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https://www.readbyqxmd.com/read/29349668/serum-mmp-9-diagnostics-prognostics-and-activation-in-acute-coronary-syndrome-and-its-recurrence
#1
Laura Lahdentausta, Jaakko Leskelä, Alina Winkelmann, Taina Tervahartiala, Timo Sorsa, Erkki Pesonen, Pirkko J Pussinen
Matrix metalloproteinase (MMP)-9 is crucial in atherosclerotic plaque rupture and tissue remodeling after a cardiac event. The balance between MMP-9 and endogenous inhibitor, tissue inhibitors of matrix metalloproteinase 1 (TIMP-1), is important in acute coronary syndrome (ACS). This is an age- and gender-matched case-control study of ACS (N = 669). Patients (45.7%) were resampled after recovery, and all were followed up for 6 years. The molecular forms of MMP-9 were investigated by gelatin zymography...
January 18, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29349515/matrix-metalloproteinase-2-and-9-activity-levels-increase-in-cutaneous-lupus-erythematosus-lesions-and-correlate-with-disease-severity
#2
Goksen Ertugrul, Didem Keles, Gulgun Oktay, Sebnem Aktan
Lupus erythematosus is a chronic autoimmune disease characterized by remissions and exacerbations. Accumulated evidence indicated that matrix metalloproteinases (MMPs) are upregulated in inflammatory cells of cutaneous lupus erythematosus (CLE); however, the activity levels of these proteases have remained uncharacterized. To elucidate the significance of MMP-2, MMP-9, and TIMP-1 in CLE pathogenesis, gelatin zymography was used to investigate pro and active levels of MMP-2 and MMP-9 in lesional and perilesional skin biopsies obtained from twenty-two CLE patients...
January 18, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29345399/glycine-improves-the-remodeling-process-of-tenocytes-in-vitro
#3
Cristiano Pedrozo Vieira, Manuela Viola, Giane Daniela Carneiro, Maria Luisa D'Angelo, Cristina Pontes Vicente, Alberto Passi, Edson Rosa Pimentel
Tendinitis changes the biochemical and morphological properties of the tendon, promoting an increase of activity of metalloproteinases and disorganization of collagen bundles. Tenocytes the primary cells in tendon, are scattered throughout the collagenic fibres, and are responsible of tendon remodeling and tissue repair in pathological condition. In vivo, glycine, component of the typical Gly-X-Y collagen tripeptide, showed beneficial effects in biochemical and biomechanical properties of Achilles tendon with tendinitis...
January 18, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29345295/upregulation-of-the-bdnf-trkb-pathway-promotes-epithelial-mesenchymal-transition-as-well-as-the-migration-and-invasion-of-cervical-cancer
#4
Yuan Yuan, Hai-Qiong Ye, Qian-Chuan Ren
Brain-derived neurotrophic factor (BDNF) has previously been demonstrated to be associated with several types of cancer. In addition, its receptor, tropomyosin related kinase B (TrkB) is involved in tumor invasion and metastasis. Epithelial-mesenchymal transition (EMT) is associated with metastasis in cancers. Thus, The aim of the present study was to examine whether BDNF/TrKB expression is linked to a poor survival and the acquisition of the EMT phenotype in cervical cancer. We found that a high positive expression of BDNF/TrKB was associated with poor survival in cervical cancer...
February 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29339258/relationship-between-very-early-brain-structure-and-neuromotor-neurological-and-neurobehavioral-function-in-infants-born-31%C3%A2-weeks-gestational-age
#5
Joanne M George, Simona Fiori, Jurgen Fripp, Kerstin Pannek, Andrea Guzzetta, Michael David, Robert S Ware, Stephen E Rose, Paul B Colditz, Roslyn N Boyd
AIM: This study aimed to examine associations between structural MRI and concurrent motor, neurological and neurobehavioral measures at 30-32 weeks postmenstrual age (PMA; 'Early'), and at term equivalent age ('Term'). METHOD: In this prospective cohort study, infants underwent Early MRI (n = 119; 73 male; median 32 weeks 1 day PMA) and Term MRI (n = 102; 61 male; median 40 weeks 4 days PMA) at 3 T. Structural images were scored generating white matter (WM), cortical gray matter, deep gray matter, cerebellar and global brain abnormality scores...
