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Milk's protein allergy

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https://www.readbyqxmd.com/read/28917235/reconfirmation-of-improved-tolerance-to-a-new-amino-acid-based-formula-by-infants-with-cow-s-milk-protein-allergy
#1
Pipop Jirapinyo, Narumon Densupsoontorn, Channagan Kangwanpornsiri, Renu Wongarn, Hathaichanok Tirapongporn, Kwanjai Chotipanang, Phakkanan Phuangphan
BACKGROUND AND OBJECTIVES: Reasons for intolerance to commercial amino acid-based formulas (cAAF) in infants diagnosed with cow's milk protein allergy (CMA) remain unknown. We assume that minute amounts of proteins, presenting in the glucose polymers derived from corn starch (cGPs), can elicit the intolerance to the cAAFs observed in some infants with CMA. By replacing cGPs with glucose polymers derived from rice starch (rGPs), a new amino acid-based (nAAF) formula has been shown to be better tolerated than an existing cAAF...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28875884/residual-allergenicity-of-amino-acid-based-and-extensively-hydrolysed-cow-s-milk-formulas
#2
M E Levin, D M Blackhurst, F Kirstein, D Kok, G F Van der Watt, A D Marais
BACKGROUND: Criteria for labelling infant feeds as suitable for the dietary management of cow's milk protein allergy (CMPA) rely on proving the hypoallergenicity of such feeds or clinical studies showing that the feeds are tolerated by 90% of children with proven CMPA. South African (SA) labelling legislation does not indicate what testing is necessary to prove hypoallergenicity. OBJECTIVES: To evaluate all extensively hydrolysed cow's milk formulas and amino acid-based formulas available in SA for residual allergen content, protein size and amino-acid content...
August 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28866384/intestinal-microbiota-in-infants-at-high-risk-for-allergy-effects-of-prebiotics-and-role-in-eczema-development
#3
Harm Wopereis, Kathleen Sim, Alexander Shaw, John O Warner, Jan Knol, J Simon Kroll
BACKGROUND: The development of gut microbiota in infancy is important in the maturation of the immune system. Deviations in colonization patterns have been associated with allergic manifestations (e.g. eczema), but exact microbiome dysfunctions underlying allergies remain unclear. We studied the gut microbiota of 138 infants at increased risk of developing allergy, participating in a clinical trial investigating the effectiveness of a partially hydrolyzed protein formula supplemented with non-digestible oligosaccharides (pHF-OS) on the prevention of eczema...
August 30, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28858242/effect-of-processing-intensity-on-immunologically-active-bovine-milk-serum-proteins
#4
Tabea Brick, Markus Ege, Sjef Boeren, Andreas Böck, Erika von Mutius, Jacques Vervoort, Kasper Hettinga
Consumption of raw cow's milk instead of industrially processed milk has been reported to protect children from developing asthma, allergies, and respiratory infections. Several heat-sensitive milk serum proteins have been implied in this effect though unbiased assessment of milk proteins in general is missing. The aim of this study was to compare the native milk serum proteome between raw cow's milk and various industrially applied processing methods, i.e., homogenization, fat separation, pasteurization, ultra-heat treatment (UHT), treatment for extended shelf-life (ESL), and conventional boiling...
August 31, 2017: Nutrients
https://www.readbyqxmd.com/read/28857182/altered-mir-193a-5p-expression-in-children-with-cow-s-milk-allergy
#5
Valeria D'Argenio, Valentina Del Monaco, Lorella Paparo, Fatima Domenica Elisa De Palma, Rita Nocerino, Francesca D'Alessio, Feliciano Visconte, Valentina Discepolo, Luigi Del Vecchio, Francesco Salvatore, Roberto Berni Canani
BACKGROUND: Cow's milk allergy (CMA) is one of the most common food allergies in children. Epigenetic mechanisms have been suggested to play a role in CMA pathogenesis. We shown that DNA methylation of Th1/Th2 cytokine genes and FoxP3 affects CMA disease course. Preliminary evidence suggest that also the miRNome could be implicated in the pathogenesis of allergy. Main study outcome was to comparatively evaluate miRNome in children with CMA and in healthy controls. METHODS: Peripheral blood mononuclear cells were obtained from children aged 4-18 months: 10 CMA patients, 9 CMA patients who outgrew CMA, and 11 healthy controls...
