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https://www.readbyqxmd.com/read/28012441/ugonin-u-stimulates-nlrp3-inflammasome-activation-and-enhances-inflammasome-mediated-pathogen-clearance
#1
Chun-Yu Chen, Chuan-Hui Yang, Yung-Fong Tsai, Chih-Chuang Liaw, Wen-Yi Chang, Tsong-Long Hwang
The NOD-like receptor pyrin domain 3 (NLRP3) inflammasome contains Nod-like receptors, a subclass of pattern recognition receptors, suggesting that this complex has a prominent role in host defenses. Various structurally diverse stimulators activate the NLRP3 inflammasome through different signaling pathways. We previously reported that ugonin U (UgU), a natural flavonoid isolated from Helminthostachys zeylanica (L) Hook, directly stimulates phospholipase C (PLC) and triggers superoxide release in human neutrophils...
April 2017: Redox Biology
https://www.readbyqxmd.com/read/27993998/the-pathogenic-role-of-nlrp3-inflammasome-activation-in-inflammatory-bowel-diseases-of-both-mice-and-humans
#2
Ling Liu, Ying Dong, Mei Ye, Shi Jin, Jianbo Yang, Maria E Joosse, Yu Sun, Jennifer Zhang, Mark Lazarev, Steven R Brant, Bashar Safar, Michael Marohn, Esteban Mezey, Xuhang Li
BACKGROUND AND AIMS: NLRP3 inflammasome is known to be involved in inflammatory bowel diseases. However, it is controversial if it is pathogenic or beneficial. This study evaluated the roles of NLRP3-inflammasome in the pathogenesis of inflammatory bowel disease in IL-10-/- mice and humans. METHODS: NLRP3 inflammasome in colonic mucosa, macrophages, and colonic epithelial cells were analyzed by Western blotting. The NLRP3 inflammasome components were studied by sucrose density gradient fractionation, chemical crosslinking and co-immunoprecipitation...
December 17, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27918955/defective-production-of-interleukin-1-beta-in-patients-with-type-2-diabetes-mellitus-restoration-by-proper-glycemic-control
#3
Foteini Kousathana, Marianna Georgitsi, Vaia Lambadiari, Evangelos J Giamarellos-Bourboulis, George Dimitriadis, Maria Mouktaroudi
The underlying immune defect of susceptibility in diabetes mellitus type 2 to infections remains unknown. The qualitative changes in cytokine biosynthesis by circulating mononuclear cells (PBMCs) and its modulation by glycemic control were investigated. PBMCs were isolated from 39 patients and 25 controls. They were stimulated with purified ligands and heat-killed bacteria in the absence/presence of glucose and NLPR3 inflammasome ligands. Experiments were repeated after 3 and 6months. Cytokine production was measured in cell supernatants; pro-interleukin(IL)-1 β was measured in cell lysates...
December 2, 2016: Cytokine
https://www.readbyqxmd.com/read/27446957/nalp3-inflammasome-related-gene-polymorphisms-in-patients-with-prehypertension-and-coronary-atherosclerosis
#4
Xin Zhao, Chonghuai Gu, Chenghui Yan, Xiaolin Zhang, Yi Li, Li Wang, Lili Ren, Yan Zhang, Junyin Peng, Zhiming Zhu, Yaling Han
Objectives. Prehypertension is an early stage of hypertension that is characterized by inflammatory factors. Inflammation also plays an essential role in the development of coronary atherosclerosis (CAS). The present study evaluated the NALP3-inflammasome and its related genes, NLRP3, NOD2, and CARD8, using SNP linkage and gene haplotypes in prehypertensive patients. Methods. A total of 576 patients with prehypertension and suspected coronary heart disease (CHD) were enrolled. According to coronary angiography, patients were divided into two groups: arterial stenosis <50% of the diameter (control) and arterial stenosis >50% of the diameter (case)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27270216/cinnamaldehyde-and-allopurinol-reduce-fructose-induced-cardiac-inflammation-and-fibrosis-by-attenuating-cd36-mediated-tlr4-6-irak4-1-signaling-to-suppress-nlrp3-inflammasome-activation
#5
Lin-Lin Kang, Dong-Mei Zhang, Chun-Hua Ma, Jian-Hua Zhang, Ke-Ke Jia, Jia-Hui Liu, Rong Wang, Ling-Dong Kong
Fructose consumption induces metabolic syndrome to increase cardiovascular disease risk. Cinnamaldehyde and allopurinol possess anti-oxidative and anti-inflammatory activity to relieve heart injury in metabolic syndrome. But the mechanisms of fructose-induced cardiac injury, and cardioprotective effects of cinnamaldehyde and allopurinol are not completely understood. In this study, fructose-fed rats displayed metabolic syndrome with elevated serum ox-LDL, cardiac oxidative stress, inflammation and fibrosis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27128945/a-cellular-gwas-approach-to-define-human-variation-in-cellular-pathways-important-to-inflammation
#6
REVIEW
Samuel I Miller, Anu Chaudhary
An understanding of common human diversity in innate immune pathways should be beneficial in understanding autoimmune diseases, susceptibility to infection, and choices of anti-inflammatory treatment. Such understanding could also result in definition of currently unknown components of human inflammation pathways. A cellular genome-wide association studies (GWAS) platform, termed Hi-HOST (High-throughput human in vitro susceptibility testing), was developed to assay in vitro cellular phenotypes of infection in genotyped lymphoblastoid cells from genetically diverse human populations...
