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https://www.readbyqxmd.com/read/28535015/the-circadian-clock-gene-per2-plays-an-important-role-in-tumor-suppression-through-regulating-tumor-associated-genes-in-human-oral-squamous-cell-carcinoma
#1
Xiaoli Su, Dan Chen, Kai Yang, Qin Zhao, Dan Zhao, Xiaoqiang Lv, Yiran Ao
Low expression of the clock gene PER2 is closely related to carcinogenesis and the development of cancer; however, the mechanism of the low expression of PER2 that led to cell malignant transformation remains unclear. This study used RNA interference (RNAi) technology to silence PER2 in SCC15 human oral squamous cell carcinoma (OSCC) cells. Then it was found that the ability of cancer cell proliferation, migration, and invasion were markedly increased (P<0.05), and the ability of cancer cell apoptosis and the number of cells in G1/G0 phase were markedly reduced (P<0...
May 19, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28533328/tendon-stem-progenitor-cells-regulate-inflammation-in-tendon-healing-via-jnk-and-stat3-signaling
#2
Solaiman Tarafder, Esther Chen, Yena Jun, Kristy Kao, Kun Hee Sim, Jungho Back, Francis Y Lee, Chang H Lee
Tendon stem/progenitor cells (TSCs) have been found in different anatomic locations and showed a promising regenerative potential. We identified a role of TSCs in the regulation of inflammation during healing of acute tendon injuries. Delivery of connective tissue growth factor (CTGF) into full-transected rat patellar tendons significantly increased the number of CD146(+) TSCs, leading to enhanced healing. In parallel, CTGF delivery significantly reduced the number of iNOS(+) M1 Mϕs and increased the expression of anti-inflammatory IL-10 at 2 d after surgery, with over 85% CD146(+) TSCs expressing IL-10...
May 22, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28527839/modulation-of-matrix-metalloproteinase-14-tissue-inhibitor-of-metalloproteinase-3-tissue-inhibitor-of-metalloproteinase-4-and-inducible-nitric-oxide-synthase-in-the-development-of-periapical-lesions
#3
Lorena Teodoro de Castro Cassanta, Virmondes Rodrigues, Jose Roberto Violatti-Filho, Benedito Alves Teixeira Neto, Vinícius Marques Tavares, Eduarda Castelo Branco Araujo Bernal, Danila Malheiros Souza, Marcelo Sivieri Araujo, Sanivia Aparecida de Lima Pereira, Denise Bertulucci Rocha Rodrigues
INTRODUCTION: Periapical cysts and granulomas are chronic lesions caused by an inflammatory immune response against microbial challenge in the root canal. Different cell types, cytokines, and molecules have been associated with periapical lesion formation and expansion. Therefore, because of the chronic inflammatory state of these lesions, the aim of this study was to evaluate the in situ expression of matrix metalloproteinase (MMP)-14 and -19, tissue inhibitor of metalloproteinase (TIMP)-3 and -4, CD68, and inducible nitric oxide synthase (iNOS) in periapical cysts and granulomas...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28526320/mercury-exposure-induces-cytoskeleton-disruption-and-loss-of-renal-function-through-epigenetic-modulation-of-mmp9-expression
#4
Hafizurrahman Khan, Radha Dutt Singh, Ratnakar Tiwari, Siddhartha Gangopadhyay, Somendu Kumar Roy, Dhirendra Singh, Vikas Srivastava
Mercury is one of the major heavy metal pollutants occurring in elemental, inorganic and organic forms. Due to ban on most inorganic mercury containing products, human exposure to mercury generally occurs as methylmercury (MeHg) by consumption of contaminated fish and other sea food. Animal and epidemiological studies indicate that MeHg affects neural and renal function. Our study is focused on nephrotoxic potential of MeHg. In this study, we have shown for the first time how MeHg could epigenetically modulate matrix metalloproteinase 9(MMP9) to promote nephrotoxicity using an animal model of sub chronic MeHg exposure...
May 16, 2017: Toxicology
https://www.readbyqxmd.com/read/28525828/peripheral-immune-factors-are-elevated-in-women-with-current-or-recent-alcohol-dependence-and-associated-with-altered-mood-and-memory
#5
Clare J Wilhelm, Bret E Fuller, Marilyn Huckans, Jennifer M Loftis
BACKGROUND: The adverse effects of alcohol on brain function result, in part, from inflammatory processes. The sex-specific neuropsychiatric consequences and inflammatory status of active alcohol dependence and early remission from dependence have not been investigated. METHODS: Neuropsychiatric symptoms, inflammatory factors, and liver enzymes were compared in a prospective cohort study of adults with (n=51) or without (n=31) a current or recent history of alcohol dependence...
