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https://www.readbyqxmd.com/read/28636071/the-role-of-homocysteine-in-seminal-vesicles-remodeling-in-rat
#1
Adel Ghoul, Elara Moudilou, Mohamed El Hadi Cherifi, Fouzia Zerrouk, Billel Chaouad, Anissa Moulahoum, Souhila Aouichat-Bouguerra, Khira Othmani, Jean-Marie Exbrayat, Yasmina Benazzoug
INTRODUCTION: Elevated plasma homocysteine (Hcy) levels have been associated with several tissue injuries including heart and liver fibrosis. In these diseases, hyperhomocysteinemia (Hhcy) plays a major role in modulating the alteration of the balance between matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMPs), leading to the pathological accumulation of extracellular matrix (ECM) proteins. Since the effect of Hhcy on ECM of seminal vesicle was not studied, the aim of our research was to check if Hcy can induce a remodeling within seminal vesicles ECM...
June 21, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28634370/microbial-antigens-stimulate-metalloprotease-7-secretion-in-human-b-lymphocytes-using-mtor-dependent-and-independent-pathways
#2
Mohamed F Ali, Harika Dasari, Virginia P Van Keulen, Divi Cornec, George Vasmatzis, Tobias Peikert, Eva M Carmona
Metalloproteinases (MMPs) contribute to tissue remodeling and acute inflammation not only by degrading extracellular matrix proteins but also by controlling the influx of chemokines through the regulation and shedding of syndecans. B-lymphocytes, in addition to their well-known function as antibody producing cells, participate in the innate immune response by secreting inflammatory cytokines and chemokines. However, there is little information about the role of B-lymphocytes in the regulation of MMPs; consequently, herein we investigated whether activated human circulating B-lymphocytes contributed to the secretion of MMPs...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28633927/dencichine-ameliorates-kidney-injury-in-induced-type-ii-diabetic-nephropathy-via-the-tgf-%C3%AE-smad-signalling-pathway
#3
Li Jie, Qiu Pengcheng, He Qiaoyan, Bi Linlin, Zhang Meng, Wang Fang, Jia Min, Yan Li, Zhang Ya, Yang Qian, Wang Siwang
Diabetic nephropathy (DN), a common complication associated with both type I and type II diabetes mellitus (DM), is a major cause of chronic nephropathy and a common cause of end-stage renal diseases (ESRD) throughout the world. This study is aimed to determine whether dencichine (De) can ameliorate renal damage in high-glucose-and-fat diet combined STZ (streptozocin) induced DN in type II DM rats and to investigate the potential underlying mechanisms. Markers of metabolism, diabetes, and renal function, and levels of extracellular matrix (ECM) collagen I (Col I), collagen IV (Col IV), fibronectin (FN) and laminin (LN), and of proteins in the TGF-β/Smad pathway were analysed through RT-PCR, western blot, immunofluorescence and immunohistochemistry...
June 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28633451/cha2ds2-vasc-score-and-blood-biomarkers-to-identify-patients-with-atrial-high-rate-episodes-and-paroxysmal-atrial-fibrillation-the-role-of-timp-4-regulation
#4
Salvatore Patanè, Francesco Patanè
No abstract text is available yet for this article.
June 19, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28627739/use-of-a-protein-engineering-strategy-to-overcome-limitations-in-the-production-of-difficult-to-express-recombinant-proteins
#5
Hirra Hussain, David I Fisher, W Mark Abbott, Robert G Roth, Alan J Dickson
Certain recombinant proteins are deemed "difficult to express" in mammalian expression systems requiring significant cell and/or process engineering to abrogate expression bottlenecks. With increasing demand for the production of recombinant proteins in mammalian cells, low protein yields can have significant consequences for industrial processes. To investigate the molecular mechanisms that restrict expression of recombinant proteins, naturally secreted model proteins were analysed from the tissue inhibitors of metalloproteinase (TIMP) protein family...
June 19, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28627704/matrix-metalloproteinase-2-and-9-contribute-to-functional-integrity-and-noise%C3%A2-induced-damage-to-the-blood-labyrinth-barrier
#6
Jun Wu, Weiju Han, Xingrui Chen, Weiwei Guo, Ke Liu, Ruoya Wang, Jishuai Zhang, Na Sai
The cochlear blood-labyrinth barrier (BLB), located in the stria vascularis, is critical for the homeostasis of cochlear solutes and ion transport. Significant disruption to the BLB occurs early during noise‑induced hearing loss. Matrix metalloproteinase (MMP)‑2 and ‑9 are important molecules known to be capable of degrading tight junction (TJ) proteins. The TJ proteins are important components of the extracellular matrix (ECM), required to maintain BLB integrity and permeability. Previous studies have demonstrated that MMP‑2 and ‑9, rich in healthy cochlea, serve an essential role in regulating the cochlear response to acoustic trauma...