2016: Pathogens
https://www.readbyqxmd.com/read/27021275/the-role-of-the-innate-immune-system-in-destruction-of-pancreatic-beta-cells-in-nod-mice-and-humans-with-type-i-diabetes
#7
REVIEW
Ningwen Tai, F Susan Wong, Li Wen
Type 1 diabetes (T1D) is an organ-specific autoimmune disease characterized by T cell-mediated destruction of the insulin-producing pancreatic β cells. A combination of genetic and environmental factors eventually leads to the loss of functional β cell mass and hyperglycemia. Both innate and adaptive immunity are involved in the development of T1D. In this review, we have highlighted the most recent findings on the role of innate immunity, especially the pattern recognition receptors (PRRs), in disease development...
July 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/26683645/chorea-in-a-patient-with-cryopyrin-associated-periodic-syndrome
#8
Christopher J Schwarzbach, Wilhelm H Schmitt, Kristina Szabo, Hansjoerg Bäzner, Michael G Hennerici, Christian Blahak
OBJECTIVE: To describe a patient with cryopyrin-associated periodic syndrome (CAPS) with an uncommon neurologic phenotype and a rare underlying genetic mutation. RESULTS: Our patient had CAPS with a rare NLPR3 missense mutation (p.Tyr859Cys) in exon 6 with chorea as the major symptom. Clinical symptoms were associated with persistent inflammatory changes of the CSF and serum and included elevated anticardiolipin immunoglobulin G; MRI showed prolonged gadolinium enhancement of 2 chronic inflammatory lesions...
January 19, 2016: Neurology
https://www.readbyqxmd.com/read/26650800/magnesium-lithospermate-b-acts-against-dextran-sodiumsulfate-induced-ulcerative-colitis-by-inhibiting-activation-of-the-nrlp3-asc-caspase-1-pathway
#9
Xiaoyun Jiang, Liang Zhong, Dayu Sun, Lan Rong
This study aimed to observe the therapeutic effects of magnesium lithospermate B on acute and chronic colitis induced by dextran sodiumsulfate (DSS) and the role of inflammasome complex (NOD-like receptor protein, NLRP; apoptosis-associated speck-like protein containing, ASC; caspase-1). Establishment of acute and chronic colitis models were by using 5% DSS oral administration in BALB/C male mice. Magnesium lithospermate B (240 mg/kg body weight) was given by subcutaneous injection. Samples were collected for biomarker assay, histological examination, immunohistochemical evaluation and western blot...
January 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/26556233/editorial-is-the-nlpr3-inflammasome-overheated-by-pneumococcal-vaccination-in-cryopyrin-associated-periodic-syndromes
#10
EDITORIAL
Insoo Kang
No abstract text is available yet for this article.
February 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26246158/tissue-specific-expression-pattern-and-histological-distribution-of-nlrp3-in-chinese-yellow-chicken
#11
Jinhui Ye, Meng Yu, Kaizhao Zhang, Jianxin Liu, Qingnan Wang, Pan Tao, Kun Jia, Ming Liao, Zhangyong Ning
Pathogen-associated molecular patterns (PAMPs) play important role in inflammation which means response of the host to stimuli. NOD-like receptor protein 3 (NLRP3) inflammasome is involved in the onset and development of inflammation. NLRP3, as one of the most important inflammasome sensors, has significant effect on the regulation of inflammasome activation to avoid the consequences of over activation. Up to date, there are no detailed tissue specific expression and distribution data about NLPR3 in chicken...
