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Asthma–COPD Overlap Syndrome

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https://www.readbyqxmd.com/read/28431499/asthma-copd-overlap-syndrome-acos-in-primary-care-of-four-latin-america-countries-the-puma-study
#1
Maria Montes de Oca, Maria Victorina Lopez Varela, Maria E Laucho-Contreras, Alejandro Casas, Eduardo Schiavi, Juan Carlos Mora
BACKGROUND: Asthma-COPD overlap syndrome (ACOS) prevalence varies depending on the studied population and definition criteria. The prevalence and clinical characteristics of ACOS in an at-risk COPD primary care population from Latin America was assessed. METHODS: Patients ≥40 years, current/ex-smokers and/or exposed to biomass, attending routine primary care visits completed a questionnaire and performed spirometry. COPD was defined as post-bronchodilator forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) < 0...
April 21, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28431471/asthma-copd-overlap-syndrome-and-precision-medicine
#2
Somchai Bovornkitti
No abstract text is available yet for this article.
March 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28362516/reply-to-bias-in-association-between-fev1-fvc-predicted-at-7-years-and-asthma-copd-overlap-syndrome
#3
Dinh S Bui, John A Burgess, Minh Bui, Michael J Abramson, E Haydn Walters, Shyamali C Dharmage
No abstract text is available yet for this article.
March 31, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28362506/bias-in-association-between-fev1-fvc-predicted-at-7-years-and-asthma-copd-overlap-syndrome
#4
Erfan Ayubi, Saeid Safiri
No abstract text is available yet for this article.
March 31, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28283854/management-of-the-asthma-copd-overlap-syndrome-acos-a-review-of-the-evidence
#5
REVIEW
Kristin L Hines, R Stokes Peebles
PURPOSE OF REVIEW: Examine the definition of the asthma-COPD overlap syndrome (ACOS) and current treatment strategies. RECENT FINDINGS: Patients with the ACOS have a lower quality of life and suffer from more complications than those affected by either disease alone. Diagnosis of ACOS is difficult because of the clinical similarities between the two diseases and the various phenotypes that comprise the syndrome. Defining treatment strategies for ACOS has been challenging because many clinical trials for asthma therapy have purposefully excluded patients with features of COPD, and COPD clinical trials have not included patients who might have an asthmatic component to their disease...
March 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28282995/understanding-copd-overlap-syndromes
#6
Tuang Yeow Poh, Micheál Mac Aogáin, Adrian Kwok Wai Chan, Anthony Chau Ang Yii, Valerie Fei Lee Yong, Pei Yee Tiew, Mariko Siyue Koh, Sanjay Haresh Chotirmall
Chronic obstructive pulmonary disease accounts for a large burden of lung disease. It can 'overlap' with other respiratory diseases including bronchiectasis, fibrosis and obstructive sleep apnea (OSA). While COPD alone confers morbidity and mortality, common features with contrasting clinical outcomes can occur in COPD 'overlap syndromes'. Areas covered: Given the large degree of heterogeneity in COPD, individual variation to treatment is adopted based on its observed phenotype, which in turn overlaps with features of other respiratory disease states such as asthma...
March 24, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28268257/risk-factors-for-incident-asthma-and-copd-in-a-cohort-of-young-adults
#7
Lisbet Krogh Traulsen, Jesper Baelum, Anders Halling, Gert Thomsen, Trine Thilsing, David Sherson, Torben Sigsgaard, Øyvind Omland, Tine Malling, Lars Rauff Skadhauge
INTRODUCTION: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. METHODS: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. RESULTS: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5...
March 7, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28260876/heterogeneity-of-asthma-copd-overlap-syndrome
#8
Hyonsoo Joo, Deokjae Han, Jae Ha Lee, Chin Kook Rhee
Many patients suffering from asthma or COPD have overlapping features of both diseases. However, a phenotypical approach for evaluating asthma-COPD overlap syndrome (ACOS) has not been established. In this report, we examined the phenotypes in patients with ACOS. Patients diagnosed with ACOS between 2011 and 2015 were identified and classified into four phenotype groups. Group A was composed of patients who smoked <10 pack years and had blood eosinophil counts ≥300. Group B was composed of patients who smoked <10 pack years and had blood eosinophil counts <300...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28255811/sagittal-lung-ct-measurements-in-the-evaluation-of-asthma-copd-overlap-syndrome-a-distinctive-phenotype-from-copd-alone
#9
Yanjuan Qu, Yiyuan Cao, Meiyan Liao, Zhiyan Lu
OBJECTIVES: This study aimed at investigating the capability of sagittal-lung computed tomography (CT) measurements in differentiating chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS). METHODS: Clinical and high-resolution CT of 229 patients including 123 pure COPD patients and 106 ACOS patients were included. Sagittal-lung CT measurements in terms of bilateral lung height (LH), anterior-posterior lung diameter (APLD), diaphragm height (DH), and anterior sterno-diaphragmatic angle (ASDA), as well as inter-pulmonary septum length (IPSL) on axial images were measured both before and after bronchodilator (BD) administration...
