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https://www.readbyqxmd.com/read/28748882/superiority-of-peginterferon-%C3%AE-2a-and-ribavirin-combination-over-peginterferon-%C3%AE-2a-monotherapy-in-the-management-of-hemodialysis-patients-with-chronic-hepatitis-c-virus-infection
#1
Saeed M G Al-Ghamdi, Nasser Alaulaqi, Abdullah A Al-Amoudi, Amenah Alghamdi, Abbas Zagnoon, Bakr Ben Sadiq
Hepatitis C virus (HCV) is a common infection affecting 15% of hemodialysis population in Saudi Arabia resulting in delay in transplantation and long-term complications. The use of peginterferon resulted in sustained virologic response (SVR) in 40%-85% of patients, especially if combined with ribavirin. The treatment is hampered by the high dropout due to anemia and requirement of blood transfusion resulting from this therapy. Some studies have shown that the addition of increasing dose of erythropoiesis-stimulating agents (ESA) and reduced dose of ribavirin results in reduced dropout rate with high SVR...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748876/end-stage-renal-disease-in-patients-with-sickle-cell-disease
#2
Ahmed M Alkhunaizi, Adil A Al-Khatti, Samir H Al-Mueilo, Abdulrazack Amir, Bedri Yousif
Sickle cell nephropathy is a severe complication of sickle cell disease (SCD) that has a wide range of manifestations, from asymptomatic microalbuminuria to end-stage renal disease (ESRD). The data on patients with SCD who develop ESRD are scarce. The aim of this study was to explore the course of patients with SCD who developed ESRD and received renal replacement therapy (RRT). The course of patients with SCD who developed ESRD and started dialysis at two centers in the Eastern Province of Saudi Arabia was retrospectively analyzed...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748753/investigating-the-practices-of-patients-and-hospitals-in-treatment-of-diabetes-a-survey-questionnaire-for-arabic-speaking-countries
#3
Irfan Anjum Manarvi, Nader Mahr Matta, Abdulrahman Yassin
Diabetes is one of the most chronic diseases prevalent in Kingdom of Saudi Arabia. Its number of patients have increased in past few decades. Best efforts to provide world class treatments to patients through public and private hospitals are in hand. However, feedback of practices observed by patients and hospitals is not being achieved to assess the treatment efficacy. Absence of an elaborated questionnaire in Arabic language is a major hurdle to seek information from patients' due to their limited knowledge of English language in which most of the survey questionnaire exist in internationally published literature...
July 27, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28748359/analysis-of-medication-errors-at-a-large-tertiary-care-hospital-in-saudi-arabia-a-retrospective-analysis
#4
Sheraz Ali, Nourah Ibrahim Aboheimed, Ibrahim Abdulaziz Al-Zaagi, Dalal Salem Al-Dossari
Background Medication errors (MEs) are common in health care settings and pose a threat for the hospitalized population. Therefore, aspects of MEs were explored in a tertiary setting serving a diverse population. Objective To examine the occurrence, severity and reporting of MEs in hospitalized patients. Methods This retrospective analysis included 10,683 ME report forms that were received by the Medication Safety Unit of King Saud Medical City (KSMC) in 2015. ME outcomes were determined according to the National Coordinating Council for Medication Error Reporting and Prevention (NCC MERP) Index for categorizing MEs algorithm...
July 26, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28745902/disability-adjusted-life-years-dalys-for-315-diseases-and-injuries-and-healthy-life-expectancy-hale-in-iran-and-its-neighboring-countries-1990-2015-findings-from-global-burden-of-disease-study-2015
#5
Sadaf G Sepanlou, Mahboubeh Parsaeian, Kristopher J Krohn, Ashkan Afshin, Farshad Farzadfar, Gholamreza Roshandel, Chante Karimkhani, Sharzad Bazargan-Hejazi, Aliasghar Ahmad Kiadaliri, Hamid Ahmadieh, Shirin Djalalinia, Hedyeh Ebrahimi, Babak Eshrati, Ali Reza Esteghamati, Maryam S Farvid, Seyed-Mohammad Fereshtehnejad, Nima Hafezi-Nejad, Mohammad Sadegh Hassanvand, Pouria Heydarpour, Farhad Islami, Seyed M Karimi, Marzieh Katibeh, Ardeshir Khosravi, Jagdish Khubchandani, Mahdi Mahdavi, Farhad Pishgar, Mostafa Qorbani, Vafa Rahimi-Movaghar, Sare Safi, Mohammad Ali Sahraian, Saeid Shahraz, Sara Sheikhbahaei, Alireza Mohammadi, Ali H Mokdad, Theo Vos, Christopher J L Murray, Maziar Moradi-Lakeh, Mohsen Naghavi, Reza Malekzadeh
BACKGROUND: Summary measures of health are essential in making estimates of health status that are comparable across time and place. They can be used for assessing the performance of health systems, informing effective policy making, and monitoring the progress of nations toward achievement of sustainable development goals. The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) provides disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) as main summary measures of health...