September 2015: Veterinary Research Communications
https://www.readbyqxmd.com/read/25879283/nlrp3-at-the-interface-of-metabolism-and-inflammation
#12
REVIEW
Moritz Haneklaus, Luke A J O'Neill
The discovery of the NLRP3 (NLR family, pyrin domain containing 3) inflammasome provided an important molecular mechanism in the induction of the central pro-inflammatory cytokine interleukin-1β (IL-1β), via activation of caspase-1, which processes pro-IL-1β into its mature active form. IL-1 has long been known to exert metabolic effects, most notably being implicated in insulin resistance and obesity. A key phenotype of the NLRP3-deficient mouse is insulin hypersensitivity. Over the past 5 years, a number of discoveries have been made suggesting a close interplay between NLRP3 and metabolism...
May 2015: Immunological Reviews
https://www.readbyqxmd.com/read/25761061/nlrp3-mediates-nf-%C3%AE%C2%BAb-activation-and-cytokine-induction-in-microbially-induced-and-sterile-inflammation
#13
Takeshi Kinoshita, Ryu Imamura, Hiroko Kushiyama, Takashi Suda
Nucleotide-binding domain and leucine-rich repeat-containing family, pyrin domain containing 3 (NLRP3) has recently emerged as a central regulator of innate immunity and inflammation in response to both sterile inflammatory and microbial invasion signals. Although its ability to drive proteolytic procaspase-1 processing has drawn more attention, NLPR3 can also activate NF-κB. To clarify the physiological relevance of this latter function, we examined the effect of NLRP3 on NF-κB activation and cytokine induction in RNA-interference-based NLRP3-knockdown cell lines generated from the human monocytic cell line THP-1...
2015: PloS One
https://www.readbyqxmd.com/read/25714839/caspase-1-activation-by-nlrp3-inflammasome-dampens-il-33-dependent-house-dust-mite-induced-allergic-lung-inflammation
#14
Fahima Madouri, Noëlline Guillou, Louis Fauconnier, Tiffany Marchiol, Nathalie Rouxel, Pauline Chenuet, Aurélie Ledru, Lionel Apetoh, François Ghiringhelli, Mathias Chamaillard, Song Guo Zheng, Fabrice Trovero, Valérie F J Quesniaux, Bernhard Ryffel, Dieudonnée Togbe
The cysteine protease caspase-1 (Casp-1) contributes to innate immunity through the assembly of NLRP3, NLRC4, AIM2, and NLRP6 inflammasomes. Here we ask whether caspase-1 activation plays a regulatory role in house dust mite (HDM)-induced experimental allergic airway inflammation. We report enhanced airway inflammation in caspase-1-deficient mice exposed to HDM with a marked eosinophil recruitment, increased expression of IL-4, IL-5, IL-13, as well as full-length and bioactive IL-33. Furthermore, mice deficient for NLRP3 failed to control eosinophil influx in the airways and displayed augmented Th2 cytokine and chemokine levels, suggesting that the NLPR3 inflammasome complex controls HDM-induced inflammation...
August 2015: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/25709906/herpes-simplex-virus-1-infection-or-simian-virus-40-mediated-immortalization-of-corneal-cells-causes-permanent-translocation-of-nlrp3-to-the-nuclei
#15
Shu-Long Wang, Ge Zhao, Wei Zhu, Xiao-Meng Dong, Ting Liu, Yuan-Yuan Li, Wen-Gang Song, Yi-Qiang Wang
AIM: To investigate into the potential involvement of pyrin containing 3 gene (NLRP3), a member of the nucleotide-binding oligomerization domain-like receptors with cytosolic pattern recognition, in the host defense of corneas against viruses. METHODS: The herpes viral keratitis model was utilized in BALB/c mice with inoculation of herpes simplex virus-1 (HSV-1). Corneal tissues removed during therapy of patients with viral keratitis as well as a Simian vacuolating virus 40 (SV40)-immortalized human corneal epithelial cell line were also examined...