May 10, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28523565/blood-brain-barrier-permeability-is-exacerbated-in-experimental-model-of-hepatic-encephalopathy-via-mmp-9-activation-and-downregulation-of-tight-junction-proteins
#6
Saurabh Dhanda, Rajat Sandhir
The present study was designed to investigate the mechanisms involved in blood-brain barrier (BBB) permeability in bile duct ligation (BDL) model of chronic hepatic encephalopathy (HE). Four weeks after BDL surgery, a significant increase was observed in serum bilirubin levels. Masson trichrome staining revealed severe hepatic fibrosis in the BDL rats. (99m)Tc-mebrofenin retention was increased in the liver of BDL rats suggesting impaired hepatobiliary transport. An increase in permeability to sodium fluorescein, Evans blue, and fluorescein isothiocyanate (FITC)-dextran along with increase in water and electrolyte content was observed in brain regions of BDL rats suggesting disrupted BBB...
May 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28522569/brain-derived-neurotrophic-factor-and-airway-fibrosis-in-asthma
#7
Michelle R Freeman, Venkatachalem Sathish, Logan J Manlove, Shengyu Wang, Rodney D Britt, Michael A Thompson, Christina M Pabelick, Y S Prakash
Airway remodeling in asthma driven by inflammation involves proliferation of epithelial cells and airway smooth muscle (ASM), as well as enhanced extracellular matrix (ECM) generation and deposition, i.e. fibrosis. Accordingly, understanding pro-fibrotic mechanisms is important for developing novel therapeutic strategies in asthma. Recent studies, including our own, have suggested a role for locally-produced growth factors such as brain-derived neurotrophic factor (BDNF) in mediating and modulating inflammation effects...
May 18, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28520923/decrease-in-expression-of-hoxa10-in-the-decidua-after-embryo-implantation-promotes-trophoblast-invasion
#8
Geeta Godbole, Pankaj Suman, Ankita Malik, Mosami Galvankar, Niraj Joshi, Asgerally Fazleabas, Satish Kumar Gupta, Deepak Modi
A central step towards successful pregnancy involves invasion of the trophoblast cells into the decidua for placentation. Herein, we show that in the human and baboon decidua, HOXA10 expression is downregulated post-implantation and this reduction is most prominent in the decidual cells juxtaposed to the invading placental villi. Intriguingly, the supernatants derived from HOXA10 depleted human decidual cells increase the invasiveness of the trophoblast cell lines ACH-3P and JEG3 in vitro; this increase is due to higher expression and activity of matrix metalloproteases (MMPs) and reduced expression of tissue inhibitors of MMPs (TIMPs) in both the cell lines...
May 17, 2017: Endocrinology
https://www.readbyqxmd.com/read/28516393/plasma-mmp2-timp4-ratio-at-follow-up-assessment-predicts-disease-progression-of-idiopathic-pulmonary-arterial-hypertension
#9
Veronika Wetzl, Svenja Lena Tiede, Lothar Faerber, Norbert Weissmann, Ralph Theo Schermuly, Hossein Ardeschir Ghofrani, Henning Gall
PURPOSE: Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) are of particular interest in the remodeling processes of pulmonary hypertension. The aim of this study was to investigate MMP/TIMP ratios of selected biomarkers (MMP2, MMP9, TIMP1, TIMP4) at follow-up examination (V2) and their prognostic value in patients with idiopathic pulmonary arterial hypertension (iPAH). METHODS: Blood samples were taken from iPAH patients during right heart catheterization at diagnosis (V1, from 2003 to 2012) and first follow-up examination (V2)...
May 17, 2017: Lung
https://www.readbyqxmd.com/read/28515079/impact-of-acetaminophen-consumption-and-resistance-exercise-on-extracellular-matrix-gene-expression-in-human-skeletal-muscle
#10
Shivam H Patel, Andrew C D'Lugos, Erica R Eldon, Donald Curtis, Jared M Dickinson, Chad C Carroll
Acetaminophen (APAP) given during chronic exercise reduces skeletal muscle collagen and cross-linking in rats. We propose that the effect of APAP on muscle ECM may, in part, be mediated by dysregulation of the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs). The purpose of this study was to evaluate the impact of APAP consumption during acute resistance exercise (RE) on several regulators of the ECM in human skeletal muscle. In a double-blinded, placebo-controlled, randomized cross-over design, recreationally active men (n=8, 25±2yr) performed two trials of knee extension...
