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https://www.readbyqxmd.com/read/28731196/microrna-106a-promotes-cell-migration-and-invasion-by-targeting-tissue-inhibitor-of-matrix-metalloproteinase-2-in-cervical-cancer
#1
Xia Li, Qi Zhou, Ling Tao, Chunxia Yu
Increasing evidence has demonstrated that miRNAs play a critical role in tumor development and progression. Previous studies have revealed that miR-106a is abnormally expressed in various cancers. However, its function and underlying mechanism in cervical cancer (CC) remains unknown. In this study, we confirmed that the expression of miR-106a was significantly upregulated in both CC cell lines and tissues by qRT-PCR. The increased expression of miR-106a was obviously associated with adverse prognostic features...
July 18, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28727135/the-role-of-metalloproteinases-in-endometrial-remodelling-during-menstrual-cycle
#2
Barbara Grzechocińska, Filip Dąbrowski, Anna Cyganek, Grzegorz Panek, Mirosław Wielgoś
Endometrium is the only tissue in the human body subject to cyclic transformations under the influence of ovarian steroid hormones. As estradiol and progesterone balance throughout the physiological menstrual cycle changes, so does the expression of metalloproteinases (MMPs). These endopeptides are responsible for keeping the balance between the process of synthesis and degradation of extracellular matrix proteins. Thus, MMP's take part in sustaining physiological stability of the endometrium. A number of MMPs found in the endometrial tissue and their activity is related to menstrual cycle phase...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28724217/chondroprotective-and-anti-nociceptive-effects-of-caffeoylquinic-acid-in-osteoarthritis-by-downregulating-catabolic-activity-and-oxidative-damage-in-chondrocytes
#3
Luping Liu, Yongmei Li
We evaluated the chondroprotective and anti-nociceptive effects of caffeoylquinic acid (CA) in a rat osteoarthritis (OA) model. Monosodium iodoacetate was injected intra-articularly in the rats to produce OA. The rats were divided into three groups: control, OA group, which received vehicle, and the CA-treated group, which received CA (50mg/kg, p.o.) for 14days. At the end of the protocol, pain was estimated by observing the paw withdrawal threshold and latency. Degeneration of cartilage was assessed through histomorphological and microscopical examination of joints...
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28721143/the-effect-of-antihypertensive-treatment-on-arterial-stiffness-and-serum-concentration-of-selected-matrix-metalloproteinases
#4
Marek Rajzer, Wiktoria Wojciechowska, Tomasz Kameczura, Agnieszka Olszanecka, Danuta Fedak, Michał Terlecki, Kalina Kawecka-Jaszcz, Danuta Czarnecka
INTRODUCTION: The aim of the study was to assess the arterial stiffness and serum levels of selected metalloproteinases (MMPs) in hypertensive patients and their changes following antihypertensive therapy. MATERIAL AND METHODS: The study group consisted of 95 patients with essential arterial hypertension (HT) stage 1 or 2 (mean age: 53.1 ±13.0 years). The control group consisted of 31 normotensives of the same age range. Hypertension patients were randomized to one of the following monotherapies for 6 months: quinapril, losartan, amlodipine, hydrochlorothiazide or bisoprolol...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28720386/cdc42-interacting-protein-4-silencing-relieves-pulmonary-fibrosis-in-stz-induced-diabetic-mice-via-the-wnt-gsk-3%C3%AE-%C3%AE-catenin-pathway
#5
Xiaoping Zhang, Ying Liu, Runxia Shao, Wei Li
Cdc42-interacting protein-4 (CIP4) has been reported to be closely associated with diabetic nephropathy in rat. However, little is known about the correlation between CIP4 and diabetic pulmonary fibrosis (PF) in mice. Here, diabetes was induced by streptozotocin (STZ), and later lung tissue was collected and subjected to hematoxylin and eosin (H & E) staining for morphological examination. The distinct up-regulation of CIP4 was observed in diabetic PF mice. CIP4 silencing increased overall weight and decreased lung weight...