July 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28743693/can-facebook-pages-be-a-mode-of-blended-learning-to-supplement-in-class-teaching-in-saudi-arabia
#6
Khurshid Anwar, Muhammad Raihan Sajid, Peter Cahusac, Abdul Ahad Shaikh, Ahmad Elgammal, Ahlam Alshedoukhy, Junaid Kashir
The aim of this study was to examine the potential of a self-designed Facebook page on Neuroscience, to supplement in-class teaching as a mode of blended learning. Posts were split into multiple choice questions (MCQs), general interest articles, neuroscience-related external links and resources, and lecture notes and PowerPoint presentations. The study was divided into three distinct phases: before, during, and after the Neuroscience block. Student responses were evaluated via a self-developed questionnaire...
September 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28743110/clinical-endocrine-and-molecular-genetic-analysis-of-a-large-cohort-of-saudi-arabian-patients-with-laron-syndrome
#7
Abdullah A Al-Ashwal, Afaf Al-Sagheir, Khushnooda Ramzan, Mohammed Al-Owain, Rabab Allam, Alya Qari, Nouf S Al-Numair, Faiqa Imtiaz
BACKGROUND/AIMS: Laron syndrome (LS) is an autosomal recessive disease characterized by marked short stature and very low serum IGF-1 and IGFBP-3 levels. This study assessed the clinical and endocrine features alongside determining the growth hormone receptor gene (GHR) mutation in Saudi Arabian patients with LS in order to establish whether or not a genotype/phenotype correlation is evident in this large cohort. SUBJECTS AND METHODS: A total of 40 Saudi Arabian patients with a suspected diagnosis of LS were recruited and subjected to a full clinical and endocrine investigation together with direct sequencing of the coding regions of the GHR gene...
July 25, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28742265/congenital-disorders-of-glycosylation-the-saudi-experience
#8
Sarah Alsubhi, Amal Alhashem, Eissa Faqeih, Majid Alfadhel, Abdullah Alfaifi, Waleed Altuwaijri, Saud Alsahli, Hesham Aldhalaan, Fowzan S Alkuraya, Khalid Hundallah, Adel Mahmoud, Ali Alasmari, Fuad Al Mutairi, Hanem Abduraouf, Layan AlRasheed, Saad Alshahwan, Brahim Tabarki
We retrospectively reviewed Saudi patients who had a congenital disorder of glycosylation (CDG). Twenty-seven Saudi patients (14 males, 13 females) from 13 unrelated families were identified. Based on molecular studies, the 27 CDG patients were classified into different subtypes: ALG9-CDG (8 patients, 29.5%), ALG3-CDG (7 patients, 26%), COG6-CDG (7 patients, 26%), MGAT2-CDG (3 patients, 11%), SLC35A2-CDG (1 patient), and PMM2-CDG (1 patient). All the patients had homozygous gene mutations. The combined carrier frequency of CDG for the encountered founder mutations in the Saudi population is 11...
July 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28740416/determinants-and-prevalence-of-depression-in-patients-with-chronic-renal-disease-and-their-caregivers
#9
Sana Hawamdeh, Aljawharah Mohammed Almari, Asrar Salem Almutairi, Wireen Leila T Dator
INTRODUCTION: This study explored the prevalence of depression among the patients with chronic kidney disease and their caregivers and its association to their demographic profile. METHODS: A descriptive, correlational, cross-sectional study that used the Hamilton rating scale tool to assess the prevalence of depression among 226 patients undergoing hemodialysis and 105 of their caregivers in a hospital in Saudi Arabia. RESULTS: Patients with chronic renal disease and their caregivers experience depression at varying levels...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28738384/sweet-taste-perception-and-dental-caries-in-13-to-15-year-olds-a-multicenter-cross-sectional-study
#10
H Ashi, C Lara-Capi, G Campus, G Klingberg, P Lingström
Dietary habits and, in particular, the intake frequency of sucrose are of major importance for the development of dental caries. The perception of sweet taste is believed to have an influence on sucrose intake and therefore affects the predisposition to dental caries. The aim was to study the caries experience and sweet taste perception and to further analyze the possible relationship between the 2 tested variables in 13- to 15-year-old children from 3 different geographical areas. A cross-sectional survey comprising 669 children (220 Italian, 224 Mexican, and 225 Saudi Arabian) was conducted...
