs (TIMP-1, TIMP-2) in the placenta from women delivering preterm as compared with term and further study the promoter DNA methylation of the MMP-9 gene in a sub-sample of term and preterm placentae...
November 11, 2017: IUBMB Life
https://www.readbyqxmd.com/read/29129649/tsg-6-a-double-edged-sword-for-osteoarthritis
#9
Ching-Heng Chou, David E Attarian, Hans-Georg Wisniewski, Philip A Band, Virginia B Kraus
PURPOSE: To explore mechanisms underlying the association of TSG-6 with osteoarthritis (OA) progression. METHODS: TSG-6-mediated heavy chain (HC) transfer (TSG-6 activity) and its association with inflammatory mediators were quantified in knee OA (n=25) synovial fluids. Paired intact and damaged cartilages from the same individuals (20 tibial and 12 meniscal) were analyzed by qRT-PCR and immunohistochemistry (IHC) for gene and protein expression of TSG-6 and components of IαI (necessary for TSG-6 activity), and for TSG-6 activity +/- spiked in IαI...
November 9, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29128090/crocus-sativus-l-aqueous-extract-reduces-atherogenesis-increases-atherosclerotic-plaque-stability-and-improves-glucose-control-in-diabetic-atherosclerotic-animals
#10
Ei Christodoulou, N P E Kadoglou, M Stasinopoulou, O A Konstandi, C Kenoutis, Z I Kakazanis, A Rizakou, N Kostomitsopoulos, G Valsami
BACKGROUND AND AIMS: We aimed to evaluate a possible atheroprotective effect of saffron aqueous extract (SFE), and its potential anti-inflammatory mechanisms, in apoE knockout (ApoE(-/-)) mice. METHODS: Fifty male, ApoE(-/-) mice, fed a high-fat diet (HFD) for 12 weeks, were randomized into 5 groups: (1) baseline group, euthanatized, without intervention, (2) three saffron groups, receiving HFD and 30,60,90 mg/kg/day of SFE, respectively, for four weeks, per os through gavage, after reconstitution in water for injection (WFI), (3) control group (COG), receiving daily HFD and the same volume of WFI (four weeks)...
November 1, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29120858/prognostic-value-of-fibrosis-related-markers-in-dilated-cardiomyopathy-a-link-between-osteopontin-and-cardiovascular-events
#11
Paweł Rubiś, Sylwia Wiśniowska-Śmiałek, Ewa Dziewięcka, Lucyna Rudnicka-Sosin, Artur Kozanecki, Piotr Podolec
INTRODUCTION: Serum markers of fibrosis provide an insight into extracellular matrix (ECM) fibrosis in heart failure (HF) and dilated cardiomyopathy (DCM). However, their role as predictors of cardiovascular (CV) events in DCM is poorly understood. METHODS: This is an observational, prospective cohort study. 70 DCM patients (48±12.1years, ejection fraction - EF 24.4±7.4) were recruited. Markers of collagen type I and III synthesis - procollagen type I and III carboxy- and amino-terminal peptides (PICP, PIIICP, PINP, PIIINP), fibrosis controlling factors - ostepontin (OPN), transforming growth factor (TGF1-β) and connective tissue growth factor (CTGF), and matrix metalloproteinases (MMP-2, MMP-9) and tissue inhibitor (TIMP-1), were measured in serum...
November 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29120852/effect-of-gestational-age-on-migration-ability-of-the-human-umbilical-cord-vein-mesenchymal-stem-cells
#12
Mobin Mohammadi, Mehdi Mohammadi, Mohammad Ali Rezaee, Tayyeb Ghadimi, Massume Abolhasani, Mohammad Reza Rahmani
PURPOSE: Migration ability of mesenchymal stem cells (MSCs) towards chemotactic mediators is a determinant factor in cell therapy. MSCs derived from different sources show different properties. Here we compared the migration ability of the term and the pre-term human umbilical cord vein MSCs (hUCV-MSCs). MATERIALS/METHODS: MSCs were isolated from term and pre-term umbilical cord vein, and cultured to passage 3-4. Migration rate of both groups was assessed in the presence of 10% FBS using chemotaxis assay...
November 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29120671/erythropoietin-reduces-collagen-deposition-after-myocardial-infarction-but-does-not-improve-cardiac-function
#13
Fernanda G Pessoa, Charles Mady, Keila C B Fonseca, Adriana M Oliveira-Fonoff, Vera M C Salemi, Mauricio R Jordao, Fabio Fernandes, Felix J A Ramires
Myocardial remodeling includes inappropriate collagen deposition in the interstitium. Erythropoietin (EPO) may have cardioprotective effects. We aimed to assess the role of EPO on myocardial remodeling during the chronic phase. We studied 60 Wistar rats divided into Control (CT), Control+EPO (CT+EPO), Infarcted+EPO (MI+EPO), and Infarcted (MI). The interstitial collagen volume fraction (ICVF) was quantified. Echocardiography was performed. We quantified ADMA and glutathione by ELISA, and RT-PCR to assess apoptosis and inflammation...
November 9, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29119662/toxoplasma-gondii-infection-shifts-dendritic-cells-into-an-amoeboid-rapid-migration-mode-encompassing-podosome-dissolution-secretion-of-timp-1-and-reduced-proteolysis-of-extracellular-matrix
#14
Einar B Ólafsson, Manuel Varas-Godoy, Antonio Barragan
Dendritic cells (DCs) infected by Toxoplasma gondii rapidly acquire a hypermigratory phenotype that promotes systemic parasite dissemination by a 'Trojan horse' mechanism in mice. Recent paradigms of leukocyte migration have identified the amoeboid migration mode of DCs as particularly suited for rapid locomotion in extracellular matrix and tissues. Here, we have developed a microscopy-based high-throughput approach to assess motility and matrix degradation by Toxoplasma-challenged murine and human DCs. DCs challenged with T...
