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https://www.readbyqxmd.com/read/28733849/novel-pacing-strategies-for-heart-failure-management
#1
REVIEW
Jordan S Leyton-Mange, Theofanie Mela
Cardiac resynchronization therapy has emerged as the gold standard for heart failure patients with left ventricular systolic dysfunction and electrical dyssynchrony from an intrinsic intraventricular conduction delay or right ventricular pacing. However, the limits imposed by the coronary sinus venous anatomy restrict the applicability of the technology for many potential recipients. Furthermore, conventional resynchronization, by virtue of utilizing a single site of epicardial origin for left ventricular activation, is non-physiological...
August 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28666487/mahaim-tachycardia-induced-cardiomyopathy
#2
Ibrahim Gul, Qamaruddin Roziman, Aamir Hameed Khan
We present the case report of a 22-year man, with incessant palpitations, chest pain, shortness of breath, and pulsations in his neck for the past 7 months. He was referred to the cardiology unit for workup of wide complex tachycardia (WCT). His echocardiography, 6 months earlier, had demonstrated severe left ventricular (LV) systolic dysfunction, severe global hypokinesia, mild tricuspid regurgitation (TR), and mild mitral regurgitation (MR) which resolved with medical therapy including beta-blockers. He underwent electrophysiological study, which revealed a decremental right sided atriofascicular pathway causing a WCT with left bundle branch block (LBBB) morphology and left axis deviation (LAD, Mahaim tachycardia)...
November 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28649507/permanent-his-bundle-pacing-at-the-time-of-atrioventricular-node-ablation-a-3-dimensional-mapping-approach
#3
Sukit Ringwala, Bradley P Knight, Nishant Verma
No abstract text is available yet for this article.
June 2017: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/28646429/decoupled-side-chain-and-backbone-dynamics-for-proton-translocation-m2-of-influenza-a
#4
Monoj Mon Kalita, Wolfgang B Fischer
The 97 amino acid bitopic membrane protein M2 of influenza A forms a tetrameric bundle in which two of the monomers are covalently linked via a cysteine bridge. In its tetrameric assembly the protein conducts protons across the viral envelope and within intracellular compartments during the infectivity cycle of the virus. A key residue in the translocation of the protons is His-37 which forms a planar tetrad in the configuration of the bundle accepting and translocating the incoming protons from the N terminal side, exterior of the virus, to the C terminal side, inside the virus...
July 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28641861/permanent-his-bundle-pacing-in-intra-hisian-conduction-block-mechanistic-insights
#5
Bengt Herweg, Paul Z Gerczuk, Aamir Sofi, Pugazhendhi Vijayaraman, S Serge Barold
We are reporting a patient with discrete intra-His conduction block and describe a refined technique of permanent His bundle pacing assuring reliable ventricular capture. Meticulous mapping of the site of block with lead placement distal to the site of block and non-selective His bundle pacing with local myocardial capture as an additional safety back up appears to be the technique of choice.
June 9, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28641799/the-continued-search-for-physiological%C3%A2-pacing-where-are-we-now
#6
REVIEW
Pugazhendhi Vijayaraman, Pierre Bordachar, Kenneth A Ellenbogen
Cardiac pacing is an effective treatment for patients with bradycardia due to sinus node dysfunction or atrioventricular block. Despite decades of technological advances, the optimal ventricular pacing site to mimic normal human ventricular physiology and best hemodynamic response remains elusive. Beginning with atrial synchronous right ventricular (RV) apical pacing, the search has continued through alternate RV pacing sites, minimizing RV pacing, biventricular pacing, left ventricular (LV) pacing, and His-bundle pacing...
June 27, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28639947/surface-electrocardiogram-could-atrioventricular-nodal-and-his-bundle-potentials-be-recorded-beat-by-beat-on-saah-electrocardiogram
#7
Qinghua Chang, Renguang Liu, Juan Chen
OBJECTIVE: The P-QRS-T wave on surface electrocardiogram (ECG) reflects the changes in atrial and ventricular electrical properties. However, the atrioventricular conduction system potentials cannot be recorded to date. This study aimed to explore the possibility of micropotential of the atrioventricular conduction system recorded by surface "SAN-Atrial-AVN-His (Saah) ECG." METHODS: We randomized 100 healthy volunteers (50 females and 50 males; mean age 25.12±1...
June 22, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28636524/his-bundle-pacing-using-dual-chamber-cardioverter-defibrillator-in-patients-with-chronic-atrial-fibrillation-different-pacing-and-sensing-features
#8
Agnieszka Sławuta, Dariusz Biały, Dorota Zyśko, Grzegorz Mazur, Jacek Gajek
No abstract text is available yet for this article.