August 30, 2017: Allergy
https://www.readbyqxmd.com/read/28852472/better-recognition-diagnosis-and-management-of-non-ige-mediated-cow-s-milk-allergy-in-infancy-imap-an-international-interpretation-of-the-map-milk-allergy-in-primary-care-guideline
#6
REVIEW
Carina Venter, Trevor Brown, Rosan Meyer, Joanne Walsh, Neil Shah, Anna Nowak-Węgrzyn, Tong-Xin Chen, David M Fleischer, Ralf G Heine, Michael Levin, Mario C Vieira, Adam T Fox
Cow's milk allergy (CMA) is one of the most common presentations of food allergy seen in early childhood. It is also one of the most complex food allergies, being implicated in IgE-mediated food allergy as well as diverse manifestations of non-IgE-mediated food allergy. For example, gastrointestinal CMA may present as food protein induced enteropathy, enterocolitis or proctocolitis. Concerns regarding the early and timely diagnosis of CMA have been highlighted over the years. In response to these, guideline papers from the United Kingdom (UK), Australia, Europe, the Americas and the World Allergy Organisation have been published...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28804604/why-whey-camel-whey-protein-as-a-new-dietary-approach-to-the-management-of-free-radicals-and-for-the-treatment-of-different-health-disorders
#7
REVIEW
Gamal Badr, Nancy K Ramadan, Leila H Sayed, Badr M Badr, Hossam M Omar, Zeliha Selamoglu
The balance between free radicals and antioxidants is an important factor for maintaining health and slowing disease progression. The use of antioxidants, particularly natural antioxidants, has become an important strategy for dealing with this cause of widespread diseases. Natural antioxidants have been used as therapeutic tools against many diseases because they are safe, effective, and inexpensive and are among the most commonly used adjuvants in the treatment of several diseases. Camel whey protein (CWP) is considered a strong natural antioxidant because it decreases oxidative stress, enhances immune system function, and increases glutathione levels...
April 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28759641/novel-sensitive-monoclonal-antibody-based-competitive-enzyme-linked-immunosorbent-assay-for-the-detection-of-raw-and-processed-bovine-beta-casein
#8
Daniela S Castillo, Alejandro Cassola
Cow milk protein allergy (CMPA) is the most common childhood food allergy, which can sometimes persist or can newly develop in adulthood with severe symptoms. CMPA's treatment is complete dietary avoidance of milk proteins. To achieve this task, patients have to be aware of milk proteins found as "hidden allergens" in food commodities. In regard to milk proteins, it has been reported that allergenicity of caseins remains unaffected upon heat treatment. For these reasons, we aimed to obtain monoclonal antibodies (mAbs) against native and denatured β-casein, one of the most abundant and antigenic caseins, in order to develop an indirect competitive ELISA (icELISA) to detect and quantify traces of this milk allergen in raw and processed foodstuffs...
2017: PloS One
https://www.readbyqxmd.com/read/28739021/single-and-multiple-food-allergies-in-infants-with-proctocolitis
#9
B T Koksal, Z Barıs, F Ozcay, O Yilmaz Ozbek
BACKGROUND: Food protein-induced allergic proctocolitis is a frequent cause of rectal bleeding in infants. Characteristics of infants with multiple food allergies have not been defined. OBJECTIVE: This study aimed to identify characteristics of infants with proctocolitis and compare infants with single and multiple food allergies. METHODS: A total of 132 infants with proctocolitis were evaluated retrospectively. All of the infants were diagnosed by a paediatric allergist and/or a paediatric gastroenterologist according to guidelines...