July 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28710453/intrinsic-dynamics-study-identifies-two-amino-acids-of-timp-1-critical-for-its-lrp-1-mediated-endocytosis-in-neurons
#6
Laurie Verzeaux, Nicolas Belloy, Jessica Thevenard-Devy, Jérôme Devy, Géraldine Ferracci, Laurent Martiny, Stéphane Dedieu, Manuel Dauchez, Hervé Emonard, Nicolas Etique, Emmanuelle Devarenne-Charpentier
The tissue inhibitor of metalloproteinases-1 (TIMP-1) exerts inhibitory activity against matrix metalloproteinases and cytokine-like effects. We previously showed that TIMP-1 reduces neurite outgrowth in mouse cortical neurons and that this cytokine-like effect depends on TIMP-1 endocytosis mediated by the low-density lipoprotein receptor-related protein-1 (LRP-1). To gain insight into the interaction between TIMP-1 and LRP-1, we considered conformational changes that occur when a ligand binds to its receptor...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704475/protective-effect-of-galectin-9-in-murine-model-of-lung-emphysema-involvement-of-neutrophil-migration-and-mmp-9-production
#7
Yuko Horio, Hidenori Ichiyasu, Keisuke Kojima, Naoki Saita, Yohei Migiyama, Toyohisa Iriki, Kazuhiko Fujii, Toshiro Niki, Mitsuomi Hirashima, Hirotsugu Kohrogi
PURPOSE: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction and pulmonary emphysema. Persistent inflammation and remodeling of the lungs and airways result in reduced lung function and a lower quality of life. Galectin (Gal)-9 plays a crucial role as an immune modulator in various diseases. However, its role in the pathogenesis of pulmonary emphysema is unknown. This study investigates whether Gal-9 is involved in pulmonary inflammation and changes in emphysema in a porcine pancreatic elastase (PPE)-induced emphysema model...
2017: PloS One
https://www.readbyqxmd.com/read/28704150/measurement-of-ph-exudate-composition-and-temperature-in-wound-healing-a-systematic-review
#8
G Power, Z Moore, T O'Connor
OBJECTIVE: To assess the potential of measurements of pH, exudate composition and temperature in wounds to predict healing outcomes and to identify the methods that are employed to measure them. METHOD: A systematic review based on the outcomes of a search strategy of quantitative primary research published in the English language was conducted. Inclusion criteria limited studies to those involving in vivo and human participants with an existing or intentionally provoked wound, defined as 'a break in the epithelial integrity of the skin', and excluded in vitro and animal studies...
July 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28703916/down-regulation-of-microrna-let-7d-inhibits-the-proliferation-and-invasion-of-trophoblast-cells-in-preeclampsia
#9
Xu Dai, Yan Cai
Preeclampsia (PE) is a serious pregnancy complication that continues to adverse effects on mother and the fetus. The study investigated the effect of microRNA let-7d (miR-let-7d) on the proliferation and invasion of trophoblast cells (TC) in PE. In situ hybridization techniques were employed to evaluate the miR-let-7d expressions in the placental tissues from 63 PE patients as well as 65 normal placental tissues. Transfection of pre-let-7d, anti-let-7d and their corresponding control sequences was performed in TCs obtained from PE...
July 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28700733/non-invasive-prediction-of-preterm-birth-in-women-with-cervical-insufficiency-or-an-asymptomatic-short-cervix-%C3%A2-25-mm-by-measurement-of-biomarkers-in-the-cervicovaginal-fluid
#10
Ha-Na Yoo, Kyo Hoon Park, Eun Young Jung, Yu Mi Kim, Song Yi Kook, Se Jeong Jeon
OBJECTIVE: To determine whether various proteins in the cervicovaginal fluid (CVF) known to be involved in immune regulation, alone or in combination with clinical risk factors, can predict spontaneous preterm delivery (SPTD) in women with cervical insufficiency or a short cervix (≤25 mm). METHODS: This retrospective cohort study included 62 asymptomatic women with cervical insufficiency (n = 27) or an asymptomatic short cervix (n = 35) at 18-27 weeks. CVF swab samples were taken for assays of vitamin D binding protein (VDBP), interleukin (IL)-8, matrix metalloproteinases (MMP)-9, tissue inhibitor of metalloproteinases (TIMP)-1, and Dickkopf-related protein 3 (DKK3) before cervical examination, and maternal blood was collected for the determination of the C-reactive protein (CRP) level...