March 3, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28243078/a-belgian-survey-on-the-diagnosis-of-asthma-copd-overlap-syndrome
#10
Didier Cataldo, Jean-Louis Corhay, Eric Derom, Renaud Louis, Eric Marchand, Alain Michils, Vincent Ninane, Rudi Peché, Charles Pilette, Walter Vincken, Wim Janssens
INTRODUCTION: Patients with chronic airway disease may present features of both asthma and COPD, commonly referred to as asthma-COPD overlap syndrome (ACOS). Recommendations on their diagnosis are diffuse and inconsistent. This survey aimed to identify consensus on criteria for diagnosing ACOS. METHODS: A Belgian expert panel developed a survey on ACOS diagnosis, which was completed by 87 pulmonologists. Answers chosen by ≥70% of survey respondents were considered as useful criteria for ACOS diagnosis...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28223792/asthma-copd-overlap-syndrome-in-the-us-a-prospective-population-based-analysis-of-patient-reported-outcomes-and-health-care-utilization
#11
Carlos A Vaz Fragoso, Terrence E Murphy, George O Agogo, Heather G Allore, Gail J McAvay
BACKGROUND: Prior work suggests that asthma-COPD overlap syndrome (ACOS) has a greater health burden than asthma alone or COPD alone. In the current study, we have further evaluated the health burden of ACOS in a nationally representative sample of the US population, focusing on patient-reported outcomes and health care utilization and on comparisons with asthma alone and COPD alone. Patient-reported outcomes are especially meaningful, as these include functional activities that are highly valued by patients and are the basis for patient-centered care...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28209039/-the-value-of-fractionated-exhaled-nitric-oxide-in-the-diagnosis-of-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome
#12
D D Deng, A Y Zhou, Q C Shuang, P Chen
Objective: To explore the diagnostic value of fractionated exhaled nitric oxide (FeNO) measurement in patients with asthma-chronic obstructive pulmonary disease(COPD) overlap syndrome (ACOS). Methods: Eighty-one patients with ACOS, 76 patients with asthma, 82 patients with COPD and 39 healthy non-smoking subjects were recruited in the study. Naku Lun breath analyzer was used to measure the level of FeNO in the 4 groups. Pulmonary function was also measured. The ROC curve was used to differentiate ACOS from patients with COPD...
February 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28149573/current-situation-of-asthma-copd-overlap-syndrome-acos-in-chinese-patients-older-than-40-years-with-airflow-limitation-rationale-and-design-for-a-multicenter-cross-sectional-trial-study-protocol
#13
Jian Kang, Wanzhen Yao, Baiqiang Cai, Ping Chen, Xia Ling, Hongyan Shang
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are the frequently occurring chronic airway diseases, and the overlapping syndrome observed in the majority of patients has been recently defined as asthma-COPD overlap syndrome (ACOS) by the Global Initiative for Chronic Obstructive Lung (GOLD, 2014) and Global initiative for Asthma (GINA, 2015). The proportion, features, and clinical practice of ACOS still remain elusive in China. We are conducting this multicenter, cross-sectional, observational study (NCT02600221) to investigate the distributions of chronic obstructive diseases in patients >40 years of age with chronic airflow limitation in China along with determination of the main clinical practice and features of these diseases...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28146643/childhood-lung-function-predicts-adult-copd-and-asthma-copd-overlap-syndrome-acos
#14
Dinh S Bui, John A Burgess, Adrian J Lowe, Jennifer L Perret, Caroline J Lodge, Minh Bui, Stephen Morrison, Bruce R Thompson, Paul S Thomas, Graham G Giles, Judith Garcia-Aymerich, Debbie Jarvis, Michael J Abramson, E Haydn Walters, Melanie C Matheson, Shyamali C Dharmage
RATIONALE: There are limited data on early life risk factors for COPD phenotypes. OBJECTIVE: To investigate the role of childhood lung function in adult spirometrically defined COPD phenotypes. METHOD: Pre-bronchodilator (BD) spirometry was performed for a cohort of 7-year old Tasmanian children. A sub-sample underwent pre-and post-BD spirometry at 45 years. For this analysis, COPD was spirometrically defined as a post-BD FEV1/FVC<lower limit of normal (LLN)...