May 17, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28510611/mmp-10-mmp-7-timp-1-and-timp-2-mrna-expression-in-esophageal-cancer
#11
Agnieszka Juchniewicz, Oksana Kowalczuk, Robert Milewski, Wojciech Laudański, Piotr Dzięgielewski, Mirosław Kozłowski, Jacek Nikliński
INTRODUCTION: Tissue inhibitors of metalloproteinases (TIMP) and the matrix metalloproteinases (MMP) are involved in the spread of cancer. METHODS: We have evaluated the matrix metalloproteinases' (MMP-10, MMP-7) and their inhibitors' (tissue inhibitors of metalloproteinases - TIMP-1, TIMP-2) mRNA expression in 61 esophageal cancer samples from patients who had undergone surgery, by using real-time quantitative RT-PCR, and correlated the results with the patient clinicopathologic features...
May 15, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28509321/evaluation-of-tissue-metalloproteinase-inhibitor-timp-1-and-survivin-levels-during-third-trimester-pregnancy-a-preliminary-report
#12
Agata Karowicz-Bilińska, Urszula Kowalska-Koprek, Dorota Estemberg, Anita Sikora-Szubert
OBJECTIVES: A proper implantation of trophoblastic cells and an appropriate metalloproteinases activity is required to cause disintegration of basal membranes of cells. The activity of tissue matrix metaloproteinases can be inhibited by their matrix inhibitors - TIMP-s. Survivin is a member of inhibitor of apoptosis proteins family (IAP), that suppresses caspase activation, influences VEGF expression and promotes proliferative action of endothelial cells. MATERIAL AND METHODS: The aim of the study was to assess concentrations of two independent anti-apoptotic factors...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28507585/ctgf-upregulation-correlates-with-mmp-9-level-in-airway-remodeling-in-a%C3%A2-murine-model-of-asthma
#13
Sheng-Chieh Lin, Hsiu-Chu Chou, Bor-Luen Chiang, Chung-Ming Chen
INTRODUCTION: Connective tissue growth factor (CTGF) mediates hypertrophy, proliferation, and extracellular matrix synthesis. Matrix metalloproteinase (MMP) plays a role in airway extracellular matrix remodeling. The correlation between CTGF and MMP in airway remodeling of asthma was unknown. This study investigated lung CTGF expression and its correlation with MMP and airway structural changes in a murine model of asthma. MATERIAL AND METHODS: Female BALB/c mice were sensitized and challenged by intraperitoneal injections and intranasal phosphate-buffered saline (PBS) or ovalbumin (OVA)...
April 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28506859/the-obstructed-bladder-expression-of-collagen-matrix-metalloproteinases-muscarinic-receptors-angiogenic-and-neurotrophic-factors-in-patients-with-benign-prostatic-hyperplasia
#14
João Arthur Brunhara Alves Barbosa, Sabrina T Reis, Marco Nunes, Yuri A Ferreira, Katia R Leite, William C Nahas, Miguel Srougi, Alberto A Antunes
OBJECTIVE: to evaluate gene expression of Collagen, Matrix Metalloproteinases (MMP) and Inhibitors, Cholinergic Muscarinic Receptors (CHRM), Angiogenic and Nerve Growth Factors (NGF) in the bladder of patients with Bladder Outlet Obstruction due to Benign Prostatic Hyperplasia METHODS: We analyzed bladder specimens from 43 patients with obstructive BPH undergoing TURP as compared to 10 age-matched controls with IPSS<8 and prostate <30g. A bladder biopsy was performed for relative gene expression analysis with qRT-PCR of Collagens I and III, MMPs 1,2,9; Tissue Inhibitors of Metalloproteinases (TIMP) 1,2 and RECK; CHRM2 and -3; VEGF, CD105; NGF and NGF receptor...
May 12, 2017: Urology
https://www.readbyqxmd.com/read/28506758/decreased-homodimerization-and-increased-timp-1-complexation-of-uteroplacental-and-uterine-arterial-matrix-metalloproteinase-9-during-hypertension-in-pregnancy
#15
Juanjuan Chen, Zongli Ren, Minglin Zhu, Raouf A Khalil
Preeclampsia is a complication of pregnancy manifested as hypertension-in-pregnancy (HTN-Preg) and often intrauterine growth restriction (IUGR). Placental ischemia could be an initiating event, but the molecular mechanisms are unclear. To test the hypothesis that dimerization of matrix metalloproteinases (MMPs) plays a role in HTN-Preg and IUGR, the levels/activity of MMP-9, tissue inhibitor of metalloproteinase (TIMP-1), and their dimerization forms were measured in the placenta, uterus, and uterine artery of normal pregnant (Preg) rats and a rat model of reduced uteroplacental perfusion pressure (RUPP)...