June 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28623785/in-vitro-studies-on-nobiletin-isolated-from-citrus-plants-and-the-bioactive-metabolites-inhibitory-action-against-gelatinase-enzymatic-activity-and-the-molecular-mechanisms-in-human-retinal-m%C3%A3-ller-cell-line
#7
Yoshiki Miyata, Terumasa Nagase, Yoshiya Katsura, Hideyo Takahashi, Hideaki Natsugari, Tetsuta Oshitari, Hiroshi Kosano
Diabetic retinopathy (DR) is the most common cause of vision loss in patients with diabetes mellitus. Despite the presence of effective therapy, DR is still a significant health burden. A recent research suggests that matrix metalloproteinases (MMPs) could be promising targets, which exert multiple actions on early- and late-stage pathogenesis of DR. Among the MMP family, gelatinases (MMP-2 and MMP-9) act as potent proinflammatory, proangiogenic, and pro-apoptotic factors. Therefore, the pharmacological inhibitory effect of gelatinases on retinal MMP-producing cells may be useful in the treatment or prevention of DR...
June 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28623423/cxcl10-suppression-of-hem-and-lymph-angiogenesis-in-inflamed-corneas-through-mmp13
#8
Nan Gao, Xiaowei Liu, Jiayin Wu, Juan Li, Chen Dong, Xinyi Wu, Xiao Xiao, Fu-Shin X Yu
Though not present in the normal adult cornea, both hem- and lymph-angiogenesis can be induced in this tissue after an inflammatory, infectious, or traumatic insult. We previously showed that the chemokine CXCL10 plays a key role in eradicating invading Candida (C.) albicans in C57BL6 mouse corneas. However, even after the clearance of pathogens, infection-induced inflammation and angiogenesis continue to progress in the cornea. The aim of this study is define the role of CXCL10 as a major angiostatic factor in modulating cornea angiogenesis in B6 mouse corneas under pathogenic conditions...
June 16, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28622396/mutant-fibulin-3-causes-proteoglycan-accumulation-and-impaired-diffusion-across-bruch-s-membrane
#9
Astrid Zayas-Santiago, Samuel D Cross, James B Stanton, Alan D Marmorstein, Lihua Y Marmorstein
Purpose: The mutation R345W in EFEMP1 (fibulin-3) causes macular degeneration. This study sought to determine whether proteoglycan content and diffusion across Bruch's membrane are altered in Efemp1ki/ki mice carrying this mutation or in Efemp1-/- mice. Methods: Proteoglycans in mouse Bruch's membranes were stained with Cupromeronic Blue (CB). Heparan sulfated proteoglycan (HSPG) and chondroitin/dermatan sulfate proteoglycan (C/DSPG) distributions were visualized following treatments with chondroitinase ABC (C-ABC) or nitrous acid...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28618427/matrix-metalloproteases-in-arterial-hypertension-and-their-trend-after-antihypertensive-treatment
#10
Eugenia Hopps, Rosalia Lo Presti, Gregorio Caimi
BACKGROUND/AIMS: Arterial hypertension is characterized by vascular remodelling, atherosclerosis and cardiovascular complications. Matrix metalloproteases (MPPs) are endopeptidases produced by all the cells present in the vascular wall and are involved in the regulation of the extracellular matrix protein turnover. MMPs contribute to blood vessel formation, remodelling, angiogenesis; whereas an altered expression or activity of MMPs or their tissue inhibitors (TIMPs) results correlated with the development and progression of cardiovascular complications...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28612558/-significance-and-expressions-of-mmp-1-timp-1-and-tgf-%C3%AE-1-in-valve-tissue-of-rheumatic-heart-disease
#11
Yi Yu, Zeng-Qi Li, Kun Chen, Ping Zhan, Jian Liao, Qin-Yun Ruan
OBJECTIVES: To explore expressions of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of metalloproteinases-1 (TIMP-1) and transforming growth factor-β1 (TGF-β1) in valve tissue of rheumatic heart disease (RHD), and to analyzed their roles in RHD. METHODS: The expressions of MMP-1, TIMP-1 and TGF-β1 proteins and mRNAs were tested by Western blot and RT-PCR methods in valve tissues in participants with (experimental group, n=30) and without RHD (control group, n=15)...