July 25, 2017: Caries Research
https://www.readbyqxmd.com/read/28736939/fetal-hemoglobin-in-sickle-cell-anemia-the-arab-indian-haplotype-and-new-therapeutic-agents
#11
REVIEW
Alawi H Habara, Elmutaz M Shaikho, Martin H Steinberg
Fetal hemoglobin (HbF) has well-known tempering effects on the symptoms of sickle cell disease and its levels vary among patients with different haplotypes of the sickle hemoglobin gene. Compared with sickle cell anemia haplotypes found in patients of African descent, HbF levels in Saudi and Indian patients with the Arab-Indian (AI) haplotype exceed that in any other haplotype by nearly two-fold. Genetic association studies have identified some loci associated with high HbF in the AI haplotype but these observations require functional confirmation...
July 24, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28735327/genotyping-and-clinicoepidemiological-characterization-of-rotavirus-acute-gastroenteritis-in-egyptian-children
#12
Niveen Saudy, Walaa Othman Elshabrawy, Ahmed Megahed, Mona F Foad, Aly F Mohamed
Group A rotavirus (RVA) acute gastroenteritis (AGE) is a common cause of severe childhood diarrhea. The dominant circulating RVA genotypes in a given region may vary between and within the geographic regions and from year to year. Our cross-sectional study was designed to determine the burden of RVA genotypes among children with AGE admitted to referral Children Hospital at Egypt prior to implementation of the vaccine. Stool samples with clinico-epidemiological data were collected from 92 children ≤ 3 years-old with AGE...
January 2, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/28735259/observational-study-on-the-palatability-and-tolerability-of-oral-prednisolone-and-oral-dexamethasone-in-children-in-saudi-arabia-and-the-uk
#13
Fahad Aljebab, Mofadhi Alanazi, Imti Choonara, Sharon Conroy
BACKGROUND: Short-course oral corticosteroids are routinely used to treat acute asthma and croup. We evaluated their tolerability and palatability in Saudi Arabian (SA) and UK children. METHODS: Prospective observational/interview study (3 months in each country). Palatability was evaluated using a 5-point facial Hedonicscale and tolerability by direct questioning of patient/parents. RESULTS: In SA, of 122 patients (2-10 years) recruited, 52 received prednisolone base tablets, 37 prednisolone sodium phosphate syrup and 33 received dexamethasone elixir...
July 22, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28734432/outbreak-of-middle-east-respiratory-syndrome-coronavirus-causes-high-fatality-after-cardiac-operations
#14
Rakan I Nazer
Middle East respiratory syndrome-coronavirus (MERS-CoV) resembles a severe form of community-acquired pneumonia initially reported in Saudi Arabia in 2012. The MERS-CoV epidemic poses a big challenge because of its high mortality. In January 2015, a patient who was potentially incubating MERS-CoV arrived from the emergency department of another hospital and was admitted with acute coronary syndrome. This resulted in an outbreak in the cardiac surgery ward that caused the deaths of 5 of 6 patients who had undergone cardiac operations...
August 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28732090/incidence-predictors-and-severity-of-adverse-events-among-whole-blood-donors
#15
Hamdan Almutairi, Mahmoud Salam, Abdulaziz Alajlan, Faisal Wani, Bushra Al-Shammari, Khaled Al-Surimi
BACKGROUND: Adverse events have been reported post blood donation. Donors might refrain from donating again due to such events which lowers the blood supply in collection centers. AIM: This study measured the incidence, predictors and severity of adverse events among donors of a single whole blood unit at one of the largest donation centers in Saudi Arabia. METHODS: A retrospective cohort was conducted in 2015 to investigate the adverse events immediately post donation...