2015: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/25680906/macrophage-inflammasome-mediates-hyperhomocysteinemia-aggravated-abdominal-aortic-aneurysm
#16
Weiliang Sun, Yanli Pang, Ziyi Liu, Lulu Sun, Bo Liu, Mingjiang Xu, Yongqiang Dong, Juan Feng, Changtao Jiang, Wei Kong, Xian Wang
Abdominal aortic aneurysm (AAA) is a serious vascular disease with high mortality. Our previous study suggested that hyperhomocysteinemia (HHcy) exaggerates the occurrence of AAA. Here, we investigated whether macrophage inflammasome is involved in HHcy-aggravated AAA formation. Two independent HHcy-aggravated AAA models, perivascular calcium phosphate-treated C57BL/6 mice and angiotensin II (Ang II)-infused apolipoprotein E-deficient (ApoE(-/-)) mice were used. NLPR3, caspase 1, and interleukin-1β (IL-1β) levels were higher in aneurysmal lesions of both HHcy models compared to controls, preferentially in macrophages...
April 2015: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/24988285/the-nucleotide-binding-domain-leucine-rich-repeat-protein-3-inflammasome-il-1-receptor-i-axis-mediates-innate-but-not-adaptive-immune-responses-after-exposure-to-particulate-matter-under-10-%C3%AE-m
#17
Jeremy A Hirota, Matthew J Gold, Paul R Hiebert, Leigh G Parkinson, Tracee Wee, Dirk Smith, Phil M Hansbro, Chris Carlsten, Stephan VanEeden, Don D Sin, Kelly M McNagny, Darryl A Knight
Exposure to particulate matter (PM), a major component of air pollution, contributes to increased morbidity and mortality worldwide. Inhaled PM induces innate immune responses by airway epithelial cells that may lead to the exacerbation or de novo development of airway disease. We have previously shown that 10-μm PM (PM10) activates the nucleotide-binding domain, leucine-rich repeat protein (NLRP) 3 inflammasome in human airway epithelial cells. Our objective was to determine the innate and adaptive immune responses mediated by the airway epithelium NLRP3 inflammasome in response to PM10 exposure...
January 2015: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/24836981/reactive-oxygen-species-activated-nlrp3-inflammasomes-prime-environment-induced-murine-dry-eye
#18
Qinxiang Zheng, Yueping Ren, Peter S Reinach, Yujing She, Bing Xiao, Shanshan Hua, Jia Qu, Wei Chen
Tear film hyperosmolarity along with exposure to oxidant stress are factors that can induce chronic ocular surface inflammation and pain. However, there is limited information on how increases in reactive oxygen species (ROS) generated by oxidant exposure can induce inflammation. There is emerging evidence in other tissues that innate immune responses to a variety of environmental stresses stem from ROS-induced cytosolic NLRP3 inflammasome activation. Once this occurs, pro-caspase-1 is converted into its catalytic active form, which in turn cleaves pro-IL-1β thereby generating its bioactive form...
August 2014: Experimental Eye Research
https://www.readbyqxmd.com/read/24013717/obesity-phenotype-is-related-to-nlrp3-inflammasome-activity-and-immunological-profile-of-visceral-adipose-tissue
#19
Nathalie Esser, Laurent L'homme, Arnaud De Roover, Laurent Kohnen, André J Scheen, Michel Moutschen, Jacques Piette, Sylvie Legrand-Poels, Nicolas Paquot
AIMS/HYPOTHESIS: Obesity is a heterogeneous condition comprising both individuals who remain metabolically healthy (MHO) and those who develop metabolic disorders (metabolically unhealthy, MUO). Adipose tissue is also heterogeneous in that its visceral component is more frequently associated with metabolic dysfunction than its subcutaneous component. The development of metabolic disorders is partly mediated by the NLR family pyrin domain containing-3 (NLRP3) inflammasome, which increases the secretion of inflammatory cytokines via activation of caspase-1...
November 2013: Diabetologia
https://www.readbyqxmd.com/read/23995473/tipping-the-inflammatory-balance-inflammasome-activation-distinguishes-metabolically-unhealthy-from-healthy-obesity
#20
Rinke Stienstra, Norbert Stefan
Expansion of adipose tissue mass, predominantly in the visceral depot, strongly associates with the development of metabolic complications that are often observed in obesity. In addition, in obesity, an increased prevalence of nonalcoholic fatty liver disease and reduced cardiorespiratory fitness are observed. However, not all obese individuals develop metabolic abnormalities. To better understand the molecular mechanisms that predispose obese humans to the development of metabolic diseases, comparing the metabolically healthy obese (MHO) vs an unhealthy obese phenotype (MUO) may be of great value...
November 2013: Diabetologia
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