July 21, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28737860/natural-history-of-immunoglobulin-e-mediated-cow-s-milk-allergy-in-a-population-of-argentine-children
#10
Natalia A Petriz, Claudio As Parisi, Julio N Busaniche, Patricia Evangelista, Romina Mehaudy, Marina Orsi
INTRODUCTION: Cow's milk protein allergy is the most common allergy in pediatrics. Immunoglobulin E (IgE)-mediated cow's milk allergy poses a higher risk for life and a worse prognosis. OBJETIVES: To describe the course of IgE-mediated cow's milk protein allergy and risk factors associated with disease persistence. PATIENTS AND METHODS: This was a descriptive, retrospective study conducted in patients seen at the Division of Pediatric Allergy of Hospital Italiano between June 2006 and June 2012 who had been diagnosed with IgE-mediated cow's milk allergy...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28732431/the-efficacy-of-oral-immunotherapy-in-patients-with-cow-s-milk-allergy
#11
Mohsen Ebrahimi, Mohammad Gharagozlou, Ali Mohebbi, Nasim Hafezi, Gholamreza Azizi, Masoud Movahedi
Cow's milk allergy is the most common type of food allergy that decrease the quality of life of patients and their families. The aim of this study was to evaluate the efficacy of oral immunotherapy in patients with cow's milk allergy. 14 patients above 3 years of age with a history of cow's milk allergy confirmed by positive double blind placebo controlled food challenge (DBPCFC) test, presence of serum IgE against cow's milk and positive SPT (skin prick test) were enrolled in this study. During the immunotherapy all patients received increasing amounts of cow's milk during three phases...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28721077/food-protein-induced-enterocolitis-syndrome-a-review-of-the-literature-with-focus-on-clinical-management
#12
REVIEW
Marine Michelet, Dominique Schluckebier, Laetitia-Marie Petit, Jean-Christoph Caubet
Food protein-induced enterocolitis syndrome (FPIES) is a potentially severe presentation of non-IgE-mediated gastrointestinal food allergy (non-IgE-GI-FA) with heterogeneous clinical manifestations. Acute FPIES is typically characterized by profuse vomiting and lethargy, occurring classically 1-4 hours after ingestion of the offending food. When continuously exposed to the incriminated food, a chronic form has been described with persistent vomiting, diarrhea, and/or failure to thrive. Although affecting mainly infants, FPIES has also been described in adults...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28712180/causes-of-chronic-non-infectious-diarrhoea-in-infants-less-than-6-months-of-age-rarely-recognized-entities
#13
Iqra Mushtaq, Huma Ashraf Cheema, Hassan Suleman Malik, Nadia Waheed, Muhammad Almas Hashmi, Hassan Suleman Malik
BACKGROUND: Non-infectious causes of chronic diarrhoea are important and easily missed. The study was done with the objectives to identify different causes of chronic non-infectious diarrhoea in infants less than 6 months of age. METHODS: All patients less than 6 months of age presenting for the first time to a Paediatric Gastroenterology tertiary care centre with a history of chronic diarrhoea and negative stool cultures were enrolled over a period of 8 months...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28698533/prevention-and-management-of-cow-s-milk-allergy-in-non-exclusively-breastfed-infants
#14
REVIEW
Yvan Vandenplas
Introduction: The prevention and management of cow milk allergy (CMA) is still debated. Since CMA is much less frequent in breastfed infants, breastfeeding should be stimulated. Method: Literature was searched using databases to find original papers and reviews on this topic. Results: Hydrolysates with a clinical proof of efficacy are recommended in the prevention and treatment of CMA. However, not all meta-analyses conclude that hydrolysates do prevent CMA or other atopic manifestations such as atopic dermatitis...
July 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28698024/the-prevalence-and-characteristics-of-cow-s-milk-protein-allergy-in-infants-and-young-children-with-iron-deficiency-anemia
#15
Fu-Ping Lai, Yao-Jong Yang
BACKGROUND: The clinical presentation of cow's milk protein allergy (CMPA) in children varies. This retrospective study aimed to investigate the prevalence and clinical manifestations of CMPA in young children who visited for evaluation of iron deficiency anemia (IDA). METHODS: Patients aged <4 years who were diagnosed as having IDA (serum ferritin <12 ng/mL) at the National Cheng Kung University Hospital, Taiwan in the period 2005-2015 were reviewed. Their clinical presentations, laboratory data, endoscopy findings, and prognosis were analyzed...