2017: PloS One
https://www.readbyqxmd.com/read/28696894/preference-of-aerosolized-pirfenidone-to-oral-intake-an-experimental-model-of-pulmonary-fibrosis-by-paraquat
#11
Rokhsana Rasooli, Hamid Rajaian, Abbas Pardakhty, Ali Mandegary
BACKGROUND: Inhalation drug delivery is a fast, effective, and safe route of delivering medication directly to the lungs. Thanks to the large surface area and highly vascularized epithelium in lung, pulmonary drug delivery has been considered as an effective route to deliver drugs to the systemic circulation. Pirfenidone (PF), an oral antifibrotic agent, has been shown to slow down the progression of the lung fibrosis. Inhalation or intrapulmonary delivery of PF appears to be a good alternative to optimize drug delivery and minimize the dosage, adverse and nonspecific effects...
July 11, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28696822/the-balance-of-tissue-inhibitor-of-metalloproteinase-1-and-matrix-metalloproteinase-9-in-the-autoimmune-inner-ear-disease-patients
#12
Logan Eisner, Andrea Vambutas, Shresh Pathak
Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a protein implicated in the control of inflammation in a number of autoimmune diseases. We hypothesized that the balance of TIMP-1 and matrix metalloproteinase-9 (MMP-9) may influence the control or perpetuation of inflammation in corticosteroid-responsive (RES) and corticosteroid-resistant (NR) autoimmune inner ear disease (AIED) patients. In the present study, we observed that plasma from AIED patients exhibited greater levels of TIMP-1 values compared with normal healthy controls...
July 11, 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28693294/upregulated-expression-of-mmp-9-in-gingival-epithelial-cells-induced-by-prolonged-stimulation-with-arecoline
#13
Osamu Uehara, Kousuke Takimoto, Tetsuro Morikawa, Fumiya Harada, Rie Takai, Bhoj Raj Adhikari, Ryoko Itatsu, Tomohisa Nakamura, Koki Yoshida, Hirofumi Matsuoka, Hiroki Nagayasu, Ichiro Saito, Malsantha Muthumala, Itsuo Chiba, Yoshihiro Abiko
Betel quid chewing is implicated in the high prevalence of oral cancer in Southeast Asian countries. One of the major components of betel quid is arecoline. In the present study, in order to characterize the association between chronic arecoline stimulation and carcinogenesis the expression level of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 mRNA in human gingival epithelial progenitor cells (HGEPs) stimulated with arecoline was assessed. The HGEPs were alternated between 3 days of incubation with arecoline (50 µg/ml), and 3 days without arecoline, for up to 30 days...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693193/allicin-inhibits-the-invasion-of-lung-adenocarcinoma-cells-by-altering-tissue-inhibitor-of-metalloproteinase-matrix-metalloproteinase-balance-via-reducing-the-activity-of-phosphoinositide-3-kinase-akt-signaling
#14
Ling Huang, Yuanhong Song, Jianping Lian, Zhiwei Wang
Allicin, the main active principle associated with Allium sativum chemistry, has various antitumor activities. However, to the best of our knowledge, there is no available information to address the anti-invasive effect and associated mechanism in lung adenocarcinoma. In the present study, cell viability assay, cell adhesion assay, western blot analysis, Transwell migration and invasion assays and reverse transcription-quantitative polymerase chain reaction were performed. Allicin was identified to inhibit the adhesion, invasion and migration of lung adenocarcinoma cells in a dose-dependent manner, accompanied by decreasing mRNA and protein levels of matrix metalloproteinase (MMP)-2 and MMP-9...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692939/oligomeric-proanthocyanidin-derived-from-grape-seeds-inhibited-nf-%C3%AE%C2%BAb-signaling-in-activated-hsc-involvement-of-jnk-erk-mapk-and-pi3k-akt-pathways
#15
Min Jiang, Yan-Ling Wu, Xia Li, Yu Zhang, Kai-Li Xia, Ben-Wen Cui, Li-Hua Lian, Ji-Xing Nan
In current study, we aimed to reveal the potential antifibrotic effects of oligomeric proanthocyanidin (OPC) from grape seeds on lipopolysaccharide (LPS)-activated, HSC-T6, a rat hepatic stellate cell line. HSC-T6 cells were treated with OPC 1h prior to LPS, and then incubated for indicated time. OPC inhibited cells viability of HSC-T6 cells and decrease protein expression of collagen I, α-smooth muscle actin (α-SMA), tissue inhibitors of metalloproteinases I (TIMP-1) on LPS-induced HSC-T6 cells. OPC also significantly inhibited phosphorylation of LPS-stimulated phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK)...