June 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28631143/post-operative-3d-ct-feedback-improves-accuracy-and-precision-in-the-learning-curve-of-anatomic-acl-femoral-tunnel-placement
#9
Luigi Sirleo, Massimo Innocenti, Matteo Innocenti, Roberto Civinini, Christian Carulli, Fabrizio Matassi
PURPOSE: To evaluate the feedback from post-operative three-dimensional computed tomography (3D-CT) on femoral tunnel placement in the learning process, to obtain an anatomic anterior cruciate ligament (ACL) reconstruction. METHODS: A series of 60 consecutive patients undergoing primary ACL reconstruction using autologous hamstrings single-bundle outside-in technique were prospectively included in the study. ACL reconstructions were performed by the same trainee-surgeon during his learning phase of anatomic ACL femoral tunnel placement...
June 19, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28630850/anterior-dislocation-of-elbow-with-neurovascular-injury-a-rare-case-report
#10
S Kailash, S Shanmuganathan
INTRODUCTION: Anterior elbow dislocation is an infrequent lesion, produced by direct trauma to the proximal ulna after a fall on the elbow in flexion and injury to the neurovascular bundle is not infrequent. Authors report a case of acute anterior dislocation of the elbow joint with neurovascular injury. CASE REPORT: A 30-year-old male admitted with a history of accidental fall followed by pain, swelling over his left elbow. Clinical, radiological, Doppler investigations revealed anterior dislocation of the elbow with brachial artery injury with posterior interosseous nerve palsy without any bony injury...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28630174/experimental-pathologic-and-clinical-findings-of-radiofrequency-catheter-ablation-of-para-hisian-region-from-the-right-ventricle-in-dogs-and-humans
#11
Yumei Xue, Xianzhang Zhan, Shulin Wu, Hongyue Wang, Yang Liu, Zili Liao, Hai Deng, Xuejing Duan, Shaoying Zeng, Dongpo Liang, Arif Elvan, Xianhong Fang, Hongtao Liao, Anand R Ramdat Misier, Jaap Jan J Smit, Andreas Metzner, Christian-Hendrik Heeger, Fangzhou Liu, Feng Wang, Zhiwei Zhang, Karl-Heinz Kuck, Siew Yen Ho, Feifan Ouyang
BACKGROUND: Ablation of para-Hisian accessory pathway (AP) poses high risks of atrioventricular block. We developed a pacing technique to differentiate the near-field (NF) from far-field His activations to avoid the complication. METHODS AND RESULTS: Three-dimensional mapping of the right ventricle was performed in 15 mongrel dogs and 23 patients with para-Hisian AP. Using different pacing outputs, the NF- and far-field His activation was identified on the ventricular aspect...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28630172/role-of-his-refractory-premature-ventricular-complexes-in-the-differential-diagnosis-of-a-left-bundle-branch-block-morphology-tachycardia
#12
REVIEW
Shiv Bagga, Parin J Patel, Eric N Prystowsky, Benzy J Padanilam
No abstract text is available yet for this article.
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28624493/expression-of-the-c-terminal-domain-of-human-apolipoprotein-a-i-using-a-chimeric-apolipoprotein
#13
Daniel E Sallee, James V C Horn, Lukas A Fuentes, Paul M M Weers
Human apolipoprotein A-I (apoA-I) is the most abundant protein in high-density lipoprotein, an anti-atherogenic lipid-protein complex responsible for reverse cholesterol transport. The protein is composed of an N-terminal helix bundle domain, and a small C-terminal (CT) domain. To facilitate study of CT-apoA-I, a novel strategy was employed to produce this small domain in a bacterial expression system. A protein construct was designed of insect apolipophorin III (apoLp-III) and residues 179-243 of apoA-I, with a unique methionine residue positioned between the two proteins and an N-terminal His-tag to facilitate purification...
June 15, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28598580/neuroanatomy-of-the-pig-cardiac-ventricles-a-stereomicroscopic-confocal-and-electron-microscope-study
#14
Neringa Pauziene, Kristina Rysevaite-Kyguoliene, Paulius Alaburda, Audrys G Pauza, Monika Skukauskaite, Aiste Masaityte, Goda Laucaityte, Inga Saburkina, Hermanas Inokaitis, Jurgita Plisiene, Dainius H Pauza
Although the pig is a model for heart disease, the neuroanatomy of cardiac ventricles (CV) in this species remains undetailed. We aimed to define the innervation pattern of pig CV, combining histochemistry for acetylcholinesterase, immunofluorescent labeling and electron microscopy. Forty nine examined pig hearts show that the major nerves supplying the ventral side of CV descend from the venous part of the heart hilum. Fewer in number and smaller in size, epicardial nerves supply the dorsal half of the CV...