January 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28608784/suppressed-mmp-9-activity-in-myocardial-infarction-related-cardiogenic-shock-implies-diminished-rage-degradation
#12
Simina-Ramona Selejan, Lisa Hewera, Matthias Hohl, Andrey Kazakov, Sebastian Ewen, Ingrid Kindermann, Michael Böhm, Andreas Link
BACKGROUND: Receptor for advanced glycation end products (RAGE) and its cleavage fragment soluble RAGE (sRAGE) are opposite players in inflammation. Enhanced monocytic RAGE expression and decreased plasma sRAGE levels are associated with higher mortality in infarction-related cardiogenic shock. Active matrix metalloproteinase-9 (MMP-9) has been implied in RAGE ectodomain cleavage and subsequently sRAGE shedding in vitro. We investigated MMP-9 activity in myocardial infarction-induced cardiogenic shock with regard to RAGE/sRAGE regulation...
July 2017: Shock
https://www.readbyqxmd.com/read/28608202/zymography-as-a-research-tool-in-the-study-of-matrix-metalloproteinase-inhibitors
#13
Zongli Ren, Juanjuan Chen, Raouf A Khalil
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade various components of the extracellular matrix (ECM) and play a role in tissue remodeling. Changes in MMPs have been observed in cancer, connective tissue disorders, and vascular disease, and both endogenous tissue inhibitors of MMPs (TIMPs) and synthetic MMP inhibitors (MMPIs) have been evaluated as modulators of MMP activity in various biological systems. Zymography is a simple technique that is commonly used to assess MMP activity and the efficacy of MMPIs...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28605336/tissue-inhibitor-of-metalloproteinase-1-timp-1-and-il-23-induced-by-polysaccharide-of-the-black-hoof-medicinal-mushroom-phellinus-linteus-agaricomycetes
#14
Soo Kyung Yoon, Soo Kyung Sung, Dong Hee Lee, Ha Won Kim
Matrix metalloproteinase-9 (MMP-9) has diverse roles associated with cell growth, migration, invasion, and angiogenesis. Tissue inhibitor of metalloproteinase-1 (TIMP-1) is known to inhibit MMP-9 by complexing with it at a 1:1 ratio. Suppressing MMP-9 activity through the overexpression of TIMP-1 allows for regulation of tumor growth and metastasis by blocking invasion and angiogenesis in the tumor microenvironment. We found that TIMP-1 and interleukin (IL)-23 are induced in RAW264.7 macrophage cells, a cell line established by Abelson leukemia virus transformation from the BALB/c mouse strain, in a dose-dependent pattern, at the transcriptional level by treatment with a crude polysaccharide fraction of Phellinus linteus (CPP) at a range of 10 to 1000 μg/mL...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28601590/hepatoprotective-effects-of-ethyl-pyruvate-against-ccl4-induced-hepatic-fibrosis-via-inhibition-of-tlr4-nf-%C3%AE%C2%BAb-signaling-and-up-regulation-of-mmps-timps-ratio
#15
Mingxiao Zhang, Xiaosong Hu, Shuai Li, Chen Lu, Juan Li, Yonghua Zong, Wenqian Qi, Huijun Yang
BACKGROUND AND AIM: Liver fibrosis is a worldwide clinical issue. It has been well established that liver fibrosis is characterized of excessive extracellular matrix (ECM) deposition in chronically damaged livers. Accumulating evidences have suggested that ethyl pyruvate (EP) is a potential useful agent for preventing from hepatic injury. The aim of this study was to evaluate the protective effects of the EP against liver fibrosis induced by carbon tetrachloride (CCl4) in rats. METHOD: Rats were randomly divided into control group, CCl4 group and CCl4+EP group, which with and without EP administration...
June 7, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28601470/tissue-and-serum-mrna-profile-of-mmps-2-9-as-a-potential-novel-biomarker-for-the-most-individual-approach-in-infantile-hemangiomas-and-cancer-disease
#16
Katarzyna Taran, Aneta Wnęk, Józef Kobos, Ewa Andrzejewska, Przemysław Przewratil
Propranolol is a widely-known beta-blocker approved for treating infantile hemangiomas (IH). The mechanisms behind the spectacular IH involution after propranolol treatment remain unclear. Recently, there is strong evidence of overexpression of numerous angiogenic factors in IH tissues, and it is reported that propranolol influences their pathways. However, a number of MMPs studies is highly limited. Here, for the first time, we propose a comprehensive approach by analyzing the expression levels of metalloproteinases-2/9 (MMPs-2/9) and tissue metalloproteinase inhibitor-2 (TIMP-2) in vivo on both, molecular and immunohistochemical levels, and in both, IH tissues and in the serum of IH patients, and relates the obtained results to the tumor's biology and systemic propranolol treatment...