June 30, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28680374/the-role-of-lipids-in-development-of-allergic-responses
#16
REVIEW
Manuel Gómez Del Moral, Eduardo Martínez-Naves
Most allergic diseases are caused by activation of Th2 type immune responses resulting in the production of specific IgE against proteins found in normally harmless substances such as pollen, mites, epithelia or food. Allergenic substances are composed, in addition to proteins, of other compounds such as carbohydrates and lipids. Those lipids are able to promote the development of Th2-type responses associated with allergy. There are lipids found in pollen, milk or insect venom that are specifically recognized by CD1 restricted unconventional T lymphocytes, which can promote allergic reactions...
June 2017: Immune Network
https://www.readbyqxmd.com/read/28679035/partially-hydrolyzed-whey-proteins-prevent-clinical-symptoms-in-a-cow-s-milk-allergy-mouse-model-and-enhance-regulatory-t-and-b-cell-frequencies
#17
M B Gea Kiewiet, B C A M van Esch, J Garssen, M M Faas, P de Vos
SCOPE: Partially hydrolyzed cow's milk proteins are used to prevent cow's milk allergy in children. Here we studied the immunomodulatory mechanisms of partial cow's milk hydrolysates in vivo. METHODS AND RESULTS: Mice were sensitized with whey or partially hydrolyzed whey using cholera toxin. Whey-specific IgE levels were measured to determine sensitization and immune cell populations from spleen, mesenteric lymph nodes and Peyer's patches after oral whey administration were measured by flowcytometry...
July 5, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28643898/identification-of-cross-reactive-b-cell-epitopes-between-bos-d-9-0101-bos-taurus-and-gly-m-5-0101-glycine-max-by-epitope-mapping-maldi-tof-ms
#18
Ángela María Candreva, Mario Ferrer-Navarro, Silvia Bronsoms, Alejandra Quiroga, Renata Curciarello, Ana Cauerhff, Silvana Petruccelli, Guillermo Horacio Docena, Sebastián Alejandro Trejo
Exposure to cow's milk constitutes one of the most common causes of food allergy. In addition, exposure to soy proteins has become relevant in a restricted proportion of milk allergic pediatric patients treated with soy formulae as a dairy substitute, because of the cross-allergenicity described between soy and milk proteins. We have previously identified several cross-reactive allergens between milk and soy that may explain this intolerance. The purpose of the present work was to identify epitopes in the purified αS1-casein and the recombinant soy allergen Gly m 5...
August 2017: Proteomics
https://www.readbyqxmd.com/read/28628759/do-infants-with-cow-s-milk-protein-allergy-have-inadequate-levels-of-vitamin-d
#19
Cristiane M Silva, Silvia A da Silva, Margarida M de C Antunes, Gisélia Alves Pontes da Silva, Emanuel Sávio Cavalcanti Sarinho, Kátia G Brandt
OBJECTIVE: To verify whether infants with cow's milk protein allergy (CMPA) have inadequate vitamin D levels. METHODS: This cross-sectional study included 120 children aged 2 years or younger, one group with CMPA and a control group. The children were recruited at the pediatric gastroenterology, allergology, and pediatric outpatient clinics of a university hospital in the Northeast of Brazil. A questionnaire was administered to the caregiver and blood samples were collected for vitamin D quantification...
June 16, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28612576/-clinical-feature-in-infants-of-breast-feeding-allergy-and-its-possible-relation-with-gastrointestinal-peptide-change-in-breast-milk
#20
Yong-Mei Xie, Shan Gao, Li-Yuan Wang, Zhi-Ling Wang, Xiao-Tang Cai, Hui Zhou
OBJECTIVES: To investigate clinical features in infants of breast milk allergy(BMA), and the possible relationship with the changes of somatostatin (SST) and motilin (MTL) in breast milk. METHODS: Twenty three cases of pure breast feeding infants with allergic gastroenteritis were collected, while another 23 normal infants with pure breast feeding were enrolled as normal controls. Samples of infant stools and breast milk were collected for the measurement of SST and MTL levels detected by by radioimmunity...
January 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
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