July 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28688092/mechanical-loading-increases-pro-inflammatory-effects-of-nitrogen-containing-bisphosphonate-in-human-periodontal-fibroblasts
#16
Collin Jacobs, Sabrina Schramm, Isabelle Dirks, Christian Walter, Andreas Pabst, Dan Meila, Cornelius Jacobs, Heinrich Wehrbein
OBJECTIVES: There is increasing evidence that inflammation and biomechanical loading can influence the effects of bisphosphonates (BP). The aim of this study was to investigate the influence of tensile strain application combined with IL-1ß and clodronate or zoledronate on human periodontal ligament fibroblasts (HPdLF) in vitro. MATERIALS AND METHODS: HPdLF were cultured with 10 nM IL-1ß and 5 μM clodronate or zoledronate for 48 h. Cells were applied to cyclic tensile strain (CTS; 3% elongation) for 12 h in vitro...
July 7, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28685672/micrornas-mediated-mmp-regulation-current-diagnostic-and-therapeutic-strategies-for-metabolic-syndrome
#17
Sharad Saxena, Aditi Jain, Vibha Rani
Metabolic syndrome (MS) is a global socioeconomic problem rapidly progressing in accordance with increasing body mass index (BMI) and age. It is a consortium of risk factors, such as dyslipidaemia, insulin resistance, leptin resistance, reduced adiponectin, glucose intolerance, hyperglycemia, and hypertension. Collectively, these factors accelerate the onset of type 2 diabetes mellitus, cardiovascular disease, stroke, and certain cancers such as breast, liver pancreatic, and colon cancer. Extracellular matrix (ECM) and basement membrane remodeling play a central role during pathogenesis of MS as they regulate diverse cell functions including proliferation, differentiation, and migration...
July 7, 2017: Current Gene Therapy
https://www.readbyqxmd.com/read/28685602/relationship-of-biomarkers-of-extracellular-matrix-with-myocardial-function-in-type-2-diabetes-mellitus
#18
Ju-Hua Liu, Yan Chen, Zhe Zhen, Lai-Ming Ho, Anita Tsang, Michele Yuen, Karen Lam, Hung-Fat Tse, Kai-Hang Yiu
AIM: The study evaluated the relationship of extracellular matrix and renin angiotensin system with myocardial dysfunction in Type 2 diabetes mellitus. METHODS: All patients underwent resting and exercise echocardiography, including conventional parameters, E/E' ratio, global longitudinal strain and diastolic function reserve index. Plasma matrix metalloproteinase-1, TIMP-1, amino-terminal propeptide of type I and type III procollagen and renin angiotensin system activity were measured...
July 7, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28684657/association-between-mmp3-and-timp3-polymorphisms-and-risk-of-osteoarthritis
#19
Zhichao Tong, Yang Liu, Bo Chen, Liang Yan, Dingjun Hao
Osteoarthritis (OA) is the most commonly occurring degenerative joint disease worldwide, and its incidence has increased in recent years. We evaluated whether there is the association between MMP-3 and TIMP-3 variants and susceptibility to OA in a Chinese population. Venous blood samples were collected from 431 female participants (200 cases and 231 controls) at Hong Hui Hospital, Xi'an Jiaotong University College of Medicine between 2015 and 2016. After genotyping the samples using standard protocols, the association between MMP-3 and TIMP-3 single nucleotide polymorphisms and risk of OA was assessed by calculating odds ratios (ORs) and 95% confidence intervals (95% CIs) using unconditional logistic regression analysis...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28684598/reduced-collagen-accumulation-and-augmented-mmp-2-activity-in-left-ventricle-of-old-rats-submitted-to-high-intensity-resistance-training
#20
Vinicius Guzzoni, Rita C Marqueti, João Luiz Quagliotti Durigan, Hernandes F Carvalho, Rafael Lino, Marcelo S Mekaro, Tayná Dos Santos, Andre Souza Mecawi, Jose Antunes-Rodrigues, Jeffrey M Hord, Jonh M Lawler, Ana Paula Davel, Heloísa Sobreiro Selistre-de-Araujo
Progressive fibrosis is a hallmark of the aging heart. Age-related fibrosis is modulated by endurance exercise training; however, little is known concerning the influence of resistance training (RT). Therefore, we investigated the chronic effects of high-intensity RT on age-associated alterations of left ventricle (LV) structure, collagen content, matrix metalloproteinase-2 (MMP-2) and extracellular matrix-related gene expression, including transforming growth factor-β (TGF-β). Young adult (3 mo.) and aged (21 mo...
July 6, 2017: Journal of Applied Physiology
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