June 3, 2017: Immunobiology
https://www.readbyqxmd.com/read/28600524/disruption-of-retinal-pigment-epithelial-cell-properties-under-the-exposure-of-cotinine
#17
Xiao-Yu Zhang, Tsz Kin Ng, Mårten Erik Brelén, Kwok Ping Chan, Di Wu, Jasmine Sum Yee Yung, Di Cao, Yumeng Wang, Shaodan Zhang, Sun On Chan, Chi Pui Pang
Cigarette smoking is a major risk factor for age-related macular degeneration (AMD), in which progressive retinal pigment epithelial (RPE) cell degeneration is a major pathological change. Nicotine is a major biologically active component in cigarette smoke. It is continuously catabolized into cotinine, which has longer half-life and higher concentration in tissue cells and fluids. Here we hypothesized that continuous exposure of cotinine has more potent effects on human RPE cell properties than nicotine. Human RPE cell line (ARPE-19) was treated continuously with 1-2 µM of nicotine and/or cotinine for 7 days...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28598286/gingival-inflammation-and-salivary-or-serum-granulocyte-secreted-enzymes-in-patients-with-polycystic-ovary-syndrome
#18
Aliye Akcalı, Nagihan Bostanci, Özgun Özçaka, Pınar Gümüş, Banu Öztürk-Ceyhan, Taina Tervahartiala, Heidi Husu, Nurcan Buduneli, Timo Sorsa, Georgios N Belibasakis
BACKGROUND: The objective of this cross-sectional study was to investigate the levels of salivary and serum matrix metalloproteinase-9 (MMP-9), myeloperoxidase (MPO), neutrophil elastase (NE) and MMP-9/tissue inhibitors of metalloproteinase (TIMP-1) ratio in polycystic ovary syndrome (PCOS) patients and systemically healthy controls, in the presence or absence of gingivitis. METHODS: Serum and salivary levels of these biomarkers were evaluated in periodontally healthy women with PCOS (Ph) (n=45); women with PCOS and gingivitis (Pg) (n=35); systemically and periodontally healthy women (Hh) (n=25); systemically healthy women with gingivitis (Hg) (n=20)...
June 9, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28598072/-the-effects-of-nf-kappab-signalling-on-the-tnf-%C3%AE-induced-ratios-of-mmps-to-timps-in-chondrocytes
#19
Lin-Yi Cai, Xiang-Li Kong, Qiang Xie, Jing Xie
OBJECTIVES: To explore the influence of the NF-κB inhibitor (bay11-7082) on tumor necrosis factor-α (TNF-α)-induced different ratios of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in chondrocytes. METHODS: Chondrocytes were isolated from the knee joint of a 1-day old mouse by trypsin digestion method. Hematoxylin-Eosin (HE) stain was used to show the morphology of isolated chondrocytes; Semi-quantitative PCR was applied to analyze the influence of bay11-7082 on gene expressions of TNF-α-induced MMPsand TIMPsin chondrocytes; Zymography was used to elucidate activities of the gelatinases induced by TNF-α and/or bay11-7082...
September 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28594820/serum-proteins-mediate-depression-s-association-with-dementia
#20
Donald R Royall, Safa Al-Rubaye, Ram Bishnoi, Raymond F Palmer
The latent variable "δ" (for "dementia") uniquely explains dementia severity. Depressive symptoms are independent predictors of δ. We explored 115 serum proteins as potential causal mediators of the effect of depressive symptoms on δ in a large, ethnically diverse, longitudinal cohort. All models were adjusted for age, apolipoprotein E, education, ethnicity, gender, hemoglobin A1c, and homocysteine, and replicated in randomly selected 50% subsets. Alpha1-antitrypsin (A1AT), FAS, Heparin-binding EGF-like Growth Factor (HB-EGF), Insulin-like Growth Factor-1 (IGF-1), Luteinizing Hormone (LH), Macrophage Inflammatory Protein type 1 alpha (MIP-1α), Resitin, S100b, Tissue Inhibitor of Metalloproteinase type 1 (TIMP-1), and Vascular Cell Adhesion Molecule type 1 (VCAM-1) each were partial mediators of depression's association with δ...
2017: PloS One
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