November 8, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/29118190/juvenile-hormone-and-20-hydroxyecdysone-coordinately-control-the-developmental-timing-of-matrix-metalloproteinase-induced-fat-body-cell-dissociation
#15
Qiangqiang Jia, Suning Liu, Di Wen, Yongxu Cheng, William G Bendena, Jian Wang, Sheng Li
Tissue remodeling is a crucial process in animal development and disease progression. Coordinately controlled by the two main insect hormones, juvenile hormone (JH) and 20-hydroxyecdysone (20E), tissues are remodeled context-specifically during insect metamorphosis. We previously discovered that two matrix metalloproteinases (Mmps) cooperatively induce fat body cell dissociation in Drosophila. However, the molecular events involved in this Mmps-mediated dissociation are unclear. Here we report that JH and 20E coordinately and precisely control the developmental timing of Mmps-induced fat body cell dissociation...
November 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29114524/effect-of-acute-and-chronic-exercise-on-plasma-matrix-metalloproteinase-and-total-antioxidant-levels
#16
Melek Tunc-Ata, Mukaddes Mergen-Dalyanoglu, Sebahat Turgut, Günfer Turgut
The relationship between acute and chronic exercise and expression of matrix metalloproteinases (MMPs) in muscles is unknown. There happen some alterations in the oxidant-antioxidant balance due to exercise. This study aimed to investigate the levels of MMP-1, tissue inhibitors of metalloproteinases (TIMP-1), hyaluronic acid (HA), total antioxidant status (TAS), and total oxidant status (TOS) following acute and chronic exercising in rats. Twenty-six Wistar Albino male rats were divided in to three groups: control, acute, and chronic groups...
October 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29113325/elevated-expression-of-mmp-2-and-timp-2-cooperatively-correlates-with-risk-of-lung-cancer
#17
Chao Cao, Ning Xu, Xiaoxia Zheng, Wenxue Zhang, Tianwen Lai, Zaichun Deng, Xiaoping Huang
Lung cancer is one of the most common form of malignant diseases and the leading cause of cancer-related mortality worldwide. It is reported that approximately two-thirds of lung cancer patients is the presence of advance disease at the time of diagnosis. Hence novel lung cancer diagnostic tests, which can be used to screen individuals at high risk, are required. In the derivation cohort, a total of 88 patients admitted into hospital with suspected lung cancer were included. Bronchial alveolar lavage fluid (BALF) and lung tissue samples were collected from included patients, and were analyzed for MMP-2 and TIMP-2 expression...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29109972/the-changing-hydrology-of-a-dammed-amazon
#18
Kelsie Timpe, David Kaplan
Developing countries around the world are expanding hydropower to meet growing energy demand. In the Brazilian Amazon, >200 dams are planned over the next 30 years, and questions about the impacts of current and future hydropower in this globally important watershed remain unanswered. In this context, we applied a hydrologic indicator method to quantify how existing Amazon dams have altered the natural flow regime and to identify predictors of alteration. The type and magnitude of hydrologic alteration varied widely by dam, but the largest changes were to critical characteristics of the flood pulse...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29109834/mechanism-of-mechanical-trauma-induced-extracellular-matrix-remodeling-of-fibroblasts-in-association-with-nrf2-are-signaling-suppression-mediating-tgf-%C3%AE-1-smad3-signaling-inhibition
#19
Jianming Tang, Bingshu Li, Cheng Liu, Yang Li, Qiannan Li, Linlin Wang, Jie Min, Ming Hu, Shasha Hong, Li Hong
Stress urinary incontinence (SUI) is a common hygienic problem affecting the quality of women's life worldwide. In this research, we revealed the involvement and regulation of extracellular matrix (ECM) remodeling, oxidative damage, and TGF-β1 signaling in the pathological mechanisms of mechanical trauma-induced SUI. We found that excessive mechanical strain significantly increased apoptosis rate, decreased cell viability and ECM production, and broke the balance of MMPs/TIMPs compared with the nonstrain control (NC) group...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29107862/gypsophila-elegans-isoorientin-2%C3%A2-o-%C3%AE-l-arabinopyranosyl-ameliorates-porcine-serum-induced-immune-liver-fibrosis-by-inhibiting-nf-%C3%AE%C2%BAb-signaling-pathway-and-suppressing-hsc-activation
#20
Facheng Bai, Quanfang Huang, Jinbin Wei, Shujuan Lv, Yuxin Chen, Chunhong Liang, Ling Wei, Zhongpeng Lu, Xing Lin
The present study was to investigate the inhibitory effect of Gypsophila elegans isoorientin-2″-O-α-l-arabinopyranosyl (GEI) on hepatic stellate cells (HSCs), to reveal the underlying mechanism of GEI against hepatic fibrosis. Our study showed that GEI significantly alleviated liver injury induced by porcine serum (PS) in rats; it notably alleviated collagen accumulation as evidenced by a significant decrease in the levels of collagen biomarkers including hyaluronic acid, laminin, hydroxyproline and procollagen III N-terminal peptide...
November 3, 2017: International Immunopharmacology
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