January 13, 2018: Early Human Development
https://www.readbyqxmd.com/read/29337896/caffeic-acid-and-metformin-inhibit-invasive-phenotype-induced-by-tgf-%C3%AE-1-in-c-4i-and-htb-35-siha-human-cervical-squamous-carcinoma-cells-by-acting-on-different-molecular-targets
#6
Malgorzata Tyszka-Czochara, Malgorzata Lasota, Marcin Majka
During the progression of epithelial cancer, the cells may lose epithelial markers and gain mesenchymal phenotype via Epithelial-Mesenchymal Transition (EMT). Such transformation of epithelial cancer cells to mesenchymal-like characteristic benefits plasticity and supports their ability to migrate. The aim of this study was to evaluate the influence of natural compound Caffeic Acid (CA) alone and in combination with antidiabetic drug Metformin (Met) on metastatic progression of two human cervical squamous cell cancer lines, C-4I and HTB-35/SiHa cells...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29337871/influence-of-kartogenin-on-chondrogenic-differentiation-of-human-bone-marrow-derived-mscs-in-2d-culture-and-in-co-cultivation-with-oa-osteochondral-explant
#7
Timea Spakova, Jana Plsikova, Denisa Harvanova, Marek Lacko, Stefan Stolfa, Jan Rosocha
Articular cartilage has limited capacity for natural regeneration and repair. In the present study, we evaluated kartogenin (KGN), a bioactive small heterocyclic molecule, for its effect on in vitro proliferation and chondrogenic differentiation of human bone marrow-derived mesenchymal stromal cells (hBMSCs) in monolayer culture and in co-culture models in vitro. OA osteochondral cylinders and hBMSCs were collected during total knee replacement. The effect of KGN on hBMSCs during 21 days of culture was monitored by real-time proliferation assay, immunofluorescence staining, histological assay, scanning electron microscopy (SEM) (imaging and multiplex enzyme-linked immunosorbent assay) ELISA assay...
January 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29336497/effects-of-treatment-with-maraviroc-a-ccr5-inhibitor-on-a-human-hepatic-stellate-cell-line
#8
N Coppola, A Perna, A Lucariello, S Martini, M Macera, M A Carleo, G Guerra, V Esposito, A De Luca
After an acute liver damage, tissue regeneration repairs lesions with degradation of deposed fibrotic material, while mechanisms of tissue restoration are persistently activated following several repeated injuries, inducing deposition of extracellular matrix. (ECM). Factors responsible for ECM remodeling have been identified in a pathway involving a family of zinc-dependent enzyme matrix metalloproteinases (MMPs), together with tissue inhibitor of metalloproteinases (TIMPs). Recent experimental models suggested a role of CCR5 receptor in the genesis of liver fibrosis...
January 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29329251/pharmacological-investigation-of-the-anti-inflammation-and-anti-oxidation-activities-of-diallyl-disulfide-in-a-rat-emphysema-model-induced-by-cigarette-smoke-extract
#9
Yan Liu, Ang Li, Xiuli Feng, Xiao Sun, Xiaosong Zhu, Zhongxi Zhao
Diallyl disulfide (DADS) is the main organosulfur ingredient in garlic, with known antioxidant and anti-inflammatory activities. The aim of the present study was to investigate the effect of DADS on reducing the inflammation and redox imbalance in a rat emphysema model that was induced by intraperitoneal injection of cigarette smoke extract (CSE). Briefly, DADS exerted an anti-inflammation effect on emphysema rats through decreasing cell influx in the bronchoalveolar lavage fluid (BALF) and suppressing pro-inflammation cytokine production including tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) via inhibiting the NF-κB pathway...
January 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29328490/galectin-1-expression-in-activated-pancreatic-satellite-cells-promotes-fibrosis-in-chronic-pancreatitis-pancreatic-cancer-via-the-tgf-%C3%AE-1-smad-pathway
#10
Dong Tang, Qi Wu, Jingqiu Zhang, Hongpeng Zhang, Zhongxu Yuan, Jiaming Xu, Yang Chong, Yuqin Huang, Qingquan Xiong, Sen Wang, Ying Tian, Yongdie Lu, Xiao Ge, Wenjing Shen, Daorong Wang
Chronic pancreatitis/pancreatic cancer (CP/PC) is characterized by fibrous connective tissue proliferation induced by activated pancreatic stellate cells (PSCs). Galectin-1 is upregulated in activated PSCs and is important for the continuing activation of PSCs. The aim of this study was to evaluate the effect of galectin-1 derived from activated PSCs on the progression of fibrosis in CP/PC. To this end, the expression of desmin, α-SMA, galectin-1, fibronectin and collagen type I in normal pancreatic, CP and PC tissues, as well as quiescent/activated PSCs, was investigated...