June 9, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28575215/comparison-of-the-effects-of-selective-and-non-selective-his-bundle-pacing-on-cardiac-electrical-and-mechanical-synchrony
#15
Jinlong Zhang, Jianghong Guo, Xiaofeng Hou, Yao Wang, Zhiyong Qian, Kebei Li, Peibing Ge, Jiangang Zou
Aims: This study aimed to assess the acute effect of selective His bundle pacing (S-HBP), non-selective His bundle pacing (NS-HBP), and right ventricular septum pacing (RVSP) on electrical synchrony and left ventricular (LV) mechanical synchrony using electrocardiogram and phase analysis of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). Methods and results: Totally 39 patients eligible for pacemaker were enrolled. Thirty-seven patients underwent successful His bundle pacing (HBP) including S-HBP in 23 and NS-HBP in 14 patients, respectively...
May 31, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28569391/permanent-his-bundle-pacing-electrophysiological-and-echocardiographic-observations-from-long-term-follow-up
#16
Pugazhendhi Vijayaraman, Gopi Dandamudi, Daniel Lustgarten, Kenneth A Ellenbogen
BACKGROUND: Permanent His bundle pacing (HBP) is a physiological alternative to right ventricular pacing. It is not known whether HBP can cause His-Purkinje conduction (HPC) disease. The aim of our study is to assess His bundle capture and its effect on left ventricular (LV) function in long-term follow-up and to determine HPC at the time of pulse generator change (GC) in patients with chronic HBP. METHODS: HB electrograms were recorded from the pacing lead at implant and GC...
June 1, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28567361/unexpected-evolution-of-a-non-stenotic-lesion-in-the-left-main-coronary-artery-of-a-patient-with-non-st-segment-elevation-myocardial-infarction
#17
Alexandru Florin Ispas, Lionel Mangin, Alexandru Paziuc, Loic Belle
A 72-year-old man was referred to our catheterization laboratory 48 hours after a non-ST-segment elevation myocardial infarction. His medical history included coronary artery disease (CAD) (percutaneous coronary intervention of the right coronary artery and chronic total occlusion of the circumflex artery), atrial fibrillation (AF), and chronic kidney disease. An electrocardiogram showed a pre-existent left bundle-branch block and the patient's maximum cardiac troponin concentration was 8.64 µg/L (upper limit of normal: 0...
June 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28543795/permanent-nonselective-his-bundle-pacing-in-an-adult-with-l-transposition-of-the-great-arteries-and-complete-av-block
#18
Adam C Kean, W Aaron Kay, Jyoti K Patel, John M Miller, Gopi Dandamudi
We report the placement of a permanent transvenous nonselective His bundle pacing lead in conjunction with a transvenous pacemaker/ICD in an adult with Levo-Transposition of the Great Arteries (L-TGA) and a stenotic coronary sinus (CS) ostium (os), which would not accommodate a transvenous LV pacing lead. Nonselective His bundle pacing provided a nearly identical ventricular activation pattern in this previously unpaced patient. Many L-TGA patients will have an eventual need for permanent pacing and, given the challenges of CS cannulation, His bundle pacing may represent a preferred modality rather than pure morphologic LV pacing or surgical systemic ventricular lead placement to achieve optimal electrical synchrony...
May 24, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28520951/non-selective-his-bundle-pacing-with-a-biphasic-waveform-enhancing-septal-resynchronization
#19
Daniel F Ortega, Luis D Barja, Emilio Logarzo, Nicolas Mangani, Analia Paolucci, Maria P Bonomini
Aims: His bundle pacing has shown to prevent detrimental effects from right ventricular apical pacing (RVA) and proved to resynchronize many conduction disturbances cases. However, the extent of His bundle pacing resynchronization is limited. An optimized stimulation waveform could expand this limit when implemented in His bundle pacing sets. In this work, we temporarily implemented RVA and Non-selective His bundle pacing with a biphasic anodal-first waveform (AF-nHB) and compared their effects against sinus rhythm (SR)...
May 17, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28520908/shortening-of-the-atrial-his-bundle-interval-during-atrial-pacing-as-a-predictor-of-successful-ablation-for-typical-atrioventricular-nodal-re-entrant-tachycardia
#20
Masahiro Nakano, Marehiko Ueda, Yusuke Kondo, Tomohiko Hayashi, Miyo Nakano, Kazuo Miyazawa, Masayuki Ishimura, Yoshio Kobayashi
Aims: Shortening of the atrial-His bundle (AH) interval during the sinus rhythm is occasionally observed after slow pathway ablation for atrioventricular nodal re-entrant tachycardia (AVNRT). In addition, high-rate atrial pacing is useful for avoiding atrioventricular block. We hypothesized that shortening of the AH interval during slow pathway ablation under high-rate atrial pacing would lead to successful ablation of typical AVNRT. Methods and results: This retrospective study included 37 patients in whom successful ablation of typical AVNRT was performed under atrial pacing...
May 17, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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