2017: PloS One
https://www.readbyqxmd.com/read/28731615/the-prevalence-of-ccr5-%C3%AE-32-mutation-in-a-cohort-of-saudi-stem-cell-donors
#16
M Alarifi, F Al-Amro, A Alalwan, A Al-Turki, H Fakhoury, N Atallah, M Al Muallimi, M Al-Balwi, M ALzahrani, A Alaskar, A Hajeer, D Jawdat
CCR5 is a chemokine receptor that also was found to be used by HIV as a co-receptor for entering target cells. A 32 bp deletion was described in certain people that rendered CCR5 non-functional. The mutant allele CCR5-Δ32 has been shown to prevent HIV infection. In addition, stem cell transplantation with the CCR5-Δ32 homozygous genotype can lead to clearance of HIV infection. In this study, our aim was to investigate the frequency of CCR5-Δ32 mutation in a cohort of stem cell donors from cord blood bank and stem cell donor registry...
July 21, 2017: HLA
https://www.readbyqxmd.com/read/28728926/diagnostic-delays-in-537-symptomatic-cases-of-mers-cov-infection-in-saudi-arabia
#17
Anwar E Ahmed
BACKGROUND: Although the literature indicates the potential outcomes of a patient's delay in seeking medical support is associated with poor clinical outcomes, delays in the diagnosis itself remain poorly understood in patients with Middle East Respiratory Syndrome - Coronavirus (MERS-CoV). This study aims to estimate the median time interval of confirmed diagnosis after symptom onset and identify its potential predictors in Saudi Arabian MERS patients. METHODS: A retrospective study involved patients confirmed with MERS who were publicly reported by the World Health Organization (WHO)...
July 17, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28725440/description-of-beduinibacterium-massiliense-gen-nov-sp-nov-massilimaliae-massiliensis-gen-nov-sp-nov-provencibacterium-massiliense-gen-nov-sp-nov-and-oscilibacter-massiliensis-sp-nov-isolated-from-a-faecal-specimen-of-a-19-year-old-healthy-saudi-arabian-bedouin
#18
S I Traore, E I Azhar, M Yasir, F Bibi, P-E Fournier, A A Jiman-Fatani, J Delerce, F Cadoret, J-C Lagier, D Raoult
We report here the main characteristics of 'Beduinibacterium massiliense' strain Marseille-P3337(T) gen. nov., sp. nov., 'Massilimaliae massiliensis' Marseille-P2963(T) gen. nov., sp. nov., 'Provencibacterium massiliense' Marseille-P2780(T) gen. nov., sp. nov. and 'Oscilibacter massiliensis' Marseille-P2778(T) sp. nov., all isolated from the stool of a Bedouin from Saudi Arabia. We used a bacterial culturomics approach combined with taxonogenomics.
September 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28725327/prevalence-of-undiagnosed-cardiovascular-risk-factors-in-adults-aged-20-40-a-cross-sectional-study-in-2016-in-jeddah-saudi-arabia
#19
Faisal Saed Alharthi, Jamilah Saad Alrahimi, Abdulrahman Ali Alotaibi, Daniah Ahmed Alhamdi, Bashair Mohammed Ibrahim, Yasmina Aymen Badeeb
BACKGROUND: Cardiovascular diseases (CVDs) are the first leading cause of death worldwide. In Saudi Arabia, CVDs are the major killers with a mortality rate of 46%. CVD risk factors are not exclusive to old populations. Thus, the purpose of this study was to approximately find the prevalence of these risk factors, particularly high blood pressure (HBP), high blood glucose (HBG), obesity, and smoking. METHODS: This cross-sectional was conducted in May 2016 and took place in the Ambulatory Care Center of King Abdulaziz Medical City, Jeddah...
June 2017: Cardiology Research
https://www.readbyqxmd.com/read/28725317/prevalence-of-metabolic-syndrome-among-the-end-stage-renal-disease-patients-on-hemodialysis
#20
Khaled A Alswat, Awwadh Althobaiti, Khulod Alsaadi, Amaal Saeed Alkhaldi, Maryam Mutlaq Alharthi, Walaa Abduraheem Abuharba, Ahmed A Alzaidi
BACKGROUND: Patients with metabolic syndrome (MetS) have a 2.6-fold greater risk of incident chronic kidney disease (CKD). The primary goal of this study was to assess the prevalence of MetS in patients with end-stage renal disease (ESRD) who are on hemodialysis (HD) and the impact of MetS presence on HD-related outcomes. METHODS: This is a cross-sectional study conducted in the Dialysis Center, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia. It was conducted among ESRD patients that attended the Dialysis Center between August 2013 and September 2016...
August 2017: Journal of Clinical Medicine Research
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