January 9, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29328461/anti%C3%A2-inflammatory-effects-of-gambogic-acid-in-murine-collagen%C3%A2-induced-arthritis-through-pi3k-akt-signaling-pathway
#11
Qing Lai Wang, Dong Zhen Yang, Cunxian Lv
Garcinia angustifolia is a dry resin secreted by Garcinia cambogia, which has the functions of breaking blood, detoxifying, stopping bleeding and killing insects. It is used for the treatment of cancer and brain edema. Gambogic acid is the primary active ingredient. The present study aimed to investigate the anti‑inflammatory and antiproliferative effects of gambogic acid on arthritis and the possible mechanisms. It was demonstrated that gambogic acid decreased arthritic scores in murine collagen‑induced arthritic mice...
January 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29326312/foxo3a-forkhead-transcription-factor-o-subfamily-member-3a-links-vascular-smooth-muscle-cell-apoptosis-matrix-breakdown-atherosclerosis-and-vascular-remodeling-through-a-novel-pathway-involving-mmp13-matrix-metalloproteinase-13
#12
Haixiang Yu, Adam Fellows, Kirsty Foote, Zhaoqing Yang, Nichola Figg, Trevor Littlewood, Martin Bennett
OBJECTIVE: Vascular smooth muscle cell (VSMC) apoptosis accelerates atherosclerosis and promotes breakdown of the extracellular matrix, but the mechanistic links between these 2 processes are unknown. The forkhead protein FOXO3a (forkhead transcription factor O subfamily member 3a) is activated in human atherosclerosis and induces a range of proapoptotic and other transcriptional targets. We, therefore, determined the mechanisms and consequences of FOXO3a activation in atherosclerosis and arterial remodeling after injury...
January 11, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29325849/coagonist-of-glp-1-and-glucagon-decreases-liver-inflammation-and-atherosclerosis-in-dyslipidemic-condition
#13
Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Brijesh Sutariya, Maulik Patel, Dhreerendra Pandey, Hiren Patel, Ramchandra Ranvir, Shekhar Kadam, Dipam Patel, Rajesh Bahekar, Mukul Jain
Dyslipidemia enhances progression of atherosclerosis. Coagonist of GLP-1 and glucagon are under clinical investigation for the treatment of obesity and diabetes. Earlier, we have observed that coagonist reduced circulating and hepatic lipids, independent of its anorexic effects. Here, we investigated the role of coagonist of GLP-1 and glucagon receptors in complications of diet-induced dyslipidemia in hamsters and humanized double transgenic mice. Hamsters fed on high fat high cholesterol diet were treated for 8 weeks with coagonist of GLP-1 and glucagon receptors (75 and 150 μg/kg)...
January 8, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29325453/age-related-lung-tissue-remodeling-due-to-the-local-distribution-of-mmp-2-timp-2-tgf-%C3%AE-and-hsp70
#14
Z Vitenberga, M Pilmane
Lung tissue remodeling requires complex interactions of matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), transforming growth factor (TGF) family and heat shock protein 70 (Hsp70). We evaluated the appearance and distribution of MMP-2, TIMP-2, TGF-β1 and Hsp70 in lung tissue using immunohistochemistry. Stained structures were graded semiquantitatively. Overall, more MMP-2, TIMP-2, TGF-β1 and Hsp70 were observed in bronchial cartilage, bronchial and alveola repithelium, and among alveolar macrophages...
January 12, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29324263/the-role-of-pro-fibrotic-biomarkers-in-paroxysmal-and-persistent-atrial-fibrillation
#15
Adina Elena Stanciu, Radu Gabriel Vatasescu, Marcel Marian Stanciu, Nafija Serdarevic, Maria Dorobantu
PURPOSE: Signaling pathways involved in electrical, structural and contractile remodeling processes behind development and progression of atrial fibrillation (AF) have not been completely elucidated, but it seems to be related to complex interactions among neurohormonal and cellular mediators. We aimed to investigate interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-β1), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), as biomarkers of atrial remodeling, in patients with paroxysmal and persistent AF, and their correlation with N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and left atrial (LA) diameter...