February 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28145647/relationship-between-fractional-exhaled-nitric-oxide-level-and-efficacy-of-inhaled-corticosteroid-in-asthma-copd-overlap-syndrome-patients-with-different-disease-severity
#15
Jia Xi Feng, Yun Lin, Jian Lin, Su Su He, Mei Fang Chen, Xiao Mai Wu, You Zu Xu
This study explored the relationship between the fractional exhaled nitric oxide (FeNO) level and the efficacy of inhaled corticosteroid (ICS) in asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) patients with different disease severity. A total of 127 ACOS patients with ACOS (case group) and 131 healthy people (control group) were enrolled in this study. Based on the severity of COPD, the ACOS patients were divided into: mild ACOS; moderate ACOS; severe ACOS; and extremely severe ACOS groups...
March 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28119742/asthma-copd-overlap-syndrome-what-we-know-and-what-we-don-t
#16
REVIEW
Don D Sin
Approximately one in four patients with chronic obstructive pulmonary disease (COPD) have asthmatic features consisting of wheezing, airway hyper-responsiveness or atopy. The Global initiative for Asthma/Globalinitiative for chronic Obstructive Lung Disease committee recently labelled these patients as having asthma-COPD overlap syndrome or ACOS. ACOS also encompasses patients with asthma, ≥40 years of age, who have been cigarette smokers (more than 5-10 pack years) or have had significant biomass exposure, and demonstrate persistent airflow limitation defined as a post-bronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity of <70%...
January 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28103123/disease-burden-of-patients-with-asthma-copd-overlap-in-a-us-claims-database-impact-of-icd-9-coding-based-definitions
#17
Keele E Wurst, Samantha St Laurent, David Hinds, Kourtney J Davis
The inclusion of an asthma/chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) population in the 2015 Global Initiative for Chronic Obstructive Lung Disease strategic documents has raised questions about the profile of these patients in clinical practice, as they are mostly excluded from asthma and COPD clinical trials. We estimated the disease burden, co-morbidities, and respiratory treatments of patients with asthma/COPD overlap, utilizing the Truven MarketScan commercial and Medicare databases...
January 19, 2017: COPD
https://www.readbyqxmd.com/read/28100824/asthma-copd-overlap-syndrome-showed-more-exacerbations-however-lower-mortality-than-copd
#18
J-W Bai, B Mao, W-L Yang, S Liang, H-W Lu, J-F Xu
BACKGROUND: Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is a new determinate syndrome whose exact characteristics remain unclear. AIM: The objective of this study is to find more difference between ACOS and COPD. DESIGN: A retrospective study of ACOS and COPD in Chinese. METHODS: Data from 65 patients with ACOS and 65 patients with COPD were retrospectively collected and analyzed. The basis of this study was to compare the two groups while ruling out differences in age, sex and smoking history...
January 18, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28089081/asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-literature-review-and-contributions-towards-a-portuguese-consensus
#19
D Araújo, E Padrão, M Morais-Almeida, J Cardoso, F Pavão, R B Leite, A C Caldas, A Marques
INTRODUCTION: Phenotypic overlap between the two main chronic airway pulmonary diseases, asthma and chronic obstructive pulmonary disease (COPD), has been the subject of debate for decades, and recently the nomenclature of asthma-COPD overlap syndrome (ACOS) was adopted for this condition. The definition of this entity in the literature is, however, very heterogeneous, it is therefore important to define how it applies to Portugal. METHODS: A literature review of ACOS was made in a first phase resulting in the drawing up of a document that was later submitted for discussion among a panel of chronic lung diseases experts, resulting in reflexions about diagnosis, treatment and clinical guidance for ACOS patients...
January 6, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28055002/identifying-possible-asthma-copd-overlap-syndrome-in-patients-with-a-new-diagnosis-of-copd-in-primary-care
#20
Camilla Boslev Baarnes, Peter Kjeldgaard, Mia Nielsen, Marc Miravitlles, Charlotte Suppli Ulrik
The asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) remains poorly characterised. Our aim was to describe an algorithm for identifying possible ACOS in adults with newly diagnosed COPD in primary care. General practitioners (n=241) consecutively recruited subjects ⩾35 years, with tobacco exposure, at least one respiratory symptom and no previous diagnosis of obstructive lung disease. Possible ACOS was defined as chronic airflow obstruction, i.e., post-bronchodilator (BD) forced expiratory volume 1/forced vital capacity (FEV1/FVC) ratio<0...
January 5, 2017: NPJ Primary Care Respiratory Medicine
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