May 12, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28504959/casticin-attenuates-liver-fibrosis-and-hepatic-stellate-cell-activation-by-blocking-tgf-%C3%AE-smad-signaling-pathway
#16
Ling Zhou, Xiaoying Dong, Linlin Wang, Lanlan Shan, Ting Li, Wanfu Xu, Yan Ding, Mingqiang Lai, Xiaojun Lin, Meng Dai, Xiaochun Bai, Chunhong Jia, Hang Zheng
Although many advances have been made in understanding the pathogenesis of liver fibrosis, few options are available for treatment. Casticin, one of the major flavonoids in Fructus Viticis extracts, has shown hepatoprotective potential, but its effects on liver fibrosis are not clear. In this study, we investigated the antifibrotic activity of casticin and its underlying mechanism in vivo and in vitro. Male mice were injected intraperitoneally with carbon tetrachloride (CCl4) or underwent bile duct ligation (BDL) to induce liver fibrosis, followed by treatment with casticin or vehicle...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28503427/expressions-of-matrix-metalloproteinases-1-and-3-and-their-tissue-inhibitors-in-the-conjunctival-tissue-and-fibroblasts-cultured-from-conjunctivochalasis
#17
Min-Hong Xiang, Xing-Ru Zhang, Zhen-Yong Zhang, Qing-Song Li, Han-Min Wang, Zhu-Mei Han, Huan-Ming Zhou, Yuan-Ling Jia, Xing-Xing Chen
AIM: To investigate the expression of matrix metalloproteinases 1 and 3 (MMP-1 and MMP-3) and their tissue inhibitors of metalloproteinases 1 and 3 (TIMP-1 and TIMP-3) in the conjunctiva of eyes with conjunctivochalasis (CCh). METHODS: The conjunctival tissue was obtained from the CCh patients and controls, the MMPs/TIMPs expression concentration was determined by enzyme-linked immuno-sorbent assay (ELISA) and immunofluorescence staining. The expression levels of MMPs/TIMPs in the CCh fibro-blasts were determined by analyzing its concentration in the cellular supernatant that was abstracted from the in vitro cultured CCh fibroblasts...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28503261/anti-photoaging-effects-of-angelica-acutiloba-root-ethanol-extract-in-human-dermal-fibroblasts
#18
Min Ah Park, Mi Ja Sim, Young Chul Kim
The effects that ultraviolet rays elicit on collagen synthesis and degradation are the most common causes of wrinkle formation and photo-aging in skin. The objectives of this study were to evaluate the effects of Angelica acutiloba root ethanol extract (AAEE) to promote collagen synthesis and inhibit collagen degradation in human dermal fibroblasts. By examining total polyphenol and flavonoid contents, electron donating ability, radical scavenging activity, and superoxide dismutase-like activity, we found that AAEE exhibited fairly good antioxidant activity...
April 2017: Toxicological Research
https://www.readbyqxmd.com/read/28499840/antimicrobial-peptide-ksl-w-promotes-gingival-fibroblast-healing-properties-in-vitro
#19
Hyun-Jin Park, Mabrouka Salem, Abdelhabib Semlali, Kai P Leung, Mahmoud Rouabhia
We investigated the effect of synthetic antimicrobial decapeptide KSL-W (KKVVFWVKFK) on normal human gingival fibroblast growth, migration, collagen gel contraction, and α-smooth muscle actin protein expression. Results show that in addition to promoting fibroblast adhesion by increasing F-actin production, peptide KSL-W promoted cell growth by increasing the S and G2/M cell cycle phases, and enhanced the secretion of metalloproteinase (MMP)-1 and MMP-2 by upregulating MMP inhibitors, such as tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in fibroblasts...
May 9, 2017: Peptides
https://www.readbyqxmd.com/read/28498459/inhibitors-of-parp-1-exert-inhibitory-effects-on-the-biological-characteristics-of-hepatocellular-carcinoma-cells-in%C3%A2-vitro
#20
Xiaorong Mao, Senrong Du, Zhongxia Yang, Liting Zhang, Xuebin Peng, Ni Jiang, Haiyu Zhou
It has been confirmed that the inhibitors of poly ADP-ribose polymerF(^9ase‑1 (PARP‑1) can inhibit the proliferation, apoptosis and invasion of tumor cells. However, the effects of inhibitors of PARP‑1 on hepatocellular carcinoma remain to be elucidated. The aim of the present study was to investigate the effect of three types of PARP‑1 inhibitor on the proliferation, apoptosis and migration of hepatocellular carcinoma in vitro. An MTT assay was performed to detect the proliferation of HepG2 cells following treatment with the PARP‑1 inhibitors, AG014699, BSI‑201 and AZD‑2281...
May 10, 2017: Molecular Medicine Reports
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