January 8, 2018: Cytokine
https://www.readbyqxmd.com/read/29321630/engineered-mesenchymal-stem-cell-sheets-patches-prevents-postoperative-pancreatic-leakage-in-a-rat-model
#16
Seong-Ryong Kim, Hye-Jin Yi, Yu Na Lee, Ji Yoon Park, Robert M Hoffman, Teruo Okano, In Kyong Shim, Song Cheol Kim
Post-operative pancreatic fistula (POPF) following pancreatic resection is a life-threatening surgical complication. Cell sheets were prepared and harvested using temperature-responsive culture dishes and transplanted as patches to seal POPF. Two different mesenchymal stem cell (MSC) sheets were compared in terms of the preventative ability for pancreatic leakage in a rat model. Both rat adipose-derived stem cell (rADSC) and bone marrow-derived stem cell (rBMSC) sheets were transplanted. Those rADSC and rBMSC sheets are created without enzymes and thus maintained their cell-cell junctions and adhesion proteins with intact fibronectin on the basal side, as well as characteristics of MSCs...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29312740/serum-metalloproteinase-2-and-tissue-inhibitor-of-metalloproteinase-2-in-lung-carcinoma-patients
#17
Magdalena Drzewiecka-Jędrzejczyk, Rafał Wlazeł, Monika Terlecka, Sławomir Jabłoński
Background: Assessment of serum extracellular matrix (ECM) metalloproteinase MMP-2 and tissue inhibitor of matrix metalloproteinase TIMP-2 concentrations in non-small cell lung carcinoma (NSCLC) patients considering TNM staging. Assessment of the prognostic value of MMP-2 and TIMP-2 concentrations in NSCLC patients. Methods: The study group consisted of 81 NSCLC patients (24 females and 57 males) aged 46 to 86 years (mean age of 67±8.2 years). The control group comprised 39 randomly selected patients (20 females and 19 males) aged 27 to 73 years (mean age of 47±15...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29312615/xrcc1-serves-as-a-potential-prognostic-indicator-for-clear-cell-renal-cell-carcinoma-and-inhibits-its-invasion-and-metastasis-through-suppressing-mmp-2-and-mmp-9
#18
Qing-Hua Liu, You Wang, Hong-Mei Yong, Ping-Fu Hou, Jie Pan, Jin Bai, Jun-Nian Zheng
X-ray repair cross-complementing group 1 (XRCC1) is a major DNA repair gene that is responsible for fixing DNA base damage and single-strand breaks by interacting with DNA components at the damage site. This study explored the clinical significance of XRCC1 in human clear cell renal cell carcinoma (ccRCC) and further examined the mechanism of the role of XRCC1 in ccRCC. The clinical relevance of XRCC1 in ccRCC was evaluated using tissue microarrays and immunohistochemical staining of two independent human ccRCC cohorts...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29312574/association-between-mmp-3-polymorphisms-among-chinese-patients-with-osteonecrosis-of-the-femoral-head
#19
Yuxin Qi, Yong Zhu, Yuju Cao, Huiqiang Wu, Mingqi Sun, Hao Wu, Linlin Pan, Guoqiang Wang, Jianzhong Wang
Many potential causative factors are related to the initiation and progression of osteonecrosis of the femoral head (ONFH). The matrix metalloproteinase/tissue inhibitor of metalloproteinases (MMPs/TIMPs) system was found to play a significant role in the development of ONFH. The aim of this study is to investigate the association between polymorphisms of MMP-3 and ONFH in the Chinese population. We selected 8 single-nucleotide polymorphisms (SNPs) in 2 genes selected from the MMPs/TIMPs system in a case-control study with 585 cases of ONFH and 507 healthy controls...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310800/matrix-metalloproteinases-vascular-remodeling-and-vascular-disease
#20
Xi Wang, Raouf A Khalil
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a propeptide sequence, a catalytic metalloproteinase domain with catalytic zinc, a hinge region or linker peptide, and a hemopexin domain. MMPs are commonly classified on the basis of their substrates and the organization of their structural domains into collagenases, gelatinases, stromelysins, matrilysins, membrane-type (MT)-MMPs, and other MMPs...
2018: Advances